|
JPH0739379B2
(ja)
|
1988-12-28 |
1995-05-01 |
クリンゲ・ファルマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
トランス‐1,1,2‐トリフェニル―ブト‐1‐エン誘導体の製造方法
|
|
PL1633724T3
(pl)
|
2003-03-12 |
2011-10-31 |
Kudos Pharm Ltd |
Pochodne ftalazynonu
|
|
CA2808646C
(en)
|
2003-09-17 |
2016-08-23 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Thalidomide analogs as tnf-alpha modulators
|
|
CA2580833C
(en)
|
2004-09-22 |
2010-12-21 |
Pfizer, Inc. |
Method of preparing poly(adp-ribose) polymerases inhibitors
|
|
BRPI0806245B1
(pt)
|
2007-01-10 |
2022-01-25 |
Msd Italia S.R.L. |
Compostos de fórmula i e seus usos
|
|
CA2681633C
(en)
|
2007-03-20 |
2018-01-09 |
Celgene Corporation |
4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
|
|
TWI389893B
(zh)
|
2007-07-06 |
2013-03-21 |
Astellas Pharma Inc |
二(芳胺基)芳基化合物
|
|
EP2188292B1
(en)
|
2007-08-08 |
2013-05-29 |
GlaxoSmithKline Intellectual Property Development Limited |
2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d]pyrimidin-4-yl) amino]benzamide derivatives as igf-1r inhibitors for the treatment of cancer
|
|
JP2011523646A
(ja)
|
2008-05-21 |
2011-08-18 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
キナーゼ阻害剤としてのリン誘導体
|
|
ES2668775T3
(es)
|
2009-06-10 |
2018-05-22 |
Chugai Seiyaku Kabushiki Kaisha |
Compuestos tetracíclicos
|
|
SG183257A1
(en)
|
2010-02-11 |
2012-09-27 |
Celgene Corp |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
|
UY33539A
(es)
|
2010-08-02 |
2012-02-29 |
Astrazeneca Ab |
Compuestos químicos alk
|
|
EP2625176B1
(en)
|
2010-10-08 |
2016-08-17 |
Xcovery Holding Company LLC |
Substitututed 6-amino-pyridazin-3-yl-carboxamide compounds as protein kinase modulators
|
|
US8927725B2
(en)
*
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
|
GB201311891D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compound
|
|
CN103396397A
(zh)
|
2013-08-14 |
2013-11-20 |
中国人民解放军军事医学科学院毒物药物研究所 |
来那度胺衍生物及其作为药物的用途
|
|
CN103787802B
(zh)
*
|
2014-02-11 |
2015-08-19 |
华东师范大学 |
一类芳基烷基硫醚化合物及其合成方法
|
|
EP4649963A3
(en)
|
2014-04-14 |
2026-05-13 |
Arvinas Operations, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
US20160022642A1
(en)
|
2014-07-25 |
2016-01-28 |
Yale University |
Compounds Useful for Promoting Protein Degradation and Methods Using Same
|
|
AU2015305449B2
(en)
*
|
2014-08-22 |
2021-05-06 |
Celgene Corporation |
Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
|
|
NZ731789A
(en)
|
2014-10-30 |
2019-04-26 |
Kangpu Biopharmaceuticals Ltd |
Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
|
|
CA2988414C
(en)
|
2015-06-04 |
2023-09-26 |
Arvinas, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
BR112018008918A8
(pt)
|
2015-11-02 |
2019-02-26 |
Univ Yale |
compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos
|
|
WO2017117474A1
(en)
|
2015-12-30 |
2017-07-06 |
Dana-Farber Cancer Institute, Inc. |
Bifunctional compounds for her3 degradation and methods of use
|
|
AU2017246452C1
(en)
|
2016-04-06 |
2021-06-03 |
The Regents Of The University Of Michigan |
MDM2 protein degraders
|
|
EP3440082A1
(en)
|
2016-04-06 |
2019-02-13 |
The Regents of The University of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
|
WO2017185031A1
(en)
|
2016-04-22 |
2017-10-26 |
Dana-Farber Cancer Institute, Inc. |
Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
|
|
WO2017185036A1
(en)
|
2016-04-22 |
2017-10-26 |
Dana Farber Cancer Institute, Inc. |
Bifunctional molecules for degradation of egfr and methods of use
|
|
CN121974842A
(zh)
|
2016-05-10 |
2026-05-05 |
C4医药公司 |
用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
|
|
WO2017197056A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Bromodomain targeting degronimers for target protein degradation
|
|
CN106432104A
(zh)
|
2016-05-16 |
2017-02-22 |
大连医科大学 |
金刚烷基喹唑啉化合物、组合物及其用途
|
|
CA3036834A1
(en)
|
2016-09-13 |
2018-03-22 |
The Regents Of The University Of Michigan |
Fused 1,4-oxazepines as bet protein degraders
|
|
ES2857743T3
(es)
|
2016-09-13 |
2021-09-29 |
Univ Michigan Regents |
1,4-diazepinas fusionadas como degradadores de proteína BET
|
|
SI3526202T1
(sl)
|
2016-10-11 |
2025-04-30 |
Arvinas Operations, Inc. |
Spojine in postopki za ciljno razgradnjo androgenskih receptorjev
|
|
MX2019005007A
(es)
|
2016-11-01 |
2019-07-18 |
Arvinas Inc |
Protac dirigidos a la proteína tau y métodos asociados de uso.
|
|
CA3042294A1
(en)
|
2016-11-22 |
2018-05-31 |
Dana-Farber Cancer Institute, Inc. |
Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
|
|
IL266842B
(en)
|
2016-12-01 |
2022-09-01 |
Arvinas Operations Inc |
History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists
|
|
IL325835A
(en)
|
2016-12-23 |
2026-03-01 |
Univ Yale |
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
|
CN110753693A
(zh)
|
2016-12-23 |
2020-02-04 |
阿尔维纳斯运营股份有限公司 |
Egfr蛋白水解靶向嵌合分子和相关使用方法
|
|
IL300417A
(en)
|
2017-01-26 |
2023-04-01 |
Arvinas Operations Inc |
Bifunctional benzothiophene compounds, preparations containing them and their use in therapy
|
|
TWI793151B
(zh)
|
2017-08-23 |
2023-02-21 |
瑞士商諾華公司 |
3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
|
|
SG11202003415XA
(en)
|
2017-10-18 |
2020-05-28 |
Novartis Ag |
Compositions and methods for selective protein degradation
|
|
WO2019114770A1
(zh)
|
2017-12-13 |
2019-06-20 |
上海科技大学 |
Alk蛋白降解剂及其抗肿瘤应用
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
BR112020020307A2
(pt)
|
2018-04-04 |
2021-01-12 |
Arvinas Operations, Inc. |
Moduladores de proteólise e métodos de uso associados
|
|
EP3778590A4
(en)
*
|
2018-04-09 |
2021-12-22 |
ShanghaiTech University |
ANTI PROTEIN DEGRADATION COMPOUND, ANTITUMOR APPLICATION, INTERMEDIATE THEREOF, AND INTERMEDIATE USE
|
|
AU2019294835B2
(en)
|
2018-06-29 |
2025-04-17 |
Dana-Farber Cancer Institute, Inc. |
Ligands to cereblon (CRBN)
|
|
CA3121667A1
(en)
|
2018-09-30 |
2020-04-02 |
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences |
Isoindoline compound, preparation method, pharmaceutical composition and use thereof
|
|
AU2019392231B2
(en)
|
2018-12-06 |
2022-10-20 |
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences |
Isoindoline compound, and preparation method, pharmaceutical composition, and application of isoindoline compound
|
|
EP3932922A4
(en)
|
2019-02-25 |
2022-05-11 |
ShanghaiTech University |
SULPHUR-CONTAINING COMPOUND BASED ON A GLUTARIMIDE FRAMEWORK AND ITS USE
|
|
CN109928956B
(zh)
|
2019-02-27 |
2020-10-13 |
杭州偶联医药科技有限公司 |
一种靶向泛素化降解egfr蛋白的化合物及其药物组合物和应用
|
|
KR20220009941A
(ko)
|
2019-03-26 |
2022-01-25 |
더 리젠츠 오브 더 유니버시티 오브 미시간 |
Stat3의 저분자 분해제
|
|
CN110204532B
(zh)
|
2019-05-15 |
2022-03-08 |
浙江工业大学 |
一种靶向egfr蛋白降解的化合物及其制备方法和应用
|
|
WO2021023233A1
(zh)
*
|
2019-08-05 |
2021-02-11 |
上海科技大学 |
Egfr蛋白降解剂及其抗肿瘤应用
|
|
CN110512980B
(zh)
|
2019-09-27 |
2024-08-30 |
苏州光格科技股份有限公司 |
一种防火门自动控制装置
|
|
CA3160713A1
(en)
|
2019-12-04 |
2021-06-10 |
Nurix Therapeutics, Inc. |
Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
|
|
CN115003295B
(zh)
|
2019-12-12 |
2025-05-06 |
冰洲石生物科技公司 |
具有雌激素受体降解活性的新型色满衍生物及其用途
|
|
AU2021226514B2
(en)
*
|
2020-02-25 |
2023-10-19 |
Shanghaitech University |
Glutarimide skeleton-based compounds and application thereof
|
|
EP4144728A4
(en)
*
|
2020-04-30 |
2023-08-23 |
Shanghaitech University |
HETEROCYCLIC COMPOUND BASED ON A GLUTARIMIDE SKELETON AND USES THEREOF
|