MX2023001912A - Tratamiento de la sepsis con moduladores de pcsk9 y ldlr. - Google Patents
Tratamiento de la sepsis con moduladores de pcsk9 y ldlr.Info
- Publication number
- MX2023001912A MX2023001912A MX2023001912A MX2023001912A MX2023001912A MX 2023001912 A MX2023001912 A MX 2023001912A MX 2023001912 A MX2023001912 A MX 2023001912A MX 2023001912 A MX2023001912 A MX 2023001912A MX 2023001912 A MX2023001912 A MX 2023001912A
- Authority
- MX
- Mexico
- Prior art keywords
- sepsis
- ldlr
- pcsk9
- methods
- modulators
- Prior art date
Links
- 206010040047 Sepsis Diseases 0.000 title abstract 3
- 101100346152 Drosophila melanogaster modSP gene Proteins 0.000 title 1
- 101150013552 LDLR gene Proteins 0.000 title 1
- 102000000853 LDL receptors Human genes 0.000 abstract 2
- 108010001831 LDL receptors Proteins 0.000 abstract 2
- 208000010718 Multiple Organ Failure Diseases 0.000 abstract 2
- 101710180553 Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 abstract 2
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 abstract 2
- 206010040070 Septic Shock Diseases 0.000 abstract 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 abstract 2
- 230000036303 septic shock Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Telephone Function (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción proporciona métodos para el tratamiento de sujetos que tienen sepsis, SIRS, choque séptico y/o MODS, métodos para la identificación de sujetos que tienen un mayor riesgo de desarrollar sepsis, SIRS, choque séptico y/o MODS, y métodos para la detección de polipéptidos variantes y moléculas de ácidos nucleicos variantes de receptor de lipoproteínas de baja densidad (LDLR) y/o proproteína convertasa subtilisina/kexina tipo 9 (PCSK9).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063069789P | 2020-08-25 | 2020-08-25 | |
PCT/US2021/047502 WO2022046873A1 (en) | 2020-08-25 | 2021-08-25 | Treatment of sepsis with pcsk9 and ldlr modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023001912A true MX2023001912A (es) | 2023-07-10 |
Family
ID=77775030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023001912A MX2023001912A (es) | 2020-08-25 | 2021-08-25 | Tratamiento de la sepsis con moduladores de pcsk9 y ldlr. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220064652A1 (es) |
EP (1) | EP4204563A1 (es) |
JP (1) | JP2023539742A (es) |
KR (1) | KR20230057410A (es) |
CN (1) | CN116171161A (es) |
AU (1) | AU2021335200A1 (es) |
CA (1) | CA3191030A1 (es) |
IL (1) | IL300439A (es) |
MX (1) | MX2023001912A (es) |
WO (1) | WO2022046873A1 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2849788B1 (en) * | 2012-05-17 | 2018-01-03 | Cyon Therapeutics Inc. | Proprotein convertase subtilisin kexin 9 (pcsk9) inhibitors for use in treating sepsis and septic shock |
US10323076B2 (en) * | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
CA3035875A1 (en) * | 2016-09-20 | 2018-03-29 | Aarhus Universitet | Compounds for treatment of lipoprotein metabolism disorders |
WO2020010186A1 (en) * | 2018-07-06 | 2020-01-09 | Derek Klarin | Pcsk9 variants |
CN113166101A (zh) * | 2018-11-27 | 2021-07-23 | 诺华股份有限公司 | 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型(PCSK9)抑制剂的环状五聚体化合物 |
-
2021
- 2021-08-25 WO PCT/US2021/047502 patent/WO2022046873A1/en active Application Filing
- 2021-08-25 CA CA3191030A patent/CA3191030A1/en active Pending
- 2021-08-25 EP EP21770398.2A patent/EP4204563A1/en active Pending
- 2021-08-25 MX MX2023001912A patent/MX2023001912A/es unknown
- 2021-08-25 JP JP2023513460A patent/JP2023539742A/ja active Pending
- 2021-08-25 KR KR1020237009863A patent/KR20230057410A/ko active Search and Examination
- 2021-08-25 CN CN202180062771.1A patent/CN116171161A/zh active Pending
- 2021-08-25 AU AU2021335200A patent/AU2021335200A1/en active Pending
- 2021-08-25 IL IL300439A patent/IL300439A/en unknown
- 2021-08-25 US US17/411,460 patent/US20220064652A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN116171161A (zh) | 2023-05-26 |
CA3191030A1 (en) | 2022-03-03 |
US20220064652A1 (en) | 2022-03-03 |
EP4204563A1 (en) | 2023-07-05 |
WO2022046873A1 (en) | 2022-03-03 |
IL300439A (en) | 2023-04-01 |
JP2023539742A (ja) | 2023-09-19 |
KR20230057410A (ko) | 2023-04-28 |
AU2021335200A1 (en) | 2023-04-27 |
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