AU2016229918B2 - Inhibitors of short-chain dehydrogenase activity for treating fibrosis - Google Patents

Inhibitors of short-chain dehydrogenase activity for treating fibrosis Download PDF

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AU2016229918B2
AU2016229918B2 AU2016229918A AU2016229918A AU2016229918B2 AU 2016229918 B2 AU2016229918 B2 AU 2016229918B2 AU 2016229918 A AU2016229918 A AU 2016229918A AU 2016229918 A AU2016229918 A AU 2016229918A AU 2016229918 B2 AU2016229918 B2 AU 2016229918B2
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alkyl
aryl
fibrosis
amino
disease
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AU2016229918A1 (en
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Amar Desai
Stanton Gerson
Won Jin HO
Sanford Markowitz
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Case Western Reserve University
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Case Western Reserve University
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Priority to AU2022287625A priority patent/AU2022287625A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Toxicology (AREA)
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  • Diabetes (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016229918A 2015-03-08 2016-03-08 Inhibitors of short-chain dehydrogenase activity for treating fibrosis Active AU2016229918B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021200610A AU2021200610B2 (en) 2015-03-08 2021-01-29 Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2022287625A AU2022287625A1 (en) 2015-03-08 2022-12-15 Inhibitors of short-chain dehydrogenase activity for treating fibrosis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562129885P 2015-03-08 2015-03-08
US62/129,885 2015-03-08
PCT/US2016/021374 WO2016144958A1 (en) 2015-03-08 2016-03-08 Inhibitors of short-chain dehydrogenase activity for treating fibrosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021200610A Division AU2021200610B2 (en) 2015-03-08 2021-01-29 Inhibitors of short-chain dehydrogenase activity for treating fibrosis

Publications (2)

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AU2016229918A1 AU2016229918A1 (en) 2017-09-28
AU2016229918B2 true AU2016229918B2 (en) 2020-10-29

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AU2016229918A Active AU2016229918B2 (en) 2015-03-08 2016-03-08 Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2021200610A Active AU2021200610B2 (en) 2015-03-08 2021-01-29 Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2022287625A Abandoned AU2022287625A1 (en) 2015-03-08 2022-12-15 Inhibitors of short-chain dehydrogenase activity for treating fibrosis

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AU2021200610A Active AU2021200610B2 (en) 2015-03-08 2021-01-29 Inhibitors of short-chain dehydrogenase activity for treating fibrosis
AU2022287625A Abandoned AU2022287625A1 (en) 2015-03-08 2022-12-15 Inhibitors of short-chain dehydrogenase activity for treating fibrosis

Country Status (8)

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US (3) US10945998B2 (https=)
EP (1) EP3267995B1 (https=)
JP (3) JP2018511581A (https=)
CN (2) CN118059093A (https=)
AU (3) AU2016229918B2 (https=)
CA (1) CA2979203A1 (https=)
HK (1) HK1250636A1 (https=)
WO (1) WO2016144958A1 (https=)

Cited By (3)

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US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity

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DK2838533T3 (da) 2012-04-16 2017-11-27 Univ Case Western Reserve Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
AU2014342811B2 (en) 2013-10-15 2019-01-03 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
CN118059093A (zh) * 2015-03-08 2024-05-24 卡斯西部储备大学 用于治疗纤维症的短链脱氢酶活性的抑制剂
JP2018511616A (ja) * 2015-04-14 2018-04-26 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物および方法
CA3059255A1 (en) 2017-04-07 2018-10-11 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
WO2018218251A1 (en) * 2017-05-26 2018-11-29 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CA3125900A1 (en) 2019-01-08 2020-07-16 Kyorin Pharmaceutical Co., Ltd. 15-pgdh inhibitor
US12304897B2 (en) 2019-01-31 2025-05-20 Kyorin Pharmaceutical Co., Ltd. 15-PGDH inhibitors
CA3168494A1 (en) 2020-01-23 2021-07-29 Roopa Rai Pgdh inhibitors and methods of making and using
KR20230011910A (ko) * 2020-02-21 2023-01-25 케이스 웨스턴 리저브 유니버시티 신장 손상을 치료하기 위한 조성물 및 방법
CR20220654A (es) * 2020-05-20 2023-08-24 Rodeo Therapeutics Corp Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta
US20230210829A1 (en) * 2020-06-11 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Rejuvenation of aged tissues by inhibition of the pge2 degrading enzyme, 15-pgdh
US20230390274A1 (en) * 2020-10-15 2023-12-07 Epirium Bio Inc. Inhaled formulations of pgdh inhibitors and methods of use thereof
US20250002919A1 (en) * 2021-10-27 2025-01-02 The Board Of Trustees Of The Leland Stanford Junior University Regeneration or rejuvenation of tissues and organs
CN114875003B (zh) * 2022-04-06 2024-05-24 浙江大学 一种短链脱氢酶的突变体、编码基因及编码基因获得方法、突变体的应用
WO2024104317A1 (zh) * 2022-11-14 2024-05-23 武汉人福创新药物研发中心有限公司 抑制15-pgdh的化合物及其用途
WO2024169790A1 (zh) * 2023-02-17 2024-08-22 武汉人福创新药物研发中心有限公司 亚砜类化合物及其用途
CN121772923A (zh) * 2023-06-28 2026-03-31 埃皮里姆生物股份有限公司 用于治疗与升高的15-pgdh相关的病况的间歇给药方法

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