JP2024501757A5 - - Google Patents
Info
- Publication number
- JP2024501757A5 JP2024501757A5 JP2023540859A JP2023540859A JP2024501757A5 JP 2024501757 A5 JP2024501757 A5 JP 2024501757A5 JP 2023540859 A JP2023540859 A JP 2023540859A JP 2023540859 A JP2023540859 A JP 2023540859A JP 2024501757 A5 JP2024501757 A5 JP 2024501757A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- binding
- ligand
- protein
- motif
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163133942P | 2021-01-05 | 2021-01-05 | |
| US202163133945P | 2021-01-05 | 2021-01-05 | |
| US63/133,942 | 2021-01-05 | ||
| US63/133,945 | 2021-01-05 | ||
| GBGB2107188.1A GB202107188D0 (en) | 2021-05-19 | 2021-05-19 | Method for producing genetically modified cells |
| GB2107188.1 | 2021-05-19 | ||
| PCT/GB2022/050004 WO2022148955A1 (en) | 2021-01-05 | 2022-01-05 | Method for producing genetically modified cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024501757A JP2024501757A (ja) | 2024-01-15 |
| JP2024501757A5 true JP2024501757A5 (https=) | 2024-12-23 |
Family
ID=81255823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023540859A Pending JP2024501757A (ja) | 2021-01-05 | 2022-01-05 | 遺伝子組換え細胞の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240067954A1 (https=) |
| EP (1) | EP4274893B1 (https=) |
| JP (1) | JP2024501757A (https=) |
| CA (1) | CA3207144A1 (https=) |
| WO (1) | WO2022148955A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11970719B2 (en) * | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024240138A1 (zh) * | 2023-05-22 | 2024-11-28 | 江西农业大学 | 基于perv逆转录酶的先导编辑系统 |
| CN121100181A (zh) * | 2023-05-26 | 2025-12-09 | 正序(上海)生物医药科技有限公司 | 基因编辑系统及其用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5061641A (en) | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| US5057301A (en) | 1988-04-06 | 1991-10-15 | Neorx Corporation | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| WO1994012520A1 (en) | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| US6165476A (en) | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US20100063258A1 (en) | 2006-06-28 | 2010-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion protein constructs |
| DK2476689T3 (en) | 2007-05-10 | 2016-01-18 | Agilent Technologies Inc | Thiocarbonbeskyttende groups for RNA synthesis |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| CN104619727B (zh) | 2012-06-25 | 2019-04-05 | 布里格姆及妇女医院股份有限公司 | 靶向治疗 |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| DK2931891T3 (da) | 2012-12-17 | 2019-08-19 | Harvard College | Rna-styret modificering af menneskelige genomer |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| US20170233762A1 (en) * | 2014-09-29 | 2017-08-17 | The Regents Of The University Of California | Scaffold rnas |
| JP7044373B2 (ja) | 2015-07-15 | 2022-03-30 | ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー | ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| EP3565608A4 (en) | 2017-01-05 | 2020-12-16 | Rutgers, The State University of New Jersey | TARGETED GENE EDITING PLATFORM INDEPENDENT OF BICATENARY DNA BREAKAGE AND ITS USES |
| AU2020466994A1 (en) * | 2019-09-17 | 2022-04-21 | Rutgers, The State University Of New Jersey | Highly efficient DNA base editors mediated by RNA-aptamer recruitment for targeted genome modification and uses thereof |
-
2022
- 2022-01-05 CA CA3207144A patent/CA3207144A1/en active Pending
- 2022-01-05 EP EP22704407.0A patent/EP4274893B1/en active Active
- 2022-01-05 JP JP2023540859A patent/JP2024501757A/ja active Pending
- 2022-01-05 WO PCT/GB2022/050004 patent/WO2022148955A1/en not_active Ceased
- 2022-01-05 US US18/270,879 patent/US20240067954A1/en active Pending
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