JP2022528067A5 - - Google Patents

Info

Publication number
JP2022528067A5
JP2022528067A5 JP2021557277A JP2021557277A JP2022528067A5 JP 2022528067 A5 JP2022528067 A5 JP 2022528067A5 JP 2021557277 A JP2021557277 A JP 2021557277A JP 2021557277 A JP2021557277 A JP 2021557277A JP 2022528067 A5 JP2022528067 A5 JP 2022528067A5
Authority
JP
Japan
Prior art keywords
amino acid
antibody
item
heavy chain
functional fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021557277A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022528067A (ja
JP7607579B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/NL2020/050217 external-priority patent/WO2020197400A1/en
Publication of JP2022528067A publication Critical patent/JP2022528067A/ja
Publication of JP2022528067A5 publication Critical patent/JP2022528067A5/ja
Application granted granted Critical
Publication of JP7607579B2 publication Critical patent/JP7607579B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021557277A 2019-03-27 2020-03-27 工学的に操作されたIgA抗体および使用方法 Active JP7607579B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962824864P 2019-03-27 2019-03-27
US62/824,864 2019-03-27
PCT/NL2020/050217 WO2020197400A1 (en) 2019-03-27 2020-03-27 Engineered iga antibodies and methods of use

Publications (3)

Publication Number Publication Date
JP2022528067A JP2022528067A (ja) 2022-06-08
JP2022528067A5 true JP2022528067A5 (enExample) 2023-04-04
JP7607579B2 JP7607579B2 (ja) 2024-12-27

Family

ID=70190056

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021557277A Active JP7607579B2 (ja) 2019-03-27 2020-03-27 工学的に操作されたIgA抗体および使用方法

Country Status (10)

Country Link
US (4) US11091562B2 (enExample)
EP (1) EP3947441A1 (enExample)
JP (1) JP7607579B2 (enExample)
KR (1) KR20220004979A (enExample)
CN (1) CN114096559B (enExample)
AU (1) AU2020248645B2 (enExample)
CA (1) CA3131705A1 (enExample)
IL (1) IL286641B2 (enExample)
SG (1) SG11202110626SA (enExample)
WO (1) WO2020197400A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12139536B2 (en) * 2017-06-08 2024-11-12 Antibody Biopharm Inc. Guided combinational therapeutic antibody
SG11202107981VA (en) * 2019-01-22 2021-08-30 Genentech Inc Immunoglobulin a antibodies and methods of production and use
CA3131705A1 (en) * 2019-03-27 2020-10-01 Umc Utrecht Holding B.V. Engineered iga antibodies and methods of use
WO2021220218A1 (en) * 2020-05-01 2021-11-04 Novartis Ag Immunoglobulin variants
CN118541392A (zh) 2021-09-28 2024-08-23 准星生物医药有限公司 多种形式的分子复合物
AU2023320547A1 (en) * 2022-08-04 2025-02-06 Lyell Immunopharma, Inc. Methods of manufacturing chimeric antigen receptor t cells
US20240316200A1 (en) * 2023-03-21 2024-09-26 Lung Biotechnology Pbc Bicistronic constructs for allogeneic gene therapy
AU2024315062A1 (en) * 2023-07-28 2026-03-12 Tigatx, Inc. Engineered iga antibodies and methods of use
WO2026123336A1 (en) * 2024-12-13 2026-06-18 The University Of Sydney Conjugates and uses thereof
CN120141946B (zh) * 2025-05-16 2025-08-12 杭州市北京航空航天大学国际创新研究院(北京航空航天大学国际创新学院) 一种用于大气中二氧化硫硫同位素测量的采集装置及分析方法

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US670417A (en) 1899-08-30 1901-03-26 Cronk Hanger Co Hand-rake.
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
JPS63502716A (ja) 1986-03-07 1988-10-13 マサチューセッツ・インステチュート・オブ・テクノロジー 糖タンパク安定性の強化方法
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
DE3889853D1 (de) 1987-11-05 1994-07-07 Hybritech Inc Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
ATE139900T1 (de) 1992-11-13 1996-07-15 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
WO1994012520A1 (en) 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
US5747654A (en) 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
US5443953A (en) 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US8236561B2 (en) 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
HK1049170A1 (zh) 1999-07-30 2003-05-02 Medarex, Inc. 包含抗-fc受體粘結劑的治療混合物
ES2376454T3 (es) 2000-12-22 2012-03-14 Grad, Carole, Legal Representative Of Howard, Kaplan Librer�?as de expresión en fago de fragmentos vh humanos.
US20030022243A1 (en) 2001-06-20 2003-01-30 Les Kondejewski Protein aggregation assays and uses thereof
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
JP4583168B2 (ja) 2002-06-03 2010-11-17 ザ インスティテュート フォー システムズ バイオロジー 糖タンパク質を定量的プロテオ−ム分析する方法
JP5087274B2 (ja) 2003-06-30 2012-12-05 ドマンティス リミテッド ポリペプチド
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
US7894724B2 (en) 2005-03-31 2011-02-22 Ciena Corporation Method and apparatus for improving dual-polarization optical communication performance
DK1999154T3 (da) 2006-03-24 2012-12-03 Merck Patent Gmbh Fremstillede heterodimere proteindomæner
EP1916257A1 (en) 2006-10-27 2008-04-30 Charite-Universitätsmedizin Berlin GD2 peptide mimotopes for anticancer vaccination
US8313730B2 (en) 2006-12-13 2012-11-20 Michael R. Simon Treatment of celiac disease with IgA
JP5675109B2 (ja) 2007-02-20 2015-02-25 アナプティスバイオ インコーポレイティッド ライブラリーの生成方法及びその使用
GB0812478D0 (en) 2008-07-09 2008-08-13 Rolls Royce Plc An apparatus and a method of measuring erosion of an edge of a turbomachine aerofoil
US10407513B2 (en) 2008-09-26 2019-09-10 Ucb Biopharma Sprl Biological products
AU2015200990B2 (en) * 2009-03-20 2016-07-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Optimized Fc variants
WO2010127369A1 (en) 2009-05-01 2010-11-04 Rational Biotechnology Inc. Eit (electrical impedance tomography) guided sonoporation, ultrasound tissue ablation and their use thereof
CN102549016B (zh) * 2009-06-30 2015-05-06 研究发展基金会 免疫球蛋白fc多肽
EP2578681B1 (en) 2010-05-24 2015-07-01 Kagoshima University Iga-binding peptide and iga purification using same
CN105859889B (zh) * 2010-11-17 2020-01-07 中外制药株式会社 具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
EP2465536A1 (en) 2010-12-14 2012-06-20 CSL Behring AG CD89 activation in therapy
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
WO2013087914A1 (en) 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
EP2636681A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Process for enriching IgA
CN104254542A (zh) 2012-03-09 2014-12-31 瑞士杰特贝林生物制品有限公司 包含分泌-样免疫球蛋白的组合物
FI3366705T3 (fi) * 2012-09-12 2023-07-28 Genzyme Corp Muuttuneen glykosylaation ja vähentyneen efektoritoiminnan omaavia fc:n sisältäviä polypeptidejä
EP2912058A1 (en) 2012-10-23 2015-09-02 The Board of Regents of The University of Texas System Antibodies with engineered igg fc domains
RU2693078C2 (ru) 2012-12-03 2019-07-01 Новиммун С.А. Анти-cd47 антитела и способы их применения
US20150263589A1 (en) 2014-03-11 2015-09-17 Varnell M. Castor Rail Barrel Direct Energy Transferor Piezoelectricity (RBDETP)
WO2015138600A2 (en) 2014-03-11 2015-09-17 The Board Of Trustees Of The Leland Stanford Junior University Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies
JP6564777B2 (ja) 2014-07-18 2019-08-21 国立感染症研究所長 多量体IgA型遺伝子組換え抗体を含む組成物及びその利用
CA3035427A1 (en) 2016-09-01 2018-03-08 Umc Utrecht Holding B.V. Cd20 antibodies
WO2019022600A1 (en) 2017-07-24 2019-01-31 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis TREATMENT OF PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA INTERACTION - CD47
JP2020534370A (ja) * 2017-09-21 2020-11-26 ユーエムセー ユトレヒト ホールディング ベイフェイUMC Utrecht Holding B.V. 神経芽腫の治療のための抗gd2抗体
GB2596411B (en) * 2018-10-29 2023-09-20 Tigatx Inc Compositions and methods comprising IgA antibody constructs
SG11202107981VA (en) 2019-01-22 2021-08-30 Genentech Inc Immunoglobulin a antibodies and methods of production and use
CA3131705A1 (en) * 2019-03-27 2020-10-01 Umc Utrecht Holding B.V. Engineered iga antibodies and methods of use

Similar Documents

Publication Publication Date Title
JP7273101B2 (ja) Cd38に結合する抗体治療剤
JP7379446B2 (ja) ヒトcd3結合抗体
JP7840511B2 (ja) 抗クローディン18抗体及びそれらの使用の方法
US11472880B2 (en) Humanized antibodies for CD3
JP7397882B2 (ja) 二重特異性抗体及びその調製方法、使用
CN104271602B (zh) 双特异性抗体
WO2015156268A1 (ja) 免疫活性化抗原結合分子
JP2023159380A (ja) PD-1とTGF-betaを標的とした四価二重特異性抗体、その製造方法および用途
JP7851303B2 (ja) ヒトcd3イプシロンに結合する新規なヒト抗体
CN116490210A (zh) Cd70抗体及其应用
CN119371536A (zh) 抗体和使用方法
JP2025083342A (ja) TGF-βRII結合タンパク質
WO2017162733A1 (en) Iga antibodies with enhanced stability
EP4714975A1 (en) Antibody binding lilrb4 and cd3, and use thereof
JP2024508597A5 (enExample)
CN115698066A (zh) 抗cd47抗体及其用途
EP4114373A1 (en) Anti-cd19 antibodies and methods of using and making thereof