DE112022000079T5 - Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten - Google Patents

Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten Download PDF

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Publication number
DE112022000079T5
DE112022000079T5 DE112022000079.1T DE112022000079T DE112022000079T5 DE 112022000079 T5 DE112022000079 T5 DE 112022000079T5 DE 112022000079 T DE112022000079 T DE 112022000079T DE 112022000079 T5 DE112022000079 T5 DE 112022000079T5
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csf1r
cell
modified
antagonist
expressing
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German (de)
English (en)
Inventor
Hayk Davtyan
Jonathan Hasselmann
Mathew BLURTON-JONES
Jean Paul Chadarevian
Robert Spitale
Sunil Gandhi
Whitney England
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University of California
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University of California Berkeley
University of California San Diego UCSD
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7153—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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DE112022000079.1T 2021-04-01 2022-04-01 Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten Withdrawn DE112022000079T5 (de)

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US202163169578P 2021-04-01 2021-04-01
US63/169,578 2021-04-01
US202163236951P 2021-08-25 2021-08-25
US63/236,951 2021-08-25
PCT/US2022/023139 WO2022212897A1 (en) 2021-04-01 2022-04-01 Genetic modification of mammalian cells to confer resistance to csf1r antagonists

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DE112022000079.1T Withdrawn DE112022000079T5 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten
DE202022003066.5U Withdrawn - After Issue DE202022003066U1 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugerzellen zur Verleihung von Resistent gegen CSF1R-Antagonisten
DE202022003132.7U Active DE202022003132U1 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugerzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten
DE202022002866.0U Active DE202022002866U1 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten

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DE202022003132.7U Active DE202022003132U1 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugerzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten
DE202022002866.0U Active DE202022002866U1 (de) 2021-04-01 2022-04-01 Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten

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EP (1) EP4314003A4 (https=)
JP (1) JP2024513003A (https=)
AU (1) AU2022252407A1 (https=)
CA (1) CA3215311A1 (https=)
DE (4) DE112022000079T5 (https=)
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CA3215311A1 (en) 2021-04-01 2022-10-06 The Regents Of The University Of California Genetic modification of mammalian cells to confer resistance to csf1r antagonists

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US20250002920A1 (en) 2025-01-02
DE202022003132U1 (de) 2025-02-17
DE202022003066U1 (de) 2024-09-19
US12421517B2 (en) 2025-09-23
US20230203500A1 (en) 2023-06-29
CA3215311A1 (en) 2022-10-06
GB202219686D0 (en) 2023-02-08
US20230248775A1 (en) 2023-08-10
AU2022252407A9 (en) 2023-10-26
JP2024513003A (ja) 2024-03-21
EP4314003A4 (en) 2025-03-12
EP4314003A1 (en) 2024-02-07
AU2022252407A1 (en) 2023-10-12
WO2022212897A1 (en) 2022-10-06
DE202022002866U1 (de) 2024-03-20
GB2612467B (en) 2025-11-19
GB2612467A (en) 2023-05-03

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