JP2024529930A5 - - Google Patents
Info
- Publication number
- JP2024529930A5 JP2024529930A5 JP2024503797A JP2024503797A JP2024529930A5 JP 2024529930 A5 JP2024529930 A5 JP 2024529930A5 JP 2024503797 A JP2024503797 A JP 2024503797A JP 2024503797 A JP2024503797 A JP 2024503797A JP 2024529930 A5 JP2024529930 A5 JP 2024529930A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- interfering rna
- sirna molecule
- modified sirna
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021107862 | 2021-07-22 | ||
| CNPCT/CN2021/107862 | 2021-07-22 | ||
| PCT/CN2022/107028 WO2023001234A1 (en) | 2021-07-22 | 2022-07-21 | Modified small interfering rna molecules with reduced off-target effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024529930A JP2024529930A (ja) | 2024-08-14 |
| JP2024529930A5 true JP2024529930A5 (https=) | 2025-07-30 |
Family
ID=84979733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024503797A Pending JP2024529930A (ja) | 2021-07-22 | 2022-07-21 | 低減されたオフターゲット効果を有する修飾低分子干渉ｒｎａ分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240425853A1 (https=) |
| EP (1) | EP4373932A1 (https=) |
| JP (1) | JP2024529930A (https=) |
| KR (1) | KR20240042457A (https=) |
| CN (1) | CN118202046A (https=) |
| CA (1) | CA3227144A1 (https=) |
| WO (1) | WO2023001234A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080188430A1 (en) * | 2001-05-18 | 2008-08-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| WO2005035759A2 (en) * | 2003-08-20 | 2005-04-21 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HYPOXIA INDUCIBLE FACTOR 1 (HIF1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2005032486A2 (en) * | 2003-10-02 | 2005-04-14 | Duke University | A NOVEL SIRNA-BASED APPROACH TO TARGET THE HIF-α FACTOR FOR GENE THERAPY |
| EP3889261A1 (en) * | 2007-08-27 | 2021-10-06 | 1Globe Health Institute LLC | Compositions of asymmetric interfering rna and uses thereof |
| CN106117289B (zh) * | 2016-06-24 | 2019-02-12 | 郑州大学 | 2’-o-moe-3’-h-硫代磷酸酯核苷单体及其合成方法 |
| CN110540990B (zh) * | 2019-07-16 | 2024-08-20 | 武汉泽智生物医药有限公司 | 沉默小眼畸形转录因子mRNA表达的siRNA分子 |
-
2022
- 2022-07-21 CN CN202280051993.8A patent/CN118202046A/zh active Pending
- 2022-07-21 KR KR1020247006025A patent/KR20240042457A/ko active Pending
- 2022-07-21 CA CA3227144A patent/CA3227144A1/en active Pending
- 2022-07-21 WO PCT/CN2022/107028 patent/WO2023001234A1/en not_active Ceased
- 2022-07-21 EP EP22845398.1A patent/EP4373932A1/en active Pending
- 2022-07-21 JP JP2024503797A patent/JP2024529930A/ja active Pending
- 2022-07-21 US US18/580,688 patent/US20240425853A1/en active Pending
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