JP2023139129A5 - - Google Patents
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- Publication number
- JP2023139129A5 JP2023139129A5 JP2023118237A JP2023118237A JP2023139129A5 JP 2023139129 A5 JP2023139129 A5 JP 2023139129A5 JP 2023118237 A JP2023118237 A JP 2023118237A JP 2023118237 A JP2023118237 A JP 2023118237A JP 2023139129 A5 JP2023139129 A5 JP 2023139129A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- mutation
- polyhydroxyalkanoic
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000035772 mutation Effects 0.000 claims 9
- 150000001413 amino acids Chemical group 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 101710096706 Poly(3-hydroxyalkanoate) polymerase Proteins 0.000 claims 4
- 101710159749 Poly(3-hydroxyalkanoate) polymerase subunit PhaC Proteins 0.000 claims 4
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- HPMGFDVTYHWBAG-UHFFFAOYSA-N 3-hydroxyhexanoic acid Chemical compound CCCC(O)CC(O)=O HPMGFDVTYHWBAG-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 241000186394 Eubacterium Species 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Chemical group C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000004475 Arginine Chemical group 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Chemical group OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Chemical group 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 241000498271 Necator Species 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical group OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Chemical group 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Chemical group SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Chemical group 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Chemical group OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical group OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 235000008729 phenylalanine Nutrition 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 235000008521 threonine Nutrition 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018004678 | 2018-01-16 | ||
| JP2018004678 | 2018-01-16 | ||
| PCT/JP2019/000453 WO2019142717A1 (ja) | 2018-01-16 | 2019-01-10 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
| JP2019566440A JP7360329B2 (ja) | 2018-01-16 | 2019-01-10 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566440A Division JP7360329B2 (ja) | 2018-01-16 | 2019-01-10 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023139129A JP2023139129A (ja) | 2023-10-03 |
| JP2023139129A5 true JP2023139129A5 (enExample) | 2023-12-26 |
| JP7579396B2 JP7579396B2 (ja) | 2024-11-07 |
Family
ID=67301317
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566440A Active JP7360329B2 (ja) | 2018-01-16 | 2019-01-10 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
| JP2023118237A Active JP7579396B2 (ja) | 2018-01-16 | 2023-07-20 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566440A Active JP7360329B2 (ja) | 2018-01-16 | 2019-01-10 | 変異型ポリヒドロキシアルカン酸合成酵素、その遺伝子および形質転換体、並びに、ポリヒドロキシアルカン酸の製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11186831B2 (enExample) |
| EP (1) | EP3741858A4 (enExample) |
| JP (2) | JP7360329B2 (enExample) |
| WO (1) | WO2019142717A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7781772B2 (ja) | 2020-11-24 | 2025-12-08 | 株式会社カネカ | ポリ（３－ヒドロキシアルカノエート）の製造方法 |
| US20240384311A1 (en) * | 2021-07-09 | 2024-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Polyhydroxyalkanoates and methods of making thereof |
| US20250109290A1 (en) | 2022-02-07 | 2025-04-03 | Kaneka Corporation | Poly(hydroxyalkanoic acid) powder and use thereof |
| EP4502027A1 (en) | 2022-03-30 | 2025-02-05 | Kaneka Corporation | Method for producing aliphatic polyester-based foam particles |
| CN114480318B (zh) | 2022-04-06 | 2022-07-29 | 深圳蓝晶生物科技有限公司 | 表达乙酰乙酰辅酶a还原酶变体的工程化微生物及提高pha中3-羟基己酸比例的方法 |
| WO2024029220A1 (ja) * | 2022-08-05 | 2024-02-08 | 株式会社カネカ | ポリヒドロキシアルカノエートの製造方法およびその利用 |
| WO2024075597A1 (ja) * | 2022-10-03 | 2024-04-11 | 株式会社カネカ | 共重合ポリヒドロキシアルカン酸混合物の製造方法、及び形質転換微生物 |
| EP4610301A1 (en) | 2022-10-24 | 2025-09-03 | Kaneka Corporation | Method for producing aliphatic polyester-based foam particles |
| EP4656699A1 (en) | 2023-01-27 | 2025-12-03 | Kaneka Corporation | Composition for hot melt adhesive, and method for producing layered product |
| WO2024166830A1 (ja) * | 2023-02-06 | 2024-08-15 | 株式会社カネカ | 形質転換微生物、及びポリヒドロキシアルカン酸の製造方法 |
| CN120641470A (zh) | 2023-02-21 | 2025-09-12 | 株式会社钟化 | 聚(3-羟基烷酸酯)系粉体及水性悬浮液 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849894A (en) * | 1995-11-29 | 1998-12-15 | Monsanto Company | Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase |
| DE60228489D1 (de) | 2001-12-10 | 2008-10-02 | Riken Wako | Verfahren zur herstellung von biologisch abbaubarem polyester |
| EP1626087A4 (en) * | 2003-05-15 | 2006-08-16 | Kaneka Corp | IMPROVED TRANSFORMANT AND METHOD FOR THE PREPARATION OF POLYESTER THEREWITH |
| JP2007259708A (ja) | 2006-03-27 | 2007-10-11 | Kaneka Corp | 新規生分解性ポリエステルの製造方法 |
| EP2295536B1 (en) * | 2008-05-26 | 2016-01-06 | Kaneka Corporation | Microorganism capable of producing improved polyhydroxyalkanoate and method of producing polyhydroxyalkanoate by using the same |
| JP6274494B2 (ja) | 2013-10-17 | 2018-02-07 | 国立研究開発法人理化学研究所 | 微生物によるポリヒドロキシアルカン酸の生産方法 |
| WO2017056442A1 (ja) | 2015-09-28 | 2017-04-06 | 株式会社カネカ | Ｐｈａ合成酵素をコードする遺伝子を有する微生物、およびそれを用いたｐｈａの製造方法 |
| WO2017104722A1 (ja) | 2015-12-16 | 2017-06-22 | 株式会社カネカ | スクロース資化性を有するｐｈａ生産微生物、及び該微生物を用いたｐｈａの製造方法 |
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2019
- 2019-01-10 US US16/962,282 patent/US11186831B2/en active Active
- 2019-01-10 JP JP2019566440A patent/JP7360329B2/ja active Active
- 2019-01-10 EP EP19740819.8A patent/EP3741858A4/en active Pending
- 2019-01-10 WO PCT/JP2019/000453 patent/WO2019142717A1/ja not_active Ceased
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2023
- 2023-07-20 JP JP2023118237A patent/JP7579396B2/ja active Active