JP2024015176A5 - - Google Patents
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- Publication number
- JP2024015176A5 JP2024015176A5 JP2023204715A JP2023204715A JP2024015176A5 JP 2024015176 A5 JP2024015176 A5 JP 2024015176A5 JP 2023204715 A JP2023204715 A JP 2023204715A JP 2023204715 A JP2023204715 A JP 2023204715A JP 2024015176 A5 JP2024015176 A5 JP 2024015176A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- decellularized
- lobe
- extracellular matrix
- regenerative cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004185 liver Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 12
- 230000001172 regenerating effect Effects 0.000 claims 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 8
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 8
- 210000002744 extracellular matrix Anatomy 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 6
- 210000005161 hepatic lobe Anatomy 0.000 claims 3
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 210000003240 portal vein Anatomy 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025046714A JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21161309P | 2009-03-31 | 2009-03-31 | |
| US61/211,613 | 2009-03-31 | ||
| JP2019095766A JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080860A Division JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046714A Division JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024015176A JP2024015176A (ja) | 2024-02-01 |
| JP2024015176A5 true JP2024015176A5 (https=) | 2024-03-29 |
Family
ID=42983078
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503673A Pending JP2012522511A (ja) | 2009-03-31 | 2010-03-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2015164446A Pending JP2016039903A (ja) | 2009-03-31 | 2015-08-24 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2017147965A Pending JP2017195900A (ja) | 2009-03-31 | 2017-07-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2019095766A Pending JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A Pending JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2023204715A Pending JP2024015176A (ja) | 2009-03-31 | 2023-12-04 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2025046714A Pending JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503673A Pending JP2012522511A (ja) | 2009-03-31 | 2010-03-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2015164446A Pending JP2016039903A (ja) | 2009-03-31 | 2015-08-24 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2017147965A Pending JP2017195900A (ja) | 2009-03-31 | 2017-07-31 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2019095766A Pending JP2019134723A (ja) | 2009-03-31 | 2019-05-22 | 臓器および組織を脱細胞化および再細胞化する方法 |
| JP2022080860A Pending JP2022107023A (ja) | 2009-03-31 | 2022-05-17 | 臓器および組織を脱細胞化および再細胞化する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046714A Pending JP2025089394A (ja) | 2009-03-31 | 2025-03-21 | 臓器および組織を脱細胞化および再細胞化する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120183944A1 (https=) |
| EP (1) | EP2413946A2 (https=) |
| JP (7) | JP2012522511A (https=) |
| KR (1) | KR20120023626A (https=) |
| CN (1) | CN102448476A (https=) |
| AU (1) | AU2010236855C1 (https=) |
| CA (1) | CA2757457C (https=) |
| IL (1) | IL215463A0 (https=) |
| MX (1) | MX2011010197A (https=) |
| RU (1) | RU2011143730A (https=) |
| SG (2) | SG10201401131WA (https=) |
| WO (1) | WO2010120539A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX369594B (es) | 2005-08-26 | 2019-11-13 | Univ Minnesota | Descelularizacion y recelularizacion de organos y tejidos. |
| EP2588592B1 (en) * | 2010-06-30 | 2017-09-06 | Miromatrix Medical Inc. | Use of perfusion decellularized organs for matched recellularization |
| RU2611361C2 (ru) | 2010-09-01 | 2017-02-21 | Риджентс Оф Дзе Юниверсити Оф Миннесота | Способы рецеллюляризации ткани или органа для улучшения приживления трансплантата |
| KR102034496B1 (ko) * | 2011-05-27 | 2019-10-22 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | 인공 근위세뇨관 시스템 및 사용 방법 |
| CN103173920B (zh) * | 2011-12-26 | 2014-08-27 | 广野精机有限公司 | 纬纱输送控线装置 |
| EP2809152B1 (en) | 2012-02-01 | 2019-11-20 | Nayacure Therapeutics Ltd | Method for inducing immune tolerance to organ transplants |
| JP2015515277A (ja) * | 2012-04-18 | 2015-05-28 | ザ ジェネラル ホスピタル コーポレイション | バイオ人工濾過器官 |
| EP2841010B1 (en) | 2012-04-24 | 2023-08-23 | Harvard Apparatus Regenerative Technology, Inc. | Supports for engineered tissue scaffolds |
| US9290738B2 (en) | 2012-06-13 | 2016-03-22 | Miromatrix Medical Inc. | Methods of decellularizing bone |
| US10111740B2 (en) | 2012-08-21 | 2018-10-30 | Regents Of The University Of Minnesota | Decellularized biologically-engineered tubular grafts |
| EP2943231A4 (en) | 2013-01-09 | 2016-12-07 | Harvard Apparatus Regenerative Tech Inc | SYNTHETIC SCAFFOLD |
| JP2016513465A (ja) | 2013-03-15 | 2016-05-16 | ミロマトリックス メディカル インコーポレイティド | 膵島細胞の再細胞化のための灌流型脱細胞化肝臓の使用 |
| US9888680B2 (en) | 2013-04-04 | 2018-02-13 | The Trustees Of Columbia University In The City Of New York | Functional recovery of human lungs for transplantation |
| RU2539918C1 (ru) * | 2013-11-29 | 2015-01-27 | Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации | Способ получения тканеспецифического матрикса для тканевой инженерии паренхиматозного органа |
| CN103751843B (zh) * | 2013-12-05 | 2015-09-16 | 南方医科大学珠江医院 | 制备全肝脏生物支架的试剂盒及全肝脏生物支架制备方法 |
| KR101637548B1 (ko) | 2013-12-24 | 2016-07-20 | 연세대학교 산학협력단 | 세포 배양 및 세포 분화를 위한 탈세포화 기관 매트릭스 동결건조 분쇄물 및 이의 제조 방법 |
| CN117694335A (zh) * | 2014-03-14 | 2024-03-15 | 通用医疗公司 | 肺生物反应器 |
| CN103966092A (zh) * | 2014-04-10 | 2014-08-06 | 欧东波 | 器官脱细胞循环灌流再生培养瓶 |
| AU2015265954A1 (en) * | 2014-05-27 | 2017-01-12 | Novahep Ab | Bioengineered allogeneic valve |
| EP3188595B1 (en) | 2014-09-02 | 2023-08-23 | United Therapeutics Corporation | Automated bioreactor system for decellularizing an organ |
| WO2016048243A1 (en) * | 2014-09-23 | 2016-03-31 | Nanyang Technological University | A bioreactor module, a bioreactor system and methods for thick tissue seeding and cultivation in an hirearchical organization and physiological mimiking conditions |
| JP2016185115A (ja) * | 2015-03-27 | 2016-10-27 | シスメックス株式会社 | 臓器灌流方法および臓器灌流装置 |
| CN106148270B (zh) * | 2015-04-13 | 2019-09-06 | 中国科学院大连化学物理研究所 | 一种用于生物人工肝支持系统的三维微肝组织单元的构建方法 |
| CN104771788B (zh) * | 2015-05-05 | 2017-08-25 | 北京帝康医药投资管理有限公司 | 一种基于大网膜脱细胞基质的组织工程皮肤及其构建方法 |
| CN106693055A (zh) * | 2015-07-26 | 2017-05-24 | 复旦大学附属华山医院 | 一种小脑脱细胞再生生物支架及其制备方法和用途 |
| CA2998130C (en) | 2015-09-11 | 2024-02-13 | The General Hospital Corporation | Regeneration of a functional pulmonary vascular bed |
| WO2017136786A1 (en) * | 2016-02-05 | 2017-08-10 | The Trustees Of Columbia University In The City Of New York | Rigionally specific tissua-derived extracellular metrix |
| KR20180133253A (ko) | 2016-04-05 | 2018-12-13 | 리젠츠 오브 더 유니버시티 오브 미네소타 | 조직에 매립되어 있는 구조적 구성요소를 갖는 공학처리된 조직, 및 제조 및 사용하는 방법 |
| ITUA20164238A1 (it) * | 2016-06-09 | 2017-12-09 | G F S P A | Metodo e apparato per la decellularizzazione di organi |
| CN107621462B (zh) * | 2016-07-13 | 2020-03-31 | 王志伟 | 一种组织透明化液sut及其制备和应用 |
| CN106267345B (zh) * | 2016-08-04 | 2019-03-26 | 中国人民解放军第三军医大学第一附属医院 | 一种具有生物活性的再生期器官去细胞生物支架的制备方法及其产品和应用 |
| US11278643B2 (en) | 2016-09-06 | 2022-03-22 | Mayo Foundation For Medical Education And Research | Use of resected liver serum for whole liver-engineering |
| CN107412865A (zh) * | 2016-10-27 | 2017-12-01 | 浙江保尔曼生物科技有限公司 | 高强度的具有抗凝血功能的去细胞化肾脏生物支架及制备方法 |
| CN107096070B (zh) * | 2017-03-09 | 2020-08-21 | 中国医学科学院阜外医院 | 一种脱细胞肺支架及其制备方法 |
| WO2019168913A1 (en) * | 2018-02-28 | 2019-09-06 | Pop Test Oncology Llc | Medical devices and uses thereof |
| CN108465126A (zh) * | 2018-05-25 | 2018-08-31 | 中国人民解放军总医院 | 模拟生理过程的膀胱脱细胞基质的制备装置 |
| WO2019241499A1 (en) | 2018-06-13 | 2019-12-19 | Miromatrix Medical Inc. | Fistula filler and deployment system |
| JP7425485B2 (ja) * | 2019-01-30 | 2024-01-31 | 国立大学法人 長崎大学 | 疾患モデル |
| JP7470709B2 (ja) * | 2019-03-21 | 2024-04-18 | ミロマトリックス メディカル インコーポレイテッド | 摘出臓器又はその一部を脱細胞化する方法 |
| US12465486B2 (en) | 2019-05-28 | 2025-11-11 | Regents Of The University Of Minnesota | Engineered valve and method of making |
| JP7758658B2 (ja) * | 2019-08-19 | 2025-10-22 | ミロマトリックス メディカル インコーポレイテッド | 脱細胞化及び再細胞化人工臓器移植片の封止 |
| EP4208214A4 (en) * | 2020-09-04 | 2025-09-17 | Tgen Tech Llc | SYSTEMS AND METHODS FOR TREATMENT OF TISSUES |
| US12383657B1 (en) | 2021-06-09 | 2025-08-12 | Reprise Biomedical, Inc. | Biologic matrix for a wound site and related methods |
| US11998662B1 (en) | 2021-06-09 | 2024-06-04 | Reprise Biomedical, Inc. | Biologic matrix for a wound site and related methods |
| KR102931913B1 (ko) | 2022-02-23 | 2026-02-27 | 주식회사 로킷헬스케어 | 향상된 재세포화 및 혈전 방지 효과를 함유하는 재세포화된 이식체 및 이의 제조방법 |
| CN114949357B (zh) * | 2022-05-20 | 2023-08-01 | 上海市第十人民医院 | 一种阴茎脱细胞支架及其制备方法和应用 |
| CN120548201A (zh) | 2022-11-18 | 2025-08-26 | 万益特健康有限责任公司 | 用于器官支持的体外血液处理 |
| CN117100912A (zh) * | 2023-06-08 | 2023-11-24 | 北京科昕恒业生物科技有限公司 | 一种肺脏脱细胞基质及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1176400A (ja) * | 1997-09-09 | 1999-03-23 | Masahito Nagaki | 人工臓器 |
| JP4222658B2 (ja) * | 1998-06-23 | 2009-02-12 | テルモ株式会社 | 細胞支持基材、培養装置および液体処理装置 |
| US20050249816A1 (en) * | 1999-12-29 | 2005-11-10 | Wake Forest University Health Services | Tissue engineered liver constructs |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| EP1387885A1 (en) * | 2001-05-01 | 2004-02-11 | Universite Du Quebec A Montreal | Tridimensional biocompatible support structure for bioartificial organs and uses thereof |
| US20030187515A1 (en) * | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| CA2481953A1 (en) * | 2002-04-04 | 2003-10-16 | Daiichi Pure Chemicals Co., Ltd. | Method of culturing liver cells over long time |
| WO2006126219A1 (en) * | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| US7824912B2 (en) * | 2005-06-23 | 2010-11-02 | Massachusetts Institute Of Technology | Methods for ex vivo propagation of adult hepatic stem cells |
| MX369594B (es) * | 2005-08-26 | 2019-11-13 | Univ Minnesota | Descelularizacion y recelularizacion de organos y tejidos. |
| JP4599315B2 (ja) * | 2006-02-23 | 2010-12-15 | クラレメディカル株式会社 | バイオ人工臓器 |
-
2010
- 2010-03-31 MX MX2011010197A patent/MX2011010197A/es active IP Right Grant
- 2010-03-31 RU RU2011143730/15A patent/RU2011143730A/ru unknown
- 2010-03-31 EP EP10723848A patent/EP2413946A2/en not_active Withdrawn
- 2010-03-31 US US13/262,286 patent/US20120183944A1/en not_active Abandoned
- 2010-03-31 SG SG10201401131WA patent/SG10201401131WA/en unknown
- 2010-03-31 JP JP2012503673A patent/JP2012522511A/ja active Pending
- 2010-03-31 CA CA2757457A patent/CA2757457C/en active Active
- 2010-03-31 SG SG2011070810A patent/SG174969A1/en unknown
- 2010-03-31 CN CN2010800248990A patent/CN102448476A/zh active Pending
- 2010-03-31 WO PCT/US2010/029463 patent/WO2010120539A2/en not_active Ceased
- 2010-03-31 KR KR1020117025607A patent/KR20120023626A/ko not_active Withdrawn
- 2010-03-31 AU AU2010236855A patent/AU2010236855C1/en active Active
-
2011
- 2011-10-02 IL IL215463A patent/IL215463A0/en unknown
-
2015
- 2015-08-24 JP JP2015164446A patent/JP2016039903A/ja active Pending
-
2017
- 2017-07-31 JP JP2017147965A patent/JP2017195900A/ja active Pending
-
2019
- 2019-05-22 JP JP2019095766A patent/JP2019134723A/ja active Pending
-
2021
- 2021-08-04 US US17/394,243 patent/US20220062349A1/en active Pending
-
2022
- 2022-05-17 JP JP2022080860A patent/JP2022107023A/ja active Pending
-
2023
- 2023-12-04 JP JP2023204715A patent/JP2024015176A/ja active Pending
-
2025
- 2025-03-21 JP JP2025046714A patent/JP2025089394A/ja active Pending
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