JP2023524036A - ペプチジルアルギニンデイミナーゼの大環状阻害剤 - Google Patents

ペプチジルアルギニンデイミナーゼの大環状阻害剤 Download PDF

Info

Publication number
JP2023524036A
JP2023524036A JP2022566059A JP2022566059A JP2023524036A JP 2023524036 A JP2023524036 A JP 2023524036A JP 2022566059 A JP2022566059 A JP 2022566059A JP 2022566059 A JP2022566059 A JP 2022566059A JP 2023524036 A JP2023524036 A JP 2023524036A
Authority
JP
Japan
Prior art keywords
optionally substituted
alkyl
pharmaceutically acceptable
acceptable salt
stereoisomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022566059A
Other languages
English (en)
Japanese (ja)
Other versions
JP7507251B2 (ja
Inventor
エダ ワイ. カナレス,
ウェン ケー. チャン,
ローラン ペ. ドゥビアン,
ペーテル ヤンサ,
ジェニファー エー. ローヤー-ドリュー,
ルイスルーベン ピー. マルティネス,
ステファン ペロー,
ゲイリー ビー. フィリップス,
ヒュン-ジュン ピュン,
ローランド ディー. サイトウ,
マイケル エス. サンギ,
アダム ジェイ. シュライアー,
マリナ イー. シャツキフ,
ジェイムズ ジー. テイラー,
ジェニファー エー. トレイバーグ,
ベルドイゼン, ジョシュア ジェイ. ヴァン
Original Assignee
ギリアード サイエンシーズ, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ギリアード サイエンシーズ, インコーポレイテッド filed Critical ギリアード サイエンシーズ, インコーポレイテッド
Publication of JP2023524036A publication Critical patent/JP2023524036A/ja
Application granted granted Critical
Publication of JP7507251B2 publication Critical patent/JP7507251B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022566059A 2020-04-30 2021-04-28 ペプチジルアルギニンデイミナーゼの大環状阻害剤 Active JP7507251B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063018411P 2020-04-30 2020-04-30
US63/018,411 2020-04-30
US202063129430P 2020-12-22 2020-12-22
US63/129,430 2020-12-22
PCT/US2021/029557 WO2021222353A1 (en) 2020-04-30 2021-04-28 Macrocyclic inhibitors of peptidylarginine deiminases

Publications (2)

Publication Number Publication Date
JP2023524036A true JP2023524036A (ja) 2023-06-08
JP7507251B2 JP7507251B2 (ja) 2024-06-27

Family

ID=76181198

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022566059A Active JP7507251B2 (ja) 2020-04-30 2021-04-28 ペプチジルアルギニンデイミナーゼの大環状阻害剤

Country Status (17)

Country Link
US (1) US11976083B2 (ko)
EP (1) EP4143189A1 (ko)
JP (1) JP7507251B2 (ko)
KR (1) KR20230004810A (ko)
CN (1) CN115551862B (ko)
AU (1) AU2021265110B2 (ko)
BR (1) BR112022021963A2 (ko)
CA (1) CA3177532A1 (ko)
CL (1) CL2022002990A1 (ko)
CO (1) CO2022015307A2 (ko)
CR (1) CR20220550A (ko)
DO (1) DOP2022000235A (ko)
IL (1) IL296923A (ko)
MX (1) MX2022013615A (ko)
PE (1) PE20230488A1 (ko)
TW (1) TWI815110B (ko)
WO (1) WO2021222353A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202241884A (zh) 2020-12-22 2022-11-01 美商基利科學股份有限公司 肽基精胺酸去亞胺酶之抑制劑
AU2022387714A1 (en) 2021-11-15 2024-05-30 Regor Pharmaceuticals, Inc. Pad4 inhibitors and use thereof
WO2024008745A1 (en) 2022-07-05 2024-01-11 Institut National de la Santé et de la Recherche Médicale Methods and composition to identify and treat subjects resisting to chemotherapy treatment
CN115960124A (zh) * 2023-02-23 2023-04-14 康化(上海)新药研发有限公司 一种2-氟-3-甲酰基-吡啶-4-硼酸频哪醇酯的合成方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015522628A (ja) * 2012-07-26 2015-08-06 グラクソ グループ リミテッドGlaxo Group L Pad4阻害剤としての2−(アザインドール−2−イル)ベンズイミダゾール
JP2018520105A (ja) * 2015-05-21 2018-07-26 グラクソスミスクライン、インテレクチュアル、プロパテ Pad4阻害剤としてのベンゾイミダゾール誘導体
JP2019505568A (ja) * 2015-12-09 2019-02-28 パドロック・セラピューティクス・インコーポレイテッド Pad4の二環式阻害剤
JP2019505597A (ja) * 2016-02-23 2019-02-28 パドロック・セラピューティクス・インコーポレイテッド Pad4のヘテロアリール阻害剤
JP2019525936A (ja) * 2016-07-27 2019-09-12 パドロック・セラピューティクス・インコーポレイテッド Pad4の共有結合性阻害剤
WO2020033520A1 (en) * 2018-08-08 2020-02-13 Bristol-Myers Squibb Company Indole and azaindole inhibitors of pad enzymes
JP2021500330A (ja) * 2017-10-18 2021-01-07 ジュビラント エピパッド エルエルシー Pad阻害剤としてのイミダゾ−ピリジン化合物
JP2021515043A (ja) * 2018-02-26 2021-06-17 南京薬捷安康生物科技有限公司Nanjing Transthera Biosciences Co., Ltd. ペプチジルアルギニンデイミナーゼ阻害剤及びその使用
JP2021534104A (ja) * 2018-08-08 2021-12-09 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Pad酵素のベンズイミダゾール阻害剤
JP2023512557A (ja) * 2020-02-06 2023-03-27 ブリストル-マイヤーズ スクイブ カンパニー 免疫抑制剤として有用な大環状pad4阻害剤
JP2023515780A (ja) * 2020-02-12 2023-04-14 ブリストル-マイヤーズ スクイブ カンパニー ヘテロ環状pad4阻害剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3821540A1 (de) 1988-06-25 1989-12-28 Boehringer Mannheim Gmbh Neue sulfonamide, verfahren zu ihrer herstellung sowie solche sulfonamide enthaltende arzneimittel
PL2152701T3 (pl) 2007-03-12 2016-10-31 Związki fenyloaminopirymidyny i ich zastosowania
EP2137179B1 (en) 2007-03-15 2015-09-02 Merck Sharp & Dohme Corp. Pyridazinone derivatives useful as glucan synthase inhibitors
GB201106520D0 (en) 2011-04-18 2011-06-01 Numedicus Ltd Pharmaceutical compounds
AR107030A1 (es) 2015-12-09 2018-03-14 Padlock Therapeutics Inc Inhibidores aza-bencimidazol de pad4
EP3510025B1 (en) 2016-09-12 2022-06-29 Padlock Therapeutics, Inc. Heteroaryl inhibitors of pad4
WO2019057910A1 (en) 2017-09-21 2019-03-28 F. Hoffmann-La Roche Ag USE OF A SOLID FRACTION SENSOR FOR EVALUATING SOLID FRACTION OF A TARGET PHARMACEUTICAL SAMPLE AND SOLID FRACTION SENSOR
EP3684767B1 (en) 2017-09-22 2024-04-24 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
EP3746430A4 (en) 2018-02-02 2021-11-03 Padforward LLC INHIBITORS OF PROTEIN ARGININE DEIMINASES
JP7447080B2 (ja) 2018-08-08 2024-03-11 ブリストル-マイヤーズ スクイブ カンパニー Pad4阻害剤としての置換チエノピロール
CN112805066A (zh) 2018-08-08 2021-05-14 百时美施贵宝公司 作为pad4抑制剂的经取代的苯并咪唑
JP2022549274A (ja) 2019-09-23 2022-11-24 ナンジン・ジェンシアン・ファーマシューティカルズ・カンパニー・リミテッド ホスホジエステラーゼ阻害剤および使用
CN112574230B (zh) 2019-09-27 2022-10-28 药捷安康(南京)科技股份有限公司 肽酰精氨酸脱亚胺酶抑制剂及其用途

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015522628A (ja) * 2012-07-26 2015-08-06 グラクソ グループ リミテッドGlaxo Group L Pad4阻害剤としての2−(アザインドール−2−イル)ベンズイミダゾール
JP2018520105A (ja) * 2015-05-21 2018-07-26 グラクソスミスクライン、インテレクチュアル、プロパテ Pad4阻害剤としてのベンゾイミダゾール誘導体
JP2019505568A (ja) * 2015-12-09 2019-02-28 パドロック・セラピューティクス・インコーポレイテッド Pad4の二環式阻害剤
JP2019505597A (ja) * 2016-02-23 2019-02-28 パドロック・セラピューティクス・インコーポレイテッド Pad4のヘテロアリール阻害剤
JP2019525936A (ja) * 2016-07-27 2019-09-12 パドロック・セラピューティクス・インコーポレイテッド Pad4の共有結合性阻害剤
JP2021500330A (ja) * 2017-10-18 2021-01-07 ジュビラント エピパッド エルエルシー Pad阻害剤としてのイミダゾ−ピリジン化合物
JP2021515043A (ja) * 2018-02-26 2021-06-17 南京薬捷安康生物科技有限公司Nanjing Transthera Biosciences Co., Ltd. ペプチジルアルギニンデイミナーゼ阻害剤及びその使用
WO2020033520A1 (en) * 2018-08-08 2020-02-13 Bristol-Myers Squibb Company Indole and azaindole inhibitors of pad enzymes
JP2021534104A (ja) * 2018-08-08 2021-12-09 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Pad酵素のベンズイミダゾール阻害剤
JP2023512557A (ja) * 2020-02-06 2023-03-27 ブリストル-マイヤーズ スクイブ カンパニー 免疫抑制剤として有用な大環状pad4阻害剤
JP2023515780A (ja) * 2020-02-12 2023-04-14 ブリストル-マイヤーズ スクイブ カンパニー ヘテロ環状pad4阻害剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAMILLE G. WERMUTH: "Part III 構造活性相関研究の基礎", 最新 創薬化学 上巻 THE PRACTICE OF MEDICINAL CHEMISTRY, vol. 第1版, JPN6023006131, pages 273 - 296, ISSN: 0005199162 *

Also Published As

Publication number Publication date
AU2021265110A1 (en) 2022-10-27
CA3177532A1 (en) 2021-11-04
EP4143189A1 (en) 2023-03-08
TWI815110B (zh) 2023-09-11
CR20220550A (es) 2022-12-15
IL296923A (en) 2022-12-01
JP7507251B2 (ja) 2024-06-27
KR20230004810A (ko) 2023-01-06
MX2022013615A (es) 2022-11-16
DOP2022000235A (es) 2022-11-30
CO2022015307A2 (es) 2023-02-16
PE20230488A1 (es) 2023-03-21
US11976083B2 (en) 2024-05-07
BR112022021963A2 (pt) 2022-12-13
WO2021222353A1 (en) 2021-11-04
US20230002412A1 (en) 2023-01-05
CL2022002990A1 (es) 2023-07-14
CN115551862B (zh) 2024-04-12
TW202206431A (zh) 2022-02-16
CN115551862A (zh) 2022-12-30
AU2021265110B2 (en) 2023-08-17

Similar Documents

Publication Publication Date Title
JP7558267B2 (ja) Glp-1r調節化合物
JP7507251B2 (ja) ペプチジルアルギニンデイミナーゼの大環状阻害剤
JP2021054840A (ja) Trkキナーゼ阻害剤としてのマクロ環化合物
TWI554512B (zh) 作為激酶抑制劑之吡咯并吡啶
KR20220042429A (ko) Rip1 억제 화합물 및 그를 제조 및 사용하는 방법
TW202016078A (zh) 作為介白素-1活性之抑制劑之磺醯脒(sulfonimidamide)化合物
JP7493586B2 (ja) Rip1阻害化合物ならびにそれを作製および使用するための方法
TW201906834A (zh) 人類免疫不全病毒複製之抑制劑
AU2010237859A1 (en) Fused pyrrolopyridine derivative
JP7257387B2 (ja) スピロ環化合物並びにその作製及び使用方法
AU2023237198A1 (en) Inhibitors of KEAP1-Nrf2 protein-protein interaction
JP2020524148A (ja) 置換5−シアノインドール化合物及びその使用
KR20240109977A (ko) Kif18a의 스피로 인돌린 억제제
TW202233637A (zh) 作為egfr抑制劑之經取代1h-吡唑并[4,3-c]吡啶及衍生物
WO2022140428A2 (en) Inhibitors of peptidylarginine deiminases
US11878965B2 (en) Inhibitors of peptidylarginine deiminases
TW202430532A (zh) 大環kras抑制劑及使用方法
TW202434589A (zh) 巨環雜環及其用途
EA041386B1 (ru) Спироциклические соединения и способы их получения и применения
TW201215606A (en) Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221207

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221207

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20231110

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240219

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240305

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240604

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240612

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240617