JP2024502114A5 - - Google Patents
Info
- Publication number
- JP2024502114A5 JP2024502114A5 JP2023541017A JP2023541017A JP2024502114A5 JP 2024502114 A5 JP2024502114 A5 JP 2024502114A5 JP 2023541017 A JP2023541017 A JP 2023541017A JP 2023541017 A JP2023541017 A JP 2023541017A JP 2024502114 A5 JP2024502114 A5 JP 2024502114A5
- Authority
- JP
- Japan
- Prior art keywords
- grna
- ligand
- base editing
- binding
- dsdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163133945P | 2021-01-05 | 2021-01-05 | |
| US63/133,945 | 2021-01-05 | ||
| PCT/US2022/011294 WO2022150372A1 (en) | 2021-01-05 | 2022-01-05 | Guide rna designs and complexes for type v cas systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502114A JP2024502114A (ja) | 2024-01-17 |
| JP2024502114A5 true JP2024502114A5 (https=) | 2025-01-15 |
Family
ID=82358142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541017A Pending JP2024502114A (ja) | 2021-01-05 | 2022-01-05 | Ｖ型ＣａｓシステムのためのガイドＲＮＡデザインおよび複合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240060088A1 (https=) |
| EP (1) | EP4274903A4 (https=) |
| JP (1) | JP2024502114A (https=) |
| CN (2) | CN117242184A (https=) |
| CA (1) | CA3207094A1 (https=) |
| WO (1) | WO2022150372A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| CA3192654A1 (en) | 2020-09-01 | 2022-03-10 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Synthetic miniature crispr-cas (casmini) system for eukaryotic genome engineering |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CN119137268A (zh) | 2022-03-01 | 2024-12-13 | 埃皮克里斯皮尔生物技术公司 | 工程化核酸酶、组合物及其使用方法 |
| WO2024235293A1 (zh) * | 2023-05-17 | 2024-11-21 | 中国科学院遗传与发育生物学研究所 | 基于环状rna的引导编辑系统 |
| CN121100181A (zh) * | 2023-05-26 | 2025-12-09 | 正序(上海)生物医药科技有限公司 | 基因编辑系统及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7044373B2 (ja) * | 2015-07-15 | 2022-03-30 | ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー | ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途 |
| EP4485466A3 (en) * | 2016-08-17 | 2025-04-02 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| EP3728576A4 (en) * | 2017-12-22 | 2021-11-24 | The Broad Institute, Inc. | CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF RNA BASES |
| AU2019265019B2 (en) * | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| KR20210126680A (ko) * | 2019-02-13 | 2021-10-20 | 빔 테라퓨틱스, 인크. | 알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법 |
-
2022
- 2022-01-05 WO PCT/US2022/011294 patent/WO2022150372A1/en not_active Ceased
- 2022-01-05 JP JP2023541017A patent/JP2024502114A/ja active Pending
- 2022-01-05 EP EP22737039.2A patent/EP4274903A4/en active Pending
- 2022-01-05 CN CN202280019354.3A patent/CN117242184A/zh active Pending
- 2022-01-05 US US18/270,747 patent/US20240060088A1/en active Pending
- 2022-01-05 CA CA3207094A patent/CA3207094A1/en active Pending
- 2022-01-05 CN CN202280015545.2A patent/CN117098844A/zh active Pending
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