JP2023518286A5 - - Google Patents

Info

Publication number
JP2023518286A5
JP2023518286A5 JP2022556522A JP2022556522A JP2023518286A5 JP 2023518286 A5 JP2023518286 A5 JP 2023518286A5 JP 2022556522 A JP2022556522 A JP 2022556522A JP 2022556522 A JP2022556522 A JP 2022556522A JP 2023518286 A5 JP2023518286 A5 JP 2023518286A5
Authority
JP
Japan
Prior art keywords
alkyl
group
alkoxy
independently selected
haloalkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022556522A
Other languages
English (en)
Japanese (ja)
Other versions
JP7474861B2 (ja
JP2023518286A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/022912 external-priority patent/WO2021188769A1/en
Publication of JP2023518286A publication Critical patent/JP2023518286A/ja
Publication of JP2023518286A5 publication Critical patent/JP2023518286A5/ja
Priority to JP2024065054A priority Critical patent/JP7648828B2/ja
Application granted granted Critical
Publication of JP7474861B2 publication Critical patent/JP7474861B2/ja
Priority to JP2025035386A priority patent/JP2025087830A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022556522A 2020-03-19 2021-03-18 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物 Active JP7474861B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024065054A JP7648828B2 (ja) 2020-03-19 2024-04-15 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
JP2025035386A JP2025087830A (ja) 2020-03-19 2025-03-06 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062991952P 2020-03-19 2020-03-19
US62/991,952 2020-03-19
US202063120875P 2020-12-03 2020-12-03
US63/120,875 2020-12-03
PCT/US2021/022912 WO2021188769A1 (en) 2020-03-19 2021-03-18 Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024065054A Division JP7648828B2 (ja) 2020-03-19 2024-04-15 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

Publications (3)

Publication Number Publication Date
JP2023518286A JP2023518286A (ja) 2023-04-28
JP2023518286A5 true JP2023518286A5 (https=) 2023-07-12
JP7474861B2 JP7474861B2 (ja) 2024-04-25

Family

ID=75660301

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022556522A Active JP7474861B2 (ja) 2020-03-19 2021-03-18 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
JP2024065054A Active JP7648828B2 (ja) 2020-03-19 2024-04-15 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
JP2025035386A Pending JP2025087830A (ja) 2020-03-19 2025-03-06 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024065054A Active JP7648828B2 (ja) 2020-03-19 2024-04-15 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
JP2025035386A Pending JP2025087830A (ja) 2020-03-19 2025-03-06 Hif-2アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

Country Status (17)

Country Link
US (4) US11407712B2 (https=)
EP (2) EP4729508A1 (https=)
JP (3) JP7474861B2 (https=)
KR (1) KR20220155593A (https=)
CN (2) CN119118872A (https=)
AU (1) AU2021240068A1 (https=)
BR (1) BR112022018600A2 (https=)
CA (1) CA3173831A1 (https=)
CL (1) CL2022002515A1 (https=)
CO (1) CO2022013274A2 (https=)
CR (1) CR20220470A (https=)
DO (1) DOP2022000194A (https=)
IL (1) IL295569B1 (https=)
MX (1) MX2022011534A (https=)
PE (1) PE20230673A1 (https=)
TW (1) TWI888507B (https=)
WO (1) WO2021188769A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119118872A (zh) 2020-03-19 2024-12-13 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
WO2022246179A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl inhibitor compounds
EP4341261A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
US12145901B1 (en) * 2021-09-17 2024-11-19 Arcus Biosciences, Inc. Process for preparing tetralin compounds
EP4419089A4 (en) * 2021-10-18 2025-09-10 Nikang Therapeutics Inc HYPOXIA-INDUCIBLE FACTOR 2-(ALPHA) INHIBITORS FOR THE TREATMENT OF BLADDER CANCER
WO2023077046A1 (en) * 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
AU2023225036A1 (en) * 2022-02-25 2024-07-11 Katholieke Universiteit Leuven Dihydroquinazolinones and related analogs for inhibiting yap/taz-tead
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
EP4558501A1 (en) 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
WO2024067463A1 (zh) * 2022-09-27 2024-04-04 苏州阿尔脉生物科技有限公司 苯并[7]环烯类衍生物、包含其的药物组合物及其医药用途
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
CN116589446B (zh) * 2023-04-19 2025-11-07 大连理工大学 一种含有n-(杂)芳基取代的四氢喹啉类化合物和应用
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024249894A2 (en) 2023-06-02 2024-12-05 Arcus Biosciences, Inc. Biomarkers for predicting cancer treatment efficacy
WO2025031396A1 (zh) * 2023-08-08 2025-02-13 杭州安道药业有限公司 取代的苯并环丁烯化合物及其在医药领域的应用
WO2025038857A1 (en) 2023-08-16 2025-02-20 Arcus Biosciences, Inc. TETRALINS TARGETING MUTANT HIF-2α
WO2025054339A1 (en) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Triazolopyridine compounds as inhibitors of kit
WO2025072330A1 (en) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Kit inhibitor compounds and methods of use thereof
US20260116868A1 (en) 2023-10-06 2026-04-30 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202523302A (zh) 2023-11-02 2025-06-16 美商阿克思生物科學有限公司 噻唑化合物及其使用方法
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound
WO2025235493A1 (en) 2024-05-07 2025-11-13 Arcus Biosciences, Inc. Casdatifan for use in the treatment of cancer
WO2025245089A1 (en) 2024-05-21 2025-11-27 Arcus Biosciences, Inc. Processes for preparing tetralin compounds
WO2026006759A1 (en) 2024-06-28 2026-01-02 Arcus Biosciences, Inc. Pharmaceutical compositions, dosage forms, and methods of making and using same

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952294A (en) 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
EP1399467A4 (en) 2001-05-09 2004-09-15 Newbiotics Inc PRODRUGS ACTIVATED BY PEPTIDDEFORMYLASE
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ox40l抗體
AU2005316739A1 (en) * 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
PT2343320T (pt) 2005-03-25 2018-01-23 Gitr Inc Anticorpos anti-gitr e as suas utilizações
PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
US8314234B2 (en) 2006-09-25 2012-11-20 Janssen Pharmaceutica N.V. Bicyclic pyrimidine kinase inhibitors
GB0704407D0 (en) 2007-03-07 2007-04-18 Glaxo Group Ltd Compounds
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
US8591886B2 (en) 2007-07-12 2013-11-26 Gitr, Inc. Combination therapies employing GITR binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
EP2249853A4 (en) 2008-01-30 2012-12-26 Univ Indiana Res & Tech Corp ESTER BASED PEPTIDE PRODRUGS
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
KR101790802B1 (ko) 2009-09-03 2017-10-27 머크 샤프 앤드 돔 코포레이션 항-gitr 항체
ES2722300T3 (es) 2009-12-10 2019-08-09 Hoffmann La Roche Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
WO2011107494A1 (de) * 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2542256B1 (en) 2010-03-04 2019-05-22 MacroGenics, Inc. Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
US9169323B2 (en) 2010-03-05 2015-10-27 Hoffmann-La Roche Inc. Antibodies against human CSF-1R
JP5989547B2 (ja) 2010-03-05 2016-09-07 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ヒトcsf−1rに対する抗体及びその使用
HRP20190047T1 (hr) 2010-05-04 2019-02-22 Five Prime Therapeutics, Inc. Protutijela koja se vežu na csf1r
MX337040B (es) 2010-09-09 2016-02-09 Pfizer Moleculas de union a 4-1bb.
JP6072771B2 (ja) 2011-04-20 2017-02-01 メディミューン,エルエルシー B7−h1およびpd−1に結合する抗体およびその他の分子
KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-pd-l1 항체 및 그의 용도
RU2658603C2 (ru) 2011-12-15 2018-06-21 Ф.Хоффманн-Ля Рош Аг Антитела против человеческого csf-1r и их применения
JO3398B1 (ar) * 2011-12-22 2019-10-20 Novartis Ag مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي
KR20140127855A (ko) 2012-02-06 2014-11-04 제넨테크, 인크. Csf1r 억제제를 사용하는 조성물 및 방법
WO2013122897A1 (en) * 2012-02-13 2013-08-22 Amgen Inc. Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
RU2670743C9 (ru) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
CN102786512A (zh) * 2012-05-31 2012-11-21 中国人民解放军军事医学科学院毒物药物研究所 N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
CN107759690A (zh) 2012-08-31 2018-03-06 戊瑞治疗有限公司 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
CA2890897A1 (en) 2012-11-14 2014-05-22 The Board Of Regents Of The University Of Texas System Inhibition of hif-2.alpha. heterodimerization with hif 1.beta. (arnt)
AU2014307958B2 (en) 2013-08-13 2018-04-05 Philip Morris Products S.A. Smoking article comprising a blind combustible heat source
PL3417851T3 (pl) * 2013-09-09 2020-12-14 Peloton Therapeutics, Inc. Etery arylowe i ich zastosowanie
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
US9884843B2 (en) 2013-12-16 2018-02-06 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
WO2016057242A1 (en) 2014-10-10 2016-04-14 The Board Of Regents Of The University Of Texas System HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
WO2016145236A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Hif-2-alpha inhibitor polymorphs
US10512626B2 (en) 2015-03-11 2019-12-24 Peloton Therapeautics, Inc. Compositions for use in treating glioblastoma
WO2016144826A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
US10278942B2 (en) * 2015-03-11 2019-05-07 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
WO2016168510A1 (en) 2015-04-17 2016-10-20 Peloton Therapeutics, Inc. Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
US20190048421A1 (en) 2015-09-21 2019-02-14 The Board Of Regents Of The University Of Texas System Biomarkers of response to hif-2-alpha inhibition in cancer and methods for the use thereof
WO2017120508A1 (en) 2016-01-08 2017-07-13 Arcus Biosciences, Inc. Modulators of 5'-nucleotidase, ecto and the use thereof
WO2018031680A1 (en) 2016-08-10 2018-02-15 Fronthera U.S. Pharmaceuticals Llc Novel compounds, uses and methods for their preparation
EP3518934A4 (en) 2016-10-03 2020-06-24 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
WO2018094148A1 (en) 2016-11-18 2018-05-24 Arcus Biosciences, Inc. Inhibitors of cd73-mediated immunosuppression
HUE064141T2 (hu) 2017-01-20 2024-02-28 Arcus Biosciences Inc Azolopirimidin rákkal összefüggõ rendellenességek kezelésére
ES2953349T3 (es) 2017-05-05 2023-11-10 Arcus Biosciences Inc Derivados de quinazolina-piridina para el tratamiento de trastornos relacionados con el cáncer
PL3634417T3 (pl) 2017-05-17 2023-09-25 Arcus Biosciences, Inc. Pochodne chinazolino-pirazolowe do leczenia chorób związanych z nowotworem
FR3071726B1 (fr) * 2017-09-29 2020-09-04 Univ Paris Sud Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses
TW201942115A (zh) 2018-02-01 2019-11-01 美商輝瑞股份有限公司 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
CN108191860B (zh) 2018-02-12 2019-12-10 中国医科大学 一种HIF-2α小分子抑制剂及其用途
EP3774709A4 (en) 2018-03-28 2021-12-22 Peloton Therapeutics, Inc. METHOD FOR REDUCING INFLAMMATION OF THE DIGESTIVE SYSTEM USING INHIBITORS OF HIF-2-ALPHA
PL3829581T3 (pl) 2018-07-27 2024-07-01 Arcus Biosciences, Inc. Antagoniści pirydonu a2r
WO2020046813A1 (en) 2018-08-27 2020-03-05 Arcus Biosciences, Inc. Cd73 inhibitors
US12171741B2 (en) 2018-09-11 2024-12-24 Nikang Therapeutics, Inc. 2,3-dihydrobenzo[b]thiophene derivatives as hypoxia inducible factor-2(alpha) inhibitors
WO2020081695A1 (en) 2018-10-17 2020-04-23 Nikang Therapeutics, Inc. Indane derivatives as hypoxia inducible factor-2(alpha) inhibitors
CN112955130A (zh) 2018-10-30 2021-06-11 佩洛通治疗公司 包含取代茚满的固体分散体和药物组合物及其制备和使用方法
TWI828800B (zh) 2018-11-16 2024-01-11 美商阿克思生物科學有限公司 Arg1及/或arg2之抑制劑
CN109776607B (zh) 2019-02-21 2021-06-04 青岛海洋生物医药研究院 芳基磷氧类和芳基磷硫类化合物及其制备方法和应用
IL287258B2 (en) 2019-04-18 2026-01-01 Nikang Therapeutics Inc Inhibitors as tetrahydro-1h-cyclopenta[cd] indene derivatives as hypoxia inducible factor -2alpha
US20220274914A1 (en) 2019-07-22 2022-09-01 Nikang Therapeutics, Inc. Tricyclic derivatives as hypoxia inducible factor-2(alpha) inhibitors
CA3162574A1 (en) 2019-11-26 2021-06-03 Merck Patent Gmbh Condensed thiophene derivatives as hypoxia inducible factor (hif) inhibitors
JP2023504623A (ja) 2019-12-04 2023-02-06 アーカス バイオサイエンシーズ,インコーポレーテッド Hif-2アルファの阻害剤
CN111303053B (zh) 2020-03-16 2023-01-17 中国海洋大学 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用
CN119118872A (zh) 2020-03-19 2024-12-13 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物

Similar Documents

Publication Publication Date Title
JP2023518286A5 (https=)
IL295569A (en) Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
JP2020111618A5 (https=)
JP2022535120A5 (https=)
JP2021516237A5 (https=)
JP2022507474A5 (https=)
JP2024521706A5 (https=)
JP2020519664A5 (https=)
JP2024521712A5 (https=)
US6833378B2 (en) Corticotropin releasing factor antagonists
JP2025023997A (ja) Fak阻害剤およびその併用薬物
JP2017530959A5 (https=)
JP2017537080A5 (https=)
JP2017525753A5 (https=)
JP2017514855A5 (https=)
JP2010526096A5 (ja) キナーゼ阻害剤として有用なチアゾールおよびピラゾール
RU2014110623A (ru) Пирролопиразиновые ингибиторы киназы
JP2016534134A5 (https=)
RU2018104092A (ru) Бициклические лактамы и способы их применения
JP2017509586A5 (https=)
JP2017509689A5 (https=)
JP2017538677A5 (https=)
JP2006515858A5 (https=)
JP2009511490A5 (https=)
JP2016519072A5 (https=)