JP7439352B2 - 歯のエナメル質を再石灰化するための組成物 - Google Patents
歯のエナメル質を再石灰化するための組成物 Download PDFInfo
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- JP7439352B2 JP7439352B2 JP2022535093A JP2022535093A JP7439352B2 JP 7439352 B2 JP7439352 B2 JP 7439352B2 JP 2022535093 A JP2022535093 A JP 2022535093A JP 2022535093 A JP2022535093 A JP 2022535093A JP 7439352 B2 JP7439352 B2 JP 7439352B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
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Description
歯の効果的な再石灰化のためには、特許請求されている組成物を、マウスガードと一緒に使用する場合は1日1~2回、又はマウスガードなしで使用する場合は1日5回まで、0.5~1.5グラムの量で15日間、歯に適用することが推奨される。
必要な量の水を計量カップで量り、次いでこの水をミキサーに入れ、そこにジェルの残りの成分を通常の条件下で加えた。この混合物を、透明で均一なジェル溶液が形成されるまで20分間撹拌した。次いで一次包装を行った。
口腔の臨床指標を、再石灰化療法の前と当該療法の15日後に、18人の12歳の学生で評価した。この参加者を、各グループ6人からなる3つのグループに分けた。適切な訓練の後に、学生には必要な数のジェルNo.1、2、3、標準のマウスガード、及びフッ化物化合物を含まない練り歯磨きを与えた。ジェルの塗布は、歯を磨いた後で就寝前の20分間、全学生が独自に実施した。実験では、TER試験、染色強度(点数)のCDERR試験、及び染色期間(日数)のCDERR試験の臨床指標を測定した。
歯科矯正治療の完了後に白亜質又は白色の斑点の形態で持続するエナメル質の脱灰領域に対する、「最良の」組成に従うジェルの効果を研究した。
「最良の」組成に従うジェルの治療及び予防的有効性を決定することを目的とした研究が、6か月間実施された。軽度の形態の歯のフッ素症のある30人と、フッ素症の形態の歯の硬組織の病理の症候がない30人が研究のために選ばれた。
1点…染色なし。
2点…薄黄色の染色。
3点…薄茶色の染色又は黄色の染色。
4点…暗褐色の染色。
Claims (5)
- 歯のエナメル質からのミネラル及び塩の喪失を特徴とする状態を治療及び/又は予防するためのジェル形態の組成物であって、
前記状態が、脱灰、歯の低ミネラル化、フッ素症、及びエナメル質上に形成される斑点又は既に形成された斑点であって、取り外し不能なデバイスによる歯科矯正治療中又は治療後に生じた斑点であり、その後のエナメル質上での齲窩の発生を特徴とし、充填材又はベニアの使用をさらに必要とする斑点から選択され、
以下の成分及び重量%で含むことを特徴とする組成物。
- 以下の成分及び重量%で含むことを特徴とする、請求項1に記載の組成物。
- 前記斑点が白亜質の、白色の又は色素沈着した斑点である、請求項1に記載の組成物。
- 非イオン性界面活性剤が、ポリソルベート-20、PEG-40硬化ヒマシ油、又はアルキルポリグリコシドである、請求項1又は2に記載の組成物。
- 防腐剤が、メチルパラベン、メチルパラベンナトリウム、フェノキシエタノール、安息香酸、安息香酸ナトリウム、ソルビン酸カリウム、及びチモールの群から選択される物質の1つである、請求項1又は2に記載の組成物。
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PCT/RU2019/001020 WO2021133191A1 (ru) | 2019-12-26 | 2019-12-26 | Состав для реминерализации эмали зубов |
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US (1) | US20230034815A1 (ja) |
EP (1) | EP4082511A4 (ja) |
JP (1) | JP7439352B2 (ja) |
KR (1) | KR20220119700A (ja) |
CN (1) | CN114929179A (ja) |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009517382A (ja) | 2005-11-25 | 2009-04-30 | “ダブリューディーエス” カンパニー | 口腔ケア用の治療及び予防組成物 |
WO2009099350A1 (en) | 2008-02-07 | 2009-08-13 | Obthestvo S Ogranichennoyj Otvetstvennostjyu "Wds" | Gel for teeth tissues remineralization |
Family Cites Families (8)
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US5645853A (en) * | 1995-08-08 | 1997-07-08 | Enamelon Inc. | Chewing gum compositions and the use thereof for remineralization of lesions in teeth |
RU2238078C1 (ru) | 2003-01-21 | 2004-10-20 | Чухаджян Ара Гарникович | Лечебно-профилактическое средство местного действия в виде самоклеящейся пленки для реминерализации твердых тканей зубов |
RU2293551C1 (ru) | 2005-05-23 | 2007-02-20 | Ооо "Вдс" | Состав для профилактики заболеваний полости рта |
RU2311168C2 (ru) * | 2006-01-26 | 2007-11-27 | Общество С Ограниченной Ответственностью "Вдс" | Состав для реминерализации тканей зубов |
RU2361600C1 (ru) | 2007-12-25 | 2009-07-20 | Государственное образовательное учреждение высшего профессионального образования Московская медицинская академия им. И.М. Сеченова Федерального агентства по здравоохранению и социальному развитию (ГОУВПО ММА им. И.М. Сеченова Росздрава) | Средство для лечения заболеваний пародонта |
EA012247B1 (ru) * | 2008-07-07 | 2009-08-28 | Общество С Ограниченной Ответственностью "Вдс" | Лечебно-профилактический состав для ухода за полостью рта |
RU2627624C1 (ru) | 2016-10-06 | 2017-08-09 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) | Средство для реминерализации твердых тканей зубов |
RU2677231C1 (ru) | 2017-10-10 | 2019-01-16 | Федеральное государственное бюджетное учреждение науки Институт химии твердого тела Уральского отделения Российской академии наук | Стоматологический гель для реминерализации твердых тканей зубов и способ реминерализации твердых тканей зубов |
-
2019
- 2019-12-26 US US17/789,098 patent/US20230034815A1/en active Pending
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009517382A (ja) | 2005-11-25 | 2009-04-30 | “ダブリューディーエス” カンパニー | 口腔ケア用の治療及び予防組成物 |
WO2009099350A1 (en) | 2008-02-07 | 2009-08-13 | Obthestvo S Ogranichennoyj Otvetstvennostjyu "Wds" | Gel for teeth tissues remineralization |
Non-Patent Citations (2)
Title |
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Klinicheskie aspektyprimeneniya applikatsionnogo gelya R.O.C.S MEDICAL MINERALS,UNIDENT TODAY,2010年,p.38-39 |
Performance of a newlydeveloped mineral gel system on erosive and erosive/abrasive enamel loss, An invitro study,Swiss Dental Journal SSO,2018年,p.2 |
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WO2021133191A1 (ru) | 2021-07-01 |
EP4082511A4 (en) | 2023-11-01 |
CN114929179A (zh) | 2022-08-19 |
JP2023508649A (ja) | 2023-03-03 |
RU2020128080A3 (ja) | 2022-02-24 |
RU2020128080A (ru) | 2022-02-24 |
BR112022012549A2 (pt) | 2022-09-06 |
EP4082511A1 (en) | 2022-11-02 |
US20230034815A1 (en) | 2023-02-02 |
KR20220119700A (ko) | 2022-08-30 |
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