JP2023073507A5 - - Google Patents

Download PDF

Info

Publication number
JP2023073507A5
JP2023073507A5 JP2023060071A JP2023060071A JP2023073507A5 JP 2023073507 A5 JP2023073507 A5 JP 2023073507A5 JP 2023060071 A JP2023060071 A JP 2023060071A JP 2023060071 A JP2023060071 A JP 2023060071A JP 2023073507 A5 JP2023073507 A5 JP 2023073507A5
Authority
JP
Japan
Prior art keywords
conjugate
independently
length
nucleotide units
occurrence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023060071A
Other languages
English (en)
Japanese (ja)
Other versions
JP7676460B2 (ja
JP2023073507A (ja
Filing date
Publication date
Priority claimed from JP2016525825A external-priority patent/JP6702862B2/ja
Application filed filed Critical
Publication of JP2023073507A publication Critical patent/JP2023073507A/ja
Publication of JP2023073507A5 publication Critical patent/JP2023073507A5/ja
Priority to JP2025075070A priority Critical patent/JP2025107295A/ja
Application granted granted Critical
Publication of JP7676460B2 publication Critical patent/JP7676460B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023060071A 2013-07-11 2023-04-03 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法 Active JP7676460B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025075070A JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361845279P 2013-07-11 2013-07-11
US61/845,279 2013-07-11
JP2016525825A JP6702862B2 (ja) 2013-07-11 2014-07-11 オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
JP2020081749A JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020081749A Division JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025075070A Division JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Publications (3)

Publication Number Publication Date
JP2023073507A JP2023073507A (ja) 2023-05-25
JP2023073507A5 true JP2023073507A5 (cg-RX-API-DMAC10.html) 2023-09-05
JP7676460B2 JP7676460B2 (ja) 2025-05-14

Family

ID=51230239

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016525825A Active JP6702862B2 (ja) 2013-07-11 2014-07-11 オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
JP2020081749A Active JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法
JP2023060071A Active JP7676460B2 (ja) 2013-07-11 2023-04-03 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法
JP2025075070A Pending JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2016525825A Active JP6702862B2 (ja) 2013-07-11 2014-07-11 オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
JP2020081749A Active JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025075070A Pending JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド-リガンドコンジュゲートおよびそれらの調製方法

Country Status (7)

Country Link
US (3) US10808246B2 (cg-RX-API-DMAC10.html)
EP (2) EP4039278A1 (cg-RX-API-DMAC10.html)
JP (4) JP6702862B2 (cg-RX-API-DMAC10.html)
AU (4) AU2014287002A1 (cg-RX-API-DMAC10.html)
CA (2) CA2917161C (cg-RX-API-DMAC10.html)
DK (1) DK3019200T3 (cg-RX-API-DMAC10.html)
WO (1) WO2015006740A2 (cg-RX-API-DMAC10.html)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201906382QA (en) 2013-05-01 2019-08-27 Ionis Pharmaceuticals Inc Compositions and methods for modulating hbv and ttr expression
SG10201809953QA (en) * 2014-05-01 2018-12-28 Ionis Pharmaceuticals Inc Compositions and methods for modulating complement factor b expression
US10570169B2 (en) 2014-05-22 2020-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
US20170145424A1 (en) * 2014-06-06 2017-05-25 Ionis Pharmaceuticals, Inc. Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds
JP7105065B2 (ja) 2014-12-15 2022-07-22 ダイセルナ ファーマシューティカルズ, インコーポレイテッド リガンド修飾二本鎖核酸
US11298427B2 (en) 2015-05-29 2022-04-12 Ascendis Pharma A/S Prodrugs comprising a pyroglutamate linker
JPWO2017010575A1 (ja) * 2015-07-16 2018-04-26 協和発酵キリン株式会社 β2GPI遺伝子発現抑制核酸複合体
CN105524124B (zh) * 2015-12-31 2018-10-30 天津英吉诺科技有限公司 一种n-乙酰氨基半乳糖的绿色合成方法
AU2017213404A1 (en) 2016-01-29 2018-09-20 Kyowa Kirin Co., Ltd. Nucleic acid conjugate
TWI842117B (zh) 2016-03-07 2024-05-11 美商愛羅海德製藥公司 治療性化合物之標靶性配體
WO2017178656A1 (en) 2016-04-14 2017-10-19 Roche Innovation Center Copenhagen A/S TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE
SG10201913477UA (en) 2016-04-29 2020-02-27 Univ Nanyang Tech G-quadruplex-containing antisense oligonucleotides
KR102520362B1 (ko) 2016-06-30 2023-04-10 쿄와 기린 가부시키가이샤 당쇄 리간드가 링커를 통해 올리고뉴클레오티드와 결합한 핵산 복합체
US11253601B2 (en) 2016-07-11 2022-02-22 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
WO2018013999A1 (en) * 2016-07-15 2018-01-18 Am Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis
KR102403408B1 (ko) 2016-09-02 2022-05-30 애로우헤드 파마슈티컬스 인코포레이티드 표적화 리간드
WO2018067900A1 (en) * 2016-10-06 2018-04-12 Ionis Pharmaceuticals, Inc. Method of conjugating oligomeric compounds
US11963974B2 (en) 2017-03-10 2024-04-23 National Center For Child Health And Development Antisense oligonucleotide and composition for prevention or treatment of glycogen storage disease type Ia
SG11201908771YA (en) * 2017-03-22 2019-10-30 Univ California Modified oligonucleotides and therapeutic uses thereof
IL321221A (en) 2017-04-05 2025-07-01 Silence Therapeutics Gmbh Products and compositions
CN110603330B (zh) 2017-04-28 2023-09-05 协和麒麟株式会社 寡核苷酸衍生物或其盐
WO2019027009A1 (ja) * 2017-08-02 2019-02-07 協和発酵キリン株式会社 核酸複合体
TW201909925A (zh) * 2017-08-02 2019-03-16 日商協和醱酵麒麟有限公司 核酸複合體
CA3075598A1 (en) * 2017-09-14 2019-03-21 Janssen Biopharma, Inc. Galnac derivatives
JP7365052B2 (ja) * 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
WO2019105403A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019105404A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
US11492620B2 (en) * 2017-12-01 2022-11-08 Suzhou Ribo Life Science Co., Ltd. Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method thereof and use thereof
WO2019105437A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
US11414665B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
JP7261494B2 (ja) 2017-12-01 2023-04-20 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
WO2019128611A1 (en) 2017-12-29 2019-07-04 Suzhou Ribo Life Science Co., Ltd. Conjugates and preparation and use thereof
WO2019140102A1 (en) 2018-01-10 2019-07-18 Translate Bio Ma, Inc. Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
US11958878B2 (en) * 2018-03-09 2024-04-16 Daiichi Sankyo Company, Limited Therapeutic agent for glycogen storage disease type IA
US20210155926A1 (en) * 2018-04-05 2021-05-27 Silence Therapeutics Gmbh siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS
BR112020022546A8 (pt) 2018-05-07 2022-05-17 Alnylam Pharmaceuticals Inc Entrega extra-hepática
CN111655849B (zh) * 2018-08-21 2024-05-10 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
JP7376952B2 (ja) * 2018-09-30 2023-11-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド siRNA複合体及びその調製方法と使用
GB2579253A (en) * 2018-11-28 2020-06-17 Pedanius Therapeutics Ltd Antibacterial antisense agents
AU2019390097A1 (en) 2018-11-30 2021-07-15 Kyowa Kirin Co., Ltd. Nucleic acid conjugate
WO2020135673A1 (zh) 2018-12-28 2020-07-02 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
GB201821269D0 (en) 2018-12-28 2019-02-13 Nippon Shinyaku Co Ltd Myostatin signal inhibitor
CN111377985B (zh) * 2018-12-29 2023-11-10 苏州瑞博生物技术股份有限公司 化合物和缀合物及其制备方法和用途
CN111377984B (zh) * 2018-12-29 2024-03-05 苏州瑞博生物技术股份有限公司 化合物和缀合物及其制备方法和用途
WO2020147847A1 (zh) * 2019-01-18 2020-07-23 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
AU2020280439B2 (en) 2019-05-22 2025-08-14 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
CN113614230B (zh) * 2019-05-22 2024-04-09 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN113227376B (zh) * 2019-05-22 2024-04-09 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
US20240200060A1 (en) * 2019-05-22 2024-06-20 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
CN111973618B (zh) * 2019-05-23 2024-02-02 苏州瑞博生物技术股份有限公司 核酸、药物组合物与siRNA缀合物及制备方法和用途
CN111973619B (zh) * 2019-05-23 2024-01-30 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
US20220315929A1 (en) 2019-05-24 2022-10-06 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition and conjugate, preparation method therefor and use thereof
CN113795582B (zh) 2019-05-24 2024-05-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
EP3978029A4 (en) * 2019-05-24 2023-07-19 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE, METHOD OF MANUFACTURE AND USE
CN112007040B (zh) * 2019-05-31 2024-01-30 苏州瑞博生物技术股份有限公司 用于治疗乙型病毒性肝炎的联合用药物
WO2021037205A1 (zh) 2019-08-29 2021-03-04 苏州瑞博生物技术股份有限公司 化合物和药物缀合物及其制备方法和用途
BR112022004461A2 (pt) 2019-09-10 2022-07-19 Daiichi Sankyo Co Ltd Conjugado de galnac-oligonucleotídeo para entrega ao fígado e método de fabricação do mesmo
EP4446336A3 (en) 2019-09-23 2025-06-25 Koranex Capital Neoglycoconjugates as vaccines and therapeutic tools
CA3160329A1 (en) * 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
CA3161669A1 (en) * 2019-11-26 2021-06-03 Dtx Pharma, Inc. Compound comprising a nucleic acid and methods
CN112876534B (zh) * 2019-11-29 2024-02-09 苏州瑞博生物技术股份有限公司 肝靶向化合物及缀合物
WO2021153047A1 (ja) * 2020-01-29 2021-08-05 住友化学株式会社 核酸オリゴマーの製造方法
CN111269279B (zh) * 2020-02-24 2022-08-05 陕西师范大学 一种在温和条件下制备卤代糖的方法
MX2022011805A (es) 2020-03-24 2023-01-11 Generation Bio Co Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con factor ix.
CA3172591A1 (en) 2020-03-24 2021-09-30 Douglas Anthony KERR Non-viral dna vectors and uses thereof for expressing gaucher therapeutics
CN113683651A (zh) * 2020-05-19 2021-11-23 上海京新生物医药有限公司 一种GalNAc中间体的制备方法
IL298406A (en) 2020-05-22 2023-01-01 Wave Life Sciences Ltd Double stranded oligonucleotide compositions and methods relating thereto
US20230235330A1 (en) 2020-06-10 2023-07-27 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Conjugate of double-stranded sirna analogue
WO2022140702A1 (en) 2020-12-23 2022-06-30 Flagship Pioneering, Inc. Compositions of modified trems and uses thereof
CN116669746B (zh) 2020-12-29 2025-09-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
WO2022189861A1 (en) 2021-03-08 2022-09-15 Tollys Carbohydrate conjugates of tlr3 ligands and uses thereof
CN117881786A (zh) 2021-04-27 2024-04-12 世代生物公司 表达治疗性抗体的非病毒dna载体及其用途
EP4329884A1 (en) 2021-04-27 2024-03-06 Generation Bio Co. Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof
WO2022246195A1 (en) * 2021-05-20 2022-11-24 Olix Us, Inc. Functional moieties and their uses and synthetic preparation
CN115572241B (zh) * 2021-06-21 2024-08-30 润佳(苏州)医药科技有限公司 双价化合物、偶联物及其用途
WO2023282344A1 (ja) 2021-07-08 2023-01-12 日本新薬株式会社 腎毒性軽減剤
US20240285770A1 (en) 2021-07-08 2024-08-29 Nippon Shinyaku Co., Ltd. Precipitation suppressing agent
TW202337473A (zh) 2021-07-08 2023-10-01 日商日本新藥股份有限公司 腎毒性減輕劑
US20240325428A1 (en) 2021-07-16 2024-10-03 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing same, and preparation method and use
EP4372086A1 (en) 2021-07-16 2024-05-22 Suzhou Ribo Life Science Co., Ltd. Double-stranded oligonucleotide, composition and conjugate containing double-stranded oligonucleotide, and preparation methods and uses
IL310547A (en) 2021-08-05 2024-03-01 Sanegene Bio Usa Inc Alkyl substituted ribose derivatives in the '1 position and methods of use
KR20240082361A (ko) 2021-09-22 2024-06-10 사네진 바이오 유에스에이 인크. 올리고뉴클레오티드의 생체내 전달에 사용하기 위한 2'-알킬 또는 3'-알킬 변형된 리보스 유도체
CN118076621A (zh) 2021-10-05 2024-05-24 美国圣因生物股份有限公司 多羟基化的环戊烷衍生物及使用方法
WO2023097251A1 (en) * 2021-11-23 2023-06-01 Yale University Oligonucleotide-containing transcription factor targeting chimeras
CN118922431A (zh) 2022-02-22 2024-11-08 美国圣因生物股份有限公司 5’-修饰的碳环核糖核苷酸衍生物及使用方法
WO2023171804A1 (ja) 2022-03-10 2023-09-14 日本新薬株式会社 抗ウイルスアンチセンスオリゴマー
JP2025509607A (ja) 2022-03-14 2025-04-11 ジェネレーション バイオ カンパニー 異種プライムブーストワクチン組成物及び使用の方法
KR20240161967A (ko) 2022-03-16 2024-11-13 다이이찌 산쿄 가부시키가이샤 트랜스페린 수용체 2 의 발현을 억제하는 siRNA
EP4495241A1 (en) 2022-03-16 2025-01-22 Daiichi Sankyo Company, Limited Chemically-modified oligonucleotide having rnai activity
WO2023207615A1 (zh) * 2022-04-26 2023-11-02 南京明德新药研发有限公司 一类含由天然核苷酸组成突出端的双链RNAi化合物
WO2023212134A2 (en) * 2022-04-28 2023-11-02 Dicerna Pharmaceuticals, Inc. Methods for synthesis of peracetylgalactosamine-1-pentanoic acid
WO2023220744A2 (en) 2022-05-13 2023-11-16 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides
US20250179492A1 (en) 2022-06-22 2025-06-05 Flagship Pioneering Innovations Vi, Llc Compositions of modified trems and uses thereof
WO2024001172A1 (en) * 2022-06-27 2024-01-04 Ractigen Therapeutics Oligonucleotide modulators activating complement factor h expression
WO2024006999A2 (en) 2022-06-30 2024-01-04 Alnylam Pharmaceuticals, Inc. Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
US20240218363A1 (en) 2022-07-11 2024-07-04 Sanegene Bio Usa Inc. Optimized 2'- modified ribose derivatives and methods of use
US20240052348A1 (en) 2022-08-05 2024-02-15 Sanegene Bio Usa Inc. Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
WO2024040222A1 (en) 2022-08-19 2024-02-22 Generation Bio Co. Cleavable closed-ended dna (cedna) and methods of use thereof
WO2024081954A2 (en) 2022-10-14 2024-04-18 Sanegene Bio Usa Inc. Small interfering rna targeting c3 and uses thereof
EP4628583A1 (en) 2022-12-02 2025-10-08 Shanghai Argo Biopharmaceutical Co., Ltd. Bicyclic abasic nucleic acid analogs and oligomeric compounds prepared therefrom
CN120569477A (zh) 2022-12-19 2025-08-29 美国圣因生物股份有限公司 靶向cfb的小干扰rna及其用途
CN116178458A (zh) * 2022-12-26 2023-05-30 成都药明康德新药开发有限公司 一种糖苷化合物的合成
WO2024160204A1 (en) * 2023-01-30 2024-08-08 Primelink Biotherapeutics (Suzhou) Co., Ltd. Polymer-oligonucleotide conjugates
US20240309383A1 (en) 2023-02-24 2024-09-19 Suzhou Sanegene Bio Inc. Small interfering rna targeting hbv and uses thereof
WO2024186673A2 (en) 2023-03-03 2024-09-12 Sanegene Bio Usa Inc. Small interfering rna targeting apoc3 and uses thereof
WO2024188174A1 (zh) 2023-03-10 2024-09-19 苏州瑞博生物技术股份有限公司 一种药物组合物及其用途
WO2024238385A2 (en) 2023-05-12 2024-11-21 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides
CN119061009A (zh) 2023-06-01 2024-12-03 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
WO2024263915A2 (en) 2023-06-21 2024-12-26 Sanegene Bio Usa Inc. Double stranded rna targeting proprotein convertase subtilisin kexin 9 (pcsk9) and methods of use thereof
CN119219716A (zh) * 2023-06-30 2024-12-31 上海维申医药有限公司 新型GalNAc的靶向递送片段及其制备和应用
WO2025016441A1 (zh) * 2023-07-19 2025-01-23 上海维申医药有限公司 新型GalNAc的靶向递送片段及其制备和应用
AU2024301344A1 (en) 2023-07-24 2026-01-29 Sanegene Bio Usa Inc. Lipid-based enhancement agent for rna delivery and therapy
WO2025042786A1 (en) 2023-08-18 2025-02-27 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
CN117384226B (zh) * 2023-09-14 2025-12-26 苏州盛诺维生物科技有限公司 一种GalNAc类化合物的合成工艺
AU2024369609A1 (en) 2023-10-31 2025-12-11 Korro Bio, Inc. Oligonucleotides comprising phosphoramidate internucleotide linkages
US20250161347A1 (en) 2023-11-22 2025-05-22 Flagship Pioneering Innovations Vii, Llc Methods and compositions for treating non-alcoholic fatty liver disease
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途
WO2025155911A1 (en) 2024-01-18 2025-07-24 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of hurler syndrome
WO2025207934A1 (en) 2024-03-28 2025-10-02 Lycia Therapeutics, Inc. Lysosomal targeting bifunctional molecules for degradation of thyroid stimulating hormone receptor autoantibodies
WO2025228441A2 (en) 2024-04-30 2025-11-06 Sanegene Bio Usa Inc. Small interfering rna targeting inhbe and uses thereof
CN118146284B (zh) * 2024-05-08 2024-07-26 北京悦康科创医药科技股份有限公司 一种GalNAc化合物、其与寡核苷酸缀合物及制备方法
WO2025245188A2 (en) 2024-05-21 2025-11-27 Flagship Pioneering Innovations Vii, Llc Methods of treating liver steatosis and non-alcoholic fatty liver disease
WO2026017140A2 (en) 2024-07-18 2026-01-22 Sanegene Bio Usa Inc. Small interfering rna targeting fxi and uses thereof

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453566A (en) 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
CA1340323C (en) 1988-09-20 1999-01-19 Arnold E. Hampel Rna catalyst for cleaving specific rna sequences
GB8822492D0 (en) 1988-09-24 1988-10-26 Considine J Apparatus for removing tumours from hollow organs of body
JP3058686B2 (ja) 1989-08-31 2000-07-04 シティ・オブ・ホープ キメラdna―rna触媒活性配列
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
US5789573A (en) 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
WO1992007065A1 (en) 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Modified ribozymes
DE4216134A1 (de) 1991-06-20 1992-12-24 Europ Lab Molekularbiolog Synthetische katalytische oligonukleotidstrukturen
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
AU687736B2 (en) 1992-05-11 1998-03-05 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting viral replication
CA2140343A1 (en) 1992-07-17 1994-02-03 Sean M. Sullivan Method and reagent for treatment of animal diseases
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5591317A (en) 1994-02-16 1997-01-07 Pitts, Jr.; M. Michael Electrostatic device for water treatment
US5631359A (en) 1994-10-11 1997-05-20 Ribozyme Pharmaceuticals, Inc. Hairpin ribozymes
AU3889595A (en) 1994-10-05 1996-05-02 Amgen, Inc. Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein
US5783683A (en) 1995-01-10 1998-07-21 Genta Inc. Antisense oligonucleotides which reduce expression of the FGFRI gene
US5681824A (en) 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US5747470A (en) 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5739119A (en) 1996-11-15 1998-04-14 Galli; Rachel L. Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
US6300319B1 (en) * 1998-06-16 2001-10-09 Isis Pharmaceuticals, Inc. Targeted oligonucleotide conjugates
AU2004220556B2 (en) 2003-03-07 2009-05-07 Alnylam Pharmaceuticals, Inc. Therapeutic compositions
CA2522637C (en) 2003-04-17 2014-01-21 Alnylam Pharmaceuticals, Inc. Modified irna agents
EP1919512B1 (en) 2005-08-10 2014-11-12 Alnylam Pharmaceuticals Inc. Chemically modified oligonucleotides for use in modulating micro rna and uses thereof
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
EP1989307B1 (en) * 2006-02-08 2012-08-08 Quark Pharmaceuticals, Inc. NOVEL TANDEM siRNAS
AU2008333811B2 (en) 2007-12-04 2014-05-01 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
CA3044980A1 (en) 2008-04-11 2009-10-15 Alnylam Pharmaceuticals, Inc. Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
WO2011100131A2 (en) * 2010-01-28 2011-08-18 Alnylam Pharmacuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
US8501930B2 (en) * 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
EP2594575A1 (en) * 2011-11-15 2013-05-22 Université de Strasbourg Mannosylated compounds useful for the prevention and the treatment of infectious diseases
BR112014011896B1 (pt) 2011-11-18 2021-01-19 Alnylam Pharmaceuticals, Inc. Agentes de rnai, composições, método de inibição de expressão de uma transtirretina(ttr), uso destes agentes, e kits
US8577565B2 (en) 2011-12-16 2013-11-05 GM Global Technology Operations LLC Limiting branch pressure to a solenoid valve in a fluid circuit
TWI595885B (zh) 2012-05-02 2017-08-21 喜納製藥公司 包含四galnac之新穎結合物及傳送寡核苷酸之方法
SE536942C2 (sv) * 2012-07-24 2014-11-11 Reiz Ismet Flexibel dragnyckel
WO2014025805A1 (en) * 2012-08-06 2014-02-13 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugated rna agents and process for their preparation
ES2657608T3 (es) * 2012-12-05 2018-03-06 Alnylam Pharmaceuticals, Inc. Composiciones de arni de pcsk9 y métodos de uso de las mismas
SG10201906382QA (en) * 2013-05-01 2019-08-27 Ionis Pharmaceuticals Inc Compositions and methods for modulating hbv and ttr expression
AU2014284152B2 (en) * 2013-06-21 2020-01-23 Ionis Pharmaceuticals, Inc. Compositions and methods for modulation of target nucleic acids
US20170145424A1 (en) * 2014-06-06 2017-05-25 Ionis Pharmaceuticals, Inc. Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds

Similar Documents

Publication Publication Date Title
JP2023073507A5 (cg-RX-API-DMAC10.html)
JP2022173349A5 (cg-RX-API-DMAC10.html)
JP2023153970A5 (cg-RX-API-DMAC10.html)
JP2024160045A5 (cg-RX-API-DMAC10.html)
JPH05505101A (ja) オリゴヌクレオチド療法における三重らせん形成
JP2018527013A5 (cg-RX-API-DMAC10.html)
JP2021072862A5 (cg-RX-API-DMAC10.html)
JP2021506246A5 (cg-RX-API-DMAC10.html)
JP2005500025A5 (cg-RX-API-DMAC10.html)
JPH10509048A (ja) ポリヌクレオチド組成物
JP2005524393A5 (cg-RX-API-DMAC10.html)
JPH10504719A (ja) 非ヌクレオチド部分を有するポリヌクレオチド試薬、ならびに合成および使用に関連する方法
JP2005517452A5 (cg-RX-API-DMAC10.html)
KR920002625A (ko) 말단에 3'-3' 또는 5'-5' 뉴클레오타이드간 결합을 갖는 올리고뉴클레오타이드 유사체
RU93004859A (ru) Полинуклеотиды, способы получения полинуклеотидов, способы гибридизации нуклеиновых кислот
JP2002501102A5 (cg-RX-API-DMAC10.html)
JPWO2019092283A5 (cg-RX-API-DMAC10.html)
JP2006502694A5 (cg-RX-API-DMAC10.html)
JP2010519915A5 (cg-RX-API-DMAC10.html)
JP2010275254A (ja) 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP2004520473A5 (cg-RX-API-DMAC10.html)
CN102439148A (zh) siRNA缀合物及其制备方法
JP2004537516A5 (cg-RX-API-DMAC10.html)
AU769619B2 (en) Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
Pero et al. Restriction cleavage map of SP01 DNA: general location of early, middle, and late genes