JP2023103379A5 - - Google Patents
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- JP2023103379A5 JP2023103379A5 JP2023080881A JP2023080881A JP2023103379A5 JP 2023103379 A5 JP2023103379 A5 JP 2023103379A5 JP 2023080881 A JP2023080881 A JP 2023080881A JP 2023080881 A JP2023080881 A JP 2023080881A JP 2023103379 A5 JP2023103379 A5 JP 2023103379A5
- Authority
- JP
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- Prior art keywords
- alkyl
- aryl
- substituted
- alkaryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 92
- 125000003118 aryl group Chemical group 0.000 claims 56
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- -1 aryl carbonate Chemical compound 0.000 claims 40
- 125000002877 alkyl aryl group Chemical group 0.000 claims 32
- 239000001257 hydrogen Substances 0.000 claims 32
- 150000002431 hydrogen Chemical class 0.000 claims 31
- 229910052757 nitrogen Inorganic materials 0.000 claims 28
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- 125000006413 ring segment Chemical group 0.000 claims 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims 18
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 16
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 16
- 125000004414 alkyl thio group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 125000002950 monocyclic group Chemical group 0.000 claims 12
- 125000003367 polycyclic group Chemical group 0.000 claims 12
- 108010051913 15-hydroxyprostaglandin dehydrogenase Proteins 0.000 claims 11
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 claims 11
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 9
- 229910019142 PO4 Inorganic materials 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000004423 acyloxy group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 125000005910 alkyl carbonate group Chemical group 0.000 claims 8
- 125000005277 alkyl imino group Chemical group 0.000 claims 8
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 125000001769 aryl amino group Chemical group 0.000 claims 8
- 125000005116 aryl carbamoyl group Chemical group 0.000 claims 8
- 125000004467 aryl imino group Chemical group 0.000 claims 8
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 8
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 8
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 8
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 8
- 125000005110 aryl thio group Chemical group 0.000 claims 8
- 150000001540 azides Chemical class 0.000 claims 8
- 239000004202 carbamide Substances 0.000 claims 8
- 235000013877 carbamide Nutrition 0.000 claims 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 8
- 125000001651 cyanato group Chemical group [*]OC#N 0.000 claims 8
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 claims 8
- 125000002462 isocyano group Chemical group *[N+]#[C-] 0.000 claims 8
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 claims 8
- RIFHJAODNHLCBH-UHFFFAOYSA-N methanethione Chemical group S=[CH] RIFHJAODNHLCBH-UHFFFAOYSA-N 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 claims 8
- 235000021317 phosphate Nutrition 0.000 claims 8
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 8
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 8
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 8
- 229940124530 sulfonamide Drugs 0.000 claims 8
- 150000003456 sulfonamides Chemical class 0.000 claims 8
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 8
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 8
- 125000003302 alkenyloxy group Chemical group 0.000 claims 7
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 7
- 125000005133 alkynyloxy group Chemical group 0.000 claims 7
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 7
- 125000004104 aryloxy group Chemical group 0.000 claims 7
- 150000007942 carboxylates Chemical class 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002170 ethers Chemical class 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 125000000394 phosphonato group Chemical group [O-]P([O-])(*)=O 0.000 claims 6
- 108060001084 Luciferase Proteins 0.000 claims 5
- 239000005089 Luciferase Substances 0.000 claims 5
- 102000008186 Collagen Human genes 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229920001436 collagen Polymers 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 238000009825 accumulation Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 2
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000002579 carboxylato group Chemical group [O-]C(*)=O 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562129885P | 2015-03-08 | 2015-03-08 | |
| US62/129,885 | 2015-03-08 | ||
| JP2020192961A JP7282067B2 (ja) | 2015-03-08 | 2020-11-20 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192961A Division JP7282067B2 (ja) | 2015-03-08 | 2020-11-20 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023103379A JP2023103379A (ja) | 2023-07-26 |
| JP2023103379A5 true JP2023103379A5 (https=) | 2023-08-21 |
Family
ID=56879350
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546676A Pending JP2018511581A (ja) | 2015-03-08 | 2016-03-08 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
| JP2020192961A Active JP7282067B2 (ja) | 2015-03-08 | 2020-11-20 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
| JP2023080881A Pending JP2023103379A (ja) | 2015-03-08 | 2023-05-16 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546676A Pending JP2018511581A (ja) | 2015-03-08 | 2016-03-08 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
| JP2020192961A Active JP7282067B2 (ja) | 2015-03-08 | 2020-11-20 | 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10945998B2 (https=) |
| EP (1) | EP3267995B1 (https=) |
| JP (3) | JP2018511581A (https=) |
| CN (2) | CN107921025A (https=) |
| AU (3) | AU2016229918B2 (https=) |
| CA (1) | CA2979203A1 (https=) |
| HK (1) | HK1250636A1 (https=) |
| WO (1) | WO2016144958A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2838533T3 (da) | 2012-04-16 | 2017-11-27 | Univ Case Western Reserve | Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet |
| US9801863B2 (en) | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
| AU2014342811B2 (en) | 2013-10-15 | 2019-01-03 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN107921025A (zh) | 2015-03-08 | 2018-04-17 | 卡斯西部储备大学 | 用于治疗纤维症的短链脱氢酶活性的抑制剂 |
| AU2016248080A1 (en) * | 2015-04-14 | 2017-11-02 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| JP2020514323A (ja) * | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
| WO2018187810A1 (en) | 2017-04-07 | 2018-10-11 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders |
| US20210317132A1 (en) * | 2017-05-26 | 2021-10-14 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| KR102921276B1 (ko) * | 2018-11-21 | 2026-02-03 | 케이스 웨스턴 리저브 유니버시티 | 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법 |
| TWI834795B (zh) | 2019-01-08 | 2024-03-11 | 日商杏林製藥股份有限公司 | 15-pgdh抑制劑 |
| EP3917911A1 (en) | 2019-01-31 | 2021-12-08 | Kyorin Pharmaceutical Co., Ltd. | 15-pgdh inhibitors |
| KR20220146458A (ko) | 2020-01-23 | 2022-11-01 | 마이오포르테 테라퓨틱스 인코포레이티드 | Pgdh 억제제 및 그의 제조 및 사용 방법 |
| JP2023515081A (ja) * | 2020-02-21 | 2023-04-12 | ケース ウエスタン リザーブ ユニバーシティ | 腎損傷を治療するための組成物および方法 |
| AU2021275122A1 (en) | 2020-05-20 | 2022-12-15 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP4164638A4 (en) * | 2020-06-11 | 2024-06-19 | The Board of Trustees of the Leland Stanford Junior University | REJUVENATION OF AGED TISSUES AND ORGANS BY INHIBITION OF THE DEGRADING ENZYME PGE2, 15-PGDH |
| WO2022082009A1 (en) * | 2020-10-15 | 2022-04-21 | Epirium Bio Inc. | Inhaled formulations of pgdh inhibitors and methods of use thereof |
| US20250002919A1 (en) * | 2021-10-27 | 2025-01-02 | The Board Of Trustees Of The Leland Stanford Junior University | Regeneration or rejuvenation of tissues and organs |
| CN114875003B (zh) * | 2022-04-06 | 2024-05-24 | 浙江大学 | 一种短链脱氢酶的突变体、编码基因及编码基因获得方法、突变体的应用 |
| CN118027057A (zh) * | 2022-11-14 | 2024-05-14 | 武汉人福创新药物研发中心有限公司 | 抑制15-pgdh的化合物及其用途 |
| TW202434211A (zh) * | 2023-02-17 | 2024-09-01 | 大陸商武漢人福創新藥物研發中心有限公司 | 亞碸類化合物及其用途 |
| CN121772923A (zh) * | 2023-06-28 | 2026-03-31 | 埃皮里姆生物股份有限公司 | 用于治疗与升高的15-pgdh相关的病况的间歇给药方法 |
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| AU2014342811B2 (en) | 2013-10-15 | 2019-01-03 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
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| CN107921025A (zh) | 2015-03-08 | 2018-04-17 | 卡斯西部储备大学 | 用于治疗纤维症的短链脱氢酶活性的抑制剂 |
| AU2016248080A1 (en) | 2015-04-14 | 2017-11-02 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| US20190275014A1 (en) | 2016-07-18 | 2019-09-12 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting cell death |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| JP2020514323A (ja) | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
| WO2018187810A1 (en) | 2017-04-07 | 2018-10-11 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders |
| JP2021134242A (ja) | 2020-02-25 | 2021-09-13 | 株式会社アイティー技研 | 鉱物油精製方法及び装置 |
| JP7574640B2 (ja) | 2020-12-23 | 2024-10-29 | 株式会社リコー | 画像処理装置、画像処理システム、方法およびプログラム |
-
2016
- 2016-03-08 CN CN201680026631.8A patent/CN107921025A/zh active Pending
- 2016-03-08 CA CA2979203A patent/CA2979203A1/en active Pending
- 2016-03-08 HK HK18110045.4A patent/HK1250636A1/zh unknown
- 2016-03-08 CN CN202311729746.1A patent/CN118059093A/zh active Pending
- 2016-03-08 US US15/556,972 patent/US10945998B2/en active Active
- 2016-03-08 WO PCT/US2016/021374 patent/WO2016144958A1/en not_active Ceased
- 2016-03-08 JP JP2017546676A patent/JP2018511581A/ja active Pending
- 2016-03-08 EP EP16762344.6A patent/EP3267995B1/en active Active
- 2016-03-08 AU AU2016229918A patent/AU2016229918B2/en active Active
-
2020
- 2020-11-20 JP JP2020192961A patent/JP7282067B2/ja active Active
- 2020-12-23 US US17/131,911 patent/US20210283113A1/en not_active Abandoned
-
2021
- 2021-01-29 AU AU2021200610A patent/AU2021200610B2/en active Active
-
2022
- 2022-12-15 AU AU2022287625A patent/AU2022287625A1/en not_active Abandoned
-
2023
- 2023-05-16 JP JP2023080881A patent/JP2023103379A/ja active Pending
-
2025
- 2025-01-17 US US19/030,930 patent/US20250295640A1/en active Pending
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