JP2022525546A - ステロール調節エレメント結合転写タンパク質切断活性化タンパク質（ｓｃａｐ）阻害剤による上昇した脂質レベルの治療 - Google Patents

ステロール調節エレメント結合転写タンパク質切断活性化タンパク質（ｓｃａｐ）阻害剤による上昇した脂質レベルの治療 Download PDF

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JP2022525546A
JP2022525546A JP2021556509A JP2021556509A JP2022525546A JP 2022525546 A JP2022525546 A JP 2022525546A JP 2021556509 A JP2021556509 A JP 2021556509A JP 2021556509 A JP2021556509 A JP 2021556509A JP 2022525546 A JP2022525546 A JP 2022525546A
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seq
scap
positions
nucleic acid
nucleotide sequence
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JP2022525546A5 (https=
Inventor
ゴン、ダ－ウェイ
エイ． ペリー、ジェームズ
シュルディナー、アラン
ゴサリア、ネハル
フート、クリストファー ファン
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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JP2021556509A 2019-03-20 2020-03-19 ステロール調節エレメント結合転写タンパク質切断活性化タンパク質（ｓｃａｐ）阻害剤による上昇した脂質レベルの治療 Pending JP2022525546A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962820895P 2019-03-20 2019-03-20
US62/820,895 2019-03-20
PCT/US2020/023564 WO2020191163A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors

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JP2022525546A true JP2022525546A (ja) 2022-05-17
JP2022525546A5 JP2022525546A5 (https=) 2023-03-20

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JP2021556509A Pending JP2022525546A (ja) 2019-03-20 2020-03-19 ステロール調節エレメント結合転写タンパク質切断活性化タンパク質（ｓｃａｐ）阻害剤による上昇した脂質レベルの治療

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US (2) US11331332B2 (https=)
EP (1) EP3942047A1 (https=)
JP (1) JP2022525546A (https=)
CN (1) CN113825839A (https=)
CA (1) CA3133002A1 (https=)
WO (1) WO2020191163A1 (https=)

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
WO2024104416A1 (zh) * 2022-11-17 2024-05-23 北京福元医药股份有限公司 抑制SCAP基因表达的siRNA、其缀合物和药物组合物及用途

Citations (3)

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JP2010503415A (ja) * 2006-09-18 2010-02-04 アルナイラム ファーマシューティカルズ インコーポレイテッド ＳＣＡＰのＲＮＡｉ調節およびその治療的使用
WO2017100542A1 (en) * 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
JP2018507234A (ja) * 2015-03-04 2018-03-15 メディベイション テクノロジーズ エルエルシー 肝臓線維症、コレステロールの上昇およびインスリン抵抗性を処置する際における使用のためのｓｒｅｂｐ遮断薬

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LT3595B (en) 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2710337B1 (fr) 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
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WO2017100542A1 (en) * 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
JP2018536689A (ja) * 2015-12-10 2018-12-13 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ステロール調節エレメント結合タンパク質（ＳＲＥＢＰ）シャペロン（ＳＣＡＰ）ｉＲＮＡ組成物およびその使用方法

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US11331332B2 (en) 2022-05-17
US20220323483A1 (en) 2022-10-13
WO2020191163A1 (en) 2020-09-24
EP3942047A1 (en) 2022-01-26
US20200297753A1 (en) 2020-09-24
CN113825839A (zh) 2021-12-21
CA3133002A1 (en) 2020-09-24

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Effective date: 20260210