KR20220004114A - 유리체내 전달을 위한 변이체 aav 캡시드 - Google Patents

유리체내 전달을 위한 변이체 aav 캡시드 Download PDF

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KR20220004114A
KR20220004114A KR1020217038123A KR20217038123A KR20220004114A KR 20220004114 A KR20220004114 A KR 20220004114A KR 1020217038123 A KR1020217038123 A KR 1020217038123A KR 20217038123 A KR20217038123 A KR 20217038123A KR 20220004114 A KR20220004114 A KR 20220004114A
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aav
gly
thr
ser
capsid protein
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안나히타 케라발라
디아나 케페다
메디 가스미
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애드베룸 바이오테크놀로지스, 인코포레이티드
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Publication of KR20220004114A publication Critical patent/KR20220004114A/ko
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217038123A 2019-04-26 2020-04-24 유리체내 전달을 위한 변이체 aav 캡시드 Pending KR20220004114A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962839548P 2019-04-26 2019-04-26
US62/839,548 2019-04-26
US201962923924P 2019-10-21 2019-10-21
US62/923,924 2019-10-21
PCT/US2020/029895 WO2020219933A1 (en) 2019-04-26 2020-04-24 Variant aav capsids for intravitreal delivery

Publications (1)

Publication Number Publication Date
KR20220004114A true KR20220004114A (ko) 2022-01-11

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KR1020217038123A Pending KR20220004114A (ko) 2019-04-26 2020-04-24 유리체내 전달을 위한 변이체 aav 캡시드

Country Status (14)

Country Link
US (1) US11510950B2 (https=)
EP (1) EP3958911A1 (https=)
JP (1) JP7623703B2 (https=)
KR (1) KR20220004114A (https=)
CN (2) CN113766934B (https=)
AU (1) AU2020262948A1 (https=)
BR (1) BR112021020957A2 (https=)
CA (1) CA3130217A1 (https=)
IL (1) IL287438A (https=)
MX (2) MX2021012311A (https=)
SG (1) SG11202108928XA (https=)
TW (2) TW202532428A (https=)
WO (1) WO2020219933A1 (https=)
ZA (1) ZA202105975B (https=)

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US12480098B1 (en) 2024-10-18 2025-11-25 Aavatar Therapeutics Co., Ltd. Adeno-associated virus variant

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EP3861010A1 (en) 2018-10-02 2021-08-11 Voyager Therapeutics, Inc. Redirection of tropism of aav capsids
CN116096734A (zh) 2020-05-13 2023-05-09 沃雅戈治疗公司 Aav衣壳的向性的重定向
CN115044614B (zh) * 2021-03-09 2023-10-20 上海目镜生物医药科技有限公司 一种用于基因靶向与表达的aav-8型血清型的改造型载体及其构建方法及应用
US12385064B2 (en) * 2021-03-26 2025-08-12 Adverum Biotechnologies, Inc. Intravitreal dosing for delivery of polynucleotides to retinal cones
CN113648432B (zh) * 2021-03-31 2024-01-19 中山大学中山眼科中心 rAAV2/Retro作为针对视网膜感光细胞的递送系统及其在制备治疗视网膜疾病药物中的应用
MX2024004936A (es) 2021-11-02 2024-05-08 Voyager Therapeutics Inc Variantes de capsides de aav y sus usos.
AU2024242380A1 (en) * 2023-03-31 2025-11-06 Exegenesis Bio Singapore Pte. Ltd. Variant aav9 capsid proteins and uses thereof
WO2024211831A1 (en) 2023-04-05 2024-10-10 Adverum Biotechnologies, Inc. Immune landscape signatures for ocular inflammation
AU2024297654A1 (en) 2023-07-13 2026-01-22 Kriya Therapeutics, Inc. Complement pathway inhibitor fusions and methods of using the same
CN117247434B (zh) * 2023-11-10 2024-02-02 上海朗昇生物科技有限公司 衣壳修饰型病毒载体及其制备和用途
CN118955654B (zh) * 2024-10-15 2025-05-16 朗信启昇(苏州)生物制药有限公司 具有变异衣壳的腺相关病毒病毒体及其用途

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Publication number Priority date Publication date Assignee Title
US12480098B1 (en) 2024-10-18 2025-11-25 Aavatar Therapeutics Co., Ltd. Adeno-associated virus variant

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JP2022529775A (ja) 2022-06-24
US20200338146A1 (en) 2020-10-29
TW202106699A (zh) 2021-02-16
JP7623703B2 (ja) 2025-01-29
CA3130217A1 (en) 2020-10-29
IL287438A (en) 2021-12-01
WO2020219933A1 (en) 2020-10-29
MX2025015023A (es) 2026-02-03
US11510950B2 (en) 2022-11-29
TW202532428A (zh) 2025-08-16
AU2020262948A1 (en) 2021-09-30
BR112021020957A2 (pt) 2021-12-14
ZA202105975B (en) 2024-12-18
CN113766934B (zh) 2024-11-08
CN119708162A (zh) 2025-03-28
SG11202108928XA (en) 2021-09-29
TWI862583B (zh) 2024-11-21
MX2021012311A (es) 2021-11-12
EP3958911A1 (en) 2022-03-02
CN113766934A (zh) 2021-12-07

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