JP2024518793A5 - - Google Patents
Info
- Publication number
- JP2024518793A5 JP2024518793A5 JP2023571310A JP2023571310A JP2024518793A5 JP 2024518793 A5 JP2024518793 A5 JP 2024518793A5 JP 2023571310 A JP2023571310 A JP 2023571310A JP 2023571310 A JP2023571310 A JP 2023571310A JP 2024518793 A5 JP2024518793 A5 JP 2024518793A5
- Authority
- JP
- Japan
- Prior art keywords
- nuclear localization
- localization signal
- protein
- cas9 effector
- effector protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163193620P | 2021-05-27 | 2021-05-27 | |
| US63/193,620 | 2021-05-27 | ||
| PCT/EP2022/064368 WO2022248645A1 (en) | 2021-05-27 | 2022-05-26 | Cas9 effector proteins with enhanced stability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024518793A JP2024518793A (ja) | 2024-05-02 |
| JP2024518793A5 true JP2024518793A5 (https=) | 2025-07-22 |
Family
ID=82117168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023571310A Pending JP2024518793A (ja) | 2021-05-27 | 2022-05-26 | 向上した安定性を有するｃａｓ９エフェクタータンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240384246A1 (https=) |
| EP (1) | EP4347805A1 (https=) |
| JP (1) | JP2024518793A (https=) |
| CN (1) | CN117396602A (https=) |
| WO (1) | WO2022248645A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115716880A (zh) * | 2022-12-07 | 2023-02-28 | 云舟生物科技(广州)股份有限公司 | 一种核定位荧光蛋白及其应用 |
| EP4678742A1 (en) * | 2024-07-10 | 2026-01-14 | Astrazeneca AB | Improved cas9 proteins |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5895309A (en) | 1998-02-09 | 1999-04-20 | Spector; Donald | Collapsible hula-hoop |
| JP2005511761A (ja) * | 2001-07-10 | 2005-04-28 | ノース・キャロライナ・ステイト・ユニヴァーシティ | ナノ粒子送達ビヒクル |
| JP2008078613A (ja) | 2006-08-24 | 2008-04-03 | Rohm Co Ltd | 窒化物半導体の製造方法及び窒化物半導体素子 |
| EP3269395A1 (en) | 2008-11-07 | 2018-01-17 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| EP2691443B1 (en) | 2011-03-28 | 2021-02-17 | Massachusetts Institute of Technology | Conjugated lipomers and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| CA2913234A1 (en) | 2013-05-22 | 2014-11-27 | Northwestern University | Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| EP4321623A3 (en) * | 2016-07-15 | 2024-05-15 | Salk Institute for Biological Studies | Methods and compositions for genome editing in non-dividing cells |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20230125856A (ko) | 2016-12-23 | 2023-08-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Pcsk9의 유전자 편집 |
| CN106632693B (zh) * | 2017-01-19 | 2021-05-25 | 上海科技大学 | 具有多个核定位序列的SpyCas9蛋白及其应用 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| CN120310773A (zh) | 2017-11-16 | 2025-07-15 | 阿斯利康(瑞典)有限公司 | 用于改善基于Cas9的敲入策略的有效性的组合物和方法 |
| WO2019213273A1 (en) * | 2018-05-01 | 2019-11-07 | The Children's Medical Center Corporation | Enhanced bcl11a rnp / crispr delivery & editing using a 3xnls-cas9 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
-
2022
- 2022-05-26 US US18/559,598 patent/US20240384246A1/en active Pending
- 2022-05-26 WO PCT/EP2022/064368 patent/WO2022248645A1/en not_active Ceased
- 2022-05-26 CN CN202280037340.4A patent/CN117396602A/zh active Pending
- 2022-05-26 JP JP2023571310A patent/JP2024518793A/ja active Pending
- 2022-05-26 EP EP22732040.5A patent/EP4347805A1/en active Pending
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