JP2023058748A5 - - Google Patents

Download PDF

Info

Publication number
JP2023058748A5
JP2023058748A5 JP2023028752A JP2023028752A JP2023058748A5 JP 2023058748 A5 JP2023058748 A5 JP 2023058748A5 JP 2023028752 A JP2023028752 A JP 2023028752A JP 2023028752 A JP2023028752 A JP 2023028752A JP 2023058748 A5 JP2023058748 A5 JP 2023058748A5
Authority
JP
Japan
Prior art keywords
cells
culture medium
composition
lineage
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023028752A
Other languages
English (en)
Japanese (ja)
Other versions
JP7720337B2 (ja
JP2023058748A (ja
Filing date
Publication date
Priority claimed from JP2021009440A external-priority patent/JP7236476B2/ja
Application filed filed Critical
Publication of JP2023058748A publication Critical patent/JP2023058748A/ja
Publication of JP2023058748A5 publication Critical patent/JP2023058748A5/ja
Priority to JP2025034583A priority Critical patent/JP2025078772A/ja
Application granted granted Critical
Publication of JP7720337B2 publication Critical patent/JP7720337B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023028752A 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物 Active JP7720337B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025034583A JP2025078772A (ja) 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562107517P 2015-01-26 2015-01-26
US62/107,517 2015-01-26
US201562251016P 2015-11-04 2015-11-04
US62/251,016 2015-11-04
JP2021009440A JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021009440A Division JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025034583A Division JP2025078772A (ja) 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2023058748A JP2023058748A (ja) 2023-04-25
JP2023058748A5 true JP2023058748A5 (cg-RX-API-DMAC7.html) 2023-09-26
JP7720337B2 JP7720337B2 (ja) 2025-08-07

Family

ID=56544232

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2017539022A Active JP6800859B2 (ja) 2015-01-26 2016-01-26 造血細胞分化を誘導するための方法および組成物
JP2019071292A Active JP6836803B2 (ja) 2015-01-26 2019-04-03 造血細胞分化を誘導するための方法および組成物
JP2021009440A Active JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物
JP2023028752A Active JP7720337B2 (ja) 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物
JP2025034583A Pending JP2025078772A (ja) 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2017539022A Active JP6800859B2 (ja) 2015-01-26 2016-01-26 造血細胞分化を誘導するための方法および組成物
JP2019071292A Active JP6836803B2 (ja) 2015-01-26 2019-04-03 造血細胞分化を誘導するための方法および組成物
JP2021009440A Active JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025034583A Pending JP2025078772A (ja) 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物

Country Status (7)

Country Link
US (5) US10626372B1 (cg-RX-API-DMAC7.html)
EP (1) EP3250680A4 (cg-RX-API-DMAC7.html)
JP (5) JP6800859B2 (cg-RX-API-DMAC7.html)
CN (2) CN114058582A (cg-RX-API-DMAC7.html)
AU (3) AU2016211671B2 (cg-RX-API-DMAC7.html)
SG (2) SG10202101358XA (cg-RX-API-DMAC7.html)
WO (1) WO2016123100A1 (cg-RX-API-DMAC7.html)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
BR112018001232A2 (pt) 2015-07-21 2018-09-25 The Children's Medical Center Corporation pd-l1 que expressa células-tronco hematopoéticas e usos
WO2017070333A1 (en) * 2015-10-20 2017-04-27 Cellular Dynamics International, Inc. Multi-lineage hematopoietic precursor cell production by genetic programming
US12642852B1 (en) 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
CN122146606A (zh) 2015-11-04 2026-06-05 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
AU2017210031C1 (en) 2016-01-20 2020-11-26 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
JP7653759B2 (ja) 2016-01-20 2025-03-31 フェイト セラピューティクス,インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
JP7215994B2 (ja) 2016-09-06 2023-01-31 ザ チルドレンズ メディカル センター コーポレーション 人工多能性幹細胞由来の免疫細胞
US11932870B2 (en) 2016-12-05 2024-03-19 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
WO2018147801A1 (en) * 2017-02-07 2018-08-16 Agency For Science, Technology And Research Methods and kits for generating mimetic innate immune cells from pluripotent stem cells
WO2018160496A1 (en) 2017-02-28 2018-09-07 The Regents Of The University Of California Differentiation and use of human microglia-like cells from pluripotent stem cells and hematopoietic progenitors
US12129487B2 (en) 2017-03-27 2024-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to obtain lymphoid progenitors
CN110891967B (zh) 2017-04-18 2025-03-14 富士胶片细胞动力公司 抗原特异性免疫效应细胞
EP3638775A1 (en) 2017-06-13 2020-04-22 Fate Therapeutics, Inc. Compositions and methods for inducing myeloid suppressive cells and use thereof
US12036241B2 (en) 2017-07-19 2024-07-16 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CN107488629A (zh) * 2017-08-14 2017-12-19 中国科学院广州生物医药与健康研究院 一种人多能干细胞的定向分化方法
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
CN111788300B (zh) * 2017-12-28 2024-08-13 株式会社钟化 细胞聚集抑制剂
SG11202006731VA (en) * 2018-01-18 2020-08-28 Agency Science Tech & Res Method for differentiation of human pluripotent stem cell lines in suspension culture
CN108300695B (zh) * 2018-02-07 2021-08-06 清华大学 一种人类多能干细胞向造血干细胞分化的方法及培养添加剂
CA3091158A1 (en) * 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
FR3079239A1 (fr) * 2018-03-23 2019-09-27 Centre National De La Recherche Scientifique Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations
EP3847243A1 (en) * 2018-09-07 2021-07-14 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
CN109182251A (zh) * 2018-10-08 2019-01-11 吉林大学 一种扩增内皮祖细胞数量的低血清培养基
US20220025330A1 (en) * 2019-01-22 2022-01-27 Washington University Compositions and methods for generating hematopoietic stem cells (hscs)
CN111607566B (zh) * 2019-02-22 2023-04-14 安徽中盛溯源生物科技有限公司 从人多能干细胞分化为造血祖细胞的方法及其应用
CN109652369B (zh) * 2019-02-28 2020-01-03 西湖生物医药科技(杭州)有限公司 利用外周血体外制备成熟红细胞的方法及制剂
CN110106146B (zh) * 2019-03-28 2021-04-02 中国人民解放军军事科学院军事医学研究院 化合物富马酸酮替芬在促进干细胞因子合成和分泌中的用途
CA3135852A1 (en) * 2019-04-03 2020-10-08 Akron Biotechnology, Llc Cryopreservation and cell culture media
JP2022528965A (ja) * 2019-04-09 2022-06-16 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 細胞集団を濃縮する方法
CN110025014A (zh) * 2019-04-18 2019-07-19 宝康士(中国)保健食品销售有限公司 混合菌株发酵制备富含益生菌和nk细胞的基底液的方法
US11453862B2 (en) 2019-07-08 2022-09-27 Immunitybio, Inc. Mononuclear cell derived NK cells
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells
CA3150037A1 (en) * 2019-08-20 2021-02-25 Adaptimmune Limited Culture medium for haematopoietic induction
TW202122577A (zh) * 2019-08-28 2021-06-16 安斯泰來再生醫藥協會 治療血管疾病之方法
EP4065690A1 (en) 2019-11-29 2022-10-05 Rutgers, the State University of New Jersey Methods for isolating umbilical cord blood plasma products, tissue and cellular exosomes, and compositions and methods of use thereof
KR20220113349A (ko) * 2019-12-11 2022-08-12 리페아론 게엠베하 생물반응기의 현탁액에서 줄기세포의 확장
EP4081035A4 (en) 2019-12-23 2024-03-27 Boston Medical Center Corporation HUMAN IPSC-BASED DERIVATION OF NK AND T CELLS USING EARLY NOTCH INDUCTION
WO2021173458A1 (en) * 2020-02-28 2021-09-02 Purdue Research Foundation Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition
IL295964A (en) 2020-02-28 2022-10-01 Takeda Pharmaceuticals Co A method for producing natural killer cells from pluripotent stem cells
EP4138893A4 (en) * 2020-04-21 2024-06-12 Intima Bioscience, Inc. Cellular vaccine platform and methods of use
CN111808812B (zh) * 2020-08-31 2020-12-15 首都医科大学附属北京友谊医院 一种用于多能干细胞向造血干细胞分化的材料和方法
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
WO2022169297A1 (ko) * 2021-02-05 2022-08-11 의료법인 성광의료재단 다능성 줄기세포 유래 조혈 내피세포로부터 림프구계세포의 분화 방법
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
CA3173780A1 (en) * 2021-03-05 2022-09-09 Ran JING Stroma-free nk cell differentiation from human pluripotent stem cells
WO2022212514A1 (en) * 2021-03-31 2022-10-06 Garuda Therapeutics, Inc. Pluripotent stem cell-derived hematopoietic lineages
DE202022003132U1 (de) 2021-04-01 2025-02-17 The Regents Of The University Of California Genetische Modifikation von Säugerzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten
CN113215086A (zh) * 2021-05-26 2021-08-06 杭州原生生物科技有限公司 一种多能干细胞诱导分化成造血干细胞的培养基及方法
CN117813374A (zh) * 2021-06-15 2024-04-02 武田药品工业株式会社 从多能干细胞产生自然杀伤细胞的方法
WO2023001833A1 (en) * 2021-07-19 2023-01-26 Repairon Immuno Gmbh Method of producing a population of immune cells from pluripotent stem cells
KR102595504B1 (ko) * 2021-10-13 2023-10-30 랩인큐브 주식회사 줄기세포의 분화가 가능한 나노 플랫폼 및 이의 제조방법
CN119137261A (zh) 2021-12-17 2024-12-13 优莫佳生物制药股份有限公司 细胞毒性先天淋巴样细胞及其用途
CN118829724A (zh) * 2022-01-20 2024-10-22 科济生物医药(上海)有限公司 诱导细胞分化的方法
CA3250617A1 (en) * 2022-01-31 2025-01-17 Healios K.K. PROCESS FOR THE PRODUCTION OF NATURAL KILLER CELLS
US20250145961A1 (en) * 2022-02-15 2025-05-08 The University Of Birmingham Generating bone marrow organoids
AU2023241513A1 (en) * 2022-04-01 2024-10-17 Therabest Co.,Ltd Natural killer cells produced from induced pluripotent stem cells, method for producing same, and use thereof
CN114752548B (zh) * 2022-04-28 2025-01-21 澳门大学 一种诱导干细胞分化为角质细胞的方法
CN114774365B (zh) * 2022-06-16 2022-08-23 呈诺再生医学科技(北京)有限公司 一种诱导iPSC分化获得CD34+细胞和NK细胞的方法及其应用
CN114958771B (zh) * 2022-06-27 2023-12-05 广东康盾创新产业集团股份公司 一种ipsc-car-nk细胞的制备方法
EP4558615A4 (en) * 2022-07-19 2026-07-15 Lung Biotechnology Pbc METHODS OF DIFFERENTIATING STROMAL CELLS OR PERICYTES
EP4577641A1 (en) * 2022-08-25 2025-07-02 Trailhead Biosystems Inc. Methods and compositions for generating hemogenic endothelial cells from pluripotent stem cells
JP2025531268A (ja) 2022-09-19 2025-09-19 チューン セラピューティクス インコーポレイテッド T細胞機能を調節するための組成物、システム、および方法
WO2024175080A1 (zh) 2023-02-24 2024-08-29 士泽生物医药(苏州)有限公司 诱导干细胞分化为nk细胞的试剂盒及其应用以及nk细胞联合tmz在治疗tmz耐药型gbm中的应用
EP4754248A1 (en) 2023-07-31 2026-06-10 Tune Therapeutics, Inc. Compositions and methods for multiplexed activation and repression of t cell gene expression
CN121909284A (zh) 2023-07-31 2026-04-21 图恩疗法股份有限公司 用于调节il-2基因表达的组合物和方法
WO2025125560A1 (en) * 2023-12-15 2025-06-19 Institut National de la Santé et de la Recherche Médicale Methods for generating myeloid cells
CN117757625B (zh) * 2023-12-20 2026-03-27 中国医学科学院输血研究所 基于一种多孔材料的诱导nk细胞的方法
WO2025219552A1 (en) * 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
GB202405750D0 (en) * 2024-04-24 2024-06-05 Plasticell Ltd Therapy

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
CA2292339A1 (en) 1997-06-13 1998-12-17 Ludwig Institute For Cancer Research Smad6 and uses thereof
ES2229515T3 (es) 1997-07-01 2005-04-16 Warner-Lambert Company Llc Derivados 4-bromo o 4-yodo del acido fenilamino benzhidroxamico y su uso como inhibidores de la mek.
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
HK1052372A1 (zh) 2000-02-24 2003-09-11 Xcyte Therapies, Inc. 细胞的同步刺激和富集
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
AU7349801A (en) 2000-07-19 2002-01-30 Warner Lambert Co Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
WO2002059285A1 (en) 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
US20040224385A1 (en) 2001-08-20 2004-11-11 Barbas Carlos F Zinc finger binding domains for cnn
SI1456380T1 (sl) 2001-11-02 2012-11-30 Giuliani Int Ltd Smad inhibitorji za zdravljenje cns bolezni
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7575925B2 (en) 2002-12-10 2009-08-18 Sunnybrook Health Sciences Centre Cell preparations comprising cells of the T cell lineage and methods of making and using them
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
KR101190912B1 (ko) 2003-11-19 2012-10-12 어레이 바이오파마 인크. Mek의 헤테로시클릭 억제제 및 그의 사용 방법
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
AU2005250408B2 (en) 2004-05-27 2010-09-23 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US20070036769A9 (en) 2004-06-03 2007-02-15 Linheng Li BMP pathway methods and compositions
TWI441637B (zh) 2005-05-18 2014-06-21 Array Biopharma Inc Mek雜環抑制劑及其使用方法
EP1992360A4 (en) 2006-02-01 2010-02-17 Univ Tokyo COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT
EP1999255A2 (en) 2006-03-24 2008-12-10 The Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth
CA2657227A1 (en) 2006-07-14 2008-01-17 Novartis Ag Pyrimidine derivatives as alk-5 inhibitors
EP2126045A4 (en) 2007-01-30 2010-05-26 Univ Georgia EARLY MESODERM CELLS, STABLE POPULATION OF MESENDODERM CELLS WITH THE ABILITY TO GENERATE ENDODERM AND MESODERM CELL LINES AND MULTIPOTENTIAL MIGRATION CELLS
US8389282B2 (en) 2007-03-30 2013-03-05 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
WO2009091826A2 (en) 2008-01-14 2009-07-23 The Board Of Regents Of The University Of Texas System Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
US10059923B2 (en) 2008-01-30 2018-08-28 Memorial Sloan Kettering Cancer Center Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
WO2009104825A1 (en) * 2008-02-18 2009-08-27 Kaist Method for inducing the defferentiation of embryonic stem cells into hemangioblast
BRPI0912201A2 (pt) 2008-05-06 2019-09-24 Advanced Cell Tech Inc células formadoras de colônias de hemangios e células de hemangio não enxertantes
AU2009322346B2 (en) 2008-12-03 2015-07-02 The Scripps Research Institute Stem cell cultures
US8993343B2 (en) 2009-01-28 2015-03-31 Korea Research Institute Of Bioscience And Biotechnology CD93 or use of soluble fragment thereof
EP2398897B1 (en) 2009-02-20 2017-06-28 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
CA2753679C (en) * 2009-02-27 2021-03-02 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
AU2010235161B2 (en) 2009-04-09 2015-01-22 Sangamo Therapeutics, Inc. Targeted integration into stem cells
MX389666B (es) 2009-10-16 2025-03-19 Scripps Research Inst Induccion de celulas pluripotentes.
PT2816112T (pt) 2009-12-10 2018-11-20 Univ Iowa State Res Found Inc Modificação do adn modificada pelo efector tal
JPWO2011096482A1 (ja) * 2010-02-03 2013-06-13 国立大学法人 東京大学 多能性幹細胞を用いた免疫機能再建法
US9206394B2 (en) 2010-02-03 2015-12-08 The University Of Tokyo Method for reconstructing immune function using pluripotent stem cells
JP5777115B2 (ja) * 2010-03-18 2015-09-09 国立大学法人京都大学 多能性幹細胞から中胚葉細胞への分化誘導法
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
CA2802249A1 (en) * 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
CA2805442C (en) 2010-07-21 2020-05-12 Sangamo Biosciences, Inc. Methods and compositions for modification of an hla locus
CN108531444A (zh) 2010-08-05 2018-09-14 威斯康星校友研究基金会 用于人多能细胞培养的简化基础培养基
CN103167876B (zh) 2010-08-12 2016-08-31 菲特治疗公司 改进的造血干细胞和祖细胞疗法
US9181529B2 (en) * 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
AU2011349443B2 (en) 2010-12-20 2015-12-24 Genentech, Inc. Anti-mesothelin antibodies and immunoconjugates
US9732319B2 (en) * 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
CA2823265C (en) 2010-12-31 2019-05-21 Universitat Fur Bodenkultur Wien Method of generating induced pluripotent stem cells and differentiated cells
US8700106B2 (en) 2011-03-09 2014-04-15 Universal Electronics Inc. System and method for provision of infrared signalling in smart phone devices
CN102732483B (zh) 2011-03-31 2014-12-03 北京大学 造血祖细胞的制备方法及其专用培养基
US20130071414A1 (en) 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
WO2013009825A1 (en) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Methods for cell reprogramming and genome engineering
JP5872041B2 (ja) 2011-08-16 2016-03-01 サムスン ライフ パブリック ウェルフェア ファンデーション 幹細胞由来微小胞を含む神経生成促進用組成物
CN102329769B (zh) 2011-09-28 2013-07-31 浙江大学 一种获得造血干细胞的方法
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US9834754B2 (en) 2011-11-21 2017-12-05 University Health Network Populations of hematopoietic progenitors and methods of enriching stem cells therefor
CN104066837B (zh) 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
US9428732B2 (en) 2011-12-05 2016-08-30 Primorigen Biosciences, Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
WO2013086436A1 (en) 2011-12-08 2013-06-13 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
EP2836226B1 (en) 2012-02-24 2017-06-28 Fred Hutchinson Cancer Research Center Compositions and methods for the treatment of hemoglobinopathies
EP4253409A3 (en) 2012-04-17 2023-12-06 University of Washington through its Center for Commercialization Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof
DK2839013T3 (da) 2012-04-18 2020-09-14 Univ Leland Stanford Junior Ikke-disruptiv-gen-targetering
WO2013163171A1 (en) 2012-04-24 2013-10-31 Kaufman Dan S Method for developing natural killer cells from stem cells
EP2853590B1 (en) 2012-05-22 2018-11-07 The University of Tokyo Method for producing antigen-specific t cells
SG10201806573TA (en) 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
US20150148292A1 (en) 2012-07-09 2015-05-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
RU2729401C2 (ru) 2012-10-02 2020-08-06 Мемориал Слоан-Кеттеринг Кэнсер Сентер Композиции и способы для иммунотерапии
JP6494515B2 (ja) 2012-10-19 2019-04-03 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 幹細胞を1又は2以上の細胞系列に分化させる方法
US9382531B2 (en) 2012-10-22 2016-07-05 Wisconsin Alumni Research Foundation Induction of hemogenic endothelium from pluripotent stem cells
CA2892448A1 (en) 2012-12-05 2014-06-12 Sangamo Biosciences, Inc. Methods and compositions for regulation of metabolic disorders
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
EP2970912B1 (en) 2013-03-13 2019-03-06 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
AU2014386824B2 (en) 2013-03-15 2019-05-09 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
EP3789487A1 (en) 2013-04-03 2021-03-10 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
EP4286517A3 (en) 2013-04-04 2024-03-13 President and Fellows of Harvard College Therapeutic uses of genome editing with crispr/cas systems
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
CN120536341A (zh) 2014-03-04 2025-08-26 菲特治疗公司 改良的重编程方法和细胞培养平台
CN113699159A (zh) 2014-03-28 2021-11-26 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法
KR20160145186A (ko) 2014-04-24 2016-12-19 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
CN103937743B (zh) 2014-04-27 2017-12-01 浙江大学 一种利用三维诱导系统获得造血干细胞的方法
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CA2974903A1 (en) 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
US20170020922A1 (en) 2015-07-16 2017-01-26 Batu Biologics Inc. Gene editing for immunological destruction of neoplasia
ES2803728T3 (es) 2015-10-05 2021-01-29 Prec Biosciences Inc Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado
US12642852B1 (en) 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
CN122146606A (zh) 2015-11-04 2026-06-05 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
JP7000311B2 (ja) 2016-03-23 2022-02-04 国立大学法人京都大学 血球分化能の高い中胚葉誘導方法
KR102614675B1 (ko) 2016-04-15 2023-12-19 메모리얼 슬로안 케터링 캔서 센터 유전자이식 t 세포 및 키메라 항원 수용체 t 세포 조성물 및 관련 방법

Similar Documents

Publication Publication Date Title
JP2025078772A5 (cg-RX-API-DMAC7.html)
JP2019103521A5 (cg-RX-API-DMAC7.html)
Wang et al. In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system
JP7720337B2 (ja) 造血細胞分化を誘導するための方法および組成物
JP2023516632A5 (cg-RX-API-DMAC7.html)
Bagley et al. Extended culture of multipotent hematopoietic progenitors without cytokine augmentation in a novel three-dimensional device
Ulloa-Montoya et al. Culture systems for pluripotent stem cells
Slukvin Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells
JP2017104129A (ja) 造血前駆体の集団および造血前駆体のための幹細胞を富化する方法
JP2022534397A5 (cg-RX-API-DMAC7.html)
JP2024521025A5 (cg-RX-API-DMAC7.html)
JP2023540212A5 (cg-RX-API-DMAC7.html)
CN114621920B (zh) 一种由造血干祖细胞向nk细胞分化的方法及培养基
CN116376822A (zh) 利用人多潜能干细胞体外制备t淋巴细胞
US20150050730A1 (en) Process for Ex Vivo Expansion of Stem Cells in a Bioreactor
CN117683713A (zh) 利用人多潜能干细胞体外制备t淋巴细胞和nk细胞
JP2024546108A5 (cg-RX-API-DMAC7.html)
JP2024523332A5 (cg-RX-API-DMAC7.html)
JP2025511790A5 (cg-RX-API-DMAC7.html)
CN119490950B (zh) 一种直接从ips诱导类器官的方法及应用
JP2024516418A5 (cg-RX-API-DMAC7.html)
CN118421559B (zh) 定向分化淋巴造血前体细胞的小分子组合、试剂盒及方法
JP2022533745A5 (cg-RX-API-DMAC7.html)
Marshall et al. T cell generation including positive and negative selection ex vivo in a three-dimensional matrix
WO2016116769A1 (en) Cell maturation process