FR3071726B1 - Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses - Google Patents

Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses Download PDF

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FR3071726B1
FR3071726B1 FR1759102A FR1759102A FR3071726B1 FR 3071726 B1 FR3071726 B1 FR 3071726B1 FR 1759102 A FR1759102 A FR 1759102A FR 1759102 A FR1759102 A FR 1759102A FR 3071726 B1 FR3071726 B1 FR 3071726B1
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group
atom
treatment
infectious diseases
proliferative
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FR1759102A
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FR3071726A1 (fr
Inventor
Samir Messaoudi
Mouad Alami
Jean-Daniel Brion
Amelie Chabrier
Adam Telerman
Robert Amson
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Centre National de la Recherche Scientifique CNRS
Universite Paris Saclay
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Centre National de la Recherche Scientifique CNRS
Universite Paris Sud Paris 11
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Priority to FR1759102A priority Critical patent/FR3071726B1/fr
Priority to JP2020518511A priority patent/JP2020536860A/ja
Priority to CA3076794A priority patent/CA3076794A1/fr
Priority to EP18792980.7A priority patent/EP3687512A1/fr
Priority to PCT/FR2018/052410 priority patent/WO2019063955A1/fr
Priority to US16/651,719 priority patent/US20200253996A1/en
Publication of FR3071726A1 publication Critical patent/FR3071726A1/fr
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    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
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    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Indole Compounds (AREA)
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Abstract

La présente invention concerne les composés de formule (I) suivante : dans laquelle : - X représente un atome d'oxygène, un atome de soufre, un atome d'azote ou un radical CH, La liaison X--Y et Y sont absents si X représente un atome d'oxygène ou de soufre, la liaison X--Y et Y sont présents si X représente un atome d'azote ou un radical CH, Lorsqu'il est présent, Y représente ? un groupe R si X représente un atome d'azote, ? un atome d'hydrogène ou un groupe -NR1 R2 si X représente un radical CH, - (Het)Ar est un cycle aromatique choisi dans le groupe constitué par les groupes aryles et hétéroaryles, - R3, R4, R5, R6 représentent, indépendamment les uns des autres, un atome d'hydrogène, un atome d'halogène, un groupe -NR12R13, un groupe -SR14, un groupe -OR14 ou un groupe -CF3, - Lorsque Y représente un groupe -N R1 R2, les groupes - N R1 R2 et (Het)Ar sont en conformation cis, ou un sel pharmaceutiquement acceptable de celui-ci, pour leur utilisation dans le traitement de maladies prolifératives et de maladies infectieuses.
FR1759102A 2017-09-29 2017-09-29 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses Expired - Fee Related FR3071726B1 (fr)

Priority Applications (6)

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FR1759102A FR3071726B1 (fr) 2017-09-29 2017-09-29 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses
JP2020518511A JP2020536860A (ja) 2017-09-29 2018-10-01 増殖性疾患、感染症、アレルギー、炎症及び／又は喘息を治療するためのｔｃｔｐ阻害剤
CA3076794A CA3076794A1 (fr) 2017-09-29 2018-10-01 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives, de maladies infectieuses, d'allergies, d'inflammations et/ou de l'asthme
EP18792980.7A EP3687512A1 (fr) 2017-09-29 2018-10-01 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives, de maladies infectieuses, d'allergies, d'inflammations et/ou de l'asthme
PCT/FR2018/052410 WO2019063955A1 (fr) 2017-09-29 2018-10-01 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives, de maladies infectieuses, d'allergies, d'inflammations et/ou de l'asthme
US16/651,719 US20200253996A1 (en) 2017-09-29 2018-10-01 Tctp inhibiting agents for the treatment of proliferative diseases, infectious diseases, allergies, inflammations and/or asthma

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FR1759102A FR3071726B1 (fr) 2017-09-29 2017-09-29 Agents inhibant la proteine tctp pour le traitement de maladies proliferatives et de maladies infectieuses
FR1759102 2017-09-29

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US4981870A (en) * 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6482440B2 (en) * 2000-09-21 2002-11-19 Phase 2 Discovery, Inc. Long acting antidepressant microparticles
WO2003096982A2 (fr) * 2002-05-16 2003-11-27 Cytovia, Inc. 4h-chromenes, 2h-chromenes substitues, chromans et analogues utilises comme activateurs de caspases et inducteurs de l'apoptose, et utilisation de ces composes
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US20100009970A1 (en) * 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
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WO2019063955A1 (fr) 2019-04-04
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