JP7661009B2 - Ｂ４ｇａｌｔ１バリアント及びその使用 - Google Patents

Ｂ４ｇａｌｔ１バリアント及びその使用 Download PDF

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Publication number
JP7661009B2
JP7661009B2 JP2019567349A JP2019567349A JP7661009B2 JP 7661009 B2 JP7661009 B2 JP 7661009B2 JP 2019567349 A JP2019567349 A JP 2019567349A JP 2019567349 A JP2019567349 A JP 2019567349A JP 7661009 B2 JP7661009 B2 JP 7661009B2
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Japan
Prior art keywords
b4galt1
nucleic acid
seq
sequence
increased
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JP2019567349A
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English (en)
Japanese (ja)
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JP2020527329A5 (https=
JP2020527329A (ja
Inventor
モンタセール、メイ
フート、クリストファー ファン
シュルディナー、アラン
デラ ガッタ、ジューシー
ヒーリー、マシュー
プールネン、マリヤ
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Priority to JP2023078115A priority Critical patent/JP2023113657A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01133—Xylosylprotein 4-beta-galactosyltransferase (2.4.1.133)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019567349A 2017-06-05 2018-06-04 Ｂ４ｇａｌｔ１バリアント及びその使用 Active JP7661009B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023078115A JP2023113657A (ja) 2017-06-05 2023-05-10 Ｂ４ｇａｌｔ１バリアント及びその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762515140P 2017-06-05 2017-06-05
US62/515,140 2017-06-05
US201762550161P 2017-08-25 2017-08-25
US62/550,161 2017-08-25
US201862659344P 2018-04-18 2018-04-18
US62/659,344 2018-04-18
PCT/US2018/035806 WO2018226560A1 (en) 2017-06-05 2018-06-04 B4galt1 variants and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023078115A Division JP2023113657A (ja) 2017-06-05 2023-05-10 Ｂ４ｇａｌｔ１バリアント及びその使用

Publications (3)

Publication Number Publication Date
JP2020527329A JP2020527329A (ja) 2020-09-10
JP2020527329A5 JP2020527329A5 (https=) 2021-07-26
JP7661009B2 true JP7661009B2 (ja) 2025-04-14

Family

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Family Applications (2)

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JP2019567349A Active JP7661009B2 (ja) 2017-06-05 2018-06-04 Ｂ４ｇａｌｔ１バリアント及びその使用
JP2023078115A Pending JP2023113657A (ja) 2017-06-05 2023-05-10 Ｂ４ｇａｌｔ１バリアント及びその使用

Family Applications After (1)

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JP2023078115A Pending JP2023113657A (ja) 2017-06-05 2023-05-10 Ｂ４ｇａｌｔ１バリアント及びその使用

Country Status (14)

Country Link
US (2) US10738284B2 (https=)
EP (1) EP3635102B1 (https=)
JP (2) JP7661009B2 (https=)
KR (1) KR102624979B1 (https=)
CN (1) CN110997906B (https=)
AU (1) AU2018282072B2 (https=)
CA (1) CA3065938A1 (https=)
DK (1) DK3635102T3 (https=)
ES (1) ES3049196T3 (https=)
FI (1) FI3635102T3 (https=)
IL (1) IL271073B2 (https=)
MX (1) MX2019014661A (https=)
SG (1) SG11201911597YA (https=)
WO (1) WO2018226560A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019014661A (es) 2017-06-05 2020-07-29 Regeneron Pharma Variantes de b4galt1 y usos de estas.
TW202145884A (zh) * 2020-03-04 2021-12-16 美商再生元醫藥公司 Ｂ４ｇａｌｔ１介導功能之囓齒動物模型
JP2025519286A (ja) 2022-06-01 2025-06-25 イー－セラピューティクス・ピーエルシー 発現および／または機能の阻害剤
CA3276262A1 (en) * 2022-12-09 2024-06-13 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of cardiovascular disease
CN115960926A (zh) * 2022-12-30 2023-04-14 南方科技大学 一种mRNA及含有mRNA的药物
EP4562159A1 (en) * 2023-07-27 2025-06-04 e-therapeutics PLC Inhibitors of expression and/or function

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Also Published As

Publication number Publication date
AU2018282072B2 (en) 2024-06-27
JP2023113657A (ja) 2023-08-16
IL271073A (en) 2020-01-30
KR20200024772A (ko) 2020-03-09
DK3635102T3 (da) 2025-10-27
CN110997906B (zh) 2024-05-07
US10738284B2 (en) 2020-08-11
SG11201911597YA (en) 2020-01-30
JP2020527329A (ja) 2020-09-10
CA3065938A1 (en) 2018-12-13
FI3635102T3 (fi) 2025-10-28
EP3635102A1 (en) 2020-04-15
US20180346888A1 (en) 2018-12-06
US12480103B2 (en) 2025-11-25
IL271073B2 (en) 2025-10-01
MX2019014661A (es) 2020-07-29
AU2018282072A1 (en) 2020-01-16
IL271073B1 (en) 2025-06-01
RU2019144018A3 (https=) 2022-03-04
CN110997906A (zh) 2020-04-10
ES3049196T3 (en) 2025-12-15
WO2018226560A1 (en) 2018-12-13
EP3635102B1 (en) 2025-08-13
KR102624979B1 (ko) 2024-01-16
US20200399617A1 (en) 2020-12-24
RU2019144018A (ru) 2021-07-09

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