CR20220470A - Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa - Google Patents

Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa

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Publication number
CR20220470A
CR20220470A CR20220470A CR20220470A CR20220470A CR 20220470 A CR20220470 A CR 20220470A CR 20220470 A CR20220470 A CR 20220470A CR 20220470 A CR20220470 A CR 20220470A CR 20220470 A CR20220470 A CR 20220470A
Authority
CR
Costa Rica
Prior art keywords
hif
2alpha
tetralin
inhibitors
compounds
Prior art date
Application number
CR20220470A
Other languages
English (en)
Inventor
Joel Worley Beatty
Manmohan Reddy Leleti
Yongli Su
Karl T Haelsig
Steven Donald Jacob
Jenna Leigh Jeffrey
Samuel Lawrie Drew
Jeremy Thomas Andre Fournier
Jay Patrick Powers
Balint Gal
Kenneth Victor Lawson
Erick Allen Lindsey
Artur Karenovich Mailyan
Guillaume Mata
Tezcan Guney
Debashis Mandal
Hyunyoung Moon
Matthew Epplin
Brandon Reid Rosen
Jaroslaw Kalisiak
Anh Thu Tran
Zhang Wang
Xuelei Yan
Clayton Hardman
Kai Yu
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of CR20220470A publication Critical patent/CR20220470A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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Abstract

En el presente documento se describen compuestos que inhiben HIF-2α, asi como composiciones que contienen los compuestos y metodos para sintetizar los compuestos. Tambien se describe el uso de dichos compuestos y composiciones para el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluidos los trastornos relacionados con el cancer y el sistema inmunitario que estan mediados, al menos en parte, por HIF-2α.
CR20220470A 2020-03-19 2021-03-18 Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa CR20220470A (es)

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US202062991952P 2020-03-19 2020-03-19
US202063120875P 2020-12-03 2020-12-03
PCT/US2021/022912 WO2021188769A1 (en) 2020-03-19 2021-03-18 Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha

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CR20220470A true CR20220470A (es) 2022-11-14

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EP (1) EP4121409A1 (es)
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