SG11202012585YA - Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use - Google Patents

Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use

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Publication number
SG11202012585YA
SG11202012585YA SG11202012585YA SG11202012585YA SG11202012585YA SG 11202012585Y A SG11202012585Y A SG 11202012585YA SG 11202012585Y A SG11202012585Y A SG 11202012585YA SG 11202012585Y A SG11202012585Y A SG 11202012585YA SG 11202012585Y A SG11202012585Y A SG 11202012585YA
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SG
Singapore
Prior art keywords
origin
cell
nucleic acid
related methods
free nucleic
Prior art date
Application number
SG11202012585YA
Inventor
Chin-Jen Ku
Francois Collin
Patrick A Arensdorf
Samuel Levy
Original Assignee
Bluestar Genomics Inc
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Publication date
Application filed by Bluestar Genomics Inc filed Critical Bluestar Genomics Inc
Publication of SG11202012585YA publication Critical patent/SG11202012585YA/en

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
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  • Computer Vision & Pattern Recognition (AREA)
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  • Hospice & Palliative Care (AREA)
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SG11202012585YA 2018-06-22 2019-06-24 Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use SG11202012585YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688975P 2018-06-22 2018-06-22
US201862746237P 2018-10-16 2018-10-16
PCT/US2019/038765 WO2019246625A1 (en) 2018-06-22 2019-06-24 Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use

Publications (1)

Publication Number Publication Date
SG11202012585YA true SG11202012585YA (en) 2021-01-28

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Country Status (9)

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US (2) US20200010880A1 (en)
EP (1) EP3810806A1 (en)
JP (1) JP2021527436A (en)
CN (1) CN112534067A (en)
AU (1) AU2019288835A1 (en)
CA (1) CA3104922A1 (en)
MX (1) MX2020013994A (en)
SG (1) SG11202012585YA (en)
WO (1) WO2019246625A1 (en)

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US10785058B2 (en) 2019-02-01 2020-09-22 Comcast Cable Communications, Llc Managing network packet flows based on device information
KR102637032B1 (en) * 2020-01-28 2024-02-15 주식회사 젠큐릭스 Composition for diagnosing bladder cancer using CpG methylation status of specific gene and uses thereof
EP4165206A2 (en) * 2020-06-16 2023-04-19 Grail, LLC Methods for analysis of cell-free rna
CN116057185A (en) 2020-08-15 2023-05-02 雷杰纳荣制药公司 Treating obesity in a subject having a variant nucleic acid molecule encoding a calcitonin receptor (CALCR)
CN112410418A (en) * 2020-11-23 2021-02-26 复旦大学附属中山医院 Dilated cardiomyopathy molecular marker
CA3201624A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Treatment of liver diseases with cell death inducing dffa like effector b (cideb) inhibitors
CN113265409B (en) * 2021-05-21 2022-05-20 北京福君基因生物科技有限公司 TIMM21 mutant gene, primer, kit and method for detecting same and application thereof
CN115961031A (en) * 2021-06-02 2023-04-14 武汉艾米森生命科技有限公司 Nucleic acid combination for liver cancer diagnosis or auxiliary diagnosis, detection kit and application thereof
CN114216947B (en) * 2021-12-16 2023-11-10 福州大学 DNA nano tetrad-based indium tin oxide field effect transistor biosensor and application thereof
CN117887854A (en) * 2022-01-24 2024-04-16 博尔诚（北京）科技有限公司 Marker for pancreatic cancer screening, probe composition and application thereof
CN115572764A (en) * 2022-03-30 2023-01-06 江苏鹍远生物技术有限公司 Tumor detection marker and application thereof
WO2023235614A1 (en) * 2022-06-02 2023-12-07 Clearnote Health, Inc. Predicting and determining efficacy of a lung cancer therapy in a patient
CN116287252B (en) * 2023-02-17 2024-03-08 上海同科生物科技有限公司 Application of long-chain non-coding RNA APCDD1L-DT in preparation of pancreatic cancer detection products

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US20230095582A1 (en) 2023-03-30
AU2019288835A1 (en) 2021-01-28
EP3810806A1 (en) 2021-04-28
CN112534067A (en) 2021-03-19
JP2021527436A (en) 2021-10-14
CA3104922A1 (en) 2019-12-26
WO2019246625A1 (en) 2019-12-26
US20200010880A1 (en) 2020-01-09
MX2020013994A (en) 2021-05-27

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