JP2023110008A5 - - Google Patents
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- Publication number
- JP2023110008A5 JP2023110008A5 JP2023090522A JP2023090522A JP2023110008A5 JP 2023110008 A5 JP2023110008 A5 JP 2023110008A5 JP 2023090522 A JP2023090522 A JP 2023090522A JP 2023090522 A JP2023090522 A JP 2023090522A JP 2023110008 A5 JP2023110008 A5 JP 2023110008A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- microorganism
- mutant polypeptide
- substituted
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001413 amino acids Chemical class 0.000 claims 24
- 235000001014 amino acid Nutrition 0.000 claims 19
- 229940024606 amino acid Drugs 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 244000005700 microbiome Species 0.000 claims 13
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 6
- 229930182816 L-glutamine Natural products 0.000 claims 6
- 241000186216 Corynebacterium Species 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000005396 glutamine synthetase Human genes 0.000 claims 2
- 108020002326 glutamine synthetase Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Chemical group OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Chemical group 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200027322A KR102198072B1 (ko) | 2020-03-04 | 2020-03-04 | 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법 |
| KR10-2020-0027322 | 2020-03-04 | ||
| JP2021562185A JP7371119B2 (ja) | 2020-03-04 | 2021-03-04 | グルタミンシンテターゼ変異型ポリペプチド及びそれを用いたｌ－グルタミン生産方法 |
| PCT/KR2021/002652 WO2021177731A1 (ko) | 2020-03-04 | 2021-03-04 | 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021562185A Division JP7371119B2 (ja) | 2020-03-04 | 2021-03-04 | グルタミンシンテターゼ変異型ポリペプチド及びそれを用いたｌ－グルタミン生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023110008A JP2023110008A (ja) | 2023-08-08 |
| JP2023110008A5 true JP2023110008A5 (https=) | 2023-08-31 |
Family
ID=74127205
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021562185A Active JP7371119B2 (ja) | 2020-03-04 | 2021-03-04 | グルタミンシンテターゼ変異型ポリペプチド及びそれを用いたｌ－グルタミン生産方法 |
| JP2023090522A Pending JP2023110008A (ja) | 2020-03-04 | 2023-05-31 | グルタミンシンテターゼ変異型ポリペプチド及びそれを用いたｌ－グルタミン生産方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021562185A Active JP7371119B2 (ja) | 2020-03-04 | 2021-03-04 | グルタミンシンテターゼ変異型ポリペプチド及びそれを用いたｌ－グルタミン生産方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12270061B2 (https=) |
| EP (1) | EP3954767A4 (https=) |
| JP (2) | JP7371119B2 (https=) |
| KR (1) | KR102198072B1 (https=) |
| CN (1) | CN114375332B (https=) |
| BR (1) | BR112021022223B1 (https=) |
| WO (1) | WO2021177731A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102198072B1 (ko) | 2020-03-04 | 2021-01-04 | 씨제이제일제당 주식회사 | 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법 |
| EP4230743A4 (en) | 2020-11-20 | 2024-04-17 | CJ Cheiljedang Corporation | MICROORGANISM WITH IMPROVED L-GLUTAMINE PRODUCTION CAPABILITY AND L-GLUTAMINE PRODUCTION PROCESS THEREFOR |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060269975A1 (en) * | 1999-07-16 | 2006-11-30 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in DNA replication, protein synthesis, and pathogenesis |
| JP4560998B2 (ja) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| RU2230114C2 (ru) * | 2001-11-30 | 2004-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот |
| JP2004187684A (ja) * | 2002-11-26 | 2004-07-08 | Ajinomoto Co Inc | Ｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| US20050014236A1 (en) * | 2003-03-03 | 2005-01-20 | Yumi Matsuzaki | Method for producing L-arginine or L-lysine by fermentation |
| JP4576850B2 (ja) * | 2003-03-03 | 2010-11-10 | 味の素株式会社 | 発酵法によるｌ−アルギニン又はｌ−リジンの製造法 |
| KR100620092B1 (ko) | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| CN100392075C (zh) * | 2006-06-29 | 2008-06-04 | 清华大学 | 谷氨酰胺合成酶及其专用表达工程菌与应用 |
| JP5048996B2 (ja) | 2006-11-10 | 2012-10-17 | 昭和電工株式会社 | 加工性に優れた耐摩耗性アルミニウム合金材およびその製造方法 |
| CN104145020B (zh) * | 2012-02-16 | 2020-06-02 | 先正达参股股份有限公司 | 工程化的杀有害生物蛋白质 |
| US9567577B2 (en) * | 2012-03-12 | 2017-02-14 | Ares Trading S.A. | Expression vector comprising a polynucleotide encoding a modified glutamine synthetase and a method for preparing a target protein employing the same |
| CN106574254A (zh) * | 2014-04-30 | 2017-04-19 | 赢创德固赛有限公司 | 使用嗜碱性细菌生产l‑氨基酸的方法 |
| KR101632642B1 (ko) | 2015-01-29 | 2016-06-22 | 씨제이제일제당 주식회사 | 신규한 프로모터 및 그의 용도 |
| MY186296A (en) | 2016-08-31 | 2021-07-06 | Cj Cheiljedang Corp | Novel promoter and use thereof |
| KR102198072B1 (ko) * | 2020-03-04 | 2021-01-04 | 씨제이제일제당 주식회사 | 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법 |
-
2020
- 2020-03-04 KR KR1020200027322A patent/KR102198072B1/ko active Active
-
2021
- 2021-03-04 EP EP21764687.6A patent/EP3954767A4/en active Pending
- 2021-03-04 BR BR112021022223-5A patent/BR112021022223B1/pt active IP Right Grant
- 2021-03-04 CN CN202180004868.7A patent/CN114375332B/zh active Active
- 2021-03-04 US US17/604,896 patent/US12270061B2/en active Active
- 2021-03-04 WO PCT/KR2021/002652 patent/WO2021177731A1/ko not_active Ceased
- 2021-03-04 JP JP2021562185A patent/JP7371119B2/ja active Active
-
2023
- 2023-05-31 JP JP2023090522A patent/JP2023110008A/ja active Pending
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