JP2023501223A5 - - Google Patents
Info
- Publication number
- JP2023501223A5 JP2023501223A5 JP2022525363A JP2022525363A JP2023501223A5 JP 2023501223 A5 JP2023501223 A5 JP 2023501223A5 JP 2022525363 A JP2022525363 A JP 2022525363A JP 2022525363 A JP2022525363 A JP 2022525363A JP 2023501223 A5 JP2023501223 A5 JP 2023501223A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- deaminase
- activity
- nucleic acid
- cas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025107892A JP2025157268A (ja) | 2019-10-30 | 2025-06-26 | Ｖ型ｃｒｉｓｐｒ－ｃａｓ塩基エディタおよびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962927914P | 2019-10-30 | 2019-10-30 | |
| US62/927,914 | 2019-10-30 | ||
| PCT/US2020/058082 WO2021087182A1 (en) | 2019-10-30 | 2020-10-30 | Type v crispr-cas base editors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025107892A Division JP2025157268A (ja) | 2019-10-30 | 2025-06-26 | Ｖ型ｃｒｉｓｐｒ－ｃａｓ塩基エディタおよびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023501223A JP2023501223A (ja) | 2023-01-18 |
| JP2023501223A5 true JP2023501223A5 (https=) | 2023-10-25 |
Family
ID=75687111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022525363A Pending JP2023501223A (ja) | 2019-10-30 | 2020-10-30 | Ｖ型ｃｒｉｓｐｒ－ｃａｓ塩基エディタおよびその使用方法 |
| JP2025107892A Pending JP2025157268A (ja) | 2019-10-30 | 2025-06-26 | Ｖ型ｃｒｉｓｐｒ－ｃａｓ塩基エディタおよびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025107892A Pending JP2025157268A (ja) | 2019-10-30 | 2025-06-26 | Ｖ型ｃｒｉｓｐｒ－ｃａｓ塩基エディタおよびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210130827A1 (https=) |
| EP (2) | EP4051788A4 (https=) |
| JP (2) | JP2023501223A (https=) |
| KR (1) | KR20220110739A (https=) |
| CN (1) | CN114867852A (https=) |
| AU (1) | AU2020372931A1 (https=) |
| CA (1) | CA3158897A1 (https=) |
| NZ (1) | NZ787352A (https=) |
| WO (1) | WO2021087182A1 (https=) |
Families Citing this family (33)
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021113788A1 (en) * | 2019-12-06 | 2021-06-10 | Pairwise Plants Services, Inc. | Recruitment methods and compounds, compositions and systems for recruitment |
| EP4100519A2 (en) * | 2020-02-05 | 2022-12-14 | The Broad Institute, Inc. | Adenine base editors and uses thereof |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| WO2022240858A1 (en) * | 2021-05-10 | 2022-11-17 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
| CN115772512B (zh) * | 2021-09-07 | 2025-12-23 | 华东师范大学 | 腺嘌呤脱氨酶、包含其的腺嘌呤碱基编辑器及其应用 |
| WO2023122663A2 (en) * | 2021-12-23 | 2023-06-29 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
| WO2023164722A1 (en) * | 2022-02-28 | 2023-08-31 | Pairwise Plants Services, Inc. | Engineered crispr-cas effector proteins and methods of use thereof |
| WO2023250384A2 (en) * | 2022-06-22 | 2023-12-28 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| CN115725533B (zh) * | 2022-11-18 | 2023-08-25 | 中国农业科学院作物科学研究所 | 一种获得抗草甘膦水稻的方法及其所用双碱基融合编辑系统 |
| CN118207185A (zh) * | 2022-12-15 | 2024-06-18 | 上海科技大学 | 一种碱基编辑系统及碱基编辑方法 |
| WO2024158777A1 (en) * | 2023-01-23 | 2024-08-02 | The General Hospital Corporation | Methods and compositions for inhibiting suppression of anti-tumor immunity by targeting ligand-receptor interactions present in the placenta |
| WO2025019273A1 (en) * | 2023-07-14 | 2025-01-23 | Epicrispr Biotechnologies, Inc. | Engineered nucleases and guide rna spacer sequences therefor, and compositions, and methods of use thereof |
| AU2024348958A1 (en) * | 2023-09-26 | 2026-04-02 | Pairwise Plants Services, Inc. | Fusion proteins, compositions comprising the same, and methods of use thereof |
| US12428636B1 (en) | 2024-07-08 | 2025-09-30 | Pairwise Plants Services, Inc. | Methods and compositions for modification of protospacer adjacent motif specificity of CAS12A |
| WO2026019798A2 (en) * | 2024-07-15 | 2026-01-22 | Cornell University | Methods to profile protein binding events on dna with single-cell resolution |
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| NZ221259A (en) | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| US6040504A (en) | 1987-11-18 | 2000-03-21 | Novartis Finance Corporation | Cotton promoter |
| ATE112314T1 (de) | 1988-05-17 | 1994-10-15 | Lubrizol Genetics Inc | Pflanzliches ubiquitinpromotorsystem. |
| US5641876A (en) | 1990-01-05 | 1997-06-24 | Cornell Research Foundation, Inc. | Rice actin gene and promoter |
| ATE225853T1 (de) | 1990-04-12 | 2002-10-15 | Syngenta Participations Ag | Gewebe-spezifische promotoren |
| US5459252A (en) | 1991-01-31 | 1995-10-17 | North Carolina State University | Root specific gene promoter |
| US5604121A (en) | 1991-08-27 | 1997-02-18 | Agricultural Genetics Company Limited | Proteins with insecticidal properties against homopteran insects and their use in plant protection |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| KR20010041129A (ko) | 1998-02-20 | 2001-05-15 | 돈 리사 로얄 | 화분 특이적 프로모터 |
| AR044724A1 (es) | 2000-03-27 | 2005-10-05 | Syngenta Participations Ag | Promotores del virus de la rizadura amarilla del cestrum |
| US7166770B2 (en) | 2000-03-27 | 2007-01-23 | Syngenta Participations Ag | Cestrum yellow leaf curling virus promoters |
| WO2005037993A2 (en) | 2003-10-06 | 2005-04-28 | Syngenta Participations Ag | Promoters functional in plant plastids |
| KR100537955B1 (ko) | 2003-10-29 | 2005-12-20 | 학교법인고려중앙학원 | 꽃가루 특이적 유전자 발현 프로모터 |
| KR102047336B1 (ko) | 2012-02-01 | 2019-11-22 | 다우 아그로사이언시즈 엘엘씨 | 신규한 클래스의 글리포세이트 저항성 유전자 |
| AU2015234204A1 (en) * | 2014-03-20 | 2016-10-06 | Universite Laval | CRISPR-based methods and products for increasing frataxin levels and uses thereof |
| US20170219596A1 (en) | 2014-07-14 | 2017-08-03 | The Regents Of The University Of California | A protein tagging system for in vivo single molecule imaging and control of gene transcription |
| KR102357893B1 (ko) | 2014-08-05 | 2022-02-04 | 맵퀘스트 에스아 | Pd-1 에 결합하는 면역학적 시약 |
| EP3858992A1 (en) | 2015-03-13 | 2021-08-04 | The Jackson Laboratory | A three-component crispr/cas complex system and uses thereof |
| US10648020B2 (en) * | 2015-06-18 | 2020-05-12 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
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| WO2018053035A1 (en) | 2016-09-13 | 2018-03-22 | The Jackson Laboratory | Targeted dna demethylation and methylation |
| KR20230125856A (ko) * | 2016-12-23 | 2023-08-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Pcsk9의 유전자 편집 |
| EP3565608A4 (en) | 2017-01-05 | 2020-12-16 | Rutgers, The State University of New Jersey | TARGETED GENE EDITING PLATFORM INDEPENDENT OF BICATENARY DNA BREAKAGE AND ITS USES |
| EP3572525A4 (en) * | 2017-01-17 | 2020-09-30 | Institute for Basic Science | PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND |
| CA3047416A1 (en) | 2017-01-20 | 2018-07-26 | The Regents Of The University Of California | Targeted gene activation in plants |
| KR20240116572A (ko) * | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018213726A1 (en) * | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CN111801345A (zh) * | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019041296A1 (zh) * | 2017-09-01 | 2019-03-07 | 上海科技大学 | 一种碱基编辑系统及方法 |
| US11649442B2 (en) * | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| CN110157727A (zh) * | 2017-12-21 | 2019-08-23 | 中国科学院遗传与发育生物学研究所 | 植物碱基编辑方法 |
| US20210079366A1 (en) * | 2017-12-22 | 2021-03-18 | The Broad Institute, Inc. | Cas12a systems, methods, and compositions for targeted rna base editing |
| CN109957569B (zh) * | 2017-12-22 | 2022-10-25 | 苏州齐禾生科生物科技有限公司 | 基于cpf1蛋白的碱基编辑系统和方法 |
| BR112020012064A2 (pt) * | 2017-12-22 | 2020-12-01 | KWS SAAT SE & Co. KGaA | regulação transcricional direcionada usando fatores de transcrição sintéticos |
| JP7013015B2 (ja) * | 2018-03-07 | 2022-02-15 | 国立大学法人広島大学 | 標的遺伝子にエフェクタータンパク質を集積するための組成物、およびその利用 |
| HUE059223T2 (hu) * | 2018-04-24 | 2022-10-28 | Kws Saat Se & Co Kgaa | Jobb emészthetõségû növények és marker haplotípusok |
-
2020
- 2020-10-30 EP EP20880833.7A patent/EP4051788A4/en not_active Withdrawn
- 2020-10-30 CN CN202080090503.6A patent/CN114867852A/zh active Pending
- 2020-10-30 KR KR1020227017585A patent/KR20220110739A/ko active Pending
- 2020-10-30 AU AU2020372931A patent/AU2020372931A1/en active Pending
- 2020-10-30 NZ NZ787352A patent/NZ787352A/en unknown
- 2020-10-30 US US17/084,721 patent/US20210130827A1/en active Pending
- 2020-10-30 WO PCT/US2020/058082 patent/WO2021087182A1/en not_active Ceased
- 2020-10-30 EP EP24175045.4A patent/EP4471149A3/en active Pending
- 2020-10-30 JP JP2022525363A patent/JP2023501223A/ja active Pending
- 2020-10-30 CA CA3158897A patent/CA3158897A1/en active Pending
-
2025
- 2025-06-26 JP JP2025107892A patent/JP2025157268A/ja active Pending
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