JP2023539742A5 - - Google Patents

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Publication number
JP2023539742A5
JP2023539742A5 JP2023513460A JP2023513460A JP2023539742A5 JP 2023539742 A5 JP2023539742 A5 JP 2023539742A5 JP 2023513460 A JP2023513460 A JP 2023513460A JP 2023513460 A JP2023513460 A JP 2023513460A JP 2023539742 A5 JP2023539742 A5 JP 2023539742A5
Authority
JP
Japan
Prior art keywords
nucleotide sequence
pcsk9
seq
ldlr
position corresponding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023513460A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023539742A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/047502 external-priority patent/WO2022046873A1/en
Publication of JP2023539742A publication Critical patent/JP2023539742A/ja
Publication of JP2023539742A5 publication Critical patent/JP2023539742A5/ja
Priority to JP2025155627A priority Critical patent/JP2026004359A/ja
Pending legal-status Critical Current

Links

JP2023513460A 2020-08-25 2021-08-25 Pcsk9調節物質及びldlr調節物質による敗血症の治療 Pending JP2023539742A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025155627A JP2026004359A (ja) 2020-08-25 2025-09-19 Pcsk9調節物質及びldlr調節物質による敗血症の治療

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063069789P 2020-08-25 2020-08-25
US63/069,789 2020-08-25
PCT/US2021/047502 WO2022046873A1 (en) 2020-08-25 2021-08-25 Treatment of sepsis with pcsk9 and ldlr modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025155627A Division JP2026004359A (ja) 2020-08-25 2025-09-19 Pcsk9調節物質及びldlr調節物質による敗血症の治療

Publications (2)

Publication Number Publication Date
JP2023539742A JP2023539742A (ja) 2023-09-19
JP2023539742A5 true JP2023539742A5 (https=) 2023-10-26

Family

ID=77775030

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2023513460A Pending JP2023539742A (ja) 2020-08-25 2021-08-25 Pcsk9調節物質及びldlr調節物質による敗血症の治療
JP2025155627A Pending JP2026004359A (ja) 2020-08-25 2025-09-19 Pcsk9調節物質及びldlr調節物質による敗血症の治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025155627A Pending JP2026004359A (ja) 2020-08-25 2025-09-19 Pcsk9調節物質及びldlr調節物質による敗血症の治療

Country Status (10)

Country Link
US (2) US12378557B2 (https=)
EP (1) EP4204563A1 (https=)
JP (2) JP2023539742A (https=)
KR (1) KR20230057410A (https=)
CN (1) CN116171161A (https=)
AU (1) AU2021335200A1 (https=)
CA (1) CA3191030A1 (https=)
IL (1) IL300439A (https=)
MX (1) MX2023001912A (https=)
WO (1) WO2022046873A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2634837A (en) 2022-06-07 2025-04-23 Scribe Therapeutics Inc Compositions and methods for the targeting of PCSK9
CN119716057B (zh) * 2024-12-10 2025-07-15 中国人民解放军总医院 Pcsk6在诊断脓毒症中的应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1471152A1 (en) 2003-04-25 2004-10-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutations in the human PCSK9 gene associated to hypercholesterolemia
KR100985090B1 (ko) 2008-05-23 2010-10-04 한국과학기술연구원 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
JP5703218B2 (ja) 2008-08-14 2015-04-15 ネステク ソシエテ アノニム 満腹感、脂質代謝及び脂肪利用に影響を及ぼすための組成物及び方法
EP2488663A4 (en) 2009-10-16 2012-09-05 Genetics Invest Pty Ltd SENSITIVITY TO MACRONUTRIENT
WO2012048414A1 (en) 2010-10-12 2012-04-19 Mcmaster University A method of regulating plasma lipoproteins
WO2013043041A2 (en) 2011-09-21 2013-03-28 Infovalley® Group Of Companies Methods and compositions for diagnosing familial hypercholesterolemia
US20150140005A1 (en) * 2012-05-17 2015-05-21 Cyon Therapeutics Inc. Methods and Uses for Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors
WO2014028946A2 (en) 2012-08-17 2014-02-20 The Broad Institute, Inc. Modulators of hepatic lipoprotein metabolism
TWI682780B (zh) 2013-05-30 2020-01-21 美商再生元醫藥公司 醫藥組成物用於製造治療與pcsk9功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
EP3052521A1 (en) * 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
WO2015073710A2 (en) 2013-11-14 2015-05-21 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Detection of atherosclerotic cardiovascular disease risk and myocardial infarction risk
US9023359B1 (en) 2014-07-15 2015-05-05 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US9034332B1 (en) 2014-07-15 2015-05-19 Kymab Limited Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
US8945560B1 (en) 2014-07-15 2015-02-03 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
WO2015092393A2 (en) 2013-12-17 2015-06-25 Kymab Limited Human targets
US8883157B1 (en) 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9051378B1 (en) 2014-07-15 2015-06-09 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9045548B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
CA2947127A1 (en) 2014-05-02 2015-11-19 Cerenis Therapeutics Holding Sa Hdl therapy markers
EP4328245A3 (en) 2014-07-15 2024-06-05 Kymab Ltd. Antibodies for use in treating conditions related to specific pcsk9 variants in specific patients populations
US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
US9150660B1 (en) 2014-07-15 2015-10-06 Kymab Limited Precision Medicine by targeting human NAV1.8 variants for treatment of pain
WO2016023916A1 (en) 2014-08-12 2016-02-18 Kymab Limited Treatment of disease using ligand binding to targets of interest
WO2016071701A1 (en) 2014-11-07 2016-05-12 Kymab Limited Treatment of disease using ligand binding to targets of interest
NL2014136B1 (en) 2015-01-14 2017-01-27 Stichting Katholieke Univ Annexin A2 SNP and von Willebrand Disease.
US10265379B2 (en) 2015-09-16 2019-04-23 Annabelle Rodriguez Oquendo Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
WO2017218798A1 (en) 2016-06-15 2017-12-21 Boston Heart Diagnostics Systems and methods for diagnosing familial hypercholesterolemia
ES2871783T3 (es) * 2016-09-20 2021-11-02 Univ Aarhus Compuestos para el tratamiento de trastornos del metabolismo de las lipoproteínas
US10337070B2 (en) 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US20190345557A1 (en) 2017-07-12 2019-11-14 The General Hospital Corporation Atrial fibrillation polygenic risk score
US20190017119A1 (en) 2017-07-12 2019-01-17 The General Hospital Corporation Genetic Risk Predictor
US20190341125A1 (en) 2017-07-12 2019-11-07 The General Hospital Corporation Inflammatory bowel disease polygenic risk score
US20190330698A1 (en) 2017-07-12 2019-10-31 The General Hospital Corporation Diabetes polygenic risk score
US20190345566A1 (en) 2017-07-12 2019-11-14 The General Hospital Corporation Cancer polygenic risk score
US11680296B2 (en) 2017-10-16 2023-06-20 Massachusetts Institute Of Technology Mycobacterium tuberculosis host-pathogen interaction
WO2019199684A1 (en) 2018-04-09 2019-10-17 The Regents Of The University Of Michigan Methods and systems for biocellular marker detection and diagnosis using a microfluidic profiling device
MX2020013994A (es) 2018-06-22 2021-05-27 Bluestar Genomics Inc Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso.
US20210285050A1 (en) 2018-07-06 2021-09-16 United States Government As Represented By The Department Of Veterans Affairs Pde3b variants
WO2020010186A1 (en) * 2018-07-06 2020-01-09 Derek Klarin Pcsk9 variants
JP2022507958A (ja) * 2018-11-27 2022-01-18 ノバルティス アーゲー 代謝障害の治療用のプロタンパク質転換酵素サブチリシン/ケキシン9型(pcsk9)阻害薬としての環状四量体化合物
EP3969620B1 (en) 2019-05-17 2025-06-25 Regeneron Pharmaceuticals, Inc. Genome-based methods for reducing cardiovascular risk
CN113874020A (zh) 2019-05-22 2021-12-31 基诺富公司 使用曲美替尼和标志物治疗神经退化性疾病的给药方法和剂量方案
US20200368239A1 (en) 2019-05-22 2020-11-26 Genuv Inc. Treatment of amyotrophic lateral sclerosis using trametinib
WO2021058597A1 (en) 2019-09-24 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of determining whether a subject is at risk of developing arterial plaques
US20210113536A1 (en) 2019-10-21 2021-04-22 United States Government as Represented by the Department of Veteran Affairs Methods and compositions for detecting and treating venous thromboembolism

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