JP2023511522A5 - - Google Patents
Info
- Publication number
- JP2023511522A5 JP2023511522A5 JP2022540677A JP2022540677A JP2023511522A5 JP 2023511522 A5 JP2023511522 A5 JP 2023511522A5 JP 2022540677 A JP2022540677 A JP 2022540677A JP 2022540677 A JP2022540677 A JP 2022540677A JP 2023511522 A5 JP2023511522 A5 JP 2023511522A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- genetically modified
- lacto
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA202000086 | 2020-01-23 | ||
| DKPA202000086 | 2020-01-23 | ||
| PCT/EP2021/051472 WO2021148614A1 (en) | 2020-01-23 | 2021-01-22 | Hmo production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023511522A JP2023511522A (ja) | 2023-03-20 |
| JP2023511522A5 true JP2023511522A5 (https=) | 2023-09-21 |
Family
ID=74556857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540677A Pending JP2023511522A (ja) | 2020-01-23 | 2021-01-22 | Ｈｍｏの産生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12428657B2 (https=) |
| EP (1) | EP4093747A1 (https=) |
| JP (1) | JP2023511522A (https=) |
| CN (1) | CN115003687B (https=) |
| AU (1) | AU2021210607A1 (https=) |
| BR (1) | BR112022014367A2 (https=) |
| WO (1) | WO2021148614A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK180952B1 (en) * | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
| CN116745430A (zh) * | 2021-01-20 | 2023-09-12 | 因比奥斯公司 | 在宿主细胞中产生包含ln3作为核心结构的寡糖 |
| EP4281564A1 (en) | 2021-01-22 | 2023-11-29 | Glycom A/S | New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos |
| DK181991B1 (en) | 2021-11-11 | 2025-05-15 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) in escherichia coli |
| EP4514989A1 (en) | 2022-04-29 | 2025-03-05 | DSM IP Assets B.V. | Hmo producing microorganism with increased robustness towards glucose gradients |
| DK182075B1 (en) * | 2022-06-13 | 2025-07-02 | Dsm Ip Assets Bv | Genetically engineered cells comprising sigma factor modifications for production of heterologous products and methods for use of same |
| DK181765B1 (en) * | 2022-07-15 | 2024-12-04 | Dsm Ip Assets Bv | Cells expressing new fucosyltransferases for in vivo synthesis of lnfp-iii, and methods and uses of same |
| EP4577061A1 (en) | 2022-08-25 | 2025-07-02 | DSM IP Assets B.V. | Hybrid method for producing complex hmos |
| CN120265786A (zh) | 2022-11-25 | 2025-07-04 | 帝斯曼知识产权资产管理有限公司 | 用于生产寡糖的双菌株系统 |
| CN117867054B (zh) * | 2023-01-09 | 2024-09-27 | 山东恒鲁生物科技有限公司 | 合成hmo的方法 |
| WO2024168219A2 (en) * | 2023-02-09 | 2024-08-15 | Amyris, Inc. | Compositions and methods for improved production of human milk oligosaccharides |
| CN120677242A (zh) | 2023-02-24 | 2025-09-19 | 帝斯曼知识产权资产管理有限公司 | 用于体内合成人乳寡糖的产物特异性转运蛋白 |
| DK181822B1 (en) * | 2023-06-07 | 2025-01-30 | Dsm Ip Assets Bv | Genetically engineered strains with reduced byproduct formation and methods and uses of same |
| DK182227B1 (en) | 2023-10-17 | 2025-12-18 | Dsm Ip Assets Bv | Genetically engineered cells comprising new fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lnfp-vi, methods using the same, and uses of new fucosyltransferases thereof. |
| DK202430472A1 (en) | 2024-08-19 | 2026-02-24 | Dsm Ip Assets Bv | Alpha-1,2 fucosyltransferase mutants with increased alpha 1,3-fucosyltransferase activity |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2440661T3 (en) | 2009-06-08 | 2018-03-12 | Jennewein Biotechnologie Gmbh | HMO synthesis |
| DE12746649T1 (de) | 2011-02-16 | 2016-09-29 | Glycosyn LLC | Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien |
| PL2927316T3 (pl) * | 2014-03-31 | 2019-05-31 | Jennewein Biotechnologie Gmbh | Całkowita fermentacja oligosacharydów |
| WO2015188834A1 (en) | 2014-06-11 | 2015-12-17 | Glycom A/S | Separation of 2'-o-fucosyllactose from fermentation broth |
| AU2015315110B2 (en) | 2014-09-09 | 2021-04-08 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| DK3233875T3 (en) | 2014-12-16 | 2022-12-19 | Glycom As | Separation of 2'-fl from a fermentation broth |
| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| ES2991621T3 (es) | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| DK3445770T3 (da) | 2016-04-19 | 2026-02-23 | Glycom As | Separering af oligosaccharider fra fermenteringssuppe |
| ES2856749T3 (es) | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
| CN111727253B (zh) | 2017-12-21 | 2024-08-27 | 格礼卡姆股份公司 | 用于体外和体内基因表达的核酸构建体 |
| US20190323052A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| US20190323053A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells |
| EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
-
2021
- 2021-01-22 CN CN202180009967.4A patent/CN115003687B/zh active Active
- 2021-01-22 WO PCT/EP2021/051472 patent/WO2021148614A1/en not_active Ceased
- 2021-01-22 BR BR112022014367A patent/BR112022014367A2/pt not_active Application Discontinuation
- 2021-01-22 AU AU2021210607A patent/AU2021210607A1/en not_active Abandoned
- 2021-01-22 JP JP2022540677A patent/JP2023511522A/ja active Pending
- 2021-01-22 US US17/759,273 patent/US12428657B2/en active Active
- 2021-01-22 EP EP21703602.9A patent/EP4093747A1/en active Pending
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