MX2020013994A - Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso. - Google Patents

Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso.

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Publication number
MX2020013994A
MX2020013994A MX2020013994A MX2020013994A MX2020013994A MX 2020013994 A MX2020013994 A MX 2020013994A MX 2020013994 A MX2020013994 A MX 2020013994A MX 2020013994 A MX2020013994 A MX 2020013994A MX 2020013994 A MX2020013994 A MX 2020013994A
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Mexico
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tissue
origin
nucleic acid
cell
hydroxymethylation
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MX2020013994A
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English (en)
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Francois Collin
Chin - Jen Ku
Patrick A Arensdorf
Samuel Levy
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Bluestar Genomics Inc
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Publication of MX2020013994A publication Critical patent/MX2020013994A/es

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Abstract

Se proporciona un método para asignar probabilísticamente un tejido de origen a un ácido nucleico en un amuestra, por ejemplo, ADN en una muestra de fluido sin células obtenido de un sujeto humano. Se genera un perfil de hidroximetilación para el ADN de muestra y luego se compara a través de un conjunto de datos de referencia de vectores de perfil de hidroximetilación, donde cada vector de perfil de hidroximetilación identifica el perfil de hidroximetilación en un sitio de referencia específico, el gen específico de tejido asociado con el sitio de referencia, y el tejido con el cual el gen y el sitio de referencia se asocian. Un tejido de origen se puede asignar probabilísticamente al ácido nucleico de muestra utilizando los resultados de la comparación. También se proporcionan otros métodos de uso.
MX2020013994A 2018-06-22 2019-06-24 Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso. MX2020013994A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688975P 2018-06-22 2018-06-22
US201862746237P 2018-10-16 2018-10-16
PCT/US2019/038765 WO2019246625A1 (en) 2018-06-22 2019-06-24 Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use

Publications (1)

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MX2020013994A true MX2020013994A (es) 2021-05-27

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US (2) US20200010880A1 (es)
EP (1) EP3810806A1 (es)
JP (2) JP2021527436A (es)
CN (1) CN112534067A (es)
AU (1) AU2019288835A1 (es)
CA (1) CA3104922A1 (es)
MX (1) MX2020013994A (es)
SG (1) SG11202012585YA (es)
WO (1) WO2019246625A1 (es)

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CN112534067A (zh) 2021-03-19
JP2021527436A (ja) 2021-10-14
US20230095582A1 (en) 2023-03-30
CA3104922A1 (en) 2019-12-26
US20200010880A1 (en) 2020-01-09
WO2019246625A1 (en) 2019-12-26
JP2024107255A (ja) 2024-08-08
SG11202012585YA (en) 2021-01-28
EP3810806A1 (en) 2021-04-28
AU2019288835A1 (en) 2021-01-28

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