JP2023017820A5 - - Google Patents

Download PDF

Info

Publication number
JP2023017820A5
JP2023017820A5 JP2022171334A JP2022171334A JP2023017820A5 JP 2023017820 A5 JP2023017820 A5 JP 2023017820A5 JP 2022171334 A JP2022171334 A JP 2022171334A JP 2022171334 A JP2022171334 A JP 2022171334A JP 2023017820 A5 JP2023017820 A5 JP 2023017820A5
Authority
JP
Japan
Prior art keywords
hetero
group
alkyl
groups
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022171334A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023017820A (ja
JP7741788B2 (ja
Filing date
Publication date
Priority claimed from JP2020019787A external-priority patent/JP7167071B2/ja
Application filed filed Critical
Publication of JP2023017820A publication Critical patent/JP2023017820A/ja
Publication of JP2023017820A5 publication Critical patent/JP2023017820A5/ja
Application granted granted Critical
Publication of JP7741788B2 publication Critical patent/JP7741788B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022171334A 2012-10-23 2022-10-26 修飾抗体、抗体コンジュゲート及びそれらを調製する方法 Active JP7741788B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261717187P 2012-10-23 2012-10-23
EP12189604 2012-10-23
EP12189604.7 2012-10-23
US61/717,187 2012-10-23
EP13188607.9 2013-10-14
EP13188607 2013-10-14
JP2020019787A JP7167071B2 (ja) 2012-10-23 2020-02-07 修飾抗体、抗体コンジュゲート及びそれらを調製する方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020019787A Division JP7167071B2 (ja) 2012-10-23 2020-02-07 修飾抗体、抗体コンジュゲート及びそれらを調製する方法

Publications (3)

Publication Number Publication Date
JP2023017820A JP2023017820A (ja) 2023-02-07
JP2023017820A5 true JP2023017820A5 (enExample) 2023-08-17
JP7741788B2 JP7741788B2 (ja) 2025-09-18

Family

ID=50544942

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015539541A Active JP6855661B2 (ja) 2012-10-23 2013-10-23 修飾抗体、抗体コンジュゲート及びそれらを調製する方法
JP2020019787A Active JP7167071B2 (ja) 2012-10-23 2020-02-07 修飾抗体、抗体コンジュゲート及びそれらを調製する方法
JP2022171334A Active JP7741788B2 (ja) 2012-10-23 2022-10-26 修飾抗体、抗体コンジュゲート及びそれらを調製する方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2015539541A Active JP6855661B2 (ja) 2012-10-23 2013-10-23 修飾抗体、抗体コンジュゲート及びそれらを調製する方法
JP2020019787A Active JP7167071B2 (ja) 2012-10-23 2020-02-07 修飾抗体、抗体コンジュゲート及びそれらを調製する方法

Country Status (17)

Country Link
US (4) US10745488B2 (enExample)
EP (3) EP2911699B2 (enExample)
JP (3) JP6855661B2 (enExample)
CN (2) CN105142672B (enExample)
CY (1) CY1120041T1 (enExample)
DK (2) DK2911699T4 (enExample)
ES (2) ES2949376T3 (enExample)
FI (2) FI3912642T3 (enExample)
HR (2) HRP20230690T1 (enExample)
HU (2) HUE038285T2 (enExample)
LT (2) LT2911699T (enExample)
PL (2) PL3912642T3 (enExample)
PT (1) PT2911699T (enExample)
RS (2) RS56953B1 (enExample)
SI (2) SI3912642T1 (enExample)
SM (2) SMT202300208T1 (enExample)
WO (1) WO2014065661A1 (enExample)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202300208T1 (it) * 2012-10-23 2023-09-06 Synaffix Bv Anticorpo modificato, coniugato di anticorpo e processo per la preparazione degli stessi
CA2902872A1 (en) 2013-03-15 2014-09-18 Regeneron Pharmaceuticals, Inc. Biologically active molecules, conjugates thereof, and therapeutic uses
WO2014177771A1 (en) * 2013-05-02 2014-11-06 Glykos Finland Oy Conjugates of a glycoprotein or a glycan with a toxic payload
MX373528B (es) 2013-08-26 2020-04-21 Regeneron Pharma Composiciones farmacéuticas que contienen diasterómeros macrólidos, métodos para su síntesis y usos terapéuticos.
WO2015057063A1 (en) * 2013-10-14 2015-04-23 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
US9987373B2 (en) 2013-10-14 2018-06-05 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
WO2015057066A1 (en) * 2013-10-14 2015-04-23 Synaffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物,以及包括其的组合物和方法
EP3097079B1 (en) 2014-01-24 2021-05-12 SynAffix B.V. Process for the cycloaddition of a hetero(aryl) 1,3-dipole compound with a (hetero)cycloalkyne
WO2015112016A1 (en) * 2014-01-24 2015-07-30 Synaffix B.V. Process for the cycloaddition of a halogenated 1,3-dipole compound with a (hetero)cycloalkyne
US10905678B2 (en) 2014-04-08 2021-02-02 University Of Georgia Research Foundation, Inc. Site-specific antibody-drug glycoconjugates and methods
WO2016001485A1 (en) 2014-06-30 2016-01-07 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
EP2974744A1 (en) 2014-07-16 2016-01-20 Stichting Katholieke Universiteit Strain-promoted oxidation controlled cycloaddition with high reaction rate
WO2016022027A1 (en) 2014-08-04 2016-02-11 Synaffix B.V. Process for the modification of a glycoprotein using a βeta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
CN107106701B (zh) * 2014-10-03 2020-11-06 西纳福克斯股份有限公司 磺酰胺接头、其缀合物及制备方法
CN107406463A (zh) * 2014-12-04 2017-11-28 细胞基因公司 生物分子共轭物
US20170369525A1 (en) * 2014-12-31 2017-12-28 Development Center For Biotechnology Site-specific conjugation through glycoproteins linkage and method thereof
US11559581B2 (en) * 2015-01-09 2023-01-24 Oxford University Innovation Limited Antibody conjugates and methods of making the antibody conjugates
BR112017020149A8 (pt) 2015-03-27 2023-05-02 Regeneron Pharma Derivados de maitansinoide, conjugados dos mesmos e métodos de uso
ES2659816T3 (es) 2015-04-23 2018-03-19 Synaffix B.V. Proceso para la modificación de una glucoproteína utilizando una glucosiltransferasa que es o que deriva de una (1,4)-n-acetilgalactosaminiltransferasa
US10988508B2 (en) * 2015-04-24 2021-04-27 University Of Delaware Synthetic N-acetyl-muramic acid derivatives and uses thereof
CN107849131A (zh) 2015-07-06 2018-03-27 瑞泽恩制药公司 多特异性抗原结合分子及其用途
WO2017032888A1 (en) * 2015-08-26 2017-03-02 Vib Vzw Means and methods for monitoring inflammation
EP3371200A4 (en) * 2015-10-07 2020-04-29 The Board of Trustees of the University of Illinois METABOLIC SUGAR PRECURSORS ACTIVABLE BY A TRIGGER FOR THE MARKING AND SELECTIVE TARGETING OF CANCER
EP3165237B1 (en) 2015-11-03 2018-12-19 Industrial Technology Research Institute Antibody-drug conjugate (adc) and method for forming the same
MA43416A (fr) 2015-12-11 2018-10-17 Regeneron Pharma Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3
EA039072B9 (ru) * 2016-01-25 2022-02-04 Регенерон Фармасьютикалз, Инк. Производные майтанзиноида, их конъюгаты и способы применения
CN108495653A (zh) * 2016-01-27 2018-09-04 免疫医疗有限责任公司 用于制备具有定义的糖基化模式抗体的方法
JP2017197512A (ja) * 2016-02-08 2017-11-02 シンアフィックス ビー.ブイ. Cd30腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
WO2017137456A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Bioconjugates containing sulfamide linkers for use in treatment
US11590239B2 (en) * 2016-02-08 2023-02-28 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates
WO2017137423A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Improved sulfamide linkers for use in bioconjugates
EP3414328B1 (en) 2016-02-08 2024-01-10 Synaffix B.V. Enzymes for trimming of glycoproteins
EP3413916A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
JP2017200902A (ja) * 2016-02-08 2017-11-09 シンアフィックス ビー.ブイ. Her2腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
WO2017137457A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
PE20181953A1 (es) 2016-03-02 2018-12-17 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
EP3448891A1 (en) 2016-04-28 2019-03-06 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
WO2017191817A1 (ja) * 2016-05-02 2017-11-09 味の素株式会社 アジド基含有Fcタンパク質
WO2017218891A1 (en) * 2016-06-17 2017-12-21 Life Technologies Corporation Site-specific crosslinking of antibodies
EP3475291B1 (en) 2016-06-28 2025-10-01 Ventana Medical Systems, Inc. Application of click chemistry for signal amplification in ihc and ish assays
EP3478324A1 (en) 2016-07-01 2019-05-08 GlaxoSmithKline Intellectual Property (No.2) Limited Antibody-drug conjugates and therapeutic methods using the same
CN109462989A (zh) * 2016-07-01 2019-03-12 第三共株式会社 Hanp-含fc分子缀合物
MX2019003325A (es) * 2016-09-23 2019-08-05 Regeneron Pharma Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos.
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
MX394528B (es) 2016-11-08 2025-03-24 Regeneron Pharma Esteroides y conjugados de proteinas de los mismos.
TWI807423B (zh) * 2016-11-14 2023-07-01 醣基生醫股份有限公司 抗體藥物複合體
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
CN110121365A (zh) 2016-12-29 2019-08-13 财团法人生物技术开发中心 制备糖蛋白-药物偶联物的方法
US20200023071A1 (en) 2017-02-06 2020-01-23 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
JP2020507584A (ja) 2017-02-10 2020-03-12 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイThe Board Of Trustees Of The University Of Illinois 癌選択的標識および標的化のためのトリガー活性化可能な糖コンジュゲート
CA3062238A1 (en) 2017-05-11 2018-11-15 Vib Vzw Glycosylation of variable immunoglobulin domains
AU2018269568B2 (en) 2017-05-18 2022-03-24 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
EP3635009A1 (en) 2017-06-07 2020-04-15 Regeneron Pharmaceuticals, Inc. Compositions and methods for internalizing enzymes
US11236059B2 (en) 2017-08-09 2022-02-01 Helmholtz-Zentrum Fuer Infektionsforschung Gmbh Targeted cytotoxic ratjadone derivatives and conjugates thereof
ES2803350T3 (es) * 2017-08-11 2021-01-26 Life Science Inkubator Sachsen Gmbh & Co Kg Novedosos conjugados de anticuerpos adecuados para su uso en inmunoensayos aislados de desplazamiento de la inactivación de la fluorescencia
JP7273716B2 (ja) * 2017-09-29 2023-05-15 第一三共株式会社 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート
SG11202004151YA (en) 2017-11-07 2020-06-29 Regeneron Pharma Hydrophilic linkers for antibody drug conjugates
JP7165193B2 (ja) 2017-11-27 2022-11-02 パーデュー、ファーマ、リミテッド、パートナーシップ ヒト組織因子を標的とするヒト化抗体
WO2019110725A1 (en) 2017-12-06 2019-06-13 Synaffix B.V. Enediyne conjugates
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CA3086926A1 (en) 2018-01-08 2019-07-11 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
MX2020011487A (es) 2018-04-30 2020-12-07 Regeneron Pharma Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos.
SG11202010909RA (en) 2018-05-09 2020-12-30 Regeneron Pharma Anti-msr1 antibodies and methods of use thereof
EP3793591A1 (en) 2018-05-17 2021-03-24 Regeneron Pharmaceuticals, Inc. Anti-cd63 antibodies, conjugates, and uses thereof
JP2019206491A (ja) * 2018-05-29 2019-12-05 国立研究開発法人理化学研究所 乳がんまたは胃がんの治療のための抗体−薬物複合体
US12103978B2 (en) 2018-06-15 2024-10-01 Shanghai Miracogen Inc. Methods and materials for treating cancer
KR20210081324A (ko) 2018-08-02 2021-07-01 다인 세라퓨틱스, 인크. 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
SG11202100934PA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
JP7576542B2 (ja) * 2018-08-02 2024-10-31 ダイン セラピューティクス,インコーポレーテッド 筋標的化複合体およびそれらの使用
JP7705793B2 (ja) * 2018-08-02 2025-07-10 ダイン セラピューティクス,インコーポレーテッド 筋強直症ジストロフィーを処置するための筋標的化複合体およびそれらの使用
CN113260384A (zh) 2018-11-05 2021-08-13 西纳福克斯股份有限公司 用于靶向表达trop-2的肿瘤的抗体缀合物
BR112021009673A2 (pt) 2018-11-20 2021-12-14 Regeneron Pharma Derivados de bis-octa-hidrofenantreno carboxamida e conjugados de proteínas dos mesmos para uso como agonistas de lxr
MA53765B2 (fr) 2018-12-21 2025-04-30 Regeneron Pharmaceuticals, Inc. Tubulysines et conjugués tubulysines-protéines
AU2019403404B2 (en) 2018-12-21 2025-05-29 Regeneron Pharmaceuticals, Inc. Rifamycin analogs and antibody-drug conjugates thereof
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CN118373810A (zh) 2018-12-27 2024-07-23 糖模拟物有限公司 抑制c-糖苷的半乳凝素-3
CA3125998A1 (en) 2019-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Traceless linkers and protein-conjugates thereof
GB201901608D0 (en) 2019-02-06 2019-03-27 Vib Vzw Vaccine adjuvant conjugates
CN113727757A (zh) 2019-02-21 2021-11-30 瑞泽恩制药公司 使用结合met的抗-met抗体和双特异性抗原结合分子治疗眼癌的方法
EP3950061A4 (en) * 2019-03-25 2022-11-16 Daiichi Sankyo Company, Limited ANTIBODY PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
SG11202109860VA (en) * 2019-03-25 2021-10-28 Daiichi Sankyo Co Ltd Anti-her2 antibody-pyrrolobenzodiazepine derivative conjugate
BR112021017350A2 (pt) * 2019-03-27 2021-11-16 Daiichi Sankyo Co Ltd Combinação de conjugado de anticorpo-derivado de pirrolobenzodiazepina e inibidor de parp
WO2020245229A1 (en) 2019-06-03 2020-12-10 Synaffix B.V. Acetal-based cleavable linkers
WO2021055350A1 (en) 2019-09-16 2021-03-25 Regeneron Pharmaceuticals, Inc. Radiolabeled met binding proteins for immuno-pet imaging
US11814428B2 (en) 2019-09-19 2023-11-14 Regeneron Pharmaceuticals, Inc. Anti-PTCRA antibody-drug conjugates and uses thereof
AU2019341067B2 (en) * 2019-09-29 2021-08-05 Mabplex International Co., Ltd. Method for producing antibody-drug conjugate intermediate by addition of acid and use thereof
GB201917388D0 (en) * 2019-11-28 2020-01-15 Cambridge Entpr Ltd Novel linker compounds
GB201918279D0 (en) 2019-12-12 2020-01-29 Vib Vzw Glycosylated single chain immunoglobulin domains
CA3163833A1 (en) * 2020-01-09 2021-07-15 Timothy B. Lowinger Site specific antibody-drug conjugates with peptide-containing linkers
CN115768483A (zh) 2020-01-13 2023-03-07 西纳福克斯股份有限公司 抗体与免疫细胞衔接器的缀合物
WO2021144314A1 (en) 2020-01-13 2021-07-22 Synaffix B.V. Via cycloaddition bilaterally functionalized antibodies
JP2023511857A (ja) 2020-01-13 2023-03-23 シンアフィックス ビー.ブイ. 付加環化を介して両側官能化された抗体
KR20220131266A (ko) 2020-01-24 2022-09-27 리제너론 파마슈티칼스 인코포레이티드 단백질-항바이러스 화합물 접합체
CA3166619A1 (en) 2020-02-28 2021-09-02 Julian Andreev Bispecific antigen binding molecules that bind her2, and methods of use thereof
CA3179154A1 (en) 2020-04-16 2021-10-21 Regeneron Pharmaceuticals, Inc. Diels-alder conjugation methods
EP4149548A4 (en) 2020-05-13 2024-05-08 Disc Medicine, Inc. ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
KR20230015348A (ko) 2020-05-25 2023-01-31 고에키 자이단 호징 고베 이료 산교 도시 스이신 기코 Th2 개재성 질환을 치료 또는 예방하기 위한 PD-1 작용제 함유 의약 조성물
CN111560078A (zh) * 2020-06-19 2020-08-21 联宁(苏州)生物制药有限公司 具有马来酰亚胺接头的双臂中间体及其合成方法
MA58646A1 (fr) 2020-06-24 2023-08-31 Regeneron Pharma Tubulysines et conjugués tubulysines-protéines
EP4172141A1 (en) 2020-06-26 2023-05-03 Synaffix B.V. Methods for the preparation of linker payload constructs
BR112023000489A2 (pt) 2020-07-13 2023-03-28 Regeneron Pharma Análogos de camptotecina conjugados a um resíduo de glutamina em uma proteína, e seu uso
NL2026400B1 (en) 2020-09-02 2022-05-04 Synaffix Bv Methods for the preparation of bioconjugates
AU2021339892A1 (en) 2020-09-14 2023-04-27 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof
WO2022058395A1 (en) 2020-09-15 2022-03-24 Synaffix B.V. Antibody-exatecan conjugates
WO2022079211A1 (en) 2020-10-16 2022-04-21 Adc Therapeutics Sa Glycoconjugates
US20240042053A1 (en) 2020-10-16 2024-02-08 University Of Georgia Research Foundation, Inc. Glycoconjugates
CA3190569A1 (en) 2020-10-22 2022-04-28 Christopher Daly Anti-fgfr2 antibodies and methods of use thereof
NL2026947B1 (en) 2020-11-20 2022-07-01 Synaffix Bv Tyrosine-based antibody conjugates
WO2022136705A1 (en) 2020-12-24 2022-06-30 Synaffix B.V. Glycan-conjugated antibodies binding to fc-gamma receptor
CA3202832A1 (en) 2020-12-31 2022-07-07 Romesh R. Subramanian Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US20250262314A1 (en) 2021-02-08 2025-08-21 Synaffix B.V. Multifunctional antibodies
AU2022253902A1 (en) 2021-04-10 2023-11-02 Genmab A/S Folr1 binding agents, conjugates thereof and methods of using the same
TW202308699A (zh) 2021-04-23 2023-03-01 美商普方生物製藥美國公司 Cd70結合劑、其結合物及其使用方法
AU2022309028A1 (en) 2021-07-09 2024-01-25 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating dystrophinopathies
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11648318B2 (en) 2021-07-09 2023-05-16 Dyne Therapeutics, Inc. Anti-transferrin receptor (TFR) antibody and uses thereof
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US20250041433A1 (en) 2021-07-28 2025-02-06 Regeneron Pharmaceuticals, Inc. Protein-antiviral compound conjugates
CN118119633A (zh) * 2021-10-20 2024-05-31 岩唐生物科技(杭州)有限责任公司 位点特异性糖蛋白偶联物及其制备方法
KR102782629B1 (ko) * 2021-11-12 2025-03-19 닥터아이앤비(주) 생산 시간을 단축하고 안정성이 개선된 의약품 제조방법
WO2023091968A1 (en) 2021-11-17 2023-05-25 Disc Medicine, Inc. Methods for treating anemia of kidney disease
US20230414775A1 (en) 2021-12-29 2023-12-28 Regeneron Pharmaceuticals, Inc. Tubulysins and protein-tubulysin conjugates
JP2025502147A (ja) 2022-01-12 2025-01-24 リジェネロン ファーマシューティカルズ,インク. タンパク質中のグルタミン残基にコンジュゲートしたカンプトテシンアナログおよびその使用
JP2025503700A (ja) 2022-01-14 2025-02-04 レジェネロン ファーマシューティカルズ, インコーポレイテッド ベルカリンa誘導体及びその抗体薬物複合体
WO2023141855A1 (en) * 2022-01-27 2023-08-03 Glyco-Therapy Biotechnology Co., Ltd. Protein conjugates with multiple payloads and methods for making the same
CA3244590A1 (en) * 2022-02-22 2023-08-31 Adc Therapeutics Sa CONJUGATION PROCESS INVOLVING A TRANSGLUTAMINASE AT THE FC REGION COMPRISING A TRUNCATED N-GLYCAN
EP4489855A1 (en) 2022-03-11 2025-01-15 Regeneron Pharmaceuticals, Inc. Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof
IL315207A (en) 2022-03-23 2024-10-01 Synaffix Bv Antibody-conjugates for targeting of tumours expressing trop-2
US20250205353A1 (en) 2022-03-23 2025-06-26 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
MX2024011519A (es) 2022-03-23 2024-09-24 Synaffix Bv Conjugados de anticuerpos para el direccionamiento contra tumores que expresan el antigeno carcinoembrionario.
CA3254479A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. ANTIBODY CONJUGATIONS FOR TARGETTING PTK7-EXPRESSING TUMORS
IL316143A (en) 2022-04-15 2024-12-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of myotonic dystrophy
EP4285934A1 (en) 2022-05-30 2023-12-06 CER Groupe Modified trimannose-oligosacharides, bisected n-glycans comprising said trimannose core and method for obtaining them
AU2023310999A1 (en) 2022-07-21 2025-01-23 Firefly Bio, Inc. Glucocorticoid receptor agonists and conjugates thereof
JP2025526869A (ja) 2022-08-15 2025-08-15 シンアフィックス ビー.ブイ. アントラサイクリン及びそのコンジュゲート
EP4344707A1 (en) 2022-09-29 2024-04-03 Emergence Therapeutics AG New anti-nectin-4 antibody drug conjugates
EP4626553A2 (en) 2022-11-30 2025-10-08 Regeneron Pharmaceuticals, Inc. Tlr7 agonists and antibody-drug-conjugates thereof
WO2024121123A1 (en) 2022-12-06 2024-06-13 Synaffix B.V. Synthesis of endo-bicyclononene
AU2023407365A1 (en) 2022-12-21 2025-07-31 Regeneron Pharmaceuticals, Inc. Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
CN120456931A (zh) * 2022-12-22 2025-08-08 詹森药业有限公司 制备抗体-多核苷酸缀合物的方法
EP4389152A1 (en) 2022-12-23 2024-06-26 Synaffix B.V. Conjugates of pbd prodrugs
WO2024150074A2 (en) 2023-01-13 2024-07-18 Takeda Pharmaceutical Company Limited Coronavirus antibodies and therapeutic uses thereof
TW202434309A (zh) 2023-01-19 2024-09-01 大陸商上海盛迪醫藥有限公司 酪胺酸酶介導的蛋白定點偶聯及其應用
EP4410313A1 (en) 2023-01-31 2024-08-07 Synaffix B.V. Homogeneous antibody-conjugates with high payload loading
CN121001751A (zh) 2023-02-09 2025-11-21 里珍纳龙药品有限公司 借助逆电子需求狄尔斯-阿尔德反应的抗体-药物缀合物
WO2024182714A1 (en) 2023-03-02 2024-09-06 Alloy Therapeutics, Inc. Anti-cd22 antibodies and uses thereof
WO2024199432A1 (en) * 2023-03-30 2024-10-03 Genequantum Healthcare (Suzhou) Co., Ltd. Site-speicfic orthogonal bioconjugate modality and application thereof
WO2024199442A1 (en) * 2023-03-30 2024-10-03 Genequantum Healthcare (Suzhou) Co., Ltd. Disaccharide linker, linker-payload containing the same and glycan chain-remodeled antibody-drug conjugate, preparation method and uses thereof
EP4450093A1 (en) 2023-04-17 2024-10-23 Synaffix B.V. Cleavable immune cell engagers
EP4450489A1 (en) 2023-04-18 2024-10-23 Synaffix B.V. Stable 4-isoxazoline conjugates
WO2024218164A1 (en) 2023-04-17 2024-10-24 Synaffix B.V. Stable 4-isoxazoline conjugates
WO2024229105A1 (en) 2023-05-02 2024-11-07 Regeneron Pharmaceuticals, Inc. Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells
WO2024231447A1 (en) 2023-05-08 2024-11-14 Sanofi Glycosylation of immunoglobulin single variable domains
WO2024251826A1 (en) 2023-06-05 2024-12-12 Vib Vzw Glyco-engineered antibody-drug-conjugates comprising an oxime linker
WO2025011557A1 (en) * 2023-07-10 2025-01-16 Surio Therapeutics Co. Ltd Functionalized auristatins, pharmaceutical compositions, and therapeutic applications
WO2025014533A1 (en) 2023-07-10 2025-01-16 Regeneron Pharmaceuticals, Inc. Anti-human cacng1 antibody-drug conjugates and uses thereof
WO2025024334A1 (en) 2023-07-21 2025-01-30 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods
WO2025027529A1 (en) 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof
AR133955A1 (es) 2023-09-26 2025-11-19 Profoundbio Us Co Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos
EP4541376A1 (en) 2023-10-17 2025-04-23 ADC Therapeutics SA Antibody-drug conjugates
WO2025096921A1 (en) 2023-11-03 2025-05-08 Regeneron Pharmaceuticals, Inc. Peptide acids as a glp1r agonist and antibody-drug conjugates thereof
WO2025117727A1 (en) 2023-11-29 2025-06-05 Regeneron Pharmaceuticals, Inc. Analogs of quinoxaline/quinoline cytotoxins, linker- payloads, protein-drug conjugates, and uses thereof
WO2025126157A1 (en) 2023-12-15 2025-06-19 Advesya Anti-il-1rap binding domains and antibody-drug conjugates thereof
EP4574174A1 (en) 2023-12-19 2025-06-25 Jack Elands Novel antibody-drug conjugates comprising an anti-(tcr)-cd3-complex binding antibody
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025163120A1 (en) 2024-02-01 2025-08-07 Adcytherix Sas ANTIBODY-DRUG CONJUGATES COMPRISING AN ANTI-INTEGRIN ΑVβ6 BINDING ANTIBODY
WO2025172468A1 (en) 2024-02-13 2025-08-21 Synaffix B.V. Method for producing azido-sugars and compounds obtained thereby
WO2025181219A1 (en) 2024-02-29 2025-09-04 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
WO2025238253A1 (en) 2024-05-16 2025-11-20 Synaffix B.V. Antibody-oligonucleotide conjugates

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20011671A7 (fi) 2001-08-20 2003-02-21 Carbion Oy Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
WO2004063344A2 (en) 2003-01-10 2004-07-29 Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health CATALYTIC DOMAINS OF β/1,4)-GALACTOSYLTRANSFERASE I HAVING ALTERED DONOR AND ACCEPTOR SPECIFICITIES, DOMAINS THAT PROMOTE IN VITRO PROTEIN FOLDING, AND METHODS FOR THEIR USE
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
CA2536882C (en) 2003-10-29 2009-12-15 Bsn Medical, Inc. Medical bandaging product
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
US20070258986A1 (en) * 2003-11-19 2007-11-08 Govt of the US as represented by the secretary, Targeted Delivery System for Bioactive Agents
JP4521490B2 (ja) * 2003-11-21 2010-08-11 国立大学法人高知大学 類似パターン検索装置、類似パターン検索方法、類似パターン検索プログラム、および分画分離装置
WO2005056783A1 (en) * 2003-12-05 2005-06-23 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Catalytic domains of beta(1,4)-galactosyltransferase i having altered metal ion specificity
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
JP2009531289A (ja) * 2006-02-10 2009-09-03 ライフ テクノロジーズ コーポレーション オリゴ糖によるタンパク質の修飾及び標識方法
EP2623610B1 (en) 2006-02-10 2015-04-29 Life Technologies Corporation Labeling and detection of post translationally modified proteins
CA2647632C (en) 2006-03-27 2017-06-27 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
WO2008143944A2 (en) * 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of glycosylation and bioconjugation
WO2009025646A1 (en) 2007-08-22 2009-02-26 Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services Alpha 1-3 n-galactosyltransferase with altered donor specificities
US8512991B2 (en) * 2007-08-22 2013-08-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
CN101925366B (zh) * 2007-11-21 2015-02-04 乔治亚大学研究基金公司 炔烃以及炔烃与1,3-偶极-官能化合物反应的方法
WO2009102820A2 (en) * 2008-02-11 2009-08-20 Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services Modified sugar substrates and methods of use
US7914904B2 (en) * 2008-03-25 2011-03-29 General Electric Company Component in a combustion system, and process for preventing slag, ash, and char buildup
EP2533810B1 (en) * 2010-02-10 2016-10-12 ImmunoGen, Inc. Cd20 antibodies and uses thereof
US8519122B2 (en) 2010-02-12 2013-08-27 The Regents Of The University Of California Compositions and methods for modification of biomolecules
EP2563753B9 (en) * 2010-04-27 2016-07-06 SynAffix B.V. Fused cyclooctyne compounds and their use in metal-free click reactions
EP2383374A1 (en) * 2010-04-29 2011-11-02 BASF Corporation Nano-particles containing carbon and a ferromagnetic metal or alloy
US20150072396A1 (en) 2011-03-04 2015-03-12 Life Technologies Corporation Compounds and Methods for Conjugation of Biomolecules
US9145361B2 (en) 2011-03-25 2015-09-29 Life Technologies Corporation SDP-containing heterobifunctional agents
ES2596194T3 (es) * 2011-04-01 2017-01-05 Wyeth Llc Conjugados de anticuerpo-fármaco
GB201115841D0 (en) 2011-09-13 2011-10-26 Genovis Ab Protein and method
SMT202300208T1 (it) * 2012-10-23 2023-09-06 Synaffix Bv Anticorpo modificato, coniugato di anticorpo e processo per la preparazione degli stessi

Similar Documents

Publication Publication Date Title
JP2023017820A5 (enExample)
JP6733993B2 (ja) スルファミドリンカー、スルファミドリンカーのコンジュゲート、及び調製の方法
RU2753416C2 (ru) Новые конъюгаты аманитина
EP0540859B1 (en) Anthracycline prodrugs
JP2025108689A (ja) カンプトテシンコンジュゲート
JP7595098B2 (ja) 薬物制御放出のための送達系
KR100680014B1 (ko) 이민 형성 폴리사카라이드, 이의 제조 방법 및 이것의 아쥬반트 및 면역자극제로서의 용도
CN113260384A (zh) 用于靶向表达trop-2的肿瘤的抗体缀合物
US20200297861A1 (en) Enediyne conjugates
FI3912642T3 (fi) Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi
EP0317957A2 (en) Drug-monoclonal antibody conjugates
PL172715B1 (pl) Sposób wytwarzania nowych koniugatów tioeterowych PL PL PL PL PL
JP2018012729A (ja) 治療剤送達のためのシクロデキストリン系ポリマー
JPH01246295A (ja) 新規なリンカーを有するアントラサイクリン・イムノコンジュゲート及びその製造方法
JP5457672B2 (ja) 間接的な化学的複合体形成によって得られるヒアルロン酸又はその誘導体の抗腫瘍性バイオ複合体、及び医薬分野におけるそれらの使用
TW201441248A (zh) 毒傘肽(amatoxin)衍生物
JP2010515718A5 (enExample)
AU2020294393A1 (en) Tetrazines for high click release speed and yield
CN112955434B (zh) 包含喹啉衍生物的药物偶联物
JP2015505557A (ja) 治療的送達のためのシクロデキストリンに基づく重合体
US20230293432A1 (en) Polymeric micelles comprising glucuronide-prodrugs
Goerlach et al. In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates
KR20190004662A (ko) 절단성 링커를 포함하는 화합물 및 이들의 용도
Xia et al. Harnessing acylhydrazone-oxime exchange reaction to achieve diverse synthesis of glycosite-specific antibody–drug conjugates
US20250177553A1 (en) Novel antibody drug conjugate