JP2023520397A5 - - Google Patents

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Publication number
JP2023520397A5
JP2023520397A5 JP2022559583A JP2022559583A JP2023520397A5 JP 2023520397 A5 JP2023520397 A5 JP 2023520397A5 JP 2022559583 A JP2022559583 A JP 2022559583A JP 2022559583 A JP2022559583 A JP 2022559583A JP 2023520397 A5 JP2023520397 A5 JP 2023520397A5
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JP
Japan
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
deuterated derivative
salt according
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Application number
JP2022559583A
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English (en)
Japanese (ja)
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JP7791102B2 (ja
JP2023520397A (ja
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Priority claimed from PCT/US2021/025623 external-priority patent/WO2021203028A1/en
Publication of JP2023520397A publication Critical patent/JP2023520397A/ja
Publication of JP2023520397A5 publication Critical patent/JP2023520397A5/ja
Application granted granted Critical
Publication of JP7791102B2 publication Critical patent/JP7791102B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022559583A 2020-04-03 2021-04-02 アルファ１－アンチトリプシンのモジュレーター Active JP7791102B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063004683P 2020-04-03 2020-04-03
US63/004,683 2020-04-03
PCT/US2021/025623 WO2021203028A1 (en) 2020-04-03 2021-04-02 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

Publications (3)

Publication Number Publication Date
JP2023520397A JP2023520397A (ja) 2023-05-17
JP2023520397A5 true JP2023520397A5 (https=) 2024-04-10
JP7791102B2 JP7791102B2 (ja) 2025-12-23

Family

ID=75674976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022559583A Active JP7791102B2 (ja) 2020-04-03 2021-04-02 アルファ１－アンチトリプシンのモジュレーター

Country Status (7)

Country Link
US (1) US20230159504A1 (https=)
EP (1) EP4126819A1 (https=)
JP (1) JP7791102B2 (https=)
CN (1) CN115697969A (https=)
AU (1) AU2021246527A1 (https=)
CA (1) CA3179189A1 (https=)
WO (1) WO2021203028A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114672A1 (en) 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１－アンチトリプシンのモジュレーター
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612503A (en) * 1949-04-19 1952-09-30 Smith Kline French Lab Basic ether-substituted isoquinolines
US2538341A (en) * 1949-09-20 1951-01-16 Smith Kline French Lab Method for producing 1-hydroxyisoquinolines
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JP2000072751A (ja) * 1998-08-26 2000-03-07 Tanabe Seiyaku Co Ltd イソキノリノン誘導体
JP2000281654A (ja) * 1999-03-26 2000-10-10 Tanabe Seiyaku Co Ltd イソキノリン誘導体
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
FR2802532A1 (fr) * 1999-12-17 2001-06-22 Sanofi Synthelabo Derives de 2-phenyl-quinoleine, leur preparation et leur application en therapeutique
EP1305308B1 (en) * 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
EP1396488A1 (en) * 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
US7723352B2 (en) * 2003-09-23 2010-05-25 Merck Sharp & Dohme Isoquinolinone potassium channel inhibitors
DK2013619T3 (en) * 2006-04-10 2017-12-04 Wisconsin Alumni Res Found METHODS FOR USING HUMAN EMBYO STEM CELLS FOR EVALUATION OF THE PHARMACEUTICAL SUBSTANCE AND OTHER CHEMICALS
US20100016285A1 (en) * 2007-01-24 2010-01-21 Mochida Pharmaceutical Co., Ltd. Heterocyclidene-n-(aryl) acetamide derivative
RU2337915C1 (ru) * 2007-03-14 2008-11-10 Общество с ограниченной ответственностью "Инжиниринговая компания "ИНКОМП-НЕФТЬ" Комплексонат нитрилотри(метиленфосфонато)-2-фенил-3-этил-8-оксихинолин натриевая соль в качестве ингибитора солеотложений
GB0722055D0 (en) * 2007-11-09 2007-12-19 Argenta Discovery Ltd Compounds
CN103239451A (zh) * 2012-02-10 2013-08-14 上海医学生命科学研究中心有限公司 吡咯并喹啉醌在治疗和/或预防肝纤维化中的应用
WO2016154051A1 (en) * 2015-03-20 2016-09-29 University Of Florida Research Foundation, Inc. Combination therapy for treating infections diseases
CN109111426B (zh) * 2017-06-23 2021-12-14 中国科学院上海药物研究所 一类稠合双环杂芳基或芳基化合物，及其用途
PE20201170A1 (es) * 2017-11-01 2020-10-28 Bristol Myers Squibb Co Compuestos biciclicos en puente como moduladores del receptor farnesoide x
CN107698505A (zh) * 2017-11-20 2018-02-16 孙婷婷 一种诺得司他的制备方法
SMT202200396T1 (it) * 2017-12-13 2022-11-18 Lupin Ltd Composti eterociclici biciclici sostituiti come inibitori di prmt5
CN111971278B (zh) * 2018-01-31 2023-08-11 默克专利有限公司 用作irak抑制剂的喹啉化合物及其用途
MX2020013853A (es) * 2018-06-22 2021-05-27 Ucl Business Ltd Compuestos innovadores.
US12173026B2 (en) * 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3620164A1 (en) * 2018-09-05 2020-03-11 Genoscience Pharma SAS Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases
CN110776459B (zh) * 2019-03-19 2023-01-24 江苏知原药业股份有限公司 7-羟基-2-喹诺酮-二硫代氨基甲酸酯类胆碱酯酶抑制剂

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