JP2022531388A5 - - Google Patents
Info
- Publication number
- JP2022531388A5 JP2022531388A5 JP2021564995A JP2021564995A JP2022531388A5 JP 2022531388 A5 JP2022531388 A5 JP 2022531388A5 JP 2021564995 A JP2021564995 A JP 2021564995A JP 2021564995 A JP2021564995 A JP 2021564995A JP 2022531388 A5 JP2022531388 A5 JP 2022531388A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- phenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025062493A JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962842849P | 2019-05-03 | 2019-05-03 | |
| US62/842,849 | 2019-05-03 | ||
| US202062982864P | 2020-02-28 | 2020-02-28 | |
| US62/982,864 | 2020-02-28 | ||
| PCT/US2020/031046 WO2020227101A1 (en) | 2019-05-03 | 2020-05-01 | Kcnt1 inhibitors and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025062493A Division JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022531388A JP2022531388A (ja) | 2022-07-06 |
| JP2022531388A5 true JP2022531388A5 (enExample) | 2023-05-11 |
| JP7667573B2 JP7667573B2 (ja) | 2025-04-23 |
Family
ID=73051241
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564995A Active JP7667573B2 (ja) | 2019-05-03 | 2020-05-01 | Ｋｃｎｔ１阻害剤および使用する方法 |
| JP2025062493A Pending JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025062493A Pending JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20220259193A1 (enExample) |
| EP (1) | EP3962481A4 (enExample) |
| JP (2) | JP7667573B2 (enExample) |
| KR (1) | KR20220016086A (enExample) |
| CN (2) | CN120817941A (enExample) |
| AU (1) | AU2020267356B2 (enExample) |
| BR (1) | BR112021022067A2 (enExample) |
| CA (1) | CA3139063A1 (enExample) |
| CL (2) | CL2021002877A1 (enExample) |
| CO (1) | CO2021016471A2 (enExample) |
| EC (1) | ECSP21087884A (enExample) |
| IL (1) | IL287768A (enExample) |
| MX (1) | MX2021013421A (enExample) |
| PE (1) | PE20220016A1 (enExample) |
| SA (1) | SA521430751B1 (enExample) |
| SG (1) | SG11202112158YA (enExample) |
| WO (1) | WO2020227101A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12590083B2 (en) | 2019-01-25 | 2026-03-31 | University Of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (SPNS2) for use in therapy |
| WO2020227097A1 (en) * | 2019-05-03 | 2020-11-12 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| CA3169779A1 (en) * | 2020-02-28 | 2021-09-02 | Andrew Mark Griffin | Kcnt1 inhibitors and methods of use |
| EP4210824A1 (en) * | 2020-09-09 | 2023-07-19 | University of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (spns2) for use in therapy |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| CN116194451B (zh) * | 2020-11-27 | 2025-07-11 | 瑞石生物医药有限公司 | 芳基或杂芳基取代五元芳杂环化合物及其用途 |
| EP4267133A4 (en) * | 2020-12-22 | 2025-01-22 | Praxis Precision Medicines, Inc. | KCNT1 INHIBITORS AND METHODS OF USE |
| WO2022231872A1 (en) * | 2021-04-29 | 2022-11-03 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| US20240368142A1 (en) * | 2021-04-29 | 2024-11-07 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| WO2023211850A1 (en) * | 2022-04-25 | 2023-11-02 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising an isoxazole or oxadiazole core and methods of use |
| WO2023239839A1 (en) * | 2022-06-08 | 2023-12-14 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising an isoxazole or oxadiazole core and methods of use |
| CN116813505B (zh) * | 2023-06-29 | 2025-09-02 | 爱斯特（成都）生物制药股份有限公司 | 一种制备o-甲基-n-苄氧羰基-l-高丝氨酸的方法 |
| WO2025117662A1 (en) * | 2023-11-29 | 2025-06-05 | Actio Biosciences, Inc. | Heterocyclic compounds useful as kcnt1 inhibitors |
| US20260109692A1 (en) | 2024-10-18 | 2026-04-23 | UCB Biopharma SRL | Kcnt1 inhibitors and methods of use |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| TW200301698A (en) * | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
| JP2005060255A (ja) * | 2003-08-20 | 2005-03-10 | Nippon Nohyaku Co Ltd | カルボキサミド類及びこれを有効成分とする有害生物防除剤 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| AU2007275221A1 (en) * | 2006-07-20 | 2008-01-24 | Allen J. Borchardt | Benzothiophene inhibitors of RHO kinase |
| JP6387360B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン |
| CA2962922C (en) | 2014-09-29 | 2021-10-26 | The Scripps Research Institute | Sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders |
| US10538516B2 (en) * | 2015-03-25 | 2020-01-21 | National Center For Geriatrics And Gerontology | Oxadiazole derivative and pharmaceutical containing same |
| EP3438091A4 (en) * | 2016-03-30 | 2019-11-27 | Ajinomoto Co., Inc. | CONNECTION WITH INCREASING ACTIVITY FOR ACTION OF GLUCAGON LIKE PEPTIDE-1 RECEPTOR |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CA3169779A1 (en) * | 2020-02-28 | 2021-09-02 | Andrew Mark Griffin | Kcnt1 inhibitors and methods of use |
| AU2021241530A1 (en) * | 2020-03-23 | 2022-10-20 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| KR20230035608A (ko) * | 2020-07-06 | 2023-03-14 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| US11773088B2 (en) * | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| EP4267133A4 (en) * | 2020-12-22 | 2025-01-22 | Praxis Precision Medicines, Inc. | KCNT1 INHIBITORS AND METHODS OF USE |
| US20240368142A1 (en) * | 2021-04-29 | 2024-11-07 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
-
2020
- 2020-05-01 CA CA3139063A patent/CA3139063A1/en active Pending
- 2020-05-01 US US17/607,802 patent/US20220259193A1/en active Pending
- 2020-05-01 CN CN202510784123.7A patent/CN120817941A/zh active Pending
- 2020-05-01 EP EP20801870.5A patent/EP3962481A4/en active Pending
- 2020-05-01 JP JP2021564995A patent/JP7667573B2/ja active Active
- 2020-05-01 WO PCT/US2020/031046 patent/WO2020227101A1/en not_active Ceased
- 2020-05-01 KR KR1020217039174A patent/KR20220016086A/ko not_active Ceased
- 2020-05-01 MX MX2021013421A patent/MX2021013421A/es unknown
- 2020-05-01 AU AU2020267356A patent/AU2020267356B2/en active Active
- 2020-05-01 BR BR112021022067A patent/BR112021022067A2/pt unknown
- 2020-05-01 CN CN202080047961.1A patent/CN114269340A/zh active Pending
- 2020-05-01 PE PE2021001828A patent/PE20220016A1/es unknown
- 2020-05-01 SG SG11202112158YA patent/SG11202112158YA/en unknown
-
2021
- 2021-11-01 IL IL287768A patent/IL287768A/en unknown
- 2021-11-02 CL CL2021002877A patent/CL2021002877A1/es unknown
- 2021-11-03 SA SA521430751A patent/SA521430751B1/ar unknown
- 2021-12-02 CO CONC2021/0016471A patent/CO2021016471A2/es unknown
- 2021-12-03 EC ECSENADI202187884A patent/ECSP21087884A/es unknown
-
2024
- 2024-07-08 CL CL2024002067A patent/CL2024002067A1/es unknown
-
2025
- 2025-04-04 JP JP2025062493A patent/JP2025102975A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022531388A5 (enExample) | ||
| JP2022530989A5 (enExample) | ||
| JP2023518838A5 (enExample) | ||
| JP4648630B2 (ja) | アミノインダゾール誘導体、その製造方法、医薬としての該方法の中間体の使用および該誘導体を含む医薬組成物 | |
| KR100806978B1 (ko) | 1,5-이치환된-3,4-디히드로-1ｈ-피리미도[4,5-ｄ]피리미딘-2-온 화합물 및 ｃｓｂｐ/ｐ38 키나제 매개된 질환의치료시 이들의 용도 | |
| JP2010513519A5 (enExample) | ||
| TW523511B (en) | Pharmaceutical composition comprising substituted imidazole compounds and process for preparing compounds | |
| CN112638877B (zh) | 用于治疗rna病毒感染的苯基/吡啶基-n-苯基/吡啶基衍生物 | |
| JP2024543475A5 (enExample) | ||
| JP2005514398A5 (enExample) | ||
| JP6816106B2 (ja) | ６−ピリジル−１，３，５−トリアジン−２，４−ジオール及び６−ピリジル−１，３，５−トリアジン−２，４−ジアミンを調製する方法 | |
| JP2023532985A5 (enExample) | ||
| JP2021501151A5 (enExample) | ||
| JP2023520924A5 (enExample) | ||
| JP2015522036A5 (enExample) | ||
| AU3592393A (en) | Imidazole derivatives and their use as cytokine inhibitors | |
| UA71535C2 (en) | Corticotropine-releasing antagonists factor, methods for the preparation thereof, pharmaceuitical composition and a method for the treatment | |
| RU2010130559A (ru) | Гербицидные пиридазиновые производные | |
| JP2006506462A5 (enExample) | ||
| JP2012532112A5 (enExample) | ||
| JP2011500758A5 (enExample) | ||
| JP2023515576A5 (enExample) | ||
| CN113831320B (zh) | 一种稠和吡唑类化合物的制备方法 | |
| KR20200135794A (ko) | 키랄 이리듐 촉매의 존재 하에서의 4-치환된 1,2-디히드로퀴놀린의 거울상이성질체선택적 수소화 | |
| JP2025066800A (ja) | Ｂａｘ阻害剤およびその使用 |