DK3635102T3 - B4galt1-varianter og anvendelser deraf - Google Patents

B4galt1-varianter og anvendelser deraf

Info

Publication number
DK3635102T3
DK3635102T3 DK18733472.7T DK18733472T DK3635102T3 DK 3635102 T3 DK3635102 T3 DK 3635102T3 DK 18733472 T DK18733472 T DK 18733472T DK 3635102 T3 DK3635102 T3 DK 3635102T3
Authority
DK
Denmark
Prior art keywords
b4galt1
variants
b4galt1 variants
Prior art date
Application number
DK18733472.7T
Other languages
Danish (da)
English (en)
Inventor
May Montasser
Hout Cristopher Van
Alan Shuldiner
Giusy Della Gatta
Matthew Healy
Marja Puurunen
Original Assignee
Regeneron Pharma
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Univ Maryland filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3635102T3 publication Critical patent/DK3635102T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01133—Xylosylprotein 4-beta-galactosyltransferase (2.4.1.133)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK18733472.7T 2017-06-05 2018-06-04 B4galt1-varianter og anvendelser deraf DK3635102T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762515140P 2017-06-05 2017-06-05
US201762550161P 2017-08-25 2017-08-25
US201862659344P 2018-04-18 2018-04-18
PCT/US2018/035806 WO2018226560A1 (en) 2017-06-05 2018-06-04 B4galt1 variants and uses thereof

Publications (1)

Publication Number Publication Date
DK3635102T3 true DK3635102T3 (da) 2025-10-27

Family

ID=62705750

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18733472.7T DK3635102T3 (da) 2017-06-05 2018-06-04 B4galt1-varianter og anvendelser deraf

Country Status (14)

Country Link
US (2) US10738284B2 (https=)
EP (1) EP3635102B1 (https=)
JP (2) JP7661009B2 (https=)
KR (1) KR102624979B1 (https=)
CN (1) CN110997906B (https=)
AU (1) AU2018282072B2 (https=)
CA (1) CA3065938A1 (https=)
DK (1) DK3635102T3 (https=)
ES (1) ES3049196T3 (https=)
FI (1) FI3635102T3 (https=)
IL (1) IL271073B2 (https=)
MX (1) MX2019014661A (https=)
SG (1) SG11201911597YA (https=)
WO (1) WO2018226560A1 (https=)

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MX2019014661A (es) 2017-06-05 2020-07-29 Regeneron Pharma Variantes de b4galt1 y usos de estas.
TW202145884A (zh) * 2020-03-04 2021-12-16 美商再生元醫藥公司 Ｂ４ｇａｌｔ１介導功能之囓齒動物模型
JP2025519286A (ja) 2022-06-01 2025-06-25 イー－セラピューティクス・ピーエルシー 発現および／または機能の阻害剤
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CN115960926A (zh) * 2022-12-30 2023-04-14 南方科技大学 一种mRNA及含有mRNA的药物
EP4562159A1 (en) * 2023-07-27 2025-06-04 e-therapeutics PLC Inhibitors of expression and/or function

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Also Published As

Publication number Publication date
AU2018282072B2 (en) 2024-06-27
JP2023113657A (ja) 2023-08-16
JP7661009B2 (ja) 2025-04-14
IL271073A (en) 2020-01-30
KR20200024772A (ko) 2020-03-09
CN110997906B (zh) 2024-05-07
US10738284B2 (en) 2020-08-11
SG11201911597YA (en) 2020-01-30
JP2020527329A (ja) 2020-09-10
CA3065938A1 (en) 2018-12-13
FI3635102T3 (fi) 2025-10-28
EP3635102A1 (en) 2020-04-15
US20180346888A1 (en) 2018-12-06
US12480103B2 (en) 2025-11-25
IL271073B2 (en) 2025-10-01
MX2019014661A (es) 2020-07-29
AU2018282072A1 (en) 2020-01-16
IL271073B1 (en) 2025-06-01
RU2019144018A3 (https=) 2022-03-04
CN110997906A (zh) 2020-04-10
ES3049196T3 (en) 2025-12-15
WO2018226560A1 (en) 2018-12-13
EP3635102B1 (en) 2025-08-13
KR102624979B1 (ko) 2024-01-16
US20200399617A1 (en) 2020-12-24
RU2019144018A (ru) 2021-07-09

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