JP2022525546A5 - - Google Patents

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Publication number
JP2022525546A5
JP2022525546A5 JP2021556509A JP2021556509A JP2022525546A5 JP 2022525546 A5 JP2022525546 A5 JP 2022525546A5 JP 2021556509 A JP2021556509 A JP 2021556509A JP 2021556509 A JP2021556509 A JP 2021556509A JP 2022525546 A5 JP2022525546 A5 JP 2022525546A5
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JP
Japan
Application number
JP2021556509A
Other languages
Japanese (ja)
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JPWO2020191163A5 (https=
JP2022525546A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/023564 external-priority patent/WO2020191163A1/en
Publication of JP2022525546A publication Critical patent/JP2022525546A/ja
Publication of JPWO2020191163A5 publication Critical patent/JPWO2020191163A5/ja
Publication of JP2022525546A5 publication Critical patent/JP2022525546A5/ja
Pending legal-status Critical Current

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JP2021556509A 2019-03-20 2020-03-19 ステロール調節エレメント結合転写タンパク質切断活性化タンパク質(scap)阻害剤による上昇した脂質レベルの治療 Pending JP2022525546A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962820895P 2019-03-20 2019-03-20
US62/820,895 2019-03-20
PCT/US2020/023564 WO2020191163A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors

Publications (3)

Publication Number Publication Date
JP2022525546A JP2022525546A (ja) 2022-05-17
JPWO2020191163A5 JPWO2020191163A5 (https=) 2023-03-20
JP2022525546A5 true JP2022525546A5 (https=) 2023-03-20

Family

ID=70285941

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021556509A Pending JP2022525546A (ja) 2019-03-20 2020-03-19 ステロール調節エレメント結合転写タンパク質切断活性化タンパク質(scap)阻害剤による上昇した脂質レベルの治療

Country Status (6)

Country Link
US (2) US11331332B2 (https=)
EP (1) EP3942047A1 (https=)
JP (1) JP2022525546A (https=)
CN (1) CN113825839A (https=)
CA (1) CA3133002A1 (https=)
WO (1) WO2020191163A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117757790A (zh) * 2022-11-17 2024-03-26 北京福元医药股份有限公司 抑制SCAP基因表达的siRNA、其缀合物和药物组合物及用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
US5631356A (en) 1992-04-03 1997-05-20 Gist-Brocades, N.V. Selective N-acylation of amino alcohols
LT3595B (en) 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2710337B1 (fr) 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US5624920A (en) 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
HRP20030498A2 (en) 2000-12-21 2005-04-30 Aventis Pharma Deutschland Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
TWI291957B (en) 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US20080249040A1 (en) 2001-05-18 2008-10-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA)
US20050014177A1 (en) 2003-05-19 2005-01-20 Koustubh Ranade Human sterol response element binding protein 1 (SREBP1) single nucleotide polymorphisms
AU2007297388A1 (en) * 2006-09-18 2008-03-27 Alnylam Pharmaceuticals, Inc. RNAi modulation of scap and therapeutic uses thereof
JP2018507234A (ja) * 2015-03-04 2018-03-15 メディベイション テクノロジーズ エルエルシー 肝臓線維症、コレステロールの上昇およびインスリン抵抗性を処置する際における使用のためのsrebp遮断薬
WO2017100542A1 (en) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
WO2019141723A1 (en) 2018-01-18 2019-07-25 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting srebp1

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