JP2023511527A5 - - Google Patents
Info
- Publication number
- JP2023511527A5 JP2023511527A5 JP2022540729A JP2022540729A JP2023511527A5 JP 2023511527 A5 JP2023511527 A5 JP 2023511527A5 JP 2022540729 A JP2022540729 A JP 2022540729A JP 2022540729 A JP2022540729 A JP 2022540729A JP 2023511527 A5 JP2023511527 A5 JP 2023511527A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- genetically modified
- lacto
- seq
- lnt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA202000085 | 2020-01-23 | ||
| DKPA202000085 | 2020-01-23 | ||
| DKPA202000833 | 2020-07-13 | ||
| DKPA202000833 | 2020-07-13 | ||
| PCT/EP2021/051473 WO2021148615A1 (en) | 2020-01-23 | 2021-01-22 | Hmo production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023511527A JP2023511527A (ja) | 2023-03-20 |
| JP2023511527A5 true JP2023511527A5 (https=) | 2023-09-22 |
Family
ID=74556858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540729A Pending JP2023511527A (ja) | 2020-01-23 | 2021-01-22 | Ｈｍｏの産生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230193335A1 (https=) |
| EP (1) | EP4093749A1 (https=) |
| JP (1) | JP2023511527A (https=) |
| CN (1) | CN114981290B (https=) |
| AU (1) | AU2021209394A1 (https=) |
| BR (1) | BR112022014414A2 (https=) |
| WO (1) | WO2021148615A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK180952B1 (en) * | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
| EP4281564A1 (en) | 2021-01-22 | 2023-11-29 | Glycom A/S | New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos |
| DK181497B1 (en) * | 2021-05-17 | 2024-03-12 | Dsm Ip Assets Bv | ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL |
| DK181991B1 (en) | 2021-11-11 | 2025-05-15 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) in escherichia coli |
| DK181683B1 (en) | 2022-03-02 | 2024-09-20 | Dsm Ip Assets Bv | Cells exprssing new sialyltransferases for in vivo synthesis of lst-a, methods using same and constructs encoding said sialyltransferases |
| CN118786221A (zh) | 2022-03-02 | 2024-10-15 | 帝斯曼知识产权资产管理有限公司 | 用于体内合成3'sl和6'sl的新型唾液酸转移酶 |
| DK181319B1 (en) | 2022-03-02 | 2023-08-10 | Dsm Ip Assets Bv | Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl |
| EP4514989A1 (en) | 2022-04-29 | 2025-03-05 | DSM IP Assets B.V. | Hmo producing microorganism with increased robustness towards glucose gradients |
| DK182075B1 (en) * | 2022-06-13 | 2025-07-02 | Dsm Ip Assets Bv | Genetically engineered cells comprising sigma factor modifications for production of heterologous products and methods for use of same |
| DK181765B1 (en) | 2022-07-15 | 2024-12-04 | Dsm Ip Assets Bv | Cells expressing new fucosyltransferases for in vivo synthesis of lnfp-iii, and methods and uses of same |
| DK181911B1 (en) * | 2022-07-15 | 2025-03-18 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING A FUCOSYLTRANSFERASE FOR IN VIVO SYNTHESIS OF COMPLEX FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES (HMOs) AND METHODS FOR PRODUCING THE HMOs AND USE OF THE ENZYME |
| EP4577061A1 (en) | 2022-08-25 | 2025-07-02 | DSM IP Assets B.V. | Hybrid method for producing complex hmos |
| CN120265786A (zh) | 2022-11-25 | 2025-07-04 | 帝斯曼知识产权资产管理有限公司 | 用于生产寡糖的双菌株系统 |
| DK182185B1 (en) * | 2022-12-14 | 2025-10-29 | Dsm Ip Assets Bv | Mutated lacto-n-biosidase,method for making the same and method for synthesizing lacto-n-biose containing carbohydrates |
| CN117867054B (zh) * | 2023-01-09 | 2024-09-27 | 山东恒鲁生物科技有限公司 | 合成hmo的方法 |
| CN120677242A (zh) | 2023-02-24 | 2025-09-19 | 帝斯曼知识产权资产管理有限公司 | 用于体内合成人乳寡糖的产物特异性转运蛋白 |
| DK181822B1 (en) | 2023-06-07 | 2025-01-30 | Dsm Ip Assets Bv | Genetically engineered strains with reduced byproduct formation and methods and uses of same |
| WO2025047865A1 (ja) * | 2023-08-30 | 2025-03-06 | キリンホールディングス株式会社 | 遺伝子改変微生物、及びオリゴ糖の製造方法 |
| WO2025047866A1 (ja) * | 2023-08-30 | 2025-03-06 | キリンホールディングス株式会社 | 遺伝子改変微生物、及びオリゴ糖の製造方法 |
| DK182227B1 (en) | 2023-10-17 | 2025-12-18 | Dsm Ip Assets Bv | Genetically engineered cells comprising new fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lnfp-vi, methods using the same, and uses of new fucosyltransferases thereof. |
| WO2025190861A1 (en) | 2024-03-11 | 2025-09-18 | Dsm Ip Assets B.V. | Fucosyltransferase mutants with low dfl formation |
| DK202430472A1 (en) | 2024-08-19 | 2026-02-24 | Dsm Ip Assets Bv | Alpha-1,2 fucosyltransferase mutants with increased alpha 1,3-fucosyltransferase activity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2440661T3 (en) | 2009-06-08 | 2018-03-12 | Jennewein Biotechnologie Gmbh | HMO synthesis |
| DE12746649T1 (de) | 2011-02-16 | 2016-09-29 | Glycosyn LLC | Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien |
| WO2015188834A1 (en) | 2014-06-11 | 2015-12-17 | Glycom A/S | Separation of 2'-o-fucosyllactose from fermentation broth |
| AU2015315110B2 (en) | 2014-09-09 | 2021-04-08 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| DK3233875T3 (en) | 2014-12-16 | 2022-12-19 | Glycom As | Separation of 2'-fl from a fermentation broth |
| EP3141610A1 (en) * | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| ES2991621T3 (es) | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| DK3445770T3 (da) | 2016-04-19 | 2026-02-23 | Glycom As | Separering af oligosaccharider fra fermenteringssuppe |
| ES2856749T3 (es) | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
| CN111727253B (zh) | 2017-12-21 | 2024-08-27 | 格礼卡姆股份公司 | 用于体外和体内基因表达的核酸构建体 |
| US20190323052A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| US20190323053A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells |
-
2021
- 2021-01-22 WO PCT/EP2021/051473 patent/WO2021148615A1/en not_active Ceased
- 2021-01-22 CN CN202180010201.8A patent/CN114981290B/zh active Active
- 2021-01-22 EP EP21703603.7A patent/EP4093749A1/en active Pending
- 2021-01-22 JP JP2022540729A patent/JP2023511527A/ja active Pending
- 2021-01-22 AU AU2021209394A patent/AU2021209394A1/en not_active Abandoned
- 2021-01-22 BR BR112022014414A patent/BR112022014414A2/pt not_active Application Discontinuation
- 2021-01-22 US US17/759,270 patent/US20230193335A1/en active Pending
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