RU2011143730A - Децеллюляризации и рецеллюляризация органов и тканей - Google Patents

Децеллюляризации и рецеллюляризация органов и тканей Download PDF

Info

Publication number
RU2011143730A
RU2011143730A RU2011143730/15A RU2011143730A RU2011143730A RU 2011143730 A RU2011143730 A RU 2011143730A RU 2011143730/15 A RU2011143730/15 A RU 2011143730/15A RU 2011143730 A RU2011143730 A RU 2011143730A RU 2011143730 A RU2011143730 A RU 2011143730A
Authority
RU
Russia
Prior art keywords
decellularized
liver
extracellular matrix
regenerative cells
decellularized liver
Prior art date
Application number
RU2011143730/15A
Other languages
English (en)
Russian (ru)
Inventor
Дорис ТЭЙЛОР
Харальд ОТТ
Original Assignee
Риджентс Оф Дзе Юниверсити Оф Миннесота
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Риджентс Оф Дзе Юниверсити Оф Миннесота filed Critical Риджентс Оф Дзе Юниверсити Оф Миннесота
Publication of RU2011143730A publication Critical patent/RU2011143730A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
RU2011143730/15A 2009-03-31 2010-03-31 Децеллюляризации и рецеллюляризация органов и тканей RU2011143730A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21161309P 2009-03-31 2009-03-31
US61/211,613 2009-03-31
PCT/US2010/029463 WO2010120539A2 (en) 2009-03-31 2010-03-31 Decellularization and recellularization of organs and tissues

Publications (1)

Publication Number Publication Date
RU2011143730A true RU2011143730A (ru) 2013-05-10

Family

ID=42983078

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011143730/15A RU2011143730A (ru) 2009-03-31 2010-03-31 Децеллюляризации и рецеллюляризация органов и тканей

Country Status (12)

Country Link
US (2) US20120183944A1 (https=)
EP (1) EP2413946A2 (https=)
JP (7) JP2012522511A (https=)
KR (1) KR20120023626A (https=)
CN (1) CN102448476A (https=)
AU (1) AU2010236855C1 (https=)
CA (1) CA2757457C (https=)
IL (1) IL215463A0 (https=)
MX (1) MX2011010197A (https=)
RU (1) RU2011143730A (https=)
SG (2) SG10201401131WA (https=)
WO (1) WO2010120539A2 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539918C1 (ru) * 2013-11-29 2015-01-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ получения тканеспецифического матрикса для тканевой инженерии паренхиматозного органа
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US10441609B2 (en) 2005-08-26 2019-10-15 Miromatrix Medical Inc. Decellularization and recellularization of solid organs
US11278643B2 (en) 2016-09-06 2022-03-22 Mayo Foundation For Medical Education And Research Use of resected liver serum for whole liver-engineering
US11452797B2 (en) 2013-03-15 2022-09-27 Miromatrix Medical Inc. Use of perfusion decellularized liver for islet cell recellularization
RU2802349C1 (ru) * 2022-09-15 2023-08-25 Роман Николаевич Комаров Способ децеллюляризации гомографта сердечно-сосудистой системы сверхкритическим диоксидом углерода
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2588592B1 (en) * 2010-06-30 2017-09-06 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
EP2714894B1 (en) * 2011-05-27 2019-10-30 DePuy Synthes Products, Inc. Bioartificial proximal tubule systems and methods of use
CN103173920B (zh) * 2011-12-26 2014-08-27 广野精机有限公司 纬纱输送控线装置
EP2809152B1 (en) 2012-02-01 2019-11-20 Nayacure Therapeutics Ltd Method for inducing immune tolerance to organ transplants
WO2013158283A1 (en) * 2012-04-18 2013-10-24 The General Hospital Corporation Bioartificial filtration organ
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
US10111740B2 (en) 2012-08-21 2018-10-30 Regents Of The University Of Minnesota Decellularized biologically-engineered tubular grafts
EP2943231A4 (en) 2013-01-09 2016-12-07 Harvard Apparatus Regenerative Tech Inc SYNTHETIC SCAFFOLD
US9888680B2 (en) 2013-04-04 2018-02-13 The Trustees Of Columbia University In The City Of New York Functional recovery of human lungs for transplantation
CN103751843B (zh) * 2013-12-05 2015-09-16 南方医科大学珠江医院 制备全肝脏生物支架的试剂盒及全肝脏生物支架制备方法
KR101637548B1 (ko) 2013-12-24 2016-07-20 연세대학교 산학협력단 세포 배양 및 세포 분화를 위한 탈세포화 기관 매트릭스 동결건조 분쇄물 및 이의 제조 방법
WO2015138999A1 (en) * 2014-03-14 2015-09-17 The General Hospital Corporation Lung bioreactor
CN103966092A (zh) * 2014-04-10 2014-08-06 欧东波 器官脱细胞循环灌流再生培养瓶
WO2015181245A1 (en) * 2014-05-27 2015-12-03 Novahep Ab Bioengineered allogeneic valve
WO2016036764A2 (en) 2014-09-02 2016-03-10 United Therapeutics Corporation Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system
EP3197999A4 (en) * 2014-09-23 2018-08-22 Nanyang Technological University A bioreactor module, a bioreactor system and methods for thick tissue seeding and cultivation in an hirearchical organization and physiological mimiking conditions
JP2016185115A (ja) * 2015-03-27 2016-10-27 シスメックス株式会社 臓器灌流方法および臓器灌流装置
CN106148270B (zh) * 2015-04-13 2019-09-06 中国科学院大连化学物理研究所 一种用于生物人工肝支持系统的三维微肝组织单元的构建方法
CN104771788B (zh) * 2015-05-05 2017-08-25 北京帝康医药投资管理有限公司 一种基于大网膜脱细胞基质的组织工程皮肤及其构建方法
CN106693055A (zh) * 2015-07-26 2017-05-24 复旦大学附属华山医院 一种小脑脱细胞再生生物支架及其制备方法和用途
JP6921807B2 (ja) 2015-09-11 2021-08-18 ザ ジェネラル ホスピタル コーポレイション 機能的肺血管床の再生
WO2017136786A1 (en) * 2016-02-05 2017-08-10 The Trustees Of Columbia University In The City Of New York Rigionally specific tissua-derived extracellular metrix
AU2017246276A1 (en) 2016-04-05 2018-11-01 Regents Of The University Of Minnesota Engineered tissues having structural components embedded therein, and methods of making and using
ITUA20164238A1 (it) * 2016-06-09 2017-12-09 G F S P A Metodo e apparato per la decellularizzazione di organi
CN107621462B (zh) * 2016-07-13 2020-03-31 王志伟 一种组织透明化液sut及其制备和应用
CN106267345B (zh) * 2016-08-04 2019-03-26 中国人民解放军第三军医大学第一附属医院 一种具有生物活性的再生期器官去细胞生物支架的制备方法及其产品和应用
CN107412865A (zh) * 2016-10-27 2017-12-01 浙江保尔曼生物科技有限公司 高强度的具有抗凝血功能的去细胞化肾脏生物支架及制备方法
CN107096070B (zh) * 2017-03-09 2020-08-21 中国医学科学院阜外医院 一种脱细胞肺支架及其制备方法
US12227727B2 (en) * 2018-02-28 2025-02-18 Pop Test Oncology Llc Medical devices and uses thereof
CN108465126A (zh) * 2018-05-25 2018-08-31 中国人民解放军总医院 模拟生理过程的膀胱脱细胞基质的制备装置
WO2020158794A1 (ja) * 2019-01-30 2020-08-06 国立大学法人 長崎大学 疾患モデル
AU2020241583A1 (en) * 2019-03-21 2021-10-14 Miromatrix Medical Inc. Improved decellularization of isolated organs
EP3975936A4 (en) 2019-05-28 2022-08-03 Regents of the University of Minnesota ENGINEERING VALVE AND METHOD OF MANUFACTURE
JP7758658B2 (ja) * 2019-08-19 2025-10-22 ミロマトリックス メディカル インコーポレイテッド 脱細胞化及び再細胞化人工臓器移植片の封止
CA3191775A1 (en) 2020-09-04 2022-03-10 Narendra R. Vyavahare Systems and methods for processing tissue
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
KR102931913B1 (ko) 2022-02-23 2026-02-27 주식회사 로킷헬스케어 향상된 재세포화 및 혈전 방지 효과를 함유하는 재세포화된 이식체 및 이의 제조방법
CN114949357B (zh) * 2022-05-20 2023-08-01 上海市第十人民医院 一种阴茎脱细胞支架及其制备方法和应用
US20260048189A1 (en) 2022-11-18 2026-02-19 Vantive Us Healthcare Llc Extracorporeal blood treatment for organ support
CN117100912A (zh) * 2023-06-08 2023-11-24 北京科昕恒业生物科技有限公司 一种肺脏脱细胞基质及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1176400A (ja) * 1997-09-09 1999-03-23 Masahito Nagaki 人工臓器
JP4222658B2 (ja) * 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
US20050249816A1 (en) * 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
EP1387885A1 (en) * 2001-05-01 2004-02-11 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
AU2002246348A1 (en) * 2002-04-04 2003-10-20 Daiichi Pure Chemicals Co., Ltd. Method of culturing liver cells over long time
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
WO2007002228A1 (en) * 2005-06-23 2007-01-04 Massachusetts Institute Of Technology Methods for ex vivo propagation of adult hepatic stem cells
PL1928519T3 (pl) * 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
JP4599315B2 (ja) * 2006-02-23 2010-12-15 クラレメディカル株式会社 バイオ人工臓器

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10441609B2 (en) 2005-08-26 2019-10-15 Miromatrix Medical Inc. Decellularization and recellularization of solid organs
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US11414644B2 (en) 2010-09-01 2022-08-16 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US12084677B2 (en) 2010-09-01 2024-09-10 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US11452797B2 (en) 2013-03-15 2022-09-27 Miromatrix Medical Inc. Use of perfusion decellularized liver for islet cell recellularization
RU2539918C1 (ru) * 2013-11-29 2015-01-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ получения тканеспецифического матрикса для тканевой инженерии паренхиматозного органа
US11278643B2 (en) 2016-09-06 2022-03-22 Mayo Foundation For Medical Education And Research Use of resected liver serum for whole liver-engineering
US12076461B2 (en) 2016-09-06 2024-09-03 Miromatrix Medical Inc. Use of resected liver serum for whole liver-engineering
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
RU2802349C1 (ru) * 2022-09-15 2023-08-25 Роман Николаевич Комаров Способ децеллюляризации гомографта сердечно-сосудистой системы сверхкритическим диоксидом углерода

Also Published As

Publication number Publication date
CA2757457A1 (en) 2010-10-21
EP2413946A2 (en) 2012-02-08
SG174969A1 (en) 2011-11-28
AU2010236855A1 (en) 2011-10-27
WO2010120539A3 (en) 2011-02-03
IL215463A0 (en) 2011-12-29
JP2019134723A (ja) 2019-08-15
KR20120023626A (ko) 2012-03-13
WO2010120539A2 (en) 2010-10-21
AU2010236855B2 (en) 2014-09-11
JP2025089394A (ja) 2025-06-12
CA2757457C (en) 2018-05-29
JP2017195900A (ja) 2017-11-02
CN102448476A (zh) 2012-05-09
MX2011010197A (es) 2011-11-18
US20220062349A1 (en) 2022-03-03
US20120183944A1 (en) 2012-07-19
AU2010236855C1 (en) 2015-04-02
JP2012522511A (ja) 2012-09-27
SG10201401131WA (en) 2014-07-30
JP2024015176A (ja) 2024-02-01
JP2022107023A (ja) 2022-07-20
JP2016039903A (ja) 2016-03-24

Similar Documents

Publication Publication Date Title
RU2011143730A (ru) Децеллюляризации и рецеллюляризация органов и тканей
Kang et al. Mesenchymal stem cells for the treatment of liver disease: present and perspectives
Yang et al. Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application
Odorico et al. Report of the key opinion leaders meeting on stem cell-derived beta cells
JP2012522511A5 (https=)
Conconi et al. Homologous muscle acellular matrix seeded with autologous myoblasts as a tissue-engineering approach to abdominal wall-defect repair
Chatzistamatiou et al. Optimizing isolation culture and freezing methods to preserve W harton's jelly's mesenchymal stem cell (MSC) properties: an MSC banking protocol validation for the H ellenic C ord B lood B ank
Pokrywczynska et al. Application of bladder acellular matrix in urinary bladder regeneration: the state of the art and future directions
Grounds Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances
Rennie et al. Applications of amniotic membrane and fluid in stem cell biology and regenerative medicine
ATE414143T1 (de) Menschliche leber-vorläuferzellen
NZ603913A (en) Method of engrafting cells from solid tissues
WO2009089110A3 (en) Methods for repair and regeneration of bone marrow
Qiang et al. Intravenous transplantation of mesenchymal stem cells attenuates oleic acid induced acute lung injury in rats
AU2009240884A8 (en) Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation
NZ609731A (en) Compositions of adult organ stem cells and uses thereof
WO2011002721A8 (en) Non-human mammal model of human hematopoietic cancer
Bannerman et al. Heart‐on‐a‐Chip Model of Epicardial–Myocardial Interaction in Ischemia Reperfusion Injury
Shafritz et al. Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells
Komatsu et al. A subcutaneous pancreatic islet transplantation platform using a clinically applicable, biodegradable Vicryl mesh scaffold‐an experimental study
WO2005099758A3 (en) Injectable bioartificial tissue matrix
Zhang et al. Functional liver tissue engineering by an adult mouse liver‐derived neuro‐glia antigen 2‐expressing stem/progenitor population
ATE552866T1 (de) Verfahren zur herstellung eines azellulären organischen gewebes
CN104928235A (zh) 基于干细胞的组合物及其在制备用于冠心病的制剂中的应用
Chachques Development of bioartificial myocardium using stem cells and nanobiotechnology templates