JP2024015176A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024015176A5 JP2024015176A5 JP2023204715A JP2023204715A JP2024015176A5 JP 2024015176 A5 JP2024015176 A5 JP 2024015176A5 JP 2023204715 A JP2023204715 A JP 2023204715A JP 2023204715 A JP2023204715 A JP 2023204715A JP 2024015176 A5 JP2024015176 A5 JP 2024015176A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- decellularized
- lobe
- extracellular matrix
- regenerative cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004185 liver Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 12
- 230000001172 regenerating effect Effects 0.000 claims 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 8
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 8
- 210000002744 extracellular matrix Anatomy 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 6
- 210000005161 hepatic lobe Anatomy 0.000 claims 3
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 210000003240 portal vein Anatomy 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025046714A JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21161309P | 2009-03-31 | 2009-03-31 | |
| US61/211,613 | 2009-03-31 | ||
| JP2019095766A JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080860A Division JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046714A Division JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024015176A JP2024015176A (ja) | 2024-02-01 |
| JP2024015176A5 true JP2024015176A5 (https=) | 2024-03-29 |
Family
ID=42983078
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503673A Pending JP2012522511A (ja) | 2009-03-31 | 2010-03-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2015164446A Pending JP2016039903A (ja) | 2009-03-31 | 2015-08-24 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2017147965A Pending JP2017195900A (ja) | 2009-03-31 | 2017-07-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2019095766A Pending JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A Pending JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2023204715A Pending JP2024015176A (ja) | 2009-03-31 | 2023-12-04 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2025046714A Pending JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503673A Pending JP2012522511A (ja) | 2009-03-31 | 2010-03-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2015164446A Pending JP2016039903A (ja) | 2009-03-31 | 2015-08-24 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2017147965A Pending JP2017195900A (ja) | 2009-03-31 | 2017-07-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2019095766A Pending JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A Pending JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046714A Pending JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120183944A1 (https=) |
| EP (1) | EP2413946A2 (https=) |
| JP (7) | JP2012522511A (https=) |
| KR (1) | KR20120023626A (https=) |
| CN (1) | CN102448476A (https=) |
| AU (1) | AU2010236855C1 (https=) |
| CA (1) | CA2757457C (https=) |
| IL (1) | IL215463A0 (https=) |
| MX (1) | MX2011010197A (https=) |
| RU (1) | RU2011143730A (https=) |
| SG (2) | SG10201401131WA (https=) |
| WO (1) | WO2010120539A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1928519T3 (pl) | 2005-08-26 | 2012-08-31 | Univ Minnesota | Decelularyzacja i recelularyzacja narządów i tkanek |
| EP2588592B1 (en) * | 2010-06-30 | 2017-09-06 | Miromatrix Medical Inc. | Use of perfusion decellularized organs for matched recellularization |
| SG188369A1 (en) | 2010-09-01 | 2013-04-30 | Univ Minnesota | Methods of recellularizing a tissue or organ for improved transplantability |
| EP2714894B1 (en) * | 2011-05-27 | 2019-10-30 | DePuy Synthes Products, Inc. | Bioartificial proximal tubule systems and methods of use |
| CN103173920B (zh) * | 2011-12-26 | 2014-08-27 | 广野精机有限公司 | 纬纱输送控线装置 |
| EP2809152B1 (en) | 2012-02-01 | 2019-11-20 | Nayacure Therapeutics Ltd | Method for inducing immune tolerance to organ transplants |
| WO2013158283A1 (en) * | 2012-04-18 | 2013-10-24 | The General Hospital Corporation | Bioartificial filtration organ |
| WO2013163358A1 (en) | 2012-04-24 | 2013-10-31 | Harvard Bioscience, Inc. | Engineered tissue scaffolds and supports therefor |
| US9290738B2 (en) | 2012-06-13 | 2016-03-22 | Miromatrix Medical Inc. | Methods of decellularizing bone |
| US10111740B2 (en) | 2012-08-21 | 2018-10-30 | Regents Of The University Of Minnesota | Decellularized biologically-engineered tubular grafts |
| EP2943231A4 (en) | 2013-01-09 | 2016-12-07 | Harvard Apparatus Regenerative Tech Inc | SYNTHETIC SCAFFOLD |
| SG10201906304TA (en) * | 2013-03-15 | 2019-08-27 | Miromatrix Medical Inc | Use of perfusion decellularized liver for islet cell recellularization |
| US9888680B2 (en) | 2013-04-04 | 2018-02-13 | The Trustees Of Columbia University In The City Of New York | Functional recovery of human lungs for transplantation |
| RU2539918C1 (ru) * | 2013-11-29 | 2015-01-27 | Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации | Способ получения тканеспецифического матрикса для тканевой инженерии паренхиматозного органа |
| CN103751843B (zh) * | 2013-12-05 | 2015-09-16 | 南方医科大学珠江医院 | 制备全肝脏生物支架的试剂盒及全肝脏生物支架制备方法 |
| KR101637548B1 (ko) | 2013-12-24 | 2016-07-20 | 연세대학교 산학협력단 | 세포 배양 및 세포 분화를 위한 탈세포화 기관 매트릭스 동결건조 분쇄물 및 이의 제조 방법 |
| WO2015138999A1 (en) * | 2014-03-14 | 2015-09-17 | The General Hospital Corporation | Lung bioreactor |
| CN103966092A (zh) * | 2014-04-10 | 2014-08-06 | 欧东波 | 器官脱细胞循环灌流再生培养瓶 |
| WO2015181245A1 (en) * | 2014-05-27 | 2015-12-03 | Novahep Ab | Bioengineered allogeneic valve |
| WO2016036764A2 (en) | 2014-09-02 | 2016-03-10 | United Therapeutics Corporation | Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system |
| EP3197999A4 (en) * | 2014-09-23 | 2018-08-22 | Nanyang Technological University | A bioreactor module, a bioreactor system and methods for thick tissue seeding and cultivation in an hirearchical organization and physiological mimiking conditions |
| JP2016185115A (ja) * | 2015-03-27 | 2016-10-27 | シスメックス株式会社 | 臓器灌流方法および臓器灌流装置 |
| CN106148270B (zh) * | 2015-04-13 | 2019-09-06 | 中国科学院大连化学物理研究所 | 一种用于生物人工肝支持系统的三维微肝组织单元的构建方法 |
| CN104771788B (zh) * | 2015-05-05 | 2017-08-25 | 北京帝康医药投资管理有限公司 | 一种基于大网膜脱细胞基质的组织工程皮肤及其构建方法 |
| CN106693055A (zh) * | 2015-07-26 | 2017-05-24 | 复旦大学附属华山医院 | 一种小脑脱细胞再生生物支架及其制备方法和用途 |
| JP6921807B2 (ja) | 2015-09-11 | 2021-08-18 | ザ ジェネラル ホスピタル コーポレイション | 機能的肺血管床の再生 |
| WO2017136786A1 (en) * | 2016-02-05 | 2017-08-10 | The Trustees Of Columbia University In The City Of New York | Rigionally specific tissua-derived extracellular metrix |
| AU2017246276A1 (en) | 2016-04-05 | 2018-11-01 | Regents Of The University Of Minnesota | Engineered tissues having structural components embedded therein, and methods of making and using |
| ITUA20164238A1 (it) * | 2016-06-09 | 2017-12-09 | G F S P A | Metodo e apparato per la decellularizzazione di organi |
| CN107621462B (zh) * | 2016-07-13 | 2020-03-31 | 王志伟 | 一种组织透明化液sut及其制备和应用 |
| CN106267345B (zh) * | 2016-08-04 | 2019-03-26 | 中国人民解放军第三军医大学第一附属医院 | 一种具有生物活性的再生期器官去细胞生物支架的制备方法及其产品和应用 |
| WO2018048899A1 (en) | 2016-09-06 | 2018-03-15 | Micromatrix Medical Inc. | Use of resected liver serum for whole liver engineering |
| CN107412865A (zh) * | 2016-10-27 | 2017-12-01 | 浙江保尔曼生物科技有限公司 | 高强度的具有抗凝血功能的去细胞化肾脏生物支架及制备方法 |
| CN107096070B (zh) * | 2017-03-09 | 2020-08-21 | 中国医学科学院阜外医院 | 一种脱细胞肺支架及其制备方法 |
| US12227727B2 (en) * | 2018-02-28 | 2025-02-18 | Pop Test Oncology Llc | Medical devices and uses thereof |
| CN108465126A (zh) * | 2018-05-25 | 2018-08-31 | 中国人民解放军总医院 | 模拟生理过程的膀胱脱细胞基质的制备装置 |
| WO2019241499A1 (en) | 2018-06-13 | 2019-12-19 | Miromatrix Medical Inc. | Fistula filler and deployment system |
| WO2020158794A1 (ja) * | 2019-01-30 | 2020-08-06 | 国立大学法人 長崎大学 | 疾患モデル |
| AU2020241583A1 (en) * | 2019-03-21 | 2021-10-14 | Miromatrix Medical Inc. | Improved decellularization of isolated organs |
| EP3975936A4 (en) | 2019-05-28 | 2022-08-03 | Regents of the University of Minnesota | ENGINEERING VALVE AND METHOD OF MANUFACTURE |
| JP7758658B2 (ja) * | 2019-08-19 | 2025-10-22 | ミロマトリックス メディカル インコーポレイテッド | 脱細胞化及び再細胞化人工臓器移植片の封止 |
| CA3191775A1 (en) | 2020-09-04 | 2022-03-10 | Narendra R. Vyavahare | Systems and methods for processing tissue |
| US11998662B1 (en) | 2021-06-09 | 2024-06-04 | Reprise Biomedical, Inc. | Biologic matrix for a wound site and related methods |
| US12383657B1 (en) | 2021-06-09 | 2025-08-12 | Reprise Biomedical, Inc. | Biologic matrix for a wound site and related methods |
| KR102931913B1 (ko) | 2022-02-23 | 2026-02-27 | 주식회사 로킷헬스케어 | 향상된 재세포화 및 혈전 방지 효과를 함유하는 재세포화된 이식체 및 이의 제조방법 |
| CN114949357B (zh) * | 2022-05-20 | 2023-08-01 | 上海市第十人民医院 | 一种阴茎脱细胞支架及其制备方法和应用 |
| US20260048189A1 (en) | 2022-11-18 | 2026-02-19 | Vantive Us Healthcare Llc | Extracorporeal blood treatment for organ support |
| CN117100912A (zh) * | 2023-06-08 | 2023-11-24 | 北京科昕恒业生物科技有限公司 | 一种肺脏脱细胞基质及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1176400A (ja) * | 1997-09-09 | 1999-03-23 | Masahito Nagaki | 人工臓器 |
| JP4222658B2 (ja) * | 1998-06-23 | 2009-02-12 | テルモ株式会社 | 細胞支持基材、培養装置および液体処理装置 |
| US20050249816A1 (en) * | 1999-12-29 | 2005-11-10 | Wake Forest University Health Services | Tissue engineered liver constructs |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| EP1387885A1 (en) * | 2001-05-01 | 2004-02-11 | Universite Du Quebec A Montreal | Tridimensional biocompatible support structure for bioartificial organs and uses thereof |
| US20030187515A1 (en) * | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| AU2002246348A1 (en) * | 2002-04-04 | 2003-10-20 | Daiichi Pure Chemicals Co., Ltd. | Method of culturing liver cells over long time |
| WO2006126219A1 (en) * | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| WO2007002228A1 (en) * | 2005-06-23 | 2007-01-04 | Massachusetts Institute Of Technology | Methods for ex vivo propagation of adult hepatic stem cells |
| PL1928519T3 (pl) * | 2005-08-26 | 2012-08-31 | Univ Minnesota | Decelularyzacja i recelularyzacja narządów i tkanek |
| JP4599315B2 (ja) * | 2006-02-23 | 2010-12-15 | クラレメディカル株式会社 | バイオ人工臓器 |
-
2010
- 2010-03-31 MX MX2011010197A patent/MX2011010197A/es active IP Right Grant
- 2010-03-31 RU RU2011143730/15A patent/RU2011143730A/ru unknown
- 2010-03-31 JP JP2012503673A patent/JP2012522511A/ja active Pending
- 2010-03-31 CN CN2010800248990A patent/CN102448476A/zh active Pending
- 2010-03-31 SG SG10201401131WA patent/SG10201401131WA/en unknown
- 2010-03-31 WO PCT/US2010/029463 patent/WO2010120539A2/en not_active Ceased
- 2010-03-31 AU AU2010236855A patent/AU2010236855C1/en active Active
- 2010-03-31 US US13/262,286 patent/US20120183944A1/en not_active Abandoned
- 2010-03-31 KR KR1020117025607A patent/KR20120023626A/ko not_active Withdrawn
- 2010-03-31 SG SG2011070810A patent/SG174969A1/en unknown
- 2010-03-31 EP EP10723848A patent/EP2413946A2/en not_active Withdrawn
- 2010-03-31 CA CA2757457A patent/CA2757457C/en active Active
-
2011
- 2011-10-02 IL IL215463A patent/IL215463A0/en unknown
-
2015
- 2015-08-24 JP JP2015164446A patent/JP2016039903A/ja active Pending
-
2017
- 2017-07-31 JP JP2017147965A patent/JP2017195900A/ja active Pending
-
2019
- 2019-05-22 JP JP2019095766A patent/JP2019134723A/ja active Pending
-
2021
- 2021-08-04 US US17/394,243 patent/US20220062349A1/en active Pending
-
2022
- 2022-05-17 JP JP2022080860A patent/JP2022107023A/ja active Pending
-
2023
- 2023-12-04 JP JP2023204715A patent/JP2024015176A/ja active Pending
-
2025
- 2025-03-21 JP JP2025046714A patent/JP2025089394A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024015176A5 (https=) | ||
| JP2025089394A5 (https=) | ||
| Agarwal et al. | Liver tissue engineering: challenges and opportunities | |
| Mazza et al. | Liver tissue engineering: From implantable tissue to whole organ engineering | |
| JP2022107023A5 (https=) | ||
| Yang et al. | Novel cell immobilization method utilizing centrifugal force to achieve high‐density hepatocyte culture in porous scaffold | |
| Guruswamy Damodaran et al. | Tissue and organ decellularization in regenerative medicine | |
| Elçin et al. | Xenotransplantation of fetal porcine hepatocytes in rats using a tissue engineering approach | |
| Tan et al. | Decellularization strategies for regenerating cardiac and skeletal muscle tissues | |
| Stile et al. | Synthesis and characterization of injectable poly (N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro | |
| Zheng et al. | Reconstruction of structure and function in tissue engineering of solid organs: toward simulation of natural development based on decellularization | |
| Dai et al. | Recent advances in liver engineering with decellularized scaffold | |
| JP2012522511A5 (https=) | ||
| Xu | Progenitor cells in vascular repair | |
| RU2011143730A (ru) | Децеллюляризации и рецеллюляризация органов и тканей | |
| Jain et al. | Applications of regenerative medicine in organ transplantation | |
| Avolio et al. | Stem cell therapy and tissue engineering for correction of congenital heart disease | |
| Shiota et al. | Progress in stem cell‐based therapy for liver disease | |
| Uygun et al. | Engineered liver for transplantation | |
| Booth et al. | Liver bioengineering: current status and future perspectives | |
| Hanjaya‐Putra et al. | Vascular engineering using human embryonic stem cells | |
| Somasekhar et al. | Current challenges and future promise for use of extracellular matrix scaffold to achieve the whole organ tissue engineering moonshot | |
| Zhang et al. | Hydrogel-based strategies for liver tissue engineering | |
| Zhu et al. | Liver progenitor cell interactions with the extracellular matrix | |
| Gleghorn et al. | Adhesive properties of laminated alginate gels for tissue engineering of layered structures |