JP2022535429A5 - - Google Patents
Info
- Publication number
- JP2022535429A5 JP2022535429A5 JP2021571993A JP2021571993A JP2022535429A5 JP 2022535429 A5 JP2022535429 A5 JP 2022535429A5 JP 2021571993 A JP2021571993 A JP 2021571993A JP 2021571993 A JP2021571993 A JP 2021571993A JP 2022535429 A5 JP2022535429 A5 JP 2022535429A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell population
- genetically modified
- genetically
- population according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015446A JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962857167P | 2019-06-04 | 2019-06-04 | |
| US62/857,167 | 2019-06-04 | ||
| US201962943697P | 2019-12-04 | 2019-12-04 | |
| US62/943,697 | 2019-12-04 | ||
| PCT/US2020/035752 WO2020247392A1 (en) | 2019-06-04 | 2020-06-02 | Combinations of engineered natural killer cells and engineered t cells for immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015446A Division JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022535429A JP2022535429A (ja) | 2022-08-08 |
| JP2022535429A5 true JP2022535429A5 (enExample) | 2023-06-09 |
| JP7629414B2 JP7629414B2 (ja) | 2025-02-13 |
Family
ID=73652681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571993A Active JP7629414B2 (ja) | 2019-06-04 | 2020-06-02 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
| JP2025015446A Pending JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015446A Pending JP2025081360A (ja) | 2019-06-04 | 2025-01-31 | 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220233593A1 (enExample) |
| EP (1) | EP3980450A4 (enExample) |
| JP (2) | JP7629414B2 (enExample) |
| CN (1) | CN114174325A (enExample) |
| AU (1) | AU2020288829A1 (enExample) |
| CA (1) | CA3140393A1 (enExample) |
| WO (1) | WO2020247392A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| AU2018219895C1 (en) | 2017-02-09 | 2024-10-03 | Indapta Therapeutics, Inc. | Engineered Natural Killer (NK) cells and compositions and methods thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| WO2021146147A1 (en) * | 2020-01-13 | 2021-07-22 | Nkarta, Inc. | Bcma-directed cellular immunotherapy compositions and methods |
| MX2022015586A (es) * | 2020-06-12 | 2023-03-15 | Nkarta Inc | Linfocitos citolíticos naturales modificados genéticamente para inmunoterapia de cáncer dirigida a cd70. |
| WO2022040577A1 (en) * | 2020-08-20 | 2022-02-24 | City Of Hope | Compositions and uses of cd45 targeted chimeric antigen receptor modified t cells |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| IL303269A (en) | 2020-12-03 | 2023-07-01 | Century Therapeutics Inc | Genetically engineered cells and uses thereof |
| EP4255453A4 (en) * | 2020-12-03 | 2025-03-26 | Nkarta, Inc. | Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| US20240299542A1 (en) * | 2021-01-05 | 2024-09-12 | City Of Hope | Natural killer cells engineered to reduce or eliminate cbl-b and uses thereof |
| JP2024513313A (ja) * | 2021-03-08 | 2024-03-25 | ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | CD66eポリペプチドに結合する分子 |
| JP2024517641A (ja) * | 2021-04-20 | 2024-04-23 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 免疫細胞の遺伝子改変および治療的使用のための方法および組成物 |
| WO2022242701A1 (en) * | 2021-05-20 | 2022-11-24 | Wuxi Biologics (Shanghai) Co., Ltd. | Genetically modified gamma-delta t cells and uses thereof |
| WO2022242700A1 (en) * | 2021-05-20 | 2022-11-24 | Wuxi Biologics (Shanghai) Co., Ltd. | Genetically modified nk cells and uses thereof |
| KR20240051112A (ko) * | 2021-07-01 | 2024-04-19 | 인답타 세라뷰틱스 인코포레이티드 | 조작된 자연 살해(nk) 세포 및 관련 방법 |
| CN117730094A (zh) * | 2021-07-16 | 2024-03-19 | 克莱格医学有限公司 | 用于肿瘤免疫学的组合物和方法 |
| US20260152721A1 (en) * | 2021-11-04 | 2026-06-04 | Aphp (Assistance Publique - Hôpitaux De Paris) | Method for generating nk cells |
| TW202405165A (zh) * | 2022-04-14 | 2024-02-01 | 日商第一三共股份有限公司 | 編碼膜型細胞激素及tnf受體超家族分子之細胞內域的多核苷酸 |
| CN114774364B (zh) * | 2022-04-26 | 2024-04-26 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| WO2024020537A2 (en) * | 2022-07-22 | 2024-01-25 | Board Of Regents, The University Of Texas System | Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy |
| CN115948341B (zh) * | 2022-11-28 | 2025-05-16 | 上海恩凯细胞技术有限公司 | 敲低nkg2a基因的car-免疫细胞及其用途 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7446190B2 (en) * | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| CN101501055B (zh) * | 2005-06-23 | 2016-05-11 | 贝勒医学院 | 负性免疫调节因子的调节和免疫疗法应用 |
| US20120192298A1 (en) * | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
| WO2012136231A1 (en) | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| EP3692794A1 (en) | 2011-09-16 | 2020-08-12 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| RU2752933C2 (ru) * | 2014-03-11 | 2021-08-11 | Селлектис | Способ создания т-клеток, пригодных для аллогенной трансплантации |
| EP3805371A1 (en) * | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| EP2963057A1 (en) * | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
| WO2016094679A1 (en) * | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| EP3256494A4 (en) * | 2015-02-10 | 2018-12-05 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
| GB201503742D0 (en) * | 2015-03-05 | 2015-04-22 | Ucl Business Plc | Chimeric antigen receptor |
| WO2016168595A1 (en) * | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP4339287A3 (en) | 2015-07-31 | 2024-05-22 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| AU2016374497B2 (en) * | 2015-12-16 | 2022-03-10 | The Walter And Eliza Hall Institute Of Medical Research | Inhibition of cytokine-induced SH2 protein in NK cells |
| EP4086285A1 (en) * | 2016-02-25 | 2022-11-09 | Cell Medica Switzerland AG | Binding members to pd-l1 |
| MX2018010484A (es) * | 2016-03-04 | 2019-01-10 | Editas Medicine Inc | Métodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cáncer. |
| US11291721B2 (en) * | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| SG10201912519VA (en) * | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Chimeric receptors and methods of use thereof |
| CA3030003A1 (en) * | 2016-07-08 | 2018-01-11 | F1 Oncology, Inc. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| CN107602703B (zh) * | 2016-08-12 | 2021-03-23 | 四川大学 | 靶向人EpCAM的基因工程化淋巴细胞及其制备方法和用途 |
| WO2018064602A1 (en) * | 2016-09-30 | 2018-04-05 | Baylor College Of Medicine | Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease |
| EP3529268B1 (en) * | 2016-10-19 | 2025-02-26 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| EP3532075A4 (en) * | 2016-10-27 | 2020-07-08 | Intima Bioscience, Inc. | VIRAL METHODS OF MANUFACTURING GENETICALLY MODIFIED CELLS |
| CN106755107B (zh) * | 2016-11-22 | 2019-10-01 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
| WO2018118494A2 (en) * | 2016-12-22 | 2018-06-28 | Xiaotong Song | Use of car-modified human natural killer cells to treat cancer |
| WO2018126074A1 (en) * | 2016-12-30 | 2018-07-05 | Celularity, Inc. | Genetically modified natural killer cells |
| CN117363636A (zh) * | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| JP2020517259A (ja) * | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| CN108728459B (zh) * | 2017-04-24 | 2023-08-04 | 上海恒润达生生物科技股份有限公司 | 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途 |
| CA3081456A1 (en) * | 2017-11-01 | 2019-05-09 | Editas Medicine, Inc. | Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy |
| CN109608547B (zh) * | 2017-12-29 | 2022-03-15 | 郑州大学第一附属医院 | 表达Her2的嵌合抗原受体、慢病毒表达载体及其应用 |
| CN109608548A (zh) * | 2017-12-29 | 2019-04-12 | 郑州大学第附属医院 | 基于人源cd20抗体的嵌合抗原受体、慢病毒表达载体及其应用 |
| ES3052818T3 (en) * | 2018-02-09 | 2026-01-14 | Us Health | Tethered interleukin-15 and interleukin-21 |
| SG11202010763VA (en) * | 2018-05-03 | 2020-11-27 | Univ Texas | Natural killer cells engineered to express chimeric antigen receptors with immune checkpoint blockade |
| CN110724199B (zh) * | 2018-07-17 | 2023-12-05 | 成都盛世君联生物技术有限公司 | Nkg2d car-t细胞及其制备和应用 |
| AU2019386140B2 (en) * | 2018-11-28 | 2026-05-28 | Board Of Regents, The University Of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| BR112021016046A2 (pt) * | 2019-02-15 | 2021-11-09 | Editas Medicine Inc | Células assassinas naturais modificadas (nk) para imunoterapia |
| KR20210137085A (ko) * | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| EP4778585A2 (en) * | 2019-05-07 | 2026-07-22 | Gracell Bioscience (Shanghai) Co., Ltd. | Engineered immune cell targeting bcma and use thereof |
| AU2020321354A1 (en) * | 2019-07-31 | 2022-03-03 | Nkarta, Inc. | Methods and compositions for enhanced expansion and cytotoxicity of natural killer cells |
| CA3163258A1 (en) * | 2019-11-27 | 2021-06-03 | Board Of Regents, The University Of Texas System | Large-scale combined car transduction and crispr gene editing of nk cells |
-
2020
- 2020-06-02 CN CN202080053244.XA patent/CN114174325A/zh active Pending
- 2020-06-02 AU AU2020288829A patent/AU2020288829A1/en active Pending
- 2020-06-02 EP EP20818539.7A patent/EP3980450A4/en active Pending
- 2020-06-02 WO PCT/US2020/035752 patent/WO2020247392A1/en not_active Ceased
- 2020-06-02 CA CA3140393A patent/CA3140393A1/en active Pending
- 2020-06-02 JP JP2021571993A patent/JP7629414B2/ja active Active
- 2020-06-02 US US17/596,166 patent/US20220233593A1/en active Pending
-
2025
- 2025-01-31 JP JP2025015446A patent/JP2025081360A/ja active Pending
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