|
JPS5432103A
(en)
|
1977-08-16 |
1979-03-09 |
Nissan Motor Co Ltd |
Preparing apparatus for composite molten metal containing solid particles in dispersed state
|
|
JPS5870649A
(ja)
|
1981-10-22 |
1983-04-27 |
Toyota Motor Corp |
ダイバ−シテイ受信システム
|
|
JPH0747045B2
(ja)
|
1986-10-15 |
1995-05-24 |
株式会社大協精工 |
積層した注射器用滑栓
|
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
US5171840A
(en)
|
1988-01-22 |
1992-12-15 |
Tadamitsu Kishimoto |
Receptor protein for human B cell stimulatory factor-2
|
|
US5216128A
(en)
|
1989-06-01 |
1993-06-01 |
Yeda Research And Development Co., Ltd. |
IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
|
|
SG42954A1
(en)
|
1989-07-20 |
1997-10-17 |
Tadamitsu Kishimoto |
Antibody to human interleukin-6 receptor
|
|
US5605690A
(en)
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5016784A
(en)
|
1990-02-15 |
1991-05-21 |
Dexus Research Inc. |
Applicator for highly reactive materials
|
|
DE07012626T1
(de)
|
1991-03-18 |
2010-01-21 |
New York University |
Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
|
|
AU668349B2
(en)
|
1991-04-25 |
1996-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin 6 receptor
|
|
US5215534A
(en)
|
1991-12-02 |
1993-06-01 |
Lawrence De Harde |
Safety syringe system
|
|
JP3100727B2
(ja)
|
1992-01-23 |
2000-10-23 |
株式会社大協精工 |
変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品
|
|
FR2694767B1
(fr)
|
1992-08-13 |
1994-10-21 |
Innotherapie Lab Sa |
Anticorps monoclonaux anti-IL6R, et leurs applications.
|
|
NZ256293A
(en)
|
1992-09-15 |
1997-06-24 |
Immunex Corp |
Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist
|
|
AU687763B2
(en)
|
1992-10-20 |
1998-03-05 |
Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service |
Interleukin-6 receptor antagonists
|
|
US5888511A
(en)
|
1993-02-26 |
1999-03-30 |
Advanced Biotherapy Concepts, Inc. |
Treatment of autoimmune diseases, including AIDS
|
|
US5888510A
(en)
|
1993-07-21 |
1999-03-30 |
Chugai Seiyaku Kabushiki Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
WO1995009873A1
(en)
|
1993-10-06 |
1995-04-13 |
Board Of Regents, The University Of Texas System |
A monoclonal anti-human il-6 receptor antibody
|
|
AU700819B2
(en)
|
1994-10-07 |
1999-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
|
|
PL182089B1
(en)
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
|
US6086874A
(en)
|
1994-12-29 |
2000-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antitumor agent effect enhancer containing IL-6 antagonist
|
|
US6261560B1
(en)
|
1995-02-13 |
2001-07-17 |
Chugai Seiyaku Kabushiki Kaisha |
Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor
|
|
JP3172057B2
(ja)
|
1995-04-05 |
2001-06-04 |
株式会社大協精工 |
ラミネートゴム栓
|
|
ZA971600B
(en)
|
1996-02-26 |
1997-09-22 |
Merck & Co Inc |
Treatment of macular edema.
|
|
DK0923941T3
(da)
|
1996-06-27 |
2006-09-18 |
Chugai Pharmaceutical Co Ltd |
Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
|
|
US7312196B2
(en)
|
1997-01-08 |
2007-12-25 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
KR20040024561A
(ko)
|
1997-08-15 |
2004-03-20 |
츄가이 세이야꾸 가부시키가이샤 |
항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는전신성 홍반성 낭창의 예방 및/또는 치료제
|
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
ATE383875T1
(de)
|
1998-03-17 |
2008-02-15 |
Chugai Pharmaceutical Co Ltd |
Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper
|
|
CA2341239C
(en)
|
1998-08-24 |
2011-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for pancreatitis comprising il-6 antagonist as an active ingredient
|
|
JP3512349B2
(ja)
|
1999-01-29 |
2004-03-29 |
株式会社大協精工 |
柱状ゴム要素の成形型
|
|
EP1224189B1
(en)
|
1999-10-07 |
2006-01-25 |
Eli Lilly And Company |
Condensed dihydroquinolinone derivatives for inhibiting mrp1
|
|
US6659982B2
(en)
|
2000-05-08 |
2003-12-09 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
US6629949B1
(en)
|
2000-05-08 |
2003-10-07 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
US8632778B2
(en)
|
2000-08-11 |
2014-01-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized anti-interleukin-6 antibody-containing preparations
|
|
US7148197B2
(en)
|
2000-08-24 |
2006-12-12 |
The Regents Of The University Of California |
Orally administered small peptides synergize statin activity
|
|
EP1327681A4
(en)
|
2000-10-20 |
2004-09-01 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibodies
|
|
AU1095202A
(en)
|
2000-10-25 |
2002-05-06 |
Chugai Pharmaceutical Co Ltd |
Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist
|
|
JP4889187B2
(ja)
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤
|
|
JP2002209975A
(ja)
|
2001-01-19 |
2002-07-30 |
Daikyo Seiko Ltd |
医薬バイアル用ラミネートゴム栓
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
CA2817619A1
(en)
|
2001-06-08 |
2002-12-08 |
Abbott Laboratories (Bermuda) Ltd. |
Methods of administering anti-tnf.alpha. antibodies
|
|
ATE454137T1
(de)
|
2001-07-25 |
2010-01-15 |
Facet Biotech Corp |
Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab
|
|
BRPI0214168B8
(pt)
|
2001-11-14 |
2021-05-25 |
Centocor Inc |
anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos
|
|
WO2003068260A1
(fr)
|
2002-02-14 |
2003-08-21 |
Chugai Seiyaku Kabushiki Kaisha |
Produits pharmaceutiques en solution contenant des anticorps
|
|
US20060275294A1
(en)
|
2002-08-22 |
2006-12-07 |
Omoigui Osemwota S |
Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimers disease and cancer
|
|
US20060078531A1
(en)
|
2004-10-12 |
2006-04-13 |
Osemwota Sota |
Method of prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease
|
|
US20060078533A1
(en)
|
2004-10-12 |
2006-04-13 |
Omoigui Osemwota S |
Method of prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer
|
|
US20060078532A1
(en)
|
2004-10-12 |
2006-04-13 |
Omoigui Osemwota S |
Method of prevention and treatment of Atherosclerosis, Peripheral vascular disease, Coronary artery disease, aging and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
PT1610820E
(pt)
|
2003-04-04 |
2010-12-16 |
Novartis Ag |
Formulações de elevada concentração de anticorpos e proteínas
|
|
ME00426B
(me)
|
2003-04-09 |
2011-10-10 |
Genentech Inc |
Liječenje autoimunih bolesti kod pacijenata sa neadekvatnim odgovorom na tnf-alfa inhibitor
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
CA2539061A1
(en)
|
2003-09-22 |
2005-03-31 |
Biovation Gmbh & Co. Kg |
Use of an antagonist of il-6 for treating il-6-mediated diseases
|
|
DE10355251A1
(de)
|
2003-11-26 |
2005-06-23 |
Merck Patent Gmbh |
Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
CA2555688C
(en)
|
2004-02-11 |
2011-11-08 |
Warner-Lambert Company Llc |
Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies
|
|
AU2005247341B2
(en)
|
2004-05-06 |
2008-05-08 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Methods and compositions for the treatment of uveitis
|
|
AU2005287406B2
(en)
|
2004-07-26 |
2011-08-18 |
Biogen Ma Inc. |
Anti-CD154 antibodies
|
|
US20070036788A1
(en)
|
2004-09-22 |
2007-02-15 |
Ahmed Sheriff |
Use of a compound for reducing the biological effectiveness of il-6
|
|
JPWO2006046661A1
(ja)
|
2004-10-28 |
2008-05-22 |
国立大学法人大阪大学 |
インターロイキン−６阻害剤
|
|
EP1828250A2
(en)
|
2004-12-16 |
2007-09-05 |
Genentech, Inc. |
Methods for treating autoimmune disorders
|
|
JP5757495B2
(ja)
|
2005-05-16 |
2015-07-29 |
アッヴィ バイオテクノロジー リミテッド |
びらん性多発性関節炎の治療のためのｔｎｆ阻害剤の使用
|
|
KR20080071192A
(ko)
|
2005-11-22 |
2008-08-01 |
와이어쓰 |
면역글로불린 융합 단백질 제형
|
|
PL1963368T6
(pl)
|
2005-12-13 |
2021-02-08 |
Eli Lilly And Company |
Przeciwciała anty-IL-17
|
|
US20070143168A1
(en)
|
2005-12-19 |
2007-06-21 |
Lucent Technologies Inc. |
Meeting scheduling service
|
|
US20080131374A1
(en)
|
2006-04-19 |
2008-06-05 |
Medich John R |
Uses and compositions for treatment of rheumatoid arthritis
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
ATE537190T1
(de)
|
2006-06-02 |
2011-12-15 |
Regeneron Pharma |
Hochaffine antikörper gegen den humanen il-6- rezeptor
|
|
JP2009540015A
(ja)
|
2006-06-14 |
2009-11-19 |
イムクローン・リミテッド・ライアビリティ・カンパニー |
抗ｅｇｆｒ抗体の凍結乾燥製剤
|
|
JP2010500876A
(ja)
|
2006-08-18 |
2010-01-14 |
アブリンクス エン．ヴェー． |
Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド
|
|
WO2008049897A1
(en)
|
2006-10-27 |
2008-05-02 |
Ablynx N.V. |
Intranasal delivery of polypeptides and proteins
|
|
AU2008255352B2
(en)
|
2007-05-31 |
2014-05-22 |
Genmab A/S |
Stable IgG4 antibodies
|
|
RU2505603C2
(ru)
|
2007-09-26 |
2014-01-27 |
Чугаи Сейяку Кабусики Кайся |
Антитело против рецептора il-6
|
|
WO2009095489A2
(en)
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
WO2009109584A1
(en)
|
2008-03-07 |
2009-09-11 |
Ferring International Center S. A. |
ANTIBODY BINDING ONLY TO IL6-sIL6R COMPLEX
|
|
TW201920257A
(zh)
|
2008-04-11 |
2019-06-01 |
日商中外製藥股份有限公司 |
重複結合複數個抗原的抗原結合分子
|
|
JP2011520898A
(ja)
|
2008-05-13 |
2011-07-21 |
ノビミューン エスアー |
抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
RU2565809C2
(ru)
|
2009-03-19 |
2015-10-20 |
Чугаи Сейяку Кабусики Кайся |
Фармацевтический состав, содержащий молекулы антител с улучшенными свойствами
|
|
JO3030B1
(ar)
|
2009-06-26 |
2016-09-05 |
Galapagos Nv |
مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
|
|
PE20120322A1
(es)
|
2009-07-07 |
2012-04-14 |
Boehringer Ingelheim Int |
Composicion farmaceutica que comprende faldaprevir o una sal del mismo en un vehiculo auto-emulsionante
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
BR112012028557A2
(pt)
|
2010-05-07 |
2019-09-24 |
Xoma Technology Ltd. |
uso de um anticorpo anti-il-1b ou de fragmentos de ligação do mesmo.
|
|
US9427531B2
(en)
|
2010-06-28 |
2016-08-30 |
Sanofi-Aventis Deutschland Gmbh |
Auto-injector
|
|
US9261526B2
(en)
|
2010-08-26 |
2016-02-16 |
Blast Motion Inc. |
Fitting system for sporting equipment
|
|
KR101933197B1
(ko)
|
2010-11-08 |
2018-12-27 |
제넨테크, 인크. |
피하 투여용 항―ｉｌ―6 수용체 항체
|
|
US8440890B1
(en)
|
2011-03-09 |
2013-05-14 |
Pioneer Hi Bred International Inc |
Maize variety inbred PH1D0D
|
|
CA2746171C
(en)
|
2011-07-13 |
2018-11-06 |
William Jani |
Retrievable stimulation frac (rsf) plug
|
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013056751A1
(en)
|
2011-10-21 |
2013-04-25 |
Abb Research Ltd |
Method and system for detecting a failed rectifier in an ac/dc convertor
|
|
US9248242B2
(en)
|
2012-04-20 |
2016-02-02 |
Safety Syringes, Inc. |
Anti-needle stick safety device for injection device
|
|
KR102149206B1
(ko)
|
2012-11-08 |
2020-08-31 |
세센 바이오, 아이엔씨. |
인터루킨-6의 길항제 및 이의 용도
|
|
US20140155827A1
(en)
|
2012-12-03 |
2014-06-05 |
Mylan, Inc. |
Medicament information system and method
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
US20160220675A1
(en)
|
2013-09-11 |
2016-08-04 |
Glenn Abrahmsohn |
Hypertonic antimicrobial therapeutic compositions
|
|
EP3683314A1
(en)
|
2013-10-07 |
2020-07-22 |
Prestige Biopharma Pte. Ltd. |
Bicistronic expression vector for antibody expression and method for producing antibody using same
|
|
KR20230155586A
(ko)
*
|
2013-11-22 |
2023-11-10 |
사노피 바이오테크놀로지 |
류마티스 관절염 치료를 위한 조성물 및 이의 이용방법
|
|
PT3071230T
(pt)
|
2013-11-22 |
2020-06-26 |
Regeneron Pharma |
Composições para o tratamento da artrite reumatoide e métodos de utilização das mesmas
|
|
IL247942B
(en)
|
2014-03-27 |
2022-09-01 |
Dyax Corp |
Compositions and methods for drops in macular edema as a result of diabetes
|
|
US10647768B2
(en)
|
2014-05-29 |
2020-05-12 |
Macrogenics, Inc. |
Multi-chain polypeptide-containing tri-specific binding molecules
|
|
JP7101479B2
(ja)
|
2014-09-16 |
2022-07-15 |
サノフィ・バイオテクノロジー |
関節リウマチ患者の健康に関連した生活の質を改善するための組成物
|
|
WO2017038986A1
(ja)
|
2015-09-03 |
2017-03-09 |
持田製薬株式会社 |
組換えタンパク質の製造方法
|
|
BR112018008900A8
(pt)
|
2015-11-03 |
2019-02-26 |
Regeneron Pharma |
composições compreendendo anticorpos para il6r para o tratamento de uveíte e edema macular e métodos de uso das mesmas
|
|
WO2017106312A1
(en)
|
2015-12-18 |
2017-06-22 |
Drexel University |
Methods of modulating levels of il-6 and pd-l1
|
|
KR20230093522A
(ko)
*
|
2016-03-07 |
2023-06-27 |
사노피 바이오테크놀로지 |
류마티스 관절염의 치료를 위한 조성물 및 방법
|
|
ES2642723B1
(es)
|
2016-05-12 |
2018-10-22 |
Servizo Galego De Saúde (Sergas) |
Uso de los niveles de anticuerpos anti-CD26 como biomarcadores de enfermedades autoinmunes y/o inflamatorias.
|
|
WO2018007442A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
KR20260109977A
(ko)
|
2018-08-29 |
2026-07-13 |
리제너론 파아마슈티컬스, 인크. |
류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물
|
|
CH715771A2
(de)
|
2019-01-23 |
2020-07-31 |
Pedretti Mauro |
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