|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US5294533A
(en)
|
1988-07-05 |
1994-03-15 |
Baylor College Of Medicine |
Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria
|
|
US5135917A
(en)
|
1990-07-12 |
1992-08-04 |
Nova Pharmaceutical Corporation |
Interleukin receptor expression inhibiting antisense oligonucleotides
|
|
US5271941A
(en)
|
1990-11-02 |
1993-12-21 |
Cho Chung Yoon S |
Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases
|
|
US5786138A
(en)
|
1993-01-29 |
1998-07-28 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Hyperstabilizing antisense nucleic acid binding agents
|
|
JPH10510700A
(ja)
|
1993-06-04 |
1998-10-20 |
アメリカ合衆国 |
アンチセンスオリゴヌクレオチドを用いてカポジ肉腫を治療する方法
|
|
US5578716A
(en)
|
1993-12-01 |
1996-11-26 |
Mcgill University |
DNA methyltransferase antisense oligonucleotides
|
|
US5641754A
(en)
|
1994-01-10 |
1997-06-24 |
The Board Of Regents Of The University Of Nebraska |
Antisense oligonucleotide compositions for selectively killing cancer cells
|
|
EP0775204A1
(en)
|
1994-08-09 |
1997-05-28 |
Novartis AG |
Antitumor antisense oligonucleotides
|
|
US5856103A
(en)
|
1994-10-07 |
1999-01-05 |
Board Of Regents The University Of Texas |
Method for selectively ranking sequences for antisense targeting
|
|
US5994320A
(en)
|
1995-02-06 |
1999-11-30 |
Regents Of The University Of Minnesota |
Antisense oligonucleotides and methods for treating central nervous system tumors
|
|
IT1275862B1
(it)
|
1995-03-03 |
1997-10-24 |
Consiglio Nazionale Ricerche |
Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento
|
|
US6040296A
(en)
|
1995-06-07 |
2000-03-21 |
East Carolina University |
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
|
|
AU7286696A
(en)
|
1995-10-13 |
1997-05-07 |
F. Hoffmann-La Roche Ag |
Antisense oligomers
|
|
CA2236825A1
(en)
|
1995-11-21 |
1997-05-29 |
Icn Pharmaceuticals, Inc. |
Inhibition of tumor growth by antisense oligonucleotides for il-8 and il-8 receptor
|
|
WO1997029757A1
(en)
|
1996-02-15 |
1997-08-21 |
National Institutes Of Health |
Rnase l activators and antisense oligonucleotides effective to treat rsv infections
|
|
US5955590A
(en)
|
1996-07-15 |
1999-09-21 |
Worcester Foundation For Biomedical Research |
Conjugates of minor groove DNA binders with antisense oligonucleotides
|
|
US6046004A
(en)
|
1997-02-27 |
2000-04-04 |
Lorne Park Research, Inc. |
Solution hybridization of nucleic acids with antisense probes having modified backbones
|
|
JPH1142091A
(ja)
|
1997-07-25 |
1999-02-16 |
Toagosei Co Ltd |
アンチセンス核酸化合物
|
|
US6046319A
(en)
|
1997-10-22 |
2000-04-04 |
University Technologies International, Inc. |
Antisense oligodeoxynucleotides regulating expression of TNF-α
|
|
US6007995A
(en)
|
1998-06-26 |
1999-12-28 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of TNFR1 expression
|
|
US6013522A
(en)
|
1999-02-23 |
2000-01-11 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of human Smad1 expression
|
|
US6025198A
(en)
|
1999-06-25 |
2000-02-15 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Ship-2 expression
|
|
US6033910A
(en)
|
1999-07-19 |
2000-03-07 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of MAP kinase kinase 6 expression
|
|
EP1476547B1
(en)
|
2002-01-23 |
2006-12-06 |
The University of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
|
US20030232410A1
(en)
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
EP2806025B1
(en)
|
2002-09-05 |
2019-04-03 |
California Institute of Technology |
Use of zinc finger nucleases to stimulate gene targeting
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
WO2005108415A2
(en)
|
2004-04-30 |
2005-11-17 |
Biogen Idec Ma Inc. |
Membrane associated molecules
|
|
US7374927B2
(en)
|
2004-05-03 |
2008-05-20 |
Affymetrix, Inc. |
Methods of analysis of degraded nucleic acid samples
|
|
KR20070060115A
(ko)
|
2004-09-16 |
2007-06-12 |
상가모 바이오사이언스 인코포레이티드 |
단백질 생산을 위한 조성물 및 방법
|
|
WO2009025645A1
(en)
|
2007-08-22 |
2009-02-26 |
Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
|
|
WO2009102820A2
(en)
*
|
2008-02-11 |
2009-08-20 |
Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services |
Modified sugar substrates and methods of use
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
HUE041436T2
(hu)
|
2009-12-10 |
2019-05-28 |
Univ Minnesota |
Tal-effektor-közvetített DNS-módosítás
|
|
GB201000688D0
(en)
*
|
2010-01-15 |
2010-03-03 |
Diagenic Asa |
Product and method
|
|
WO2011145121A1
(en)
|
2010-05-18 |
2011-11-24 |
Scatolificio Mogliani S.N.C. Di Mogliani Mauro E Andrea |
Cardboard box for stable stacking with other identical specimens
|
|
RU2444378C1
(ru)
|
2010-09-06 |
2012-03-10 |
Олег Германович Макеев |
Способ лечения коронарной недостаточности при моделируемой ишемии миокарда
|
|
EP3241902B1
(en)
|
2012-05-25 |
2018-02-28 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
EP4357457B1
(en)
|
2012-10-23 |
2024-10-16 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
EP3363902B1
(en)
|
2012-12-06 |
2019-11-27 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
WO2014093718A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
WO2014131833A1
(en)
|
2013-02-27 |
2014-09-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) |
Gene editing in the oocyte by cas9 nucleases
|
|
AU2014227653B2
(en)
|
2013-03-15 |
2017-04-20 |
The General Hospital Corporation |
Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing
|
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いたゲノム編集の治療的使用
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
MX2019014661A
(es)
|
2017-06-05 |
2020-07-29 |
Regeneron Pharma |
Variantes de b4galt1 y usos de estas.
|