JP2024513003A - Ｃｓｆ１ｒアンタゴニストに対する耐性を付与するための哺乳動物細胞の遺伝子改変 - Google Patents

Ｃｓｆ１ｒアンタゴニストに対する耐性を付与するための哺乳動物細胞の遺伝子改変 Download PDF

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JP2024513003A
JP2024513003A JP2023559849A JP2023559849A JP2024513003A JP 2024513003 A JP2024513003 A JP 2024513003A JP 2023559849 A JP2023559849 A JP 2023559849A JP 2023559849 A JP2023559849 A JP 2023559849A JP 2024513003 A JP2024513003 A JP 2024513003A
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csf1r
cell
modified
cells
antagonist
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ダフチャン、ハイク
ハッセルマン、ジョナサン
－ ジョーンズ、マシュー ブラートン
チャダレビアン、ジャン、ポール
スピテール、ロバート
ガンジー、スニール
イングランド、ホイットニー
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University of California San Diego UCSD
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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JP2023559849A 2021-04-01 2022-04-01 Ｃｓｆ１ｒアンタゴニストに対する耐性を付与するための哺乳動物細胞の遺伝子改変 Pending JP2024513003A (ja)

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US202163169578P 2021-04-01 2021-04-01
US63/169,578 2021-04-01
US202163236951P 2021-08-25 2021-08-25
US63/236,951 2021-08-25
PCT/US2022/023139 WO2022212897A1 (en) 2021-04-01 2022-04-01 Genetic modification of mammalian cells to confer resistance to csf1r antagonists

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JP2024513003A true JP2024513003A (ja) 2024-03-21
JP2024513003A5 JP2024513003A5 (https=) 2025-04-03

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US (3) US12421517B2 (https=)
EP (1) EP4314003A4 (https=)
JP (1) JP2024513003A (https=)
AU (1) AU2022252407A1 (https=)
CA (1) CA3215311A1 (https=)
DE (4) DE112022000079T5 (https=)
GB (1) GB2612467B (https=)
WO (1) WO2022212897A1 (https=)

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US12612599B2 (en) 2018-09-10 2026-04-28 Savanna Biotherapeutics, Inc. Compositions and methods for microglia replacement therapy
CA3215311A1 (en) 2021-04-01 2022-10-06 The Regents Of The University Of California Genetic modification of mammalian cells to confer resistance to csf1r antagonists

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US20250002920A1 (en) 2025-01-02
DE202022003132U1 (de) 2025-02-17
DE202022003066U1 (de) 2024-09-19
US12421517B2 (en) 2025-09-23
US20230203500A1 (en) 2023-06-29
CA3215311A1 (en) 2022-10-06
GB202219686D0 (en) 2023-02-08
US20230248775A1 (en) 2023-08-10
AU2022252407A9 (en) 2023-10-26
EP4314003A4 (en) 2025-03-12
DE112022000079T5 (de) 2023-06-15
EP4314003A1 (en) 2024-02-07
AU2022252407A1 (en) 2023-10-12
WO2022212897A1 (en) 2022-10-06
DE202022002866U1 (de) 2024-03-20
GB2612467B (en) 2025-11-19
GB2612467A (en) 2023-05-03

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