DOP2022000194A - Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa - Google Patents

Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa

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Publication number
DOP2022000194A
DOP2022000194A DO2022000194A DO2022000194A DOP2022000194A DO P2022000194 A DOP2022000194 A DO P2022000194A DO 2022000194 A DO2022000194 A DO 2022000194A DO 2022000194 A DO2022000194 A DO 2022000194A DO P2022000194 A DOP2022000194 A DO P2022000194A
Authority
DO
Dominican Republic
Prior art keywords
hif
compounds
2alph
tetraline
inhibitors
Prior art date
Application number
DO2022000194A
Other languages
English (en)
Inventor
Guney Tezcan
Worley Beatty Joel
Epplin Matthew
Thomas Andre Fournier Jeremy
Gal Balint
T Haelsig Karl
HARDMAN Clayton
Donald Jacob Steven
Leigh JEFFREY Jenna
Kalisiak Jaroslaw
Karenovich Mailyan Artur
Victor Lawson Kenneth
Reddy Leleti Manmohan
Allen Lindsey Erick
Mandal Debashis
Mata Guillaume
Moon Hyunyoung
Patrick Powers Jay
Reid Rosen Brandon
Su Yongli
Thu Tran Anh
Wang Zhang
Yan Xuelei
Yu Kai
Lawrie Drew Samuel
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of DOP2022000194A publication Critical patent/DOP2022000194A/es

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    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
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    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Abstract

En el presente documento se describen compuestos que inhiben HIF-2a, así como composiciones que contienen los compuestos y métodos para sintetizar los compuestos. También se describe el uso de dichos compuestos y composiciones para el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluidos los trastornos relacionados con el cáncer y el sistema inmunitario que están mediados, al menos en parte, por HIF-2a.
DO2022000194A 2020-03-19 2022-09-16 Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa DOP2022000194A (es)

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US202062991952P 2020-03-19 2020-03-19
US202063120875P 2020-12-03 2020-12-03
PCT/US2021/022912 WO2021188769A1 (en) 2020-03-19 2021-03-18 Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha

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DOP2022000194A true DOP2022000194A (es) 2022-11-15

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