JP2022535429A5 - - Google Patents
Info
- Publication number
- JP2022535429A5 JP2022535429A5 JP2021571993A JP2021571993A JP2022535429A5 JP 2022535429 A5 JP2022535429 A5 JP 2022535429A5 JP 2021571993 A JP2021571993 A JP 2021571993A JP 2021571993 A JP2021571993 A JP 2021571993A JP 2022535429 A5 JP2022535429 A5 JP 2022535429A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell population
- genetically modified
- genetically
- population according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015446A JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962857167P | 2019-06-04 | 2019-06-04 | |
| US62/857,167 | 2019-06-04 | ||
| US201962943697P | 2019-12-04 | 2019-12-04 | |
| US62/943,697 | 2019-12-04 | ||
| PCT/US2020/035752 WO2020247392A1 (en) | 2019-06-04 | 2020-06-02 | Combinations of engineered natural killer cells and engineered t cells for immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015446A Division JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022535429A JP2022535429A (ja) | 2022-08-08 |
| JP2022535429A5 true JP2022535429A5 (enExample) | 2023-06-09 |
| JP7629414B2 JP7629414B2 (ja) | 2025-02-13 |
Family
ID=73652681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571993A Active JP7629414B2 (ja) | 2019-06-04 | 2020-06-02 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
| JP2025015446A Pending JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015446A Pending JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220233593A1 (enExample) |
| EP (1) | EP3980450A4 (enExample) |
| JP (2) | JP7629414B2 (enExample) |
| CN (1) | CN114174325A (enExample) |
| AU (1) | AU2020288829A1 (enExample) |
| CA (1) | CA3140393A1 (enExample) |
| WO (1) | WO2020247392A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| CN110546265A (zh) | 2017-02-09 | 2019-12-06 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞及其组合物和方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| EP3749685A4 (en) | 2018-02-09 | 2021-12-22 | National University of Singapore | ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CA3120563A1 (en) | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| AU2021207795A1 (en) * | 2020-01-13 | 2022-07-28 | Nkarta, Inc. | BCMA-directed cellular immunotherapy compositions and methods |
| AU2021286655A1 (en) * | 2020-06-12 | 2023-01-05 | Nkarta, Inc. | Genetically modified natural killer cells for CD70-directed cancer immunotherapy |
| WO2022040577A1 (en) * | 2020-08-20 | 2022-02-24 | City Of Hope | Compositions and uses of cd45 targeted chimeric antigen receptor modified t cells |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| EP4255453A4 (en) * | 2020-12-03 | 2025-03-26 | Nkarta, Inc. | Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| WO2022150392A1 (en) * | 2021-01-05 | 2022-07-14 | City Of Hope | Natural killer cells engineered to reduce or eliminate cbl-b and uses thereof |
| US20240166760A1 (en) * | 2021-03-08 | 2024-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | MOLECULES THAT BIND TO CD66e POLYPEPTIDES |
| EP4326291A4 (en) * | 2021-04-20 | 2025-03-12 | Board of Regents, The University of Texas System | Methods and compositions for genetic modification and therapeutic use of immune cells |
| WO2022242701A1 (en) * | 2021-05-20 | 2022-11-24 | Wuxi Biologics (Shanghai) Co., Ltd. | Genetically modified gamma-delta t cells and uses thereof |
| CN117355600A (zh) * | 2021-05-20 | 2024-01-05 | 上海药明生物技术有限公司 | 遗传修饰的nk细胞及其用途 |
| US20240316102A1 (en) * | 2021-07-01 | 2024-09-26 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and related methods |
| WO2023284874A1 (zh) * | 2021-07-16 | 2023-01-19 | 克莱格医学有限公司 | 用于肿瘤免疫学的组合物和方法 |
| WO2023079082A1 (en) * | 2021-11-04 | 2023-05-11 | Aphp (Assistance Publique - Hôpitaux De Paris) | Method for generating nk cells |
| WO2023199961A1 (ja) * | 2022-04-14 | 2023-10-19 | 第一三共株式会社 | 膜型サイトカイン及びtnf受容体スーパーファミリー分子の細胞内ドメインをコードするポリヌクレオチド |
| CN114774364B (zh) * | 2022-04-26 | 2024-04-26 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| US20260021183A1 (en) * | 2022-07-22 | 2026-01-22 | Board Of Regents, The University Of Texas System | Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy |
| CN115948341B (zh) * | 2022-11-28 | 2025-05-16 | 上海恩凯细胞技术有限公司 | 敲低nkg2a基因的car-免疫细胞及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7446190B2 (en) * | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US7868159B2 (en) * | 2005-06-23 | 2011-01-11 | Baylor College Of Medicine | Modulation of negative immune regulators and applications for immunotherapy |
| US20120192298A1 (en) * | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
| WO2012136231A1 (en) * | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| EP3326467B1 (en) * | 2011-09-16 | 2020-03-11 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| JP6681837B2 (ja) * | 2014-03-11 | 2020-04-15 | セレクティスCellectis | 同種移植に適合するt細胞を作製するための方法 |
| DK3143134T3 (da) * | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| CN116059378A (zh) * | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| CN116199790A (zh) * | 2015-02-10 | 2023-06-02 | 米纳瓦生物技术公司 | 人源化抗MUCl*抗体 |
| GB201503742D0 (en) * | 2015-03-05 | 2015-04-22 | Ucl Business Plc | Chimeric antigen receptor |
| AU2016249005B2 (en) * | 2015-04-17 | 2022-06-16 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| GB2592821B (en) * | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
| EP3827838B1 (en) * | 2015-12-16 | 2023-06-07 | The Walter and Eliza Hall Institute of Medical Research | Inhibition of cytokine-induced sh2 protein in nk cells |
| EP3423580A1 (en) * | 2016-03-04 | 2019-01-09 | Editas Medicine, Inc. | Crispr-cpf1-related methods, compositions and components for cancer immunotherapy |
| WO2017165464A1 (en) * | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| WO2018064602A1 (en) * | 2016-09-30 | 2018-04-05 | Baylor College Of Medicine | Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease |
| EP3529268B1 (en) * | 2016-10-19 | 2025-02-26 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| AU2017347854B2 (en) * | 2016-10-27 | 2022-12-08 | Intima Bioscience, Inc. | Viral methods of T cell therapy |
| US20180100016A1 (en) * | 2016-12-22 | 2018-04-12 | Xiaotong Song | Use of car-modified human natural killer cells to treat cancer |
| JP2020503043A (ja) * | 2016-12-30 | 2020-01-30 | セルラリティ インコーポレイテッド | 遺伝子改変されたナチュラルキラー細胞 |
| BR112019019917A2 (pt) * | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| EP3612210A4 (en) * | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS |
| CN108728459B (zh) * | 2017-04-24 | 2023-08-04 | 上海恒润达生生物科技股份有限公司 | 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途 |
| WO2019089884A2 (en) * | 2017-11-01 | 2019-05-09 | Editas Medicine, Inc. | Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy |
| EP3749770B9 (en) * | 2018-02-09 | 2025-12-17 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Tethered interleukin-15 and interleukin-21 |
| KR20210005240A (ko) * | 2018-05-03 | 2021-01-13 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 면역 관문 차단과 함께 키메라 항원 수용체를 발현하도록 가공된 천연 킬러 세포 |
| CN110724199B (zh) * | 2018-07-17 | 2023-12-05 | 成都盛世君联生物技术有限公司 | Nkg2d car-t细胞及其制备和应用 |
| MX2021006208A (es) * | 2018-11-28 | 2021-10-01 | Univ Texas | Edición por multiplexación del genoma de células inmunitarias para mejorar la funcionalidad y resistencia al entorno supresor. |
| PE20211959A1 (es) * | 2019-02-15 | 2021-09-30 | Editas Medicine Inc | Celulas asesinas naturales (nk) modificadas para inmunoterapia |
| EP3773918A4 (en) * | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| US11840575B2 (en) * | 2019-05-07 | 2023-12-12 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Engineered immune cells targeting BCMA and their uses thereof |
| JP7724765B2 (ja) * | 2019-07-31 | 2025-08-18 | ンカルタ・インコーポレイテッド | ナチュラルキラー細胞の増殖を亢進する、および細胞障害性を増強するための方法および組成物 |
| CA3163258A1 (en) * | 2019-11-27 | 2021-06-03 | Board Of Regents, The University Of Texas System | Large-scale combined car transduction and crispr gene editing of nk cells |
-
2020
- 2020-06-02 AU AU2020288829A patent/AU2020288829A1/en active Pending
- 2020-06-02 CN CN202080053244.XA patent/CN114174325A/zh active Pending
- 2020-06-02 CA CA3140393A patent/CA3140393A1/en active Pending
- 2020-06-02 JP JP2021571993A patent/JP7629414B2/ja active Active
- 2020-06-02 US US17/596,166 patent/US20220233593A1/en active Pending
- 2020-06-02 WO PCT/US2020/035752 patent/WO2020247392A1/en not_active Ceased
- 2020-06-02 EP EP20818539.7A patent/EP3980450A4/en active Pending
-
2025
- 2025-01-31 JP JP2025015446A patent/JP2025081360A/ja active Pending
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