JP2023529211A - Ｚｂｔｂ３２阻害剤及びその使用 - Google Patents

Ｚｂｔｂ３２阻害剤及びその使用 Download PDF

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JP2023529211A
JP2023529211A JP2022575951A JP2022575951A JP2023529211A JP 2023529211 A JP2023529211 A JP 2023529211A JP 2022575951 A JP2022575951 A JP 2022575951A JP 2022575951 A JP2022575951 A JP 2022575951A JP 2023529211 A JP2023529211 A JP 2023529211A
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cell
zbtb32
inhibitor
cancer
gene
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JP2023529211A5 (https=
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シルバ，マリア エステベス
ガン，イェ
シュー，ユーフェイ
オーランド，エレナ
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ノバルティス アーゲー
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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JP2022575951A 2020-06-11 2021-06-11 Ｚｂｔｂ３２阻害剤及びその使用 Pending JP2023529211A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063037826P 2020-06-11 2020-06-11
US63/037,826 2020-06-11
PCT/US2021/037048 WO2021252920A1 (en) 2020-06-11 2021-06-11 Zbtb32 inhibitors and uses thereof

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JP2023529211A true JP2023529211A (ja) 2023-07-07
JP2023529211A5 JP2023529211A5 (https=) 2024-06-19

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US (1) US20230332104A1 (https=)
EP (1) EP4165169A1 (https=)
JP (1) JP2023529211A (https=)
KR (1) KR20230024967A (https=)
CN (1) CN116096862A (https=)
AU (1) AU2021288224A1 (https=)
CA (1) CA3185455A1 (https=)
IL (1) IL298473A (https=)
WO (1) WO2021252920A1 (https=)

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JP6647868B2 (ja) 2013-02-20 2020-02-14 ノバルティス アーゲー ヒト化抗ＥＧＦＲｖＩＩＩキメラ抗原受容体を用いたがんの処置
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
JP6961490B2 (ja) 2015-04-08 2021-11-05 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
CA2992551A1 (en) 2015-07-21 2017-01-26 Novartis Ag Methods for improving the efficacy and expansion of immune cells
BR112019006781A2 (pt) 2016-10-07 2019-07-30 Novartis Ag receptores de antígeno quiméricos para o tratamento de câncer
AU2018351050B2 (en) 2017-10-18 2025-09-18 Novartis Ag Compositions and methods for selective protein degradation
TWI890660B (zh) 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma 嵌合抗原受體及其用途
IL293215A (en) 2019-11-26 2022-07-01 Novartis Ag Chimeric antigen receptors that bind bcma and cd19 and their uses
EP4065157A1 (en) 2019-11-26 2022-10-05 Novartis AG Cd19 and cd22 chimeric antigen receptors and uses thereof
EP4472646A1 (en) * 2022-02-01 2024-12-11 Sana Biotechnology, Inc. Cd3-targeted lentiviral vectors and uses thereof
WO2024173766A1 (en) * 2023-02-17 2024-08-22 Differentiated Therapeutics, Inc. Cyclin dependent kinase degraders and methods of use thereof
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