JP2022540413A - しみる歯及び歯周疾患防止用練り歯磨き及びその製造方法 - Google Patents
しみる歯及び歯周疾患防止用練り歯磨き及びその製造方法 Download PDFInfo
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
Description
(1)練り歯磨き組成物は、湿潤剤(グリセリン、ソルビトール液)、起泡剤(ラウリル硫酸ナトリウム)、甘味剤(キシリトール)、薬効成分(プロポリス)、香料(メントール)、溶剤(精製水)、増白剤(二酸化チタン)などで練り歯磨きを構成する基本的材料は市中で購入した。
口臭があると自覚している男女20名を臨床的実験対象とした後、同じ種類の食事をするようにし、その後、ハリメーター(halimeter:モデルSB-17,U.S.A)を利用して、口臭の程度を定量化して、口臭の弱い人(60以下)、非常に強い人(350以上)は、実験から除外した後、比較例及び実施例の群に5名ずつ分けて測定した後、平均値が各群の間で同様に調節した。翌日、再現性のために、男女20名に同じ食事をさせた後、30分及び60分後の初期口臭程度を測定し、各組成物別(実施例)に歯ブラシと練り歯磨きを提供した後、同じ方法で3分間歯磨きし、30分及び60分後に末期口臭程度を測定した。
本実験は、比較的同じ環境にいる被検者20名を対象とし、被検者全員が実験の前に1次口腔精密検査を実施して、基準線を求めた。検査方法は、単一ブラインドテストで、実験前の4週間の残留効果除去期間の間に被検者全員に同一歯磨剤及び歯ブラシを提供した。
比較的同じしみる歯を有する被検者25名を対象として実施した。被検者全員に実験前に9℃の冷水を5回飲用するようにして、しみる程度を精密に測定して、基準線(baseline)を求めた。
Claims (5)
- 練り歯磨き組成物の総重量に対して、電子を失ったミネラルを0.5~15%を添加した、ことを特徴とする電子を失ったミネラルが含有された練り歯磨き。
- 請求項1の練り歯磨きを製造する方法であって、
ミネラルを洗浄するステップと、
イオン化して電子を失ったミネラルを製造するステップと、
電子を失ったミネラルを粉碎するステップと、
練り歯磨きの基本材料に香料を混合する基本組成物混合ステップと、
粉砕された電子を失ったミネラルに精製水を混合して、ミネラル精製水を製造するステップと、
ミネラル精製水に混合組成物を混合して熟成させるステップと、を含む、ことを特徴とする電子を失ったミネラルを含有した練り歯磨きの製造方法。 - 前記電子を失ったミネラルは、練り歯磨き組成物の総重量の0.1~15%が添加された、ことを特徴とする請求項2に記載の電子を失ったミネラルを含有した練り歯磨きの製造方法。
- 前記電子を失ったミネラルは、ミネラルを多量に含有した食品、漢方薬剤、及びミネラル含有鉱物の少なくとも何れか一つを、850℃以上で、15分以上加熱して、ミネラルが電子を失うようにして作われた、ことを特徴とする請求項2に記載の電子を失ったミネラルを含有した練り歯磨きの製造方法。
- 前記ミネラル精製水は、精製水の総重量に対して、有機酸1~50重量%と、電子を失ったミネラルを1~50重量%を混合して作われた、ことを特徴とする請求項2に記載の電子を失ったミネラルを含有した練り歯磨きの製造方法。
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KR10-2019-0078729 | 2019-07-01 | ||
KR1020190078729A KR102221917B1 (ko) | 2019-07-01 | 2019-07-01 | 시린 이 및 치주질환 방지용 치약의 제조방법 |
PCT/KR2020/008335 WO2021002637A1 (ko) | 2019-07-01 | 2020-06-26 | 시린 이 및 치주질환 방지용 치약 및 그 제조방법 |
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Country Status (7)
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US (1) | US20220354774A1 (ja) |
EP (1) | EP4014955A4 (ja) |
JP (1) | JP2022540413A (ja) |
KR (1) | KR102221917B1 (ja) |
CN (1) | CN114080214A (ja) |
BR (1) | BR112021026657A2 (ja) |
WO (1) | WO2021002637A1 (ja) |
Citations (8)
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---|---|---|---|---|
JPH0959137A (ja) * | 1995-08-21 | 1997-03-04 | Sanai Fujita | 歯磨剤 |
JP2000072610A (ja) * | 1998-08-31 | 2000-03-07 | Daikei Shokuhin:Kk | 殺菌剤、その製造方法、練歯磨、殺菌水、食品の殺菌方法、種子の殺菌保存方法、ほたて貝殻焼成物添加食品、その製造方法 |
JP2000143467A (ja) * | 1998-11-16 | 2000-05-23 | Toyo Denka Kogyo Co Ltd | 歯磨き剤 |
JP2001131049A (ja) * | 1999-11-04 | 2001-05-15 | Lion Corp | 皮膚外用剤 |
JP2002370954A (ja) * | 2001-06-12 | 2002-12-24 | Yoshinobu Nomiyama | 歯みがき剤及びその製造方法 |
US20100143271A1 (en) * | 2008-12-10 | 2010-06-10 | Taipei Medical University | Method for preparing amorphous calcium phosphate and oral care composition containing amorphous calcium phosphate prepared by the same |
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KR20170029106A (ko) | 2015-09-07 | 2017-03-15 | 이상수 | 유산균 발효 허브 추출물을 함유하는 치약 조성물 |
KR101818530B1 (ko) | 2015-12-21 | 2018-01-15 | 주식회사 청화팜 | 천연 한방 물질을 사용한 치약 조성물 |
KR101899237B1 (ko) * | 2017-02-27 | 2018-09-14 | 김동환 | 항균성치약에 첨가되는 유기산 조성물 및 그의 제조방법 |
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US20100143271A1 (en) * | 2008-12-10 | 2010-06-10 | Taipei Medical University | Method for preparing amorphous calcium phosphate and oral care composition containing amorphous calcium phosphate prepared by the same |
JP2017500331A (ja) * | 2013-12-19 | 2017-01-05 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | 酸化亜鉛及びクエン酸亜鉛を含む歯磨剤組成物 |
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KR20210002895A (ko) | 2021-01-11 |
KR102221917B1 (ko) | 2021-03-03 |
US20220354774A1 (en) | 2022-11-10 |
WO2021002637A1 (ko) | 2021-01-07 |
BR112021026657A2 (pt) | 2022-02-15 |
CN114080214A (zh) | 2022-02-22 |
EP4014955A1 (en) | 2022-06-22 |
EP4014955A4 (en) | 2023-11-15 |
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