JP2022529775A5 - - Google Patents
Info
- Publication number
- JP2022529775A5 JP2022529775A5 JP2021561683A JP2021561683A JP2022529775A5 JP 2022529775 A5 JP2022529775 A5 JP 2022529775A5 JP 2021561683 A JP2021561683 A JP 2021561683A JP 2021561683 A JP2021561683 A JP 2021561683A JP 2022529775 A5 JP2022529775 A5 JP 2022529775A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- capsid protein
- retinal
- disease
- diabetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962839548P | 2019-04-26 | 2019-04-26 | |
| US62/839,548 | 2019-04-26 | ||
| US201962923924P | 2019-10-21 | 2019-10-21 | |
| US62/923,924 | 2019-10-21 | ||
| PCT/US2020/029895 WO2020219933A1 (en) | 2019-04-26 | 2020-04-24 | Variant aav capsids for intravitreal delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022529775A JP2022529775A (ja) | 2022-06-24 |
| JP2022529775A5 true JP2022529775A5 (https=) | 2023-05-11 |
| JP7623703B2 JP7623703B2 (ja) | 2025-01-29 |
Family
ID=70740759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021561683A Active JP7623703B2 (ja) | 2019-04-26 | 2020-04-24 | 硝子体内送達のためのバリアントａａｖキャプシド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11510950B2 (https=) |
| EP (1) | EP3958911A1 (https=) |
| JP (1) | JP7623703B2 (https=) |
| KR (1) | KR20220004114A (https=) |
| CN (2) | CN113766934B (https=) |
| AU (1) | AU2020262948A1 (https=) |
| BR (1) | BR112021020957A2 (https=) |
| CA (1) | CA3130217A1 (https=) |
| IL (1) | IL287438A (https=) |
| MX (2) | MX2021012311A (https=) |
| SG (1) | SG11202108928XA (https=) |
| TW (2) | TW202532428A (https=) |
| WO (1) | WO2020219933A1 (https=) |
| ZA (1) | ZA202105975B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020041498A1 (en) * | 2018-08-21 | 2020-02-27 | Massachusetts Eye And Ear Infirmary | Compositions and methods for modulating transduction efficiency of adeno-associated viruses |
| CN113166208B (zh) | 2018-10-02 | 2024-11-22 | 沃雅戈治疗公司 | 重新定向aav衣壳的嗜性 |
| TWI900553B (zh) | 2020-05-13 | 2025-10-11 | 美商航海家醫療公司 | Aav蛋白殼之趨性重定向 |
| CN115044614B (zh) * | 2021-03-09 | 2023-10-20 | 上海目镜生物医药科技有限公司 | 一种用于基因靶向与表达的aav-8型血清型的改造型载体及其构建方法及应用 |
| US12385064B2 (en) * | 2021-03-26 | 2025-08-12 | Adverum Biotechnologies, Inc. | Intravitreal dosing for delivery of polynucleotides to retinal cones |
| CN113648432B (zh) * | 2021-03-31 | 2024-01-19 | 中山大学中山眼科中心 | rAAV2/Retro作为针对视网膜感光细胞的递送系统及其在制备治疗视网膜疾病药物中的应用 |
| EP4426716A1 (en) | 2021-11-02 | 2024-09-11 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| EP4688807A1 (en) * | 2023-03-31 | 2026-02-11 | Exegenesis Bio Singapore Pte. Ltd. | Variant aav9 capsid proteins and uses thereof |
| EP4689184A1 (en) | 2023-04-05 | 2026-02-11 | Adverum Biotechnologies, Inc. | Immune landscape signatures for ocular inflammation |
| KR20260039752A (ko) | 2023-07-13 | 2026-03-20 | 크리야 테라퓨틱스, 인크. | 보체 경로 억제제 융합체 및 그의 사용 방법 |
| CN117247434B (zh) * | 2023-11-10 | 2024-02-02 | 上海朗昇生物科技有限公司 | 衣壳修饰型病毒载体及其制备和用途 |
| KR20260014488A (ko) * | 2024-07-22 | 2026-01-30 | 한국생명공학연구원 | 변이체 캡시드를 포함하는 아데노-연관 바이러스 및 이의 용도 |
| CN118955654B (zh) * | 2024-10-15 | 2025-05-16 | 朗信启昇(苏州)生物制药有限公司 | 具有变异衣壳的腺相关病毒病毒体及其用途 |
| WO2026084101A1 (ko) * | 2024-10-18 | 2026-04-23 | 주식회사 아바타테라퓨틱스 | 아데노연관바이러스 변이체 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| CA2158745C (en) | 1993-03-25 | 2007-06-19 | Richard L. Kendall | Inhibitor of vascular endothelial cell growth factor |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| EP1919497B1 (en) | 2005-07-22 | 2020-02-12 | The Board of Trustees of the Leland Stanford Junior University | Light-activated cation channel and uses thereof |
| CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| EP2287323A1 (en) * | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| CN105755044A (zh) * | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| TWI698240B (zh) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| US11021519B2 (en) * | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| AU2017259968A1 (en) | 2016-05-03 | 2018-11-15 | Adverum Biotechnologies, Inc. | Organotypic pig retina culture system |
| US11364308B2 (en) * | 2016-05-13 | 2022-06-21 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| AU2017302013B2 (en) | 2016-07-29 | 2022-05-26 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CA3040179A1 (en) * | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| JP2020510424A (ja) * | 2017-02-28 | 2020-04-09 | アドヴェラム バイオテクノロジーズ， インコーポレイテッド | 改変ａａｖカプシドおよびその使用 |
-
2020
- 2020-04-23 TW TW113141337A patent/TW202532428A/zh unknown
- 2020-04-23 TW TW109113631A patent/TWI862583B/zh active
- 2020-04-24 WO PCT/US2020/029895 patent/WO2020219933A1/en not_active Ceased
- 2020-04-24 KR KR1020217038123A patent/KR20220004114A/ko active Pending
- 2020-04-24 CN CN202080031274.0A patent/CN113766934B/zh active Active
- 2020-04-24 CN CN202411569264.9A patent/CN119708162A/zh active Pending
- 2020-04-24 US US16/858,042 patent/US11510950B2/en active Active
- 2020-04-24 CA CA3130217A patent/CA3130217A1/en active Pending
- 2020-04-24 AU AU2020262948A patent/AU2020262948A1/en active Pending
- 2020-04-24 BR BR112021020957A patent/BR112021020957A2/pt unknown
- 2020-04-24 JP JP2021561683A patent/JP7623703B2/ja active Active
- 2020-04-24 SG SG11202108928XA patent/SG11202108928XA/en unknown
- 2020-04-24 MX MX2021012311A patent/MX2021012311A/es unknown
- 2020-04-24 EP EP20726600.8A patent/EP3958911A1/en active Pending
-
2021
- 2021-08-19 ZA ZA2021/05975A patent/ZA202105975B/en unknown
- 2021-10-07 MX MX2025015023A patent/MX2025015023A/es unknown
- 2021-10-20 IL IL287438A patent/IL287438A/en unknown
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