JP2022512830A5 - - Google Patents
Info
- Publication number
- JP2022512830A5 JP2022512830A5 JP2021523064A JP2021523064A JP2022512830A5 JP 2022512830 A5 JP2022512830 A5 JP 2022512830A5 JP 2021523064 A JP2021523064 A JP 2021523064A JP 2021523064 A JP2021523064 A JP 2021523064A JP 2022512830 A5 JP2022512830 A5 JP 2022512830A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkylene
- antibody
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382759.1 | 2018-10-25 | ||
| EP18382759 | 2018-10-25 | ||
| PCT/EP2019/079188 WO2020084115A1 (en) | 2018-10-25 | 2019-10-25 | Antibody drug conjugates comprising ecteinascidin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512830A JP2022512830A (ja) | 2022-02-07 |
| JP2022512830A5 true JP2022512830A5 (cg-RX-API-DMAC10.html) | 2024-03-21 |
| JP7629400B2 JP7629400B2 (ja) | 2025-02-13 |
Family
ID=64426824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523064A Active JP7629400B2 (ja) | 2018-10-25 | 2019-10-25 | エクテナサイジン誘導体を含む薬物抗体複合体 |
Country Status (37)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3615544T (lt) * | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
| WO2021218896A1 (zh) * | 2020-04-26 | 2021-11-04 | 江苏恒瑞医药股份有限公司 | 海鞘素类衍生物及其制备方法与医药用途 |
| US11124568B1 (en) * | 2020-08-19 | 2021-09-21 | Vitruviae LLC | CD3/CD25 antibodies for neuro-immune diseases |
| IL308389A (en) * | 2021-05-19 | 2024-01-01 | Pharma Mar Sa | Dosing regimens for acubactadine |
| KR102625740B1 (ko) * | 2021-07-15 | 2024-01-17 | 주식회사 새한비엠 | 폐수지 재료 및 미네랄 바인더를 이용한 단열차음재의 제조 방법 및 그 단열차음재 |
| KR20250079227A (ko) * | 2022-10-25 | 2025-06-04 | 머크 샤프 앤드 돔 엘엘씨 | 엑사테칸-유래 adc 링커-페이로드, 제약 조성물, 및 그의 용도 |
| WO2024155565A2 (en) * | 2023-01-17 | 2024-07-25 | Yarrow Therapeutics, Inc. | Ecteinascidin derivative antibody drug conjugates |
| WO2024186263A1 (en) | 2023-03-07 | 2024-09-12 | Axcynsis Therapeutics Pte. Ltd. | Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives |
| CN118878690B (zh) * | 2023-11-28 | 2026-01-09 | 南京大学 | 一种抗地高辛纳米抗体的制备及其应用 |
| WO2025228595A1 (en) * | 2024-04-30 | 2025-11-06 | Pharma Mar, S.A. | Use of compound ia in the treatment of cancers including combination therapy with atezolizumab. |
| WO2025228597A1 (en) * | 2024-04-30 | 2025-11-06 | Pharma Mar, S.A. | Combination of compound ia and a topoisomerase i inhibitor in the treatment of cancer |
| WO2025233522A1 (en) * | 2024-05-10 | 2025-11-13 | Pharma Mar, S.A. | Synthetic process for an ecteinascidin |
| WO2026098196A1 (zh) * | 2024-11-08 | 2026-05-15 | 映恩生物科技(上海)有限公司 | 海鞘素类化合物、其偶联物及其制备方法和用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| DE69308573T2 (de) | 1992-08-17 | 1997-08-07 | Genentech Inc | Bispezifische immunoadhesine |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| ES2369542T3 (es) | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa. |
| US7662387B2 (en) | 2003-02-20 | 2010-02-16 | Seattle Genetics | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| AU2005281359A1 (en) | 2004-08-26 | 2006-03-16 | Apparao Satyam | Prodrugs and codrugs containing novel bio-cleavable disulfide linkers |
| JP4993645B2 (ja) | 2004-12-01 | 2012-08-08 | ジェネンテック， インコーポレイテッド | 抗体薬剤結合体および方法 |
| US7811572B2 (en) | 2005-08-24 | 2010-10-12 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| EP1864682A1 (en) | 2006-06-09 | 2007-12-12 | Sanofi-Aventis | Leptomycin derivatives |
| EP2404912A3 (en) | 2006-06-16 | 2012-07-25 | Pharma Mar S.A. | Process and intermediates for the preparation of antitumoral dihydropyran-2-one compounds |
| HRP20140015T1 (hr) | 2007-12-20 | 2014-02-14 | Pharma Mar, S.A. | Antitumorski spojevi |
| MY155653A (en) | 2008-05-23 | 2015-11-13 | Wyeth Llc | Triazine compounds as p13 kinase and mtor inhibitors |
| AU2009270988A1 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
| WO2010149688A2 (en) | 2009-06-24 | 2010-12-29 | Pharma Mar, S.A. | Antitumoral compounds |
| WO2011147828A1 (en) | 2010-05-25 | 2011-12-01 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| GB201506405D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| IT201700041639A1 (it) | 2017-04-13 | 2018-10-13 | M C Automations S R L | Dispositivo di trasferimento per macchine incartatrici di prodotti dolciari |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
| CR20220581A (es) * | 2020-04-21 | 2023-01-09 | Pharma Mar Sa | Conjugados de anticuerpos de fármacos |
-
2019
- 2019-10-23 TW TW108138205A patent/TWI824043B/zh active
- 2019-10-24 AR ARP190103069A patent/AR117657A1/es unknown
- 2019-10-25 EP EP19790550.8A patent/EP3870234B1/en active Active
- 2019-10-25 UA UAA202102699A patent/UA129803C2/uk unknown
- 2019-10-25 BR BR112021007718-9A patent/BR112021007718A2/pt unknown
- 2019-10-25 JP JP2021523064A patent/JP7629400B2/ja active Active
- 2019-10-25 SG SG11202104154WA patent/SG11202104154WA/en unknown
- 2019-10-25 KR KR1020217015900A patent/KR20210086669A/ko active Pending
- 2019-10-25 PL PL19790550.8T patent/PL3870234T3/pl unknown
- 2019-10-25 HU HUE19790550A patent/HUE061606T2/hu unknown
- 2019-10-25 PT PT197905508T patent/PT3870234T/pt unknown
- 2019-10-25 LT LTEPPCT/EP2019/079188T patent/LT3870234T/lt unknown
- 2019-10-25 IL IL282577A patent/IL282577B2/en unknown
- 2019-10-25 ES ES19790550T patent/ES2939494T3/es active Active
- 2019-10-25 FI FIEP19790550.8T patent/FI3870234T3/fi active
- 2019-10-25 SI SI201930466T patent/SI3870234T1/sl unknown
- 2019-10-25 MA MA59661A patent/MA59661B1/fr unknown
- 2019-10-25 US US17/288,567 patent/US12653900B2/en active Active
- 2019-10-25 DK DK19790550.8T patent/DK3870234T3/da active
- 2019-10-25 AU AU2019368687A patent/AU2019368687B2/en active Active
- 2019-10-25 CN CN201980084790.7A patent/CN113226377B/zh active Active
- 2019-10-25 MD MDE20210819T patent/MD3870234T2/ro unknown
- 2019-10-25 WO PCT/EP2019/079188 patent/WO2020084115A1/en not_active Ceased
- 2019-10-25 RS RS20230219A patent/RS64068B1/sr unknown
- 2019-10-25 EA EA202191131A patent/EA202191131A1/ru unknown
- 2019-10-25 MY MYPI2021002234A patent/MY206221A/en unknown
- 2019-10-25 HR HRP20230275TT patent/HRP20230275T1/hr unknown
- 2019-10-25 MX MX2021004746A patent/MX2021004746A/es unknown
- 2019-10-25 SM SM20230076T patent/SMT202300076T1/it unknown
- 2019-10-25 CA CA3117268A patent/CA3117268C/en active Active
-
2021
- 2021-04-22 CL CL2021001039A patent/CL2021001039A1/es unknown
- 2021-04-23 PH PH12021550930A patent/PH12021550930A1/en unknown
- 2021-04-25 JO JOJO/P/2021/0083A patent/JOP20210083B1/ar active
- 2021-04-25 SA SA521421855A patent/SA521421855B1/ar unknown
- 2021-05-20 EC ECSENADI202135414A patent/ECSP21035414A/es unknown
- 2021-05-21 ZA ZA2021/03478A patent/ZA202103478B/en unknown
- 2021-05-24 CO CONC2021/0006838A patent/CO2021006838A2/es unknown
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