CA3133002A1 - Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors - Google Patents

Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors Download PDF

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Publication number
CA3133002A1
CA3133002A1 CA3133002A CA3133002A CA3133002A1 CA 3133002 A1 CA3133002 A1 CA 3133002A1 CA 3133002 A CA3133002 A CA 3133002A CA 3133002 A CA3133002 A CA 3133002A CA 3133002 A1 CA3133002 A1 CA 3133002A1
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CA
Canada
Prior art keywords
seq
scap
positions
nucleotide sequence
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3133002A
Other languages
English (en)
French (fr)
Inventor
Da-Wei Gong
James A. Perry
Alan Shuldiner
Nehal GOSALIA
Cristopher Van Hout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
University of Maryland Baltimore
Original Assignee
Regeneron Pharmaceuticals Inc
University of Maryland Baltimore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc, University of Maryland Baltimore filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3133002A1 publication Critical patent/CA3133002A1/en
Pending legal-status Critical Current

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA3133002A 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors Pending CA3133002A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962820895P 2019-03-20 2019-03-20
US62/820,895 2019-03-20
PCT/US2020/023564 WO2020191163A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors

Publications (1)

Publication Number Publication Date
CA3133002A1 true CA3133002A1 (en) 2020-09-24

Family

ID=70285941

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Application Number Title Priority Date Filing Date
CA3133002A Pending CA3133002A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors

Country Status (6)

Country Link
US (2) US11331332B2 (https=)
EP (1) EP3942047A1 (https=)
JP (1) JP2022525546A (https=)
CN (1) CN113825839A (https=)
CA (1) CA3133002A1 (https=)
WO (1) WO2020191163A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117757790A (zh) * 2022-11-17 2024-03-26 北京福元医药股份有限公司 抑制SCAP基因表达的siRNA、其缀合物和药物组合物及用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
US5631356A (en) 1992-04-03 1997-05-20 Gist-Brocades, N.V. Selective N-acylation of amino alcohols
LT3595B (en) 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2710337B1 (fr) 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US5624920A (en) 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
HRP20030498A2 (en) 2000-12-21 2005-04-30 Aventis Pharma Deutschland Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
TWI291957B (en) 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US20080249040A1 (en) 2001-05-18 2008-10-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA)
US20050014177A1 (en) 2003-05-19 2005-01-20 Koustubh Ranade Human sterol response element binding protein 1 (SREBP1) single nucleotide polymorphisms
AU2007297388A1 (en) * 2006-09-18 2008-03-27 Alnylam Pharmaceuticals, Inc. RNAi modulation of scap and therapeutic uses thereof
JP2018507234A (ja) * 2015-03-04 2018-03-15 メディベイション テクノロジーズ エルエルシー 肝臓線維症、コレステロールの上昇およびインスリン抵抗性を処置する際における使用のためのｓｒｅｂｐ遮断薬
WO2017100542A1 (en) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
WO2019141723A1 (en) 2018-01-18 2019-07-25 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting srebp1

Also Published As

Publication number Publication date
WO2020191163A1 (en) 2020-09-24
US20200297753A1 (en) 2020-09-24
US20220323483A1 (en) 2022-10-13
EP3942047A1 (en) 2022-01-26
CN113825839A (zh) 2021-12-21
US11331332B2 (en) 2022-05-17
JP2022525546A (ja) 2022-05-17

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