JP2024501121A5 - - Google Patents

Info

Publication number
JP2024501121A5
JP2024501121A5 JP2023531534A JP2023531534A JP2024501121A5 JP 2024501121 A5 JP2024501121 A5 JP 2024501121A5 JP 2023531534 A JP2023531534 A JP 2023531534A JP 2023531534 A JP2023531534 A JP 2023531534A JP 2024501121 A5 JP2024501121 A5 JP 2024501121A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
antibody
acid sequence
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023531534A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024501121A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2021/082872 external-priority patent/WO2022112356A1/en
Publication of JP2024501121A publication Critical patent/JP2024501121A/ja
Publication of JP2024501121A5 publication Critical patent/JP2024501121A5/ja
Pending legal-status Critical Current

Links

JP2023531534A 2020-11-25 2021-11-24 癌の処置 Pending JP2024501121A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063118198P 2020-11-25 2020-11-25
US63/118,198 2020-11-25
US202163229589P 2021-08-05 2021-08-05
US63/229,589 2021-08-05
PCT/EP2021/082872 WO2022112356A1 (en) 2020-11-25 2021-11-24 Treatment of cancer

Publications (2)

Publication Number Publication Date
JP2024501121A JP2024501121A (ja) 2024-01-11
JP2024501121A5 true JP2024501121A5 (enExample) 2024-11-29

Family

ID=78819544

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023531534A Pending JP2024501121A (ja) 2020-11-25 2021-11-24 癌の処置

Country Status (9)

Country Link
US (1) US20240325557A1 (enExample)
EP (1) EP4251207A1 (enExample)
JP (1) JP2024501121A (enExample)
KR (1) KR20230112656A (enExample)
AU (1) AU2021387795A1 (enExample)
CA (1) CA3196198A1 (enExample)
IL (1) IL302818A (enExample)
MX (1) MX2023005873A (enExample)
WO (1) WO2022112356A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114845740B (zh) 2020-01-31 2026-06-02 先天制药公司 癌症的治疗
EP4285935A1 (en) * 2022-06-03 2023-12-06 Emergence Therapeutics AG Novel anti-nectin-4 antibody camptothecin derivative conjugates
JP2025519421A (ja) * 2022-06-09 2025-06-26 ベイジーン スイッツァランド ゲーエムベーハー 抗体薬物複合体
EP4309676A1 (en) * 2022-07-22 2024-01-24 Emergence Therapeutics AG Novel anti-nectin-4 antibody camptothecin derivative conjugates
EP4593824A2 (en) * 2022-09-28 2025-08-06 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
EP4344707A1 (en) * 2022-09-29 2024-04-03 Emergence Therapeutics AG New anti-nectin-4 antibody drug conjugates
KR20250079213A (ko) 2022-10-09 2025-06-04 라노바 메디신즈 리미티드 화합물, 조성물 및 방법
EP4534101A1 (en) 2023-10-02 2025-04-09 Eli Lilly and Company Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload
EP4534102A1 (en) 2023-10-02 2025-04-09 Eli Lilly and Company Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload
KR20260113065A (ko) * 2023-11-15 2026-07-21 머크 샤프 앤드 돔 엘엘씨 인간 넥틴-4 결합제
KR20250177512A (ko) * 2024-06-14 2025-12-24 삼성바이오에피스 주식회사 신규한 항-넥틴-4 항체 및 이의 용도
US20260062472A1 (en) * 2024-08-28 2026-03-05 Earendil Labs Inc. Bispecific antibody and use thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
WO1999061061A1 (fr) 1998-05-22 1999-12-02 Daiichi Pharmaceutical Co., Ltd. Composites medicamenteux
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
US7375234B2 (en) 2002-05-30 2008-05-20 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
AU2003293666A1 (en) 2002-11-11 2004-06-03 Basf Aktiengesellschaft Method for the production of 2-keto-l-gulonic acid-c4-c10 alkyl esters
WO2004043493A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
ES2605443T3 (es) 2003-11-06 2017-03-14 Seattle Genetics, Inc. Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
CA2556752C (en) 2004-02-23 2016-02-02 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
ES2398975T3 (es) 2004-03-01 2013-03-25 Spirogen Sàrl Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
US7807619B2 (en) 2004-11-01 2010-10-05 The Regents Of The University Of California Compositions and methods for modification of biomolecules
ES2708763T3 (es) 2005-07-07 2019-04-11 Seattle Genetics Inc Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
EP2907525B1 (en) 2007-11-21 2018-05-16 University Of Georgia Research Foundation, Inc. Dibenzocyclooctene-compounds for bioorthogonal reactions
US20110301056A1 (en) * 2008-12-12 2011-12-08 Oncotherapy Science, Inc. Nectin-4 for target genes of cancer therapy and diagnosis
FR2949469A1 (fr) 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
WO2011121453A2 (en) 2010-03-30 2011-10-06 Clavis Pharma Asa Methods and compositions for treating or ameliorating cancer using gemcitabine-5'-elaidate
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
ES2874306T3 (es) 2010-09-29 2021-11-04 Agensys Inc Conjugados de anticuerpos y fármacos (CAF) que se unen a las proteínas 191P4D12
SI2675480T1 (sl) 2011-02-15 2019-05-31 Immunogen, Inc. Metode priprave konjugatov
CA2858806A1 (en) 2011-12-23 2013-06-27 Innate Pharma Enzymatic conjugation of polypeptides
WO2013177481A1 (en) 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof
WO2014202773A1 (en) 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
PT3057585T (pt) 2013-10-15 2020-10-21 Seagen Inc Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
EP3733209A1 (en) 2014-10-03 2020-11-04 Synaffix B.V. Sulfamide linker, conjugates thereof, and methods of preparation
ES2885854T3 (es) 2014-10-14 2021-12-15 Polytherics Ltd Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG
US11274160B2 (en) 2017-03-02 2022-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale Antibodies having specificity to Nectin-4 and uses thereof
TWI870338B (zh) * 2017-06-05 2025-01-21 美商艾澤西公司 粘附分子-4結合蛋白及其使用方法
EP3700577A1 (en) 2017-10-23 2020-09-02 Mablink Bioscience Ligand-drug-conjugate comprising a single molecular weight polysarcosine
CN113613679A (zh) 2019-03-19 2021-11-05 保罗·谢勒学院 基于甘氨酸的接头的转谷氨酰胺酶缀合方法
AU2020364959B2 (en) * 2019-10-07 2026-07-09 Centre National De La Recherche Scientifique - Cnrs - Antibodies having specificity for Nectin-4 and uses thereof
CN112646038B (zh) * 2019-10-11 2025-06-03 迈威(上海)生物科技股份有限公司 抗人Trop-2抗体及其应用
US20230025600A1 (en) * 2019-11-25 2023-01-26 Agensys, Inc. Treatment of cancers with antibody drug conjugates (adc) that bind to 191p4d12 proteins
CN114845740B (zh) * 2020-01-31 2026-06-02 先天制药公司 癌症的治疗
CN113527486B (zh) * 2020-04-21 2025-12-02 迈威(上海)生物科技股份有限公司 一种抗Nectin-4的抗体及其应用
IL298903A (en) * 2020-06-18 2023-02-01 Bioatla Llc Antibodies against nectin-4 are conditionally active
US20230270871A1 (en) * 2020-06-19 2023-08-31 Agensys, Inc. Markers for use in methods for treating cancers with antibody drug conjugates (adc)

Similar Documents

Publication Publication Date Title
JP7377327B2 (ja) Bcmaモノクローナル抗体薬剤コンジュゲート
JP7696635B2 (ja) 抗-il1rap抗体および抗体薬物コンジュゲート
JP2023522229A5 (enExample)
EP4087613A1 (en) Anti-slc34a2 antibodies, antibody drug conjugates, and methods of use thereof
TWI549968B (zh) 抗體-藥物共軛體
CN114222752B (zh) 抗组织因子抗体-药物缀合物及相关方法
JP2023520930A (ja) 電荷多様性リンカー
JP2019536740A5 (enExample)
JP2018127469A5 (enExample)
JP2017535246A5 (enExample)
IL305954A (en) Nectin-4 protein antibody and extacan compounds
HRP20220172T1 (hr) Protutijela protiv cd71 koja se mogu aktivirati, te postupci njihove uporabe
JP2018520092A5 (enExample)
JP2016531914A5 (enExample)
CA2519113A1 (en) Antibodies against insulin-like growth factor i receptor and uses thereof
TWI845724B (zh) 用於偶聯的多肽複合物及其應用
WO2024235136A9 (zh) 杂环类化合物及其制备方法和用途
EP3675907A1 (en) Anti-egfr antibody drug conjugates (adc) and uses thereof
CA3162282A1 (en) Treatment of cancers with antibody drug conjugates (adc) that bind to 191p4d12 proteins
JP2025513721A5 (enExample)
EP3675908A1 (en) Anti-egfr antibody drug conjugates (adc) and uses thereof
JP2015529656A (ja) 抗etbr抗体および免疫複合体
JPWO2021251459A5 (enExample)
JP2023506158A5 (enExample)
KR20240150773A (ko) 항체 및 약물 접합체 및 이의 용도