CN117242184A - 向导RNA设计及用于V型Cas系统的复合物 - Google Patents

向导RNA设计及用于V型Cas系统的复合物 Download PDF

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Publication number
CN117242184A
CN117242184A CN202280019354.3A CN202280019354A CN117242184A CN 117242184 A CN117242184 A CN 117242184A CN 202280019354 A CN202280019354 A CN 202280019354A CN 117242184 A CN117242184 A CN 117242184A
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grna
ligand binding
complex
leu
linker
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Chinese (zh)
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H·B·马查多
K·亨普希尔
R·布拉斯伯格
A·史密斯
M·D·拉什顿
P·佩雷斯-杜兰
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HAPLOGEN GENOMICS GmbH
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CN202280019354.3A 2021-01-05 2022-01-05 向导RNA设计及用于V型Cas系统的复合物 Pending CN117242184A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163133945P 2021-01-05 2021-01-05
US63/133,945 2021-01-05
PCT/US2022/011294 WO2022150372A1 (en) 2021-01-05 2022-01-05 Guide rna designs and complexes for type v cas systems

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CN202280019354.3A Pending CN117242184A (zh) 2021-01-05 2022-01-05 向导RNA设计及用于V型Cas系统的复合物
CN202280015545.2A Pending CN117098844A (zh) 2021-01-05 2022-01-05 用于生产基因修饰细胞的方法

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US (1) US20240060088A1 (https=)
EP (1) EP4274903A4 (https=)
JP (1) JP2024502114A (https=)
CN (2) CN117242184A (https=)
CA (1) CA3207094A1 (https=)
WO (1) WO2022150372A1 (https=)

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WO2020051562A2 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for improving base editing
EP3847254A4 (en) 2018-09-07 2022-08-10 Beam Therapeutics Inc. COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
AU2020215730A1 (en) 2019-01-31 2021-07-29 Beam Therapeutics Inc. Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
CA3192654A1 (en) 2020-09-01 2022-03-10 The Board Of Trustees Of The Leland Stanford Junior Unversity Synthetic miniature crispr-cas (casmini) system for eukaryotic genome engineering
CA3196831A1 (en) 2020-09-25 2022-03-31 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
CN119137268A (zh) 2022-03-01 2024-12-13 埃皮克里斯皮尔生物技术公司 工程化核酸酶、组合物及其使用方法
WO2024235293A1 (zh) * 2023-05-17 2024-11-21 中国科学院遗传与发育生物学研究所 基于环状rna的引导编辑系统
CN121100181A (zh) * 2023-05-26 2025-12-09 正序(上海)生物医药科技有限公司 基因编辑系统及其用途

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JP7044373B2 (ja) * 2015-07-15 2022-03-30 ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
EP4485466A3 (en) * 2016-08-17 2025-04-02 The Broad Institute Inc. Novel crispr enzymes and systems
EP3728576A4 (en) * 2017-12-22 2021-11-24 The Broad Institute, Inc. CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF RNA BASES
AU2019265019B2 (en) * 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
KR20210126680A (ko) * 2019-02-13 2021-10-20 빔 테라퓨틱스, 인크. 알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법

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CA3207094A1 (en) 2022-07-14
EP4274903A1 (en) 2023-11-15
CN117098844A (zh) 2023-11-21
JP2024502114A (ja) 2024-01-17
EP4274903A4 (en) 2025-04-16
US20240060088A1 (en) 2024-02-22
WO2022150372A1 (en) 2022-07-14

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