JP2022548221A - シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法 - Google Patents

シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法 Download PDF

Info

Publication number
JP2022548221A
JP2022548221A JP2022515794A JP2022515794A JP2022548221A JP 2022548221 A JP2022548221 A JP 2022548221A JP 2022515794 A JP2022515794 A JP 2022515794A JP 2022515794 A JP2022515794 A JP 2022515794A JP 2022548221 A JP2022548221 A JP 2022548221A
Authority
JP
Japan
Prior art keywords
nanoemulsion
castor oil
less
cyclosporine
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022515794A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022548221A5 (OSRAM
Inventor
イ，ジョンヨブ
シン，ユンジェ
ソ，ヒョンウォン
キム，デフン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taejoon Pharmaceutical Co Ltd
Original Assignee
Taejoon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taejoon Pharmaceutical Co Ltd filed Critical Taejoon Pharmaceutical Co Ltd
Publication of JP2022548221A publication Critical patent/JP2022548221A/ja
Publication of JP2022548221A5 publication Critical patent/JP2022548221A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022515794A 2019-09-09 2020-09-04 シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法 Pending JP2022548221A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20190111776 2019-09-09
KR10-2019-0111776 2019-09-09
PCT/KR2020/011977 WO2021049825A1 (ko) 2019-09-09 2020-09-04 사이클로스포린 및 멘톨 함유 나노 에멀젼 점안 조성물 및 그의 제조 방법

Publications (2)

Publication Number Publication Date
JP2022548221A true JP2022548221A (ja) 2022-11-17
JP2022548221A5 JP2022548221A5 (OSRAM) 2023-09-12

Family

ID=74867274

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022515794A Pending JP2022548221A (ja) 2019-09-09 2020-09-04 シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法

Country Status (8)

Country Link
US (1) US12576126B2 (OSRAM)
EP (1) EP4029493A4 (OSRAM)
JP (1) JP2022548221A (OSRAM)
KR (2) KR102273481B1 (OSRAM)
CN (1) CN114364372A (OSRAM)
CA (1) CA3149270A1 (OSRAM)
PH (1) PH12022550500A1 (OSRAM)
WO (1) WO2021049825A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023190283A1 (ja) * 2022-03-28 2023-10-05 中外製薬株式会社 ポリオキシエチレン構造を含む油性成分を含有する化合物製剤
IL294896A (en) * 2022-07-20 2024-02-01 LYOTROPIC DELIVERY SYSTEMS Ltd Topical administration of cyclosporine to the eye

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008714A1 (ja) * 2011-07-08 2013-01-17 ロート製薬株式会社 眼科用水性組成物
JP2016519162A (ja) * 2013-05-20 2016-06-30 テジュン ファーム． カンパニー リミテッド シクロスポリンを含有するナノエマルジョン点眼組成物およびその製造方法
CN105726479A (zh) * 2016-03-24 2016-07-06 北京茗泽中和药物研究有限公司 环孢素眼用乳剂
WO2018071619A1 (en) * 2016-10-12 2018-04-19 Ps Therapies Ltd Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
WO2019111917A1 (ja) * 2017-12-07 2019-06-13 ライオン株式会社 水性眼科用組成物及びエマルション粒子の微粒化方法
CN110090294A (zh) * 2019-04-09 2019-08-06 嘉兴市爵拓科技有限公司 具有改善的干燥保护和保留的眼用组合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635796B2 (en) 1990-03-16 2003-10-21 Sevenson Environmental Services, Inc. Reduction of leachability and solubility of radionuclides and radioactive substances in contaminated soils and materials
KR0167613B1 (ko) 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
KR100336090B1 (ko) 1998-06-27 2002-05-27 윤승원 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
US8663692B1 (en) 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
CN101448259A (zh) 2001-06-27 2009-06-03 诺基亚西门子通信公司 用于无线通信网中承载授权的方法和系统
WO2003053472A1 (en) 2001-12-21 2003-07-03 Senju Pharmaceutical Co., Ltd. Eye drops
MXPA04009385A (es) 2002-03-26 2005-01-25 Teva Pharma Microparticulas de drogas.
CN1232539C (zh) * 2002-05-10 2005-12-21 刘云清 有机药物与倍他环糊精衍生物的配合物及其制备方法
JP2006524190A (ja) * 2003-02-20 2006-10-26 テバ ファーマシューティカル インダストリーズ リミティド 薬剤のメントール溶液
US20070008894A1 (en) 2004-10-19 2007-01-11 Idt Corporation Telecommunications-based link monitoring system
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
KR100669510B1 (ko) 2005-08-17 2007-01-16 보람제약주식회사 사이크로스포린을 함유한 나노 에멀젼 농축액 조성물 및 그제조방법
CN101244256A (zh) * 2007-02-16 2008-08-20 中国科学院上海药物研究所 一种环孢菌素a眼用微/亚微乳原位凝胶制剂及其制备方法
EP2575854B1 (en) * 2010-05-25 2016-03-09 Allergan, Inc. Cyclosporin emulsions
WO2012015211A2 (ko) 2010-07-30 2012-02-02 주식회사종근당 사이클로스포린 에이 함유 점안제 조성물
WO2012074588A2 (en) 2010-08-30 2012-06-07 President And Fellows Of Harvard College Shear controlled release for stenotic lesions and thrombolytic therapies
US8455991B2 (en) 2010-09-24 2013-06-04 Stats Chippac Ltd. Integrated circuit packaging system with warpage control and method of manufacture thereof
KR101211902B1 (ko) 2012-04-30 2012-12-13 주식회사 휴온스 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물
US10963928B2 (en) 2014-08-21 2021-03-30 Stubhub, Inc. Crowdsourcing seat quality in a venue
ES2630106T3 (es) 2014-10-07 2017-08-18 Cyprumed Gmbh Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos
KR20170032808A (ko) * 2015-09-15 2017-03-23 주식회사 엘지생활건강 멘톨 또는 멘톨 유도체를 포함하는 용해성 미세바늘 패치
US11583496B2 (en) 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008714A1 (ja) * 2011-07-08 2013-01-17 ロート製薬株式会社 眼科用水性組成物
JP2016519162A (ja) * 2013-05-20 2016-06-30 テジュン ファーム． カンパニー リミテッド シクロスポリンを含有するナノエマルジョン点眼組成物およびその製造方法
CN105726479A (zh) * 2016-03-24 2016-07-06 北京茗泽中和药物研究有限公司 环孢素眼用乳剂
WO2018071619A1 (en) * 2016-10-12 2018-04-19 Ps Therapies Ltd Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
WO2019111917A1 (ja) * 2017-12-07 2019-06-13 ライオン株式会社 水性眼科用組成物及びエマルション粒子の微粒化方法
CN110090294A (zh) * 2019-04-09 2019-08-06 嘉兴市爵拓科技有限公司 具有改善的干燥保护和保留的眼用组合物

Also Published As

Publication number Publication date
KR20210030215A (ko) 2021-03-17
CA3149270A1 (en) 2021-03-18
WO2021049825A1 (ko) 2021-03-18
KR102638866B1 (ko) 2024-02-21
KR102273481B1 (ko) 2021-07-06
US12576126B2 (en) 2026-03-17
US20240041974A1 (en) 2024-02-08
KR20210084389A (ko) 2021-07-07
EP4029493A1 (en) 2022-07-20
PH12022550500A1 (en) 2023-10-18
EP4029493A4 (en) 2023-10-04
CN114364372A (zh) 2022-04-15

Similar Documents

Publication Publication Date Title
JP5441058B2 (ja) 四級アンモニウム化合物を含む組成物
EP2437723B1 (en) Omega-3 oil containing ophthalmic emulsions
CN101674804A (zh) 包含前列腺素的眼科用水包油型乳剂
WO2014204791A1 (en) Ophthalmic lipophilic and hydrophilic drug delivery vehicle formulations
CN103764120A (zh) 聚乙二醇15羟基硬脂酸酯制剂
AU2010256679B2 (en) Therapeutic ophthalmic emulsions
JP6603785B2 (ja) 水溶性高分子を含む水性液剤
KR20160123400A (ko) 자기보존 에멀젼
KR20150127256A (ko) 눈의 후안부로의 약물 전달을 위한 안구용 제제
JP2022538659A (ja) 薬剤を含む水性組成物のｐＨを安定化させるための方法
KR102365008B1 (ko) 디쿠아포솔을 포함하는 점안 조성물
KR102638866B1 (ko) 사이클로스포린 및 멘톨 함유 나노 에멀젼 점안 조성물 및 그의 제조 방법
KR20230092814A (ko) 브린졸라미드 및 티몰롤을 함유하는 투명 복합점안제
JP2002506808A (ja) グリコーゲン含有眼用溶液
CN110022856B (zh) 用于降低眼压的眼用组合物
WO2020138135A1 (ja) 眼科用組成物
EP2977044A1 (en) Two-layer separation-type eye drop containing squalane
JP5627235B2 (ja) 眼科用組成物
US20140302099A1 (en) Ophthalmic Composition Containing Cyclosporine And method For Preparing Same
AU2014250656B2 (en) Omega-3 oil containing ophthalmic emulsions
WO2024110503A1 (en) Methods for treating eyetear film deficiency
WO2025108987A1 (en) Compositions and methods for treating eyetear film deficiency and redeye
EA050512B1 (ru) СПОСОБ СТАБИЛИЗАЦИИ рН ВОДНОЙ КОМПОЗИЦИИ, СОДЕРЖАЩЕЙ ЛЕКАРСТВЕННОЕ СРЕДСТВО
JPH0273014A (ja) 眼科用α―メチル―４―（２’―チエニルカルボニル）フェニル酢酸リジン液剤の製法
McCann Advances and challenges in topical ocular medications

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230904

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230904

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20240722

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240903

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250401

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250930