JP2005505250A5 - - Google Patents
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- JP2005505250A5 JP2005505250A5 JP2002587384A JP2002587384A JP2005505250A5 JP 2005505250 A5 JP2005505250 A5 JP 2005505250A5 JP 2002587384 A JP2002587384 A JP 2002587384A JP 2002587384 A JP2002587384 A JP 2002587384A JP 2005505250 A5 JP2005505250 A5 JP 2005505250A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- modified
- mutant
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000013090 Thioredoxin-Disulfide Reductase Human genes 0.000 claims 41
- 108010079911 Thioredoxin-disulfide reductase Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 241000196324 Embryophyta Species 0.000 claims 14
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 235000018102 proteins Nutrition 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 10
- 239000004475 Arginine Chemical group 0.000 claims 7
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical group C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 7
- 235000009697 arginine Nutrition 0.000 claims 7
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 235000004400 serine Nutrition 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical group CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Chemical group CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical group OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Chemical group OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Chemical group 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical group OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical group CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical group CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 3
- 101710204410 Scaffold protein Proteins 0.000 claims 3
- 102000002933 Thioredoxin Human genes 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Chemical group 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Chemical group C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical group CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Chemical group OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Chemical group SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Chemical group 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Chemical group OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 235000004554 glutamine Nutrition 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Chemical group CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- 229930182817 methionine Chemical group 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical group OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- 108060008226 thioredoxin Proteins 0.000 claims 3
- 235000008521 threonine Nutrition 0.000 claims 3
- 239000004474 valine Chemical group 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 102000008300 Mutant Proteins Human genes 0.000 claims 2
- 108010021466 Mutant Proteins Proteins 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 235000018977 lysine Nutrition 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 229940094937 thioredoxin Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000219194 Arabidopsis Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000186362 Mycobacterium leprae Species 0.000 claims 1
- 241000221961 Neurospora crassa Species 0.000 claims 1
- 101710089395 Oleosin Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000002009 allergenic effect Effects 0.000 claims 1
- 210000003763 chloroplast Anatomy 0.000 claims 1
- 235000019621 digestibility Nutrition 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28902901P | 2001-05-04 | 2001-05-04 | |
| US37060902P | 2002-04-05 | 2002-04-05 | |
| US37668202P | 2002-04-29 | 2002-04-29 | |
| PCT/US2002/014358 WO2002090300A2 (en) | 2001-05-04 | 2002-05-06 | Nucleic acids and proteins with thioredoxin reductase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505250A JP2005505250A (ja) | 2005-02-24 |
| JP2005505250A5 true JP2005505250A5 (enExample) | 2005-09-15 |
Family
ID=30119062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587384A Pending JP2005505250A (ja) | 2001-05-04 | 2002-05-06 | 核酸およびチオレドキシンレダクターゼ活性を有するタンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7071307B2 (enExample) |
| EP (1) | EP1507852A4 (enExample) |
| JP (1) | JP2005505250A (enExample) |
| CA (1) | CA2447407A1 (enExample) |
| WO (1) | WO2002090300A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030211511A1 (en) * | 2001-05-04 | 2003-11-13 | Briggs Steven P. | Nucleic acids and proteins with thioredoxin reductase activity |
| EP1507852A4 (en) * | 2001-05-04 | 2005-12-28 | Xencor Inc | NUCLEIC ACIDS AND PROTEINS WITH THIORODOXIN REDUCED EFFECT |
| WO2004024868A2 (en) * | 2002-09-10 | 2004-03-25 | National Jewish Medical And Research Center | Product and process for liquefaction of mucus or sputum |
| EP1633865B1 (en) | 2003-06-18 | 2011-09-28 | Bayer Pharma Aktiengesellschaft | New biological entities and the use thereof |
| EP1833961B1 (en) | 2004-10-15 | 2011-07-20 | Monell Chemical Senses Center | Methods for culturing mammalian taste cells |
| EP1829968A4 (en) * | 2004-12-20 | 2008-09-10 | Ajinomoto Kk | PROTEIN MUTANT WITH PEPTIDE PRODUCTION ACTIVITY |
| WO2012075911A1 (zh) * | 2010-12-06 | 2012-06-14 | Li Jianyuan | 重组人prx-6蛋白在治疗烧烫伤和/或角膜损伤中的用途 |
| AU2014232520B2 (en) * | 2013-03-15 | 2019-04-04 | Orpro Therapeutics, Inc. | Product and process for mucus viscosity normalization |
| CN105671012A (zh) * | 2016-04-13 | 2016-06-15 | 深圳大学 | 一种雨生红球藻硒蛋白及其编码基因与应用 |
| CN117500917A (zh) * | 2021-06-23 | 2024-02-02 | 松下知识产权经营株式会社 | 融合蛋白、融合蛋白的制造方法、电极、氧化还原装置、氧化还原方法、二硫键的切断方法和过敏原的灭活方法 |
| CN115778837B (zh) * | 2022-11-21 | 2024-04-02 | 安徽品赫生物科技有限公司 | 一种协同增效的亮肤修护冻干粉及其制备方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| DE4133644A1 (de) * | 1991-10-11 | 1993-04-15 | Nukem Gmbh | Halbleiterbauelement, verfahren zu dessen herstellung sowie hierzu benutzte anordnung |
| US5952034A (en) | 1991-10-12 | 1999-09-14 | The Regents Of The University Of California | Increasing the digestibility of food proteins by thioredoxin reduction |
| CA2121137A1 (en) * | 1991-10-12 | 1993-04-29 | Bob B. Buchanan | Use of thiol redox proteins for reducing disulfide bonds |
| EP1255209A3 (en) | 1997-04-11 | 2009-02-11 | California Institute Of Technology | Apparatus and method for automated protein design |
| JP2002510966A (ja) | 1997-04-11 | 2002-04-09 | カリフォルニア・インスティテュート・オブ・テクノロジー | 自動蛋白質デザインのための装置および方法 |
| US7585645B2 (en) | 1997-05-27 | 2009-09-08 | Sembiosys Genetics Inc. | Thioredoxin and thioredoxin reductase containing oil body based products |
| US20020048772A1 (en) | 2000-02-10 | 2002-04-25 | Dahiyat Bassil I. | Protein design automation for protein libraries |
| AU774334B2 (en) | 1998-10-16 | 2004-06-24 | Xencor | Protein design automation for protein libraries |
| US7315786B2 (en) | 1998-10-16 | 2008-01-01 | Xencor | Protein design automation for protein libraries |
| US6403312B1 (en) | 1998-10-16 | 2002-06-11 | Xencor | Protein design automatic for protein libraries |
| US20030049654A1 (en) | 1998-10-16 | 2003-03-13 | Xencor | Protein design automation for protein libraries |
| EP1033405A3 (en) * | 1999-02-25 | 2001-08-01 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
| AU770629B2 (en) * | 1999-03-31 | 2004-02-26 | Regents Of The University Of California, The | Barley gene for thioredoxin and NADP-thioredoxin reductase |
| DK1255826T3 (da) | 2000-02-10 | 2006-01-30 | Xencor Inc | Automatisering af proteindesign for proteinbiblioteker |
| US6423518B1 (en) | 2000-09-11 | 2002-07-23 | Rutgers, The State University | Design and production of mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency |
| US6576452B1 (en) | 2000-10-04 | 2003-06-10 | Genencor International, Inc. | 2,5-diketo-L-gluconic acid reductases and methods of use |
| US20090197337A1 (en) * | 2000-12-19 | 2009-08-06 | Van Rooijen Gijs | Methods for the production of multimeric proteins and related compositions |
| US20030211511A1 (en) | 2001-05-04 | 2003-11-13 | Briggs Steven P. | Nucleic acids and proteins with thioredoxin reductase activity |
| EP1507852A4 (en) * | 2001-05-04 | 2005-12-28 | Xencor Inc | NUCLEIC ACIDS AND PROTEINS WITH THIORODOXIN REDUCED EFFECT |
| US20030130827A1 (en) | 2001-08-10 | 2003-07-10 | Joerg Bentzien | Protein design automation for protein libraries |
| AU2003226032A1 (en) * | 2002-04-11 | 2003-10-27 | The Regents Of The University Of California | Low allergen plant and animal genotypes |
| US8014867B2 (en) * | 2004-12-17 | 2011-09-06 | Cardiac Pacemakers, Inc. | MRI operation modes for implantable medical devices |
| US7917213B2 (en) * | 2005-11-04 | 2011-03-29 | Kenergy, Inc. | MRI compatible implanted electronic medical lead |
| US7729770B2 (en) * | 2006-04-26 | 2010-06-01 | Medtronic, Inc. | Isolation circuitry and method for gradient field safety in an implantable medical device |
| US7610101B2 (en) * | 2006-11-30 | 2009-10-27 | Cardiac Pacemakers, Inc. | RF rejecting lead |
| US9345888B2 (en) * | 2007-03-09 | 2016-05-24 | Cardiac Pacemakers, Inc. | MRI compatible implantable medical devices and methods |
| US8086321B2 (en) * | 2007-12-06 | 2011-12-27 | Cardiac Pacemakers, Inc. | Selectively connecting the tip electrode during therapy for MRI shielding |
| US8032228B2 (en) * | 2007-12-06 | 2011-10-04 | Cardiac Pacemakers, Inc. | Method and apparatus for disconnecting the tip electrode during MRI |
| US8311637B2 (en) * | 2008-02-11 | 2012-11-13 | Cardiac Pacemakers, Inc. | Magnetic core flux canceling of ferrites in MRI |
| US8160717B2 (en) * | 2008-02-19 | 2012-04-17 | Cardiac Pacemakers, Inc. | Model reference identification and cancellation of magnetically-induced voltages in a gradient magnetic field |
| US8571661B2 (en) * | 2008-10-02 | 2013-10-29 | Cardiac Pacemakers, Inc. | Implantable medical device responsive to MRI induced capture threshold changes |
| EP2398553B1 (en) * | 2009-02-19 | 2015-07-22 | Cardiac Pacemakers, Inc. | Systems for providing arrhythmia therapy in mri environments |
-
2002
- 2002-05-06 EP EP02739225A patent/EP1507852A4/en not_active Withdrawn
- 2002-05-06 CA CA002447407A patent/CA2447407A1/en not_active Abandoned
- 2002-05-06 US US10/141,531 patent/US7071307B2/en not_active Expired - Fee Related
- 2002-05-06 WO PCT/US2002/014358 patent/WO2002090300A2/en not_active Ceased
- 2002-05-06 JP JP2002587384A patent/JP2005505250A/ja active Pending
-
2005
- 2005-12-22 US US11/317,571 patent/US20060149482A1/en not_active Abandoned
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