CL2022002515A1 - Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa - Google Patents

Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa

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Publication number
CL2022002515A1
CL2022002515A1 CL2022002515A CL2022002515A CL2022002515A1 CL 2022002515 A1 CL2022002515 A1 CL 2022002515A1 CL 2022002515 A CL2022002515 A CL 2022002515A CL 2022002515 A CL2022002515 A CL 2022002515A CL 2022002515 A1 CL2022002515 A1 CL 2022002515A1
Authority
CL
Chile
Prior art keywords
hif
compounds
2alpha
tetralin
inhibitors
Prior art date
Application number
CL2022002515A
Other languages
English (en)
Spanish (es)
Inventor
Joel Worley Beatty
Samuel Lawrie Drew
Matthew Epplin
Jeremy Thomas Andre Fournier
Balint Gal
Tezcan Guney
Karl T Haelsig
Clayton Hardman
Steven Donald Jacob
Jenna Leigh Jeffrey
Jaroslaw Kalisiak
Kenneth Victor Lawson
Manmohan Reddy Leleti
Erick Allen Lindsey
Artur Karenovich Mailyan
Debashis Mandal
Guillaume Mata
Hyunyoung Moon
Jay Patrick Powers
Brandon Reid Rosen
Yongli Su
Anh Thu Tran
Zhang Wang
Xuelei Yan
Kai Yu
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of CL2022002515A1 publication Critical patent/CL2022002515A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/52—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of six-membered aromatic rings being part of condensed ring systems
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CL2022002515A 2020-03-19 2022-09-14 Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa CL2022002515A1 (es)

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